1 00:00:00,000 --> 00:00:07,080 Hello, I'm Kenna. I'm Koelle and welcome back to diagnosing a killer of the mental breakdown 2 00:00:07,200 --> 00:00:09,200 The mental breakdown 3 00:00:09,960 --> 00:00:11,960 Mindel breakdown 4 00:00:12,800 --> 00:00:14,800 Wish they could have seen your face 5 00:00:14,800 --> 00:00:44,280 So we're back today with another mental breakdown for you all I have something a little 6 00:00:44,280 --> 00:01:08,280 different today it's not a typical mental breakdown like we do we usually pinpoint a specific mental disorder this doesn't have really much to do with mental disorders but it does have a lot to do with how drugs affect the brain and the body 7 00:01:08,280 --> 00:01:21,280 So I decided to research the top 10 most dangerous drugs in the United States so these are all United States statistics and we're gonna count down from 10 to 1. 8 00:01:21,280 --> 00:01:24,280 You know we like a good countdown. Oh love a good countdown. 9 00:01:24,280 --> 00:01:28,280 Coming into the top one of the top 10. 10 00:01:28,280 --> 00:01:38,280 So we're just gonna go ahead and get right on into it. A lot of this I will say is I don't want to say common knowledge but you might know a lot of the things that I'm gonna talk about. 11 00:01:38,280 --> 00:01:43,280 So we're gonna get into it and we're just gonna act like nobody knows anything about drugs at all. 12 00:01:43,280 --> 00:01:47,280 Okay, we're all straight edge. We've never used drugs before. 13 00:01:47,280 --> 00:01:59,280 Okay, okay so number 10 on our countdown is diazepam more commonly referred to as benzo diazepines or benzos which is the street name I guess. 14 00:01:59,280 --> 00:02:01,280 That's the cool name. 15 00:02:01,280 --> 00:02:10,280 Yeah and brand names for this drug range from I think it's distat diazepam intensil and valium. Valium is the most I think common of those. 16 00:02:10,280 --> 00:02:20,280 Other types of the drug that are prescribed are known as Xanax, Kalanipin, Ativan, Resturil, and Halicin and Liberia. 17 00:02:20,280 --> 00:02:23,280 Liberia? Where are you from? I can't understand. 18 00:02:23,280 --> 00:02:27,280 So all these words that we probably have heard before. 19 00:02:27,280 --> 00:02:33,280 Those are all like the brand names, bunch of different but they're all the same. They're all opioid. 20 00:02:33,280 --> 00:02:45,280 This drug is one of the most commonly prescribed in the US and it's typically used to treat anxiety disorders, panic attacks, and even seizures because it actually has a calming effect on the brain for people that need to have it. 21 00:02:45,280 --> 00:02:52,280 It's like a chemical imbalance. If they're prescribed this it's for a reason. It's not gonna calm an effect for everybody that takes it. 22 00:02:52,280 --> 00:03:00,280 So benzos are a group of psychoactive drugs that can change an individual's mental state affecting the way the brain and the nervous system work. 23 00:03:00,280 --> 00:03:08,280 These drugs are also depressants so they're used to slow down the activity in the central nervous system, therefore reducing feelings of uneasiness and tension. 24 00:03:08,280 --> 00:03:16,280 Okay. You would see how someone would maybe abuse these drugs because it gives them a calming sensation or like a downer or whatever. 25 00:03:16,280 --> 00:03:28,280 Exactly. But then that's where it becomes dangerous and scary because let's say I'm prescribed this for a reason and I am expressing to you how, oh wow, it makes me feel so good, like it makes me calm, but you don't need it. 26 00:03:28,280 --> 00:03:35,280 So when you take it, it might have an alternative effect on you and even though it works for me, it might not do the same thing to someone else. 27 00:03:35,280 --> 00:03:39,280 Which is why it's really important to not take anybody else's prescriptions, kids. 28 00:03:39,280 --> 00:03:43,280 Never done that. 29 00:03:43,280 --> 00:03:50,280 Unfortunately, long-term use of the drugs can have negative effects on the brain and can actually become pretty harmful of abuse, like we just said. 30 00:03:50,280 --> 00:04:01,280 Taking these drugs in larger doses than prescribed or recreationally using them can cause mental confusion, memory issues, permanent brain changes, and even an increased risk of dementia and Alzheimer's. 31 00:04:01,280 --> 00:04:02,280 What? 32 00:04:02,280 --> 00:04:05,280 Yeah. Because it messes with the white matter in your brain. 33 00:04:05,280 --> 00:04:06,280 Oh. 34 00:04:06,280 --> 00:04:07,280 We'll get into that later. 35 00:04:07,280 --> 00:04:21,280 This drug can also quickly become addictive if abused. When abused, this drug tranquilizes and sedates the brain and increases the amount of gamma, amyobutric acid, or GABA in the brain. 36 00:04:21,280 --> 00:04:22,280 Good job. 37 00:04:22,280 --> 00:04:23,280 Thank you. 38 00:04:23,280 --> 00:04:30,280 So GABA is a chemical messenger in the brain that blocks certain chemicals and slows down nerve impulses, again, therefore making you calm. 39 00:04:30,280 --> 00:04:40,280 Excess use of these drugs can lead to memory challenges, decreased emotional regulation, impulsive behavior, labored... Jesus, labored... 40 00:04:40,280 --> 00:04:41,280 Labored. 41 00:04:41,280 --> 00:04:44,280 Impulsive behavior, labored breathing, etc. 42 00:04:44,280 --> 00:04:51,280 As the brain becomes used to the increased levels of GABA produced by the drug, it actually stops producing the GABA on its own. 43 00:04:51,280 --> 00:04:58,280 So when this happens, the user begins to feel more anxious, stressed, and fearful than when they did before taking the drug, encouraging them to take more. 44 00:04:58,280 --> 00:04:59,280 Oh my gosh. 45 00:04:59,280 --> 00:05:00,280 It literally rewires your brain. 46 00:05:00,280 --> 00:05:01,280 That is scary. 47 00:05:01,280 --> 00:05:02,280 It is scary. 48 00:05:02,280 --> 00:05:09,280 This can actually trigger an elevated heart rate, insomnia, panic attacks, paranoia, mood swings, and even hallucinations. 49 00:05:09,280 --> 00:05:11,280 Yeah, that sounds like a great train to be on. 50 00:05:11,280 --> 00:05:12,280 Just give me some of those. 51 00:05:12,280 --> 00:05:13,280 Seriously. 52 00:05:13,280 --> 00:05:14,280 No. 53 00:05:14,280 --> 00:05:21,280 High doses of this drug consumed over a long period of time can also cause brain damage similar to that caused by alcoholism. 54 00:05:21,280 --> 00:05:29,280 These symptoms can include memory loss, difficulty completing familiar tasks, poor judgment, loss of inhibition, and difficulty processing new information. 55 00:05:29,280 --> 00:05:33,280 So it literally gives you short-term memory loss if you abuse this drug. 56 00:05:33,280 --> 00:05:34,280 That's crazy. 57 00:05:34,280 --> 00:05:35,280 Or it can. 58 00:05:35,280 --> 00:05:44,280 All in all, this drug is super common again for prescription, and it will work for people to which it's prescribed for, but recreational use is just not a good idea, especially long-term. 59 00:05:44,280 --> 00:05:47,280 Coming in at number nine. 60 00:05:47,280 --> 00:05:49,280 How was it? 61 00:05:49,280 --> 00:05:51,280 You may have heard this one before. 62 00:05:51,280 --> 00:05:53,280 It is called hydrocodone. 63 00:05:53,280 --> 00:06:01,280 Hydrocodone is an opioid, similarly to the last one, that is used to treat pain and also serves as a cough suppressant, which I did not know. 64 00:06:01,280 --> 00:06:02,280 I didn't know that. 65 00:06:02,280 --> 00:06:04,280 I did not know that. 66 00:06:04,280 --> 00:06:09,280 It's usually given as the combination, I also didn't know this, of acetaminophen, which is Tylenol. 67 00:06:09,280 --> 00:06:14,280 So it's a pill that has acetaminophen and hydrocodone, or ibuprofen and hydrocodone. 68 00:06:14,280 --> 00:06:17,280 So it's a combination of a painkiller and a cough suppressant. 69 00:06:17,280 --> 00:06:18,280 Interesting. 70 00:06:18,280 --> 00:06:19,280 I don't know. 71 00:06:19,280 --> 00:06:24,280 So I guess you would maybe be prescribed that then if you had the flu or something, essentially. 72 00:06:24,280 --> 00:06:25,280 Yes, you could. 73 00:06:25,280 --> 00:06:29,280 Like if you have body aches and pains, also if you have a really nasty cough. 74 00:06:29,280 --> 00:06:38,280 Yes, it's also prescribed for pain severe enough to require an opioid, and it's in combination with homotrophine methyl bromine to relieve the cough. 75 00:06:38,280 --> 00:06:40,280 That's what the drug is that relieves the cough. 76 00:06:40,280 --> 00:06:41,280 Interesting. 77 00:06:41,280 --> 00:06:43,280 See, I knew about the pain relief, but cough suppressant. 78 00:06:43,280 --> 00:06:52,280 Well, when you think of someone being prescribed hydrocodone, it's usually after a dental procedure or a surgery or something traumatic, injury-wise. 79 00:06:52,280 --> 00:06:59,280 The effects of hydrocodone are similar to those of morphine and heroin, because all three drugs interact with the same part of the brain. 80 00:06:59,280 --> 00:07:00,280 Hmm. 81 00:07:00,280 --> 00:07:11,280 Hydrocodone also interacts with the brain's reward system, which reinforces continued use by allowing the body to adjust to its presence, and in short time, come to depend on it, similarly to number 10. 82 00:07:11,280 --> 00:07:13,280 Long term addiction to hydrocodone... 83 00:07:13,280 --> 00:07:14,280 Hydrocodone. 84 00:07:14,280 --> 00:07:15,280 Hydrocodone. 85 00:07:15,280 --> 00:07:16,280 Are you itchy? 86 00:07:16,280 --> 00:07:17,280 Are you itchy? 87 00:07:17,280 --> 00:07:19,280 Do you experience itch? 88 00:07:19,280 --> 00:07:37,280 Long term addiction to hydrocodone can lead to severe health consequences, especially because, over time, the drug affects the user's ability to feel pain, and therefore, they don't know that they're as ill as they are, and many times, individuals will not become aware that they have these health issues until they're in detox. 89 00:07:37,280 --> 00:07:43,280 So they could have a serious illness or injury, and the drug will just mask it, and they won't even be able to feel it. 90 00:07:43,280 --> 00:07:56,280 Like, their kidneys could be giving out, or like, well, because your body, you know, your kidneys, you know, everybody knows, I think, that your kidneys and your liver process, all that stuff, so if there was damage done to any of those organs, you might not even know. 91 00:07:56,280 --> 00:08:00,280 Well, if you have a kidney infection or something because of it, you won't even know, because it's killing the pain. 92 00:08:00,280 --> 00:08:01,280 That's so scary. 93 00:08:01,280 --> 00:08:02,280 That's so scary. 94 00:08:02,280 --> 00:08:12,280 This drug also has many negative effects on other parts of the body, including gastrointestinal problems. This is a little yucky, just as a warning. 95 00:08:12,280 --> 00:08:20,280 Since the drug causes constipation, there's actually risk of hemorrhoids, fecal, and paction, or even rectal prolapse from taking it over time. 96 00:08:20,280 --> 00:08:22,280 That's so funny. I can't even imagine. 97 00:08:22,280 --> 00:08:32,280 That reminds me of this movie called Spun, and they do like a butt ton of heroin. No, I shouldn't say butt ton of heroin if I'm talking about poop. 98 00:08:32,280 --> 00:08:49,280 But they do a bunch of heroin, I guess it is, and, yeah, one is her name, Mina Savari, and she's like, sitting on the toilet for like 20 minutes, and she's just trying, and then it's just like this little tiny deer turd, like, you know, that's it. 99 00:08:49,280 --> 00:08:55,280 That's all you get. That's scary to think that you could be all blocked up like that. 100 00:08:55,280 --> 00:08:59,280 And then it goes into your stomach, like, it grows, like it can push back out. 101 00:08:59,280 --> 00:09:02,280 That's the reaction. That's exactly what that is. 102 00:09:02,280 --> 00:09:06,280 This drug can also cause respiratory damage if not used responsibly. 103 00:09:06,280 --> 00:09:11,280 Use of the drug decreases the user's breathing and, in turn, their oxygen intake. 104 00:09:11,280 --> 00:09:15,280 This can be, of course, detrimental to various organs, especially the brain. 105 00:09:15,280 --> 00:09:21,280 This can also increase the risk of sudden death for individuals who suffer from sleep apnea or lung disease. 106 00:09:21,280 --> 00:09:23,280 I think I have sleep apnea. 107 00:09:23,280 --> 00:09:28,280 I constantly wake myself up like, and you know dad has it. 108 00:09:28,280 --> 00:09:32,280 Yeah, I used to get it all the time when I was pregnant, but it's very common in pregnant women. 109 00:09:32,280 --> 00:09:34,280 People who are bruise hydro- 110 00:09:34,280 --> 00:09:36,280 Bruise hydro-conin. 111 00:09:36,280 --> 00:09:40,280 People who are suddenly like a sim. 112 00:09:40,280 --> 00:09:42,280 Those two, Brune, Hina, Conan. 113 00:09:42,280 --> 00:09:44,280 Conan. 114 00:09:44,280 --> 00:09:51,280 People who abuse hydrocodone by crushing and snorting it also run the risk of serious lung damage. 115 00:09:51,280 --> 00:09:55,280 Another system that can be damaged by hydrocodone use is the endocrine system. 116 00:09:55,280 --> 00:10:00,280 The use of this drug decreases hormone levels in the body, such as estrogen or testosterone, of course, 117 00:10:00,280 --> 00:10:04,280 which can lead to infertility in both men and women. 118 00:10:04,280 --> 00:10:05,280 Holy shit. 119 00:10:05,280 --> 00:10:07,280 I was surprised to read that. I was like, what? 120 00:10:07,280 --> 00:10:08,280 Damn. 121 00:10:08,280 --> 00:10:15,280 Low hormone levels can also lead to depression, anxiety, chronic fatigue syndrome, osteoporosis due to loss of muscle mass, 122 00:10:15,280 --> 00:10:18,280 and increased risk of bone fractures. 123 00:10:18,280 --> 00:10:27,280 A study even found that hormone levels in women addicted to hydrocodone were between 30 and 70% lower in estrogen levels than the average. 124 00:10:27,280 --> 00:10:29,280 Isn't that wild? 125 00:10:29,280 --> 00:10:31,280 Just for what is wild? 126 00:10:31,280 --> 00:10:40,280 I mean, I understand that people that get addicted can't help it, you know, if it becomes a psychosis of some kind. 127 00:10:40,280 --> 00:10:45,280 Well, it's scary because I mean, people get prescribed this all the time, you know, for pain. 128 00:10:45,280 --> 00:10:48,280 That is absolutely creepy. 129 00:10:48,280 --> 00:10:53,280 Significant abuse of hydrocodone can also alter how chemicals are released and absorbed in the brain, 130 00:10:53,280 --> 00:10:57,280 especially mood-regulating neurotransmitters such as serotonin and dopamine. 131 00:10:57,280 --> 00:11:04,280 Consuming high doses of hydrocodone for long periods of time can cause large doses of these chemicals to flood the brain, 132 00:11:04,280 --> 00:11:11,280 and over time this will change the structures associated with emotional control, rational thinking, memory, and learning. 133 00:11:11,280 --> 00:11:18,280 So your brain now can't produce those happy chemicals on its own, so you need more of the drug to fill that. 134 00:11:18,280 --> 00:11:26,280 Losing a limb is also a possibility with abuse of hydrocodone due to the loss of blood flow that occurs during use. 135 00:11:26,280 --> 00:11:29,280 Because of the oxygen intake or something? 136 00:11:29,280 --> 00:11:34,280 It slows down everything so blood doesn't move and regulate as much. 137 00:11:34,280 --> 00:11:41,280 Lastly, abuse of this drug comes along with a high risk of liver damage or failure due to the combination with painkillers, of course. 138 00:11:41,280 --> 00:11:44,280 That is number nine. 139 00:11:44,280 --> 00:11:46,280 God, that is a lot. 140 00:11:46,280 --> 00:11:48,280 Moving down to number eight. 141 00:11:48,280 --> 00:11:51,280 Okay, so it's odd that this is on here. 142 00:11:51,280 --> 00:11:53,280 Methadone. 143 00:11:53,280 --> 00:11:56,280 Yeah, why is that odd that that's on there? 144 00:11:56,280 --> 00:12:04,280 Because that's used to eliminate withdrawal symptoms from opioids, but it's also an opioid in itself, so I'll explain a little more about it. 145 00:12:04,280 --> 00:12:09,280 People get addicted to that. It's almost, I don't know if you have it on there, but like Narcam, too. 146 00:12:09,280 --> 00:12:12,280 No, it's not, but yes, it is. It's not on here, but yes, I know what you're saying. 147 00:12:12,280 --> 00:12:18,280 So if you don't know what methadone is, it's a synthetic opioid agonist that is used to eliminate withdrawal symptoms 148 00:12:18,280 --> 00:12:22,280 and reduce drug cravings by acting on opioid receptors in the brain. 149 00:12:22,280 --> 00:12:27,280 This is the same receptor as that other opioids, such as heroin, morphine, and medications, activate. 150 00:12:27,280 --> 00:12:34,280 This being said, although it's used to treat withdrawal symptoms, it's landing on number eight on our list due to its danger. 151 00:12:34,280 --> 00:12:35,280 I wonder why. 152 00:12:35,280 --> 00:12:38,280 It's wild, right? It's like, okay, you're overdosing. 153 00:12:38,280 --> 00:12:39,280 No, I'm being sarcastic. 154 00:12:39,280 --> 00:12:44,280 I know. I'm like, it's okay, you're overdosing. Let me go ahead and give you this drug that you're just going to continue to abuse. 155 00:12:44,280 --> 00:12:45,280 Yeah. 156 00:12:45,280 --> 00:12:50,280 And since it's, I mean, a legal prescription, it's easier to obtain. 157 00:12:50,280 --> 00:12:52,280 The doctor said I could have it, right? 158 00:12:52,280 --> 00:12:59,280 Long-term use of methadone can lead to cardiovascular issues, often as a result of injecting methadone and potentially collapsed veins, 159 00:12:59,280 --> 00:13:07,280 respiratory issues as a result of chronically reduced respiration rates, menstrual cycle changes in women or sexual dysfunction in men, 160 00:13:07,280 --> 00:13:13,280 issues with judgment, a tendency to engage in risky behaviors and lack of personal hygiene, 161 00:13:13,280 --> 00:13:17,280 the development of physical dependence, of course, and the development of an opioid use disorder. 162 00:13:17,280 --> 00:13:21,280 So I'm not going to get too far into that one because it's pretty much the same thing as what we just talked about. 163 00:13:21,280 --> 00:13:22,280 Yeah. 164 00:13:22,280 --> 00:13:25,280 The symptoms and stuff of abuse. 165 00:13:25,280 --> 00:13:27,280 Now we're going on number seven. 166 00:13:27,280 --> 00:13:28,280 Number seven. 167 00:13:28,280 --> 00:13:29,280 Morphine. 168 00:13:29,280 --> 00:13:30,280 Morphine. 169 00:13:30,280 --> 00:13:33,280 Also used in hospitals everywhere. 170 00:13:33,280 --> 00:13:36,280 Like many of the drugs on this list, morphine... 171 00:13:36,280 --> 00:13:38,280 Morphine. 172 00:13:38,280 --> 00:13:40,280 Morphine hammer. 173 00:13:40,280 --> 00:13:43,280 Morphine. 174 00:13:43,280 --> 00:13:47,280 That's all I'm going to see. 175 00:13:47,280 --> 00:13:48,280 Morphine. 176 00:13:48,280 --> 00:13:50,280 Can I get morepine, please? 177 00:13:50,280 --> 00:13:54,280 I have a prescription for morepine. 178 00:13:54,280 --> 00:13:58,280 Oh, it's good. 179 00:13:58,280 --> 00:14:05,280 Morphine, like many of the drugs on this list, is an opioid derived from the opium poppy plant, indigenous to Southeast Asia. 180 00:14:05,280 --> 00:14:06,280 Just a fun fact. 181 00:14:06,280 --> 00:14:12,280 The effects of morphine include an absence of pain, deep relaxation, and a dream-like state of euphoria. 182 00:14:12,280 --> 00:14:17,280 Morphine is also used as anesthesia associated with surgery or pain management in terminal patients. 183 00:14:17,280 --> 00:14:21,280 It's actually typically prescribed for cancer patients that are terminal. 184 00:14:21,280 --> 00:14:25,280 Some doctors may also prescribe it for short-term pain following an injury. 185 00:14:25,280 --> 00:14:30,280 This can be prescribed and administered via IV, injection, or even in pill form, which I did not know. 186 00:14:30,280 --> 00:14:32,280 You could take morphine in a pill. 187 00:14:32,280 --> 00:14:33,280 Really? 188 00:14:33,280 --> 00:14:34,280 Yeah, I didn't know that. 189 00:14:34,280 --> 00:14:35,280 When I think of morphine, I think of a pill. 190 00:14:35,280 --> 00:14:37,280 I think of an IV when I think of morphine. 191 00:14:37,280 --> 00:14:44,280 Morphine works by binding to the opioid receptors in the brain, thereby blocking signals from the nervous system, similarly to hydrocodone. 192 00:14:44,280 --> 00:14:46,280 Pappies, yes. 193 00:14:46,280 --> 00:14:47,280 Pappies. 194 00:14:47,280 --> 00:14:48,280 Pappies. 195 00:14:48,280 --> 00:14:51,280 From Wizard of Oz? 196 00:14:51,280 --> 00:14:52,280 Yeah, my precious. 197 00:14:52,280 --> 00:14:54,280 Didn't she say my precious, too? 198 00:14:54,280 --> 00:14:56,280 No, you're thinking of gollum. 199 00:14:56,280 --> 00:15:01,280 No, I know he says that, but she says, like, I'll get you my precious. 200 00:15:01,280 --> 00:15:02,280 Pretty. 201 00:15:02,280 --> 00:15:03,280 Oh, my precious. 202 00:15:03,280 --> 00:15:04,280 My pretty. 203 00:15:04,280 --> 00:15:05,280 What she says. 204 00:15:05,280 --> 00:15:07,280 Okay, so this is interesting. 205 00:15:07,280 --> 00:15:34,280 And as little as one month of daily usage, morphine can cause significant effects on the brain, including reduced neuroplasticity, psychomotor impairment, decreased gray matter volume in the amygdala, diminished reflex response, disrupted brain synapse causing impaired memory, reduced respiration and heart rates due to changes in the neural activity in the brain stem, and interference with the brain's chemical messenger production, distribution, and reabsorption. 206 00:15:34,280 --> 00:15:41,280 Like, in one month of daily use, you can, like, get, like, fucked up. 207 00:15:41,280 --> 00:15:47,280 It's so hard because, like, I'm, like, legalized marijuana, legalized most all of the things, honestly. 208 00:15:47,280 --> 00:15:49,280 I mean, the answer Dan's doing quite well. 209 00:15:49,280 --> 00:15:58,280 People are gonna do what they're gonna do, and I think that it's a waste of taxpayer money to have people put it, put away because of drug abuse or drug abuse. 210 00:15:58,280 --> 00:16:00,280 Yeah, agreed. 211 00:16:00,280 --> 00:16:05,280 Me personally, I can't hear what you're saying and be like, that sounds like fun. 212 00:16:05,280 --> 00:16:06,280 Literally, though. 213 00:16:06,280 --> 00:16:07,280 I can't. 214 00:16:07,280 --> 00:16:11,280 I can't listen to that and be like, wow, that sounds like, but that would be cool for a weekend. 215 00:16:11,280 --> 00:16:13,280 That's not what people do, though. 216 00:16:13,280 --> 00:16:18,280 They graduate from little things to little things, and then they hang out with people, and then they're like, oh, try this drug. 217 00:16:18,280 --> 00:16:19,280 He's like, look, I just did it. 218 00:16:19,280 --> 00:16:20,280 I'm fine. 219 00:16:20,280 --> 00:16:22,280 You know, and they're like, all right, fuck it, like once. 220 00:16:22,280 --> 00:16:23,280 Right. 221 00:16:23,280 --> 00:16:25,280 I mean, I've never been there, but, you know, it's like how it works. 222 00:16:25,280 --> 00:16:35,280 Or like you said, I mean, a lot of the times people get prescribed this, and then they go down a deep dark hole, and a lot of the times when people do get prescribed things like this for pain management, 223 00:16:35,280 --> 00:16:38,280 they don't have a lot of other things to do. 224 00:16:38,280 --> 00:16:39,280 Yeah. 225 00:16:39,280 --> 00:16:50,280 Usually if it is a traumatic injury or something like that, they're in a bed where they're recovering and they get depressed, and then it kind of makes all the depressive go away, too. 226 00:16:50,280 --> 00:16:59,280 At the same time, it relieves your pain as well. I can see how someone just gets stuck in a cycle of just thinking that they constantly need it. 227 00:16:59,280 --> 00:17:01,280 Me personally, I'm terrified of pain. 228 00:17:01,280 --> 00:17:02,280 Oh, yeah. 229 00:17:02,280 --> 00:17:03,280 I am terrified of pain. 230 00:17:03,280 --> 00:17:04,280 Pain or pain killers. 231 00:17:04,280 --> 00:17:05,280 Pain. 232 00:17:05,280 --> 00:17:07,280 Like, in general, I do not like to feel pain. 233 00:17:07,280 --> 00:17:09,280 I don't like to feel weak. 234 00:17:09,280 --> 00:17:18,280 And so when I had my wisdom teeth taken out and they were giving me Vicodin or whatever it was, it was it then? 235 00:17:18,280 --> 00:17:21,280 I was definitely in the hospital. I was taking Vicodin. 236 00:17:21,280 --> 00:17:22,280 Some sort of, yeah. 237 00:17:22,280 --> 00:17:31,280 And I remember taking more than was prescribed to me because I was afraid to feel the pain. 238 00:17:31,280 --> 00:17:34,280 Okay, that's so odd that you say that because I'm the exact opposite. 239 00:17:34,280 --> 00:17:35,280 Really? 240 00:17:35,280 --> 00:17:38,280 I'm like, I will not take pain medication unless I absolutely have to. 241 00:17:38,280 --> 00:17:39,280 I'm that way now. 242 00:17:39,280 --> 00:17:41,280 I'll have a headache for like three days before I'll take it. 243 00:17:41,280 --> 00:17:42,280 I'm the same way now. 244 00:17:42,280 --> 00:17:43,280 I'm a pro-fantasy. 245 00:17:43,280 --> 00:17:50,280 I used to, but that's when it started becoming scary for me was like, I knew I wasn't doing something the right way. 246 00:17:50,280 --> 00:17:54,280 I knew I was doing it because I was afraid to feel that pain. 247 00:17:54,280 --> 00:18:07,280 And, you know, I, although I've gone through some traumas in my life, I have never thought of using medication like that to get rid of that. 248 00:18:07,280 --> 00:18:09,280 But it did feel good in the moment. 249 00:18:09,280 --> 00:18:10,280 And I was like, oh no. 250 00:18:10,280 --> 00:18:11,280 No, yeah. 251 00:18:11,280 --> 00:18:12,280 And that's what I'm afraid of, I think. 252 00:18:12,280 --> 00:18:13,280 Yeah. 253 00:18:13,280 --> 00:18:14,280 Like, mom and I are similar in this. 254 00:18:14,280 --> 00:18:21,280 Like when I had my, I had like a hip surgery like a couple of years ago and they prescribed me tramadol and I took it for like three days and then that was it. 255 00:18:21,280 --> 00:18:22,280 And mom does the same thing. 256 00:18:22,280 --> 00:18:27,280 If there's any narcotic that she gets prescribed, she takes it for the first like couple days and then she like throws it out. 257 00:18:27,280 --> 00:18:28,280 Yeah. 258 00:18:28,280 --> 00:18:29,280 She'll, you know, dispose of it properly. 259 00:18:29,280 --> 00:18:30,280 Obviously. 260 00:18:30,280 --> 00:18:34,280 But yeah, I think I'm more afraid of the adverse side effects than I am of the pain. 261 00:18:34,280 --> 00:18:35,280 Like I'd rather have the pain. 262 00:18:35,280 --> 00:18:36,280 Yeah. 263 00:18:36,280 --> 00:18:38,280 You know, it's funny that we're opposite like that. 264 00:18:38,280 --> 00:18:43,280 Now I won't take a, I won't take Tylenol unless I absolutely have to. 265 00:18:43,280 --> 00:18:44,280 I think I took Tylenol two days ago. 266 00:18:44,280 --> 00:18:48,280 I had a really massive headache for like 12 hours straight. 267 00:18:48,280 --> 00:18:49,280 And I was like, all right, fine. 268 00:18:49,280 --> 00:18:52,280 I'll take one, you know, or two or whatever. 269 00:18:52,280 --> 00:18:53,280 That's what I was just saying earlier. 270 00:18:53,280 --> 00:19:00,280 I'm sure the listeners have noticed that I frequently clear my throat and I try to cut it out every time we record. 271 00:19:00,280 --> 00:19:04,280 But sometimes I can't because then it cuts out like important information. 272 00:19:04,280 --> 00:19:09,280 However, I'm prescribed allergy medication that I just simply don't take. 273 00:19:09,280 --> 00:19:12,280 I actually took an allergy pill before we started recording. 274 00:19:12,280 --> 00:19:14,280 And I feel like I sound a little better. 275 00:19:14,280 --> 00:19:16,280 I know I usually sound congested. 276 00:19:16,280 --> 00:19:20,280 I just, it's not bad enough for me to think like, oh, I better take this. 277 00:19:20,280 --> 00:19:21,280 Right. 278 00:19:21,280 --> 00:19:23,280 Well, it's just not in the forefront of your mind. 279 00:19:23,280 --> 00:19:24,280 Yeah. 280 00:19:24,280 --> 00:19:25,280 There's other things to do. 281 00:19:25,280 --> 00:19:26,280 So it kind of distracts you from that. 282 00:19:26,280 --> 00:19:28,280 And then you're like, oh crap, I didn't even take it. 283 00:19:28,280 --> 00:19:29,280 By the way. 284 00:19:29,280 --> 00:19:30,280 Yeah. 285 00:19:30,280 --> 00:19:31,280 All right. 286 00:19:31,280 --> 00:19:32,280 Back to the mental breakdown. 287 00:19:32,280 --> 00:19:33,280 That's enough about us. 288 00:19:33,280 --> 00:19:43,280 So similarly to hydrocodone, morphine has a profound effect on the brain's reward system and causes the brain to release a flood of those feel good chemicals that I mentioned earlier. 289 00:19:43,280 --> 00:19:48,280 And once addicted to morphine, the user will experience extremely harsh withdrawal symptoms. 290 00:19:48,280 --> 00:19:53,280 So after that month of daily use, what's all symptoms are a given guaranteed. 291 00:19:53,280 --> 00:20:00,280 These include nausea, vomiting, stomach cramps, chills, excessive yawning, which I thought was interesting. 292 00:20:00,280 --> 00:20:01,280 That is interesting. 293 00:20:01,280 --> 00:20:04,280 Dizziness, muscle aches, rapid breathing, et cetera. 294 00:20:04,280 --> 00:20:07,280 Especially because we don't know where yon's come from, apparently. 295 00:20:07,280 --> 00:20:09,280 According to science. 296 00:20:09,280 --> 00:20:15,280 So morphine addiction is not a guarantee of abuse, but when it does happen, it can be deadly. 297 00:20:15,280 --> 00:20:16,280 Hmm. 298 00:20:16,280 --> 00:20:17,280 Number six. 299 00:20:17,280 --> 00:20:18,280 Number six. 300 00:20:18,280 --> 00:20:19,280 And the least. 301 00:20:19,280 --> 00:20:20,280 This is oxycodone. 302 00:20:20,280 --> 00:20:21,280 So not hydrocodone. 303 00:20:21,280 --> 00:20:22,280 Not oxycodone. 304 00:20:22,280 --> 00:20:23,280 Oxy. 305 00:20:23,280 --> 00:20:32,280 Number six on our list, which is very similar to hydrocodone, is oxycodone as it is prescribed for serious pain, dental surgery, sports injuries and cancer. 306 00:20:32,280 --> 00:20:36,280 The most common brands of this drug are OxyContin, Perkocet, and Vicodin. 307 00:20:36,280 --> 00:20:39,280 Sometimes people refer to this drug as Happy Pills. 308 00:20:39,280 --> 00:20:42,280 Hillbilly heroin, which is fucking hilarious. 309 00:20:42,280 --> 00:20:43,280 That is awful. 310 00:20:43,280 --> 00:20:44,280 I love that. 311 00:20:44,280 --> 00:20:48,280 O-C-Oxy-Perks or Vikes. 312 00:20:48,280 --> 00:20:50,280 I love shortening words. 313 00:20:50,280 --> 00:20:51,280 That's like one of my favorite. 314 00:20:51,280 --> 00:20:55,280 Perk's are like, what is your volume? 315 00:20:55,280 --> 00:20:59,280 It's like one of the first episodes we ever did. 316 00:20:59,280 --> 00:21:01,280 And you were like, soup's cash. 317 00:21:01,280 --> 00:21:02,280 Soup's cash. 318 00:21:02,280 --> 00:21:03,280 So good. 319 00:21:03,280 --> 00:21:04,280 Soup's cash. 320 00:21:04,280 --> 00:21:07,280 Forget about soup's cash. 321 00:21:07,280 --> 00:21:12,280 Most of the dangers that come along with oxycodone are the same of hydrocodone, so I'm not going to repeat all those because I already said them. 322 00:21:12,280 --> 00:21:18,280 But I do believe that this one's higher on the list due to the simple fact that it's prescribed more often than hydrocodone. 323 00:21:18,280 --> 00:21:21,280 But they have this very similar effect. 324 00:21:21,280 --> 00:21:30,280 A few other things that weren't listed as symptoms of hydrocodone abuse but are for oxycodone are low blood pressure, decreased alertness, and memory loss. 325 00:21:30,280 --> 00:21:31,280 So interesting. 326 00:21:31,280 --> 00:21:32,280 Number five. 327 00:21:32,280 --> 00:21:33,280 Number five. 328 00:21:33,280 --> 00:21:36,280 This is Alprazolam. 329 00:21:36,280 --> 00:21:37,280 Alprazolam? 330 00:21:37,280 --> 00:21:38,280 Yeah. 331 00:21:38,280 --> 00:21:39,280 It's Xanax. 332 00:21:39,280 --> 00:21:40,280 Oh, okay. 333 00:21:40,280 --> 00:21:41,280 That's the drug name of the drug. 334 00:21:41,280 --> 00:21:42,280 I would have no idea. 335 00:21:42,280 --> 00:21:43,280 So that's the brand name Xanax. 336 00:21:43,280 --> 00:21:45,280 The name of the drug is Alprazolam. 337 00:21:45,280 --> 00:21:51,280 And this is another opioid, actually, I think like six of ten are opioids on this list, which is crazy. 338 00:21:51,280 --> 00:21:54,280 Yeah, I mean, it's literally called a crisis for a reason. 339 00:21:54,280 --> 00:21:55,280 Yeah. 340 00:21:55,280 --> 00:21:56,280 There's so much. 341 00:21:56,280 --> 00:21:57,280 There's so much. 342 00:21:57,280 --> 00:22:00,280 Again, this is very similar to the first drug that we talked about, Diazepam. 343 00:22:00,280 --> 00:22:02,280 So I'm not going to repeat all of the effects. 344 00:22:02,280 --> 00:22:05,280 The same thing goes for Xanax though, as it does for oxycodone. 345 00:22:05,280 --> 00:22:11,280 I just believe it's frequently prescribed more than the other one, so that's higher on the list. 346 00:22:11,280 --> 00:22:12,280 Number four. 347 00:22:12,280 --> 00:22:13,280 Number four. 348 00:22:13,280 --> 00:22:14,280 That was really quick. 349 00:22:14,280 --> 00:22:19,280 Now we're going away from the opioids, and we're going straight into meth and pedamine. 350 00:22:19,280 --> 00:22:20,280 Yes! 351 00:22:20,280 --> 00:22:21,280 Meth. 352 00:22:21,280 --> 00:22:22,280 Yeah, stop. 353 00:22:22,280 --> 00:22:23,280 Yeah, stop. 354 00:22:23,280 --> 00:22:24,280 Yeah, stop. 355 00:22:24,280 --> 00:22:30,280 Now we've gotten to the first drug on the list that is not commonly prescribed to patients. 356 00:22:30,280 --> 00:22:32,280 Oh, is it actually methamphetamines? 357 00:22:32,280 --> 00:22:33,280 Yeah. 358 00:22:33,280 --> 00:22:34,280 Oh, okay. 359 00:22:34,280 --> 00:22:35,280 But it's strictly for recreational use. 360 00:22:35,280 --> 00:22:40,280 I'm talking like meth, like not methamphetamines as a whole, like meth and pedamine. 361 00:22:40,280 --> 00:22:41,280 Which? 362 00:22:41,280 --> 00:22:42,280 The meth. 363 00:22:42,280 --> 00:22:43,280 The meth, yeah, crystal. 364 00:22:43,280 --> 00:22:44,280 Crystal. 365 00:22:44,280 --> 00:22:45,280 Like my middle name. 366 00:22:45,280 --> 00:22:49,280 You know, people say like, oh, that's my middle name. 367 00:22:49,280 --> 00:22:50,280 This is actually my middle name. 368 00:22:50,280 --> 00:22:51,280 No, I don't know that. 369 00:22:51,280 --> 00:22:52,280 Meth and pedamine is my middle name. 370 00:22:52,280 --> 00:22:53,280 I'm just kidding. 371 00:22:53,280 --> 00:22:55,280 Yeah, like, dangerous, my middle name. 372 00:22:55,280 --> 00:22:56,280 Oh. 373 00:22:56,280 --> 00:22:57,280 People say things like that. 374 00:22:57,280 --> 00:22:58,280 Yeah. 375 00:22:58,280 --> 00:22:59,280 My name, middle name is crystal. 376 00:22:59,280 --> 00:23:01,280 But it's not still the same, so it's okay. 377 00:23:01,280 --> 00:23:03,280 Why am I like bragging about that? 378 00:23:03,280 --> 00:23:04,280 I don't know. 379 00:23:04,280 --> 00:23:05,280 Crystal meth. 380 00:23:05,280 --> 00:23:08,280 Kana, crystal meth. 381 00:23:08,280 --> 00:23:13,600 As is the case with many drugs, tolerance to meth's pleasurable effects develops when 382 00:23:13,600 --> 00:23:18,280 it's taken repeatedly, encouraging its users to continuously abuse the drug and develop 383 00:23:18,280 --> 00:23:19,280 an addiction. 384 00:23:19,280 --> 00:23:22,880 This will also encourage users to switch the method of how they get the drug into their 385 00:23:22,880 --> 00:23:23,880 system. 386 00:23:23,880 --> 00:23:27,880 Because I didn't know this, but of course, I mean, I know this, that, you know, people 387 00:23:27,880 --> 00:23:30,080 can smoke, inject, and snort meth. 388 00:23:30,080 --> 00:23:31,080 They all do. 389 00:23:31,080 --> 00:23:36,280 But they switch it because if they snort, snort, snort, the effect isn't as strong anymore, 390 00:23:36,280 --> 00:23:38,280 and then when they shoot it, it is. 391 00:23:38,280 --> 00:23:39,280 Yeah. 392 00:23:39,280 --> 00:23:40,280 I didn't know that. 393 00:23:40,280 --> 00:23:41,280 That's odd. 394 00:23:41,280 --> 00:23:44,280 That's why people shove drugs up their butts, too. 395 00:23:44,280 --> 00:23:45,280 Okay. 396 00:23:45,280 --> 00:23:47,280 Moving forward. 397 00:23:47,280 --> 00:23:51,440 Chronic meth users will develop difficulty feeling any pleasure other than when using 398 00:23:51,440 --> 00:23:54,080 the drug, fueling further abuse. 399 00:23:54,080 --> 00:23:57,280 An addiction to being, addiction to being addicted. 400 00:23:57,280 --> 00:24:01,680 In addition to being addicted to meth, people who use it experience symptoms such as significant 401 00:24:01,680 --> 00:24:06,480 anxiety, confusion, insomnia, mood disturbances, and violent behavior. 402 00:24:06,480 --> 00:24:11,160 They may also display a number of psychotic features, including paranoia, visual and auditory 403 00:24:11,160 --> 00:24:17,400 hallucinations, and delusions, most commonly being like insects crawling under the skin. 404 00:24:17,400 --> 00:24:21,200 You know, they have like people that abuse meth and vitamins have usually have sores 405 00:24:21,200 --> 00:24:22,200 and stuff. 406 00:24:22,200 --> 00:24:24,120 Right, they usually pick and stuff, because they, yeah. 407 00:24:24,120 --> 00:24:28,280 Psychotic symptoms can sometimes last for months or even years after a person has quit 408 00:24:28,280 --> 00:24:34,120 meth and stress has been shown to precipitate spontaneous recurrence of psychosis in past 409 00:24:34,120 --> 00:24:35,120 users. 410 00:24:35,120 --> 00:24:40,200 So you can be clean from meth for almost a year and still experience those psychotic 411 00:24:40,200 --> 00:24:41,200 symptoms. 412 00:24:41,200 --> 00:24:42,200 It's really scary. 413 00:24:42,200 --> 00:24:45,400 Like the itchiness and stuff? 414 00:24:45,400 --> 00:24:49,800 Once off the drugs, symptoms of withdrawal from the drug include depression, anxiety, 415 00:24:49,800 --> 00:24:53,600 fatigue, and of course, an intense craving for the drug. 416 00:24:53,600 --> 00:24:57,840 In addition to this, neuroimaging studies have demonstrated alterations in the activity 417 00:24:57,840 --> 00:25:02,800 of the dopamine system that are associated with reduced motor speed and impaired verbal 418 00:25:02,800 --> 00:25:03,800 learning. 419 00:25:03,800 --> 00:25:07,800 Studies in chronic users have also revealed several structural and functional changes in 420 00:25:07,800 --> 00:25:12,040 area of the brain associated with memory and emotion, which may account for many of 421 00:25:12,040 --> 00:25:15,960 the emotional and cognitive problems observed in these individuals. 422 00:25:15,960 --> 00:25:20,280 Research in primate models have found that meth alters brain structures involved in decision 423 00:25:20,280 --> 00:25:25,040 making and impairs the ability to suppress habitual behaviors that have become useless 424 00:25:25,040 --> 00:25:26,840 or counterproductive. 425 00:25:26,840 --> 00:25:30,840 The two effects were correlated, suggesting that the structural change underlies the decline 426 00:25:30,840 --> 00:25:32,840 in mental flexibility. 427 00:25:32,840 --> 00:25:37,320 So chronic use of this like really messes up your brain for the long run, which is really 428 00:25:37,320 --> 00:25:38,320 sad. 429 00:25:38,320 --> 00:25:39,320 That is sad. 430 00:25:39,320 --> 00:25:42,480 These changes in brain structure and function could explain why meth addiction is so hard 431 00:25:42,480 --> 00:25:45,520 to treat and the relapse rate is actually really high. 432 00:25:45,520 --> 00:25:50,680 Well, if you're already experiencing the symptoms and you're clean and sober, it's like, might 433 00:25:50,680 --> 00:25:51,760 as well just fucking do it. 434 00:25:51,760 --> 00:25:52,760 I mean, I don't know. 435 00:25:52,760 --> 00:25:53,760 Or it might help. 436 00:25:53,760 --> 00:25:54,760 It might help with the symptoms. 437 00:25:54,760 --> 00:25:55,760 Yeah, exactly. 438 00:25:55,760 --> 00:25:56,760 Number three. 439 00:25:56,760 --> 00:25:57,760 Number three. 440 00:25:57,760 --> 00:25:58,760 Number three. 441 00:25:58,760 --> 00:25:59,760 Number three. 442 00:25:59,760 --> 00:26:00,760 Number three. 443 00:26:00,760 --> 00:26:01,760 Cocaine. 444 00:26:01,760 --> 00:26:02,760 Cocaine. 445 00:26:02,760 --> 00:26:07,000 Cocaine is a stimulant that is very common in the United States and is extremely dangerous 446 00:26:07,000 --> 00:26:10,080 to the brain, especially the mental health. 447 00:26:10,080 --> 00:26:14,400 Both free-base cocaine, which is commonly referred to as crack and powdered cocaine, can cause 448 00:26:14,400 --> 00:26:20,320 long-term damage to mental health, which appears in the form of mood or emotional disturbances. 449 00:26:20,320 --> 00:26:24,440 Because the drug directly interferes with dopamine being reabsorbed by neurons, one 450 00:26:24,440 --> 00:26:27,520 of the symptoms of the come down is serious depression. 451 00:26:27,520 --> 00:26:31,240 If the brain does not reach its original equilibrium, then a person who has struggled 452 00:26:31,240 --> 00:26:35,720 with cocaine abuse may require ongoing mental health treatment. 453 00:26:35,720 --> 00:26:37,760 Like even after there's like off of it? 454 00:26:37,760 --> 00:26:38,760 Yes. 455 00:26:38,760 --> 00:26:43,920 This is actually the one that correlates most with mental illness. 456 00:26:43,920 --> 00:26:49,120 You can like permanently make yourself mentally ill from abusing cocaine. 457 00:26:49,120 --> 00:26:52,240 If you didn't have it before, you can have it after. 458 00:26:52,240 --> 00:26:53,240 Wow. 459 00:26:53,240 --> 00:26:55,640 That's literally mind-blowing. 460 00:26:55,640 --> 00:27:00,600 Other serious long-term changes to mood and mental health include auditory hallucinations, 461 00:27:00,600 --> 00:27:03,120 restlessness, paranoia, and psychosis. 462 00:27:03,120 --> 00:27:07,520 Okay, so you remember when we talked about a couple of mental breakdowns ago, how people 463 00:27:07,520 --> 00:27:11,840 have a pre-... they're predisposed to developing a mental illness and some people aren't, which 464 00:27:11,840 --> 00:27:16,440 is why two people can go to the same war and only one will come back with PTSD? 465 00:27:16,440 --> 00:27:17,880 Same thing with cocaine. 466 00:27:17,880 --> 00:27:21,680 People who have increased potential to develop psychosis or schizophrenia are more likely 467 00:27:21,680 --> 00:27:24,880 to trigger this condition if they binge cocaine. 468 00:27:24,880 --> 00:27:31,200 So it might be hereditary or something, but it might not show any signs of it until after 469 00:27:31,200 --> 00:27:32,200 you use coke? 470 00:27:32,200 --> 00:27:33,200 Yes. 471 00:27:33,200 --> 00:27:35,040 Similarly to... it's called epigenetics. 472 00:27:35,040 --> 00:27:40,840 It's a really like extremely interesting study, but it shows like this person is predisposed 473 00:27:40,840 --> 00:27:45,880 to developing, let's say schizophrenia and then an environmental trauma will happen to 474 00:27:45,880 --> 00:27:49,440 them and then that will push them over the edge to develop... this is the trauma that 475 00:27:49,440 --> 00:27:50,440 cocaine is. 476 00:27:50,440 --> 00:27:52,160 Wow, interesting. 477 00:27:52,160 --> 00:27:53,160 That is incredible. 478 00:27:53,160 --> 00:27:57,160 Tell me you learned something on the podcast. 479 00:27:57,160 --> 00:28:01,240 This drug also increases stress hormones like cortisol in the brain, which can in turn raise 480 00:28:01,240 --> 00:28:06,160 blood pressure permanently damaging the cardiovascular system. 481 00:28:06,160 --> 00:28:11,600 I'm sure we've all seen someone that is addicted to cocaine do usually have like a beat red 482 00:28:11,600 --> 00:28:14,680 face or something because their blood pressure is so high. 483 00:28:14,680 --> 00:28:15,680 Interesting. 484 00:28:15,680 --> 00:28:20,160 If the user does not happen to develop psychosis or paranoia, they could develop anxiety, panic 485 00:28:20,160 --> 00:28:23,520 disorders or problems with aggression or violence. 486 00:28:23,520 --> 00:28:27,400 One of the most serious long term effects from cocaine abuse is damage to the cardiovascular 487 00:28:27,400 --> 00:28:28,400 system. 488 00:28:28,400 --> 00:28:32,280 This can lead to damage to many other organ systems, including the brain. 489 00:28:32,280 --> 00:28:36,040 If the linings of the veins and arteries are damaged, it can lead to chronic headaches 490 00:28:36,040 --> 00:28:39,160 as blood flow to the brain becomes restricted. 491 00:28:39,160 --> 00:28:43,640 This damage can also cause blood clots, which can lead to a stroke and the drug can also 492 00:28:43,640 --> 00:28:50,240 cause seizures either during binging or chronic abuse or cause a seizure disorder to develop, 493 00:28:50,240 --> 00:28:52,840 which requires long term treatment. 494 00:28:52,840 --> 00:28:54,520 That is incredible to me. 495 00:28:54,520 --> 00:28:59,000 I feel like I know so many people that just like recreationally use coke every once in 496 00:28:59,000 --> 00:29:02,600 a while and you're going to have a stroke. 497 00:29:02,600 --> 00:29:04,280 I mean, you're going to have what? 498 00:29:04,280 --> 00:29:05,280 Chronic headaches? 499 00:29:05,280 --> 00:29:06,280 Yeah, it's scary. 500 00:29:06,280 --> 00:29:07,280 And you don't realize. 501 00:29:07,280 --> 00:29:11,040 I mean, this is such a party drug if you will. 502 00:29:11,040 --> 00:29:14,000 You don't realize how fucking scary it is. 503 00:29:14,000 --> 00:29:18,960 Well, and I think because it doesn't, you feel like the effects of cocaine isn't that 504 00:29:18,960 --> 00:29:19,960 long lasting. 505 00:29:19,960 --> 00:29:21,240 So you think you're in the clear. 506 00:29:21,240 --> 00:29:25,760 Like it's like not to compare cocaine with weed because I feel like you could, whatever, 507 00:29:25,760 --> 00:29:26,760 that's a different story. 508 00:29:26,760 --> 00:29:28,720 That's a different topic. 509 00:29:28,720 --> 00:29:34,600 But I feel like people think that the high that you get isn't long term, so the effects 510 00:29:34,600 --> 00:29:35,600 wouldn't be long term. 511 00:29:35,600 --> 00:29:36,600 Yeah. 512 00:29:36,600 --> 00:29:38,280 No, it's actually quite the contrary. 513 00:29:38,280 --> 00:29:41,280 That is incredible. 514 00:29:41,280 --> 00:29:45,640 People who struggle with cocaine addiction also show reduced levels of glucose metabolism 515 00:29:45,640 --> 00:29:52,040 in many areas of the brain, suggesting that neurons underperform or begin to die. 516 00:29:52,040 --> 00:29:54,440 This is so interesting. 517 00:29:54,440 --> 00:29:59,880 Prolonged use of cocaine can actually speed up the process of losing healthy brain tissues 518 00:29:59,880 --> 00:30:05,280 and can even cause the cells to begin to cannibalize themselves. 519 00:30:05,280 --> 00:30:11,280 Your brain will literally eat itself if you abuse cocaine for long enough. 520 00:30:11,280 --> 00:30:15,160 Oh wait, like so how would you know? 521 00:30:15,160 --> 00:30:16,160 Is it like memory loss? 522 00:30:16,160 --> 00:30:17,600 Yeah, well that's one of that. 523 00:30:17,600 --> 00:30:19,840 White matter starts to deteriorate. 524 00:30:19,840 --> 00:30:23,920 Similarly to Parkinson's disease or dementia Alzheimer's is because that white matter is 525 00:30:23,920 --> 00:30:28,120 fading and it's usually due to old age, but this is like expediting the process. 526 00:30:28,120 --> 00:30:29,120 Oh my God. 527 00:30:29,120 --> 00:30:30,120 Yeah. 528 00:30:30,120 --> 00:30:32,120 Moving on to number two. 529 00:30:32,120 --> 00:30:33,120 Number two. 530 00:30:33,120 --> 00:30:35,160 Go to number two. 531 00:30:35,160 --> 00:30:37,840 Number two is heroin. 532 00:30:37,840 --> 00:30:40,320 Heroin, heroin. 533 00:30:40,320 --> 00:30:41,320 Heroin. 534 00:30:41,320 --> 00:30:46,240 Another opioid on the list, heroin is extremely dangerous and highly addictive. 535 00:30:46,240 --> 00:30:50,760 When used heroin stops the brain from producing its own opioids, making it more difficult 536 00:30:50,760 --> 00:30:56,680 to fight the pain on the user's own, encouraging more drug use and leading to addiction. 537 00:30:56,680 --> 00:31:01,360 Once your brain becomes physically dependent on the drug, withdrawal symptoms are a guarantee, 538 00:31:01,360 --> 00:31:05,840 similarly to morphine, making it much more dangerous to come off of the drug. 539 00:31:05,840 --> 00:31:10,480 Long-term use of heroin can severely impair the brain, allowing harmful proteins to build 540 00:31:10,480 --> 00:31:11,480 up. 541 00:31:11,480 --> 00:31:16,840 Use can also inflame the brain and cause structural damage, similarly to those with Alzheimer's 542 00:31:16,840 --> 00:31:17,960 disease. 543 00:31:17,960 --> 00:31:22,800 When this happens, the user can experience things like mental decline, confusion, personality 544 00:31:22,800 --> 00:31:28,920 changes, lack of restraint, depression, nervousness, paranoia, and memory loss. 545 00:31:28,920 --> 00:31:33,160 A drug can make your personality change. 546 00:31:33,160 --> 00:31:38,120 It's just so interesting, but it's so scary to know. 547 00:31:38,120 --> 00:31:41,560 And it's often that you use it once in your hopes. 548 00:31:41,560 --> 00:31:42,840 Yeah, exactly. 549 00:31:42,840 --> 00:31:47,000 Abuse of this drug also causes the white matter in the brain to be destroyed, which can negatively 550 00:31:47,000 --> 00:31:50,160 impact the user's ability to reason and make decisions. 551 00:31:50,160 --> 00:31:54,080 It makes it much harder to regulate behavior and deal with stress. 552 00:31:54,080 --> 00:31:58,880 Abusers can also expect to experience reduced sex hormones as a result of use, causing depression, 553 00:31:58,880 --> 00:32:03,120 chronic fatigue, osteoporosis, and loss of muscle mass. 554 00:32:03,120 --> 00:32:07,800 Hypogonadism, or failure of the tessis in men and ovaries in women, is another side-effect 555 00:32:07,800 --> 00:32:09,160 of chronic misuse. 556 00:32:09,160 --> 00:32:13,360 Lastly, heroin abuse can cause respiratory suppression, which can decrease the amount 557 00:32:13,360 --> 00:32:18,120 of oxygen to the brain, disruption of the balance of neurotransmitters by again flooding 558 00:32:18,120 --> 00:32:22,080 the brain with that dopamine, and altering the vascular structure of the brain, which 559 00:32:22,080 --> 00:32:27,320 can lead to stroke, aneurysms, and other cerebrovascular changes that damage the brain. 560 00:32:27,320 --> 00:32:31,720 I feel like when people overdose on heroin, it's very common and quite often that they 561 00:32:31,720 --> 00:32:35,200 stop breathing when they're sleeping or they vomit when they're asleep because their breathing 562 00:32:35,200 --> 00:32:36,200 is so shallow. 563 00:32:36,200 --> 00:32:37,200 Right. 564 00:32:37,200 --> 00:32:38,200 It's so scary. 565 00:32:38,200 --> 00:32:45,600 Yeah, even if you were to aspirate on your own vomit because you can't expel anything, 566 00:32:45,600 --> 00:32:48,280 you can't get that deep breath. 567 00:32:48,280 --> 00:32:49,280 I know. 568 00:32:49,280 --> 00:32:51,800 It makes me feel like I need to take a deep breath just thinking about it. 569 00:32:51,800 --> 00:32:52,800 Cluster foam again. 570 00:32:52,800 --> 00:32:54,000 It's like climbing through a cave. 571 00:32:54,000 --> 00:32:55,000 All right. 572 00:32:55,000 --> 00:32:58,360 Let's get down to number one, most dangerous drug. 573 00:32:58,360 --> 00:32:59,360 What do you think it is? 574 00:32:59,360 --> 00:33:00,360 Most dangerous drug. 575 00:33:00,360 --> 00:33:01,360 Oh, I don't know. 576 00:33:01,360 --> 00:33:02,360 There's some money. 577 00:33:02,360 --> 00:33:03,360 Is it acid? 578 00:33:03,360 --> 00:33:04,360 No, I don't want to. 579 00:33:04,360 --> 00:33:05,360 No, I'm kidding. 580 00:33:05,360 --> 00:33:09,360 I'm sure it's not weed. 581 00:33:09,360 --> 00:33:10,360 It's not acid. 582 00:33:10,360 --> 00:33:11,360 It's not acid. 583 00:33:11,360 --> 00:33:12,360 It's not LSD. 584 00:33:12,360 --> 00:33:13,360 It's not PCP? 585 00:33:13,360 --> 00:33:14,360 No. 586 00:33:14,360 --> 00:33:15,360 It's... 587 00:33:15,360 --> 00:33:17,880 But what have we been talking about this whole time? 588 00:33:17,880 --> 00:33:19,480 What types of drugs? 589 00:33:19,480 --> 00:33:20,480 Opioids? 590 00:33:20,480 --> 00:33:21,480 Okay, so... 591 00:33:21,480 --> 00:33:23,600 You already did heroin. 592 00:33:23,600 --> 00:33:24,600 You already did meth. 593 00:33:24,600 --> 00:33:25,600 Fentanyl. 594 00:33:25,600 --> 00:33:26,600 Oh, fentanyl. 595 00:33:26,600 --> 00:33:28,400 See, you don't even think about fentanyl. 596 00:33:28,400 --> 00:33:29,400 Yeah, fentanyl is... 597 00:33:29,400 --> 00:33:30,400 Oh, don't worry. 598 00:33:30,400 --> 00:33:31,800 It's also used in hospitals. 599 00:33:31,800 --> 00:33:32,800 Oh, don't worry. 600 00:33:32,800 --> 00:33:34,400 It's prescribed by a doctor. 601 00:33:34,400 --> 00:33:35,400 Literally. 602 00:33:35,400 --> 00:33:40,760 I love how pharmaceutical companies are just like, yeah, we're going to take this thing 603 00:33:40,760 --> 00:33:44,160 that is illegal and we're going to make it legal and we're going to deal to people. 604 00:33:44,160 --> 00:33:47,280 We're going to make it legal for us. 605 00:33:47,280 --> 00:33:51,120 So it's no surprise that this monster comes in at number one most dangerous drug in the 606 00:33:51,120 --> 00:33:56,240 United States as it is a hundred times more potent than morphine. 607 00:33:56,240 --> 00:34:00,600 Fentanyl is extremely legal for recreational use in the US due to its high death rate, 608 00:34:00,600 --> 00:34:05,880 but somehow it's still allowed to be prescribed in very specific circumstances in medicine. 609 00:34:05,880 --> 00:34:09,520 Just like other opioids, fentanyl works by binding to the opioid receptors in the brain 610 00:34:09,520 --> 00:34:12,200 and floods it with dopamine, like we've talked about. 611 00:34:12,200 --> 00:34:15,920 The effects are very similar to heroin, but much more powerful. 612 00:34:15,920 --> 00:34:21,080 In addition to euphoria and relaxation, other side effects of the drug can include nausea, 613 00:34:21,080 --> 00:34:26,640 drowning, drowningness, drowsiness, that's what I meant to say. 614 00:34:26,640 --> 00:34:27,640 Drowning yourself. 615 00:34:27,640 --> 00:34:30,240 Don't do it in a pool. 616 00:34:30,240 --> 00:34:31,480 Don't do it. 617 00:34:31,480 --> 00:34:37,280 Sedation, confusion, respiratory depression, or arrest, coma, and death. 618 00:34:37,280 --> 00:34:41,720 Due to the powerful nature of the drug, when it binds to the opioid receptors of the brain, 619 00:34:41,720 --> 00:34:46,200 everything slows down, including breathing and in turn, oxygen intake. 620 00:34:46,200 --> 00:34:47,200 What? 621 00:34:47,200 --> 00:34:51,120 Don't get a pool. 622 00:34:51,120 --> 00:34:53,120 Don't get a pool. 623 00:34:53,120 --> 00:34:54,920 Don't get a pool. 624 00:34:54,920 --> 00:35:01,160 Don't just buy a pool. 625 00:35:01,160 --> 00:35:05,080 This drug can also make impulsive decisions like buying pools. 626 00:35:05,080 --> 00:35:07,080 Like buying pools. 627 00:35:07,080 --> 00:35:09,080 Just drown yourself in it. 628 00:35:09,080 --> 00:35:11,360 It's terrible. 629 00:35:11,360 --> 00:35:15,200 Taking too much of the drug can cause the user to stop breathing altogether, which is 630 00:35:15,200 --> 00:35:17,200 terrifying. 631 00:35:17,200 --> 00:35:21,160 All of the other side effects of this drug are the same as most opioids, however, due 632 00:35:21,160 --> 00:35:26,200 to the potency, withdrawal is much more dangerous than the others, and is likely to result in 633 00:35:26,200 --> 00:35:32,800 terrible symptoms such as restlessness, sweating, irritability, nausea, vomiting, weakness, cramps, 634 00:35:32,800 --> 00:35:36,120 insomnia, and high blood pressure. 635 00:35:36,120 --> 00:35:37,120 It's what? 636 00:35:37,120 --> 00:35:39,600 Why would you ever put yourself in that situation? 637 00:35:39,600 --> 00:35:40,600 Yeah. 638 00:35:40,600 --> 00:35:44,280 I mean, I guess that, I mean, well, again, clearly it's prescribed. 639 00:35:44,280 --> 00:35:47,240 So sometimes you might not have a choice. 640 00:35:47,240 --> 00:35:48,240 Yeah, it's true. 641 00:35:48,240 --> 00:35:49,240 I mean, you're on it for months in the hospital life. 642 00:35:49,240 --> 00:35:50,240 If somebody's trying to save your life, yeah. 643 00:35:50,240 --> 00:35:54,920 Covering from a motorcycle accident or something, and then they just send you off on your merry 644 00:35:54,920 --> 00:35:56,680 way. 645 00:35:56,680 --> 00:35:58,480 So that is my mental breakdown. 646 00:35:58,480 --> 00:36:02,800 I did want to add very quickly at the end, if you or somebody you know is struggling with 647 00:36:02,800 --> 00:36:09,960 addiction, you can call the 24-hour line at 1-800-662-4357, or you can visit the website 648 00:36:09,960 --> 00:36:14,840 at www.samhsa.gov. 649 00:36:14,840 --> 00:36:16,640 So I just wanted to pepper that in there. 650 00:36:16,640 --> 00:36:17,640 Pepper that in. 651 00:36:17,640 --> 00:36:21,440 Yeah, it's really wild, and we definitely want to make it clear that we know that drug 652 00:36:21,440 --> 00:36:25,440 addiction is not something that people choose, and it is an illness. 653 00:36:25,440 --> 00:36:30,880 And I just thought it was super interesting to tackle that and also showcase how it affects 654 00:36:30,880 --> 00:36:31,880 the brain. 655 00:36:31,880 --> 00:36:33,640 And the cocaine thing with mental health was really interesting. 656 00:36:33,640 --> 00:36:36,800 I did not know that before I dove into this. 657 00:36:36,800 --> 00:36:41,680 I can't wait at the next party that I'm at to be like, before you do that cocaine, so 658 00:36:41,680 --> 00:36:42,680 yeah. 659 00:36:42,680 --> 00:36:45,480 Are you predisposed to a mental illness? 660 00:36:45,480 --> 00:36:47,000 Does mental illness run in your family? 661 00:36:47,000 --> 00:36:48,000 This could trigger an event. 662 00:36:48,000 --> 00:36:49,000 This could trigger your... 663 00:36:49,000 --> 00:36:50,000 To drown yourself. 664 00:36:50,000 --> 00:36:51,000 This could be triggering. 665 00:36:51,000 --> 00:36:52,000 You might buy a pool. 666 00:36:52,000 --> 00:36:53,000 You might buy a pool. 667 00:36:53,000 --> 00:36:54,000 Oh my God. 668 00:36:54,000 --> 00:36:55,000 All right, that's our mental breakdown. 669 00:36:55,000 --> 00:37:05,600 We are going to come back with another case pretty soon, and then of course, back to 670 00:37:05,600 --> 00:37:07,560 back, we know that... 671 00:37:07,560 --> 00:37:10,800 I'm sure it's known by now that we do a case and then a mental breakdown and then a case 672 00:37:10,800 --> 00:37:11,800 and then a breakdown. 673 00:37:11,800 --> 00:37:12,800 Yeah. 674 00:37:12,800 --> 00:37:13,800 Until next time. 675 00:37:13,800 --> 00:37:14,800 Love you. 676 00:37:14,800 --> 00:37:15,800 Love you. 677 00:37:15,800 --> 00:37:16,800 Bye. 678 00:37:16,800 --> 00:37:35,800 Bye.