WEBVTT

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All right, so have you heard about this computer

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powered by real human brain cells? Oh yeah, this

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is wild stuff. It sounds like science fiction,

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right? It really does. But we've been going through

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all this material. This is actually real. This

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is not a movie. And this Australian company,

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Cortical Labs, they just launched this thing

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called the CL1. I've been following them for

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a while. Yeah, and the crazy thing is it combines

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like Living human brain cells with like silicon

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hardware right to make a new kind of AI. It's

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really a fundamental shift I think yeah You know

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moving beyond just the the silicon based AI that

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we're used to right into this whole other realm

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of what they're calling synthetic biological

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intelligence, right? So the co1 it's not just

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another you know, complex algorithm or something

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like that. It's like it's actually using the

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learning capabilities of neurons, like, you know,

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real biological, real biological material. Yeah.

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And then the advantages are like. almost unbelievable.

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It's like more flexible, learns way faster, uses

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a lot less energy, and it's potentially way more

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efficient. Much more efficient, yeah. Than the

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AI that we have now. Right. And this synthetic

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biological intelligence, or SBI as they're calling

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it. Catchy. Yeah, they just introduced it officially

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in Barcelona on March 2nd, 2025. Very recent.

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Yeah. just the other day. And scientists are

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really excited about it because they think this

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could be like a huge breakthrough. I think so

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too. Especially for like medical research. Think

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about it a whole new way to like approach health

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challenges and stuff. Absolutely. And I think

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what's really interesting from a bigger picture

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perspective is that traditional AI, it could

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be so powerful, but it takes so much computing

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power. Yeah. So much energy. So much energy.

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But to think about how efficient our own biological

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systems are for computation, it's a really compelling

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idea. And the fact that these brain cells, they

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can evolve and learn constantly, it's a game

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changer. Yeah, it's not just static. It's alive.

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It's alive and it's constantly learning. And

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the way they do it is they take regular blood

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or skin cells and they do this. crazy science,

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and they turn them into stem cells. And then

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the stem cells can become any kind of cell in

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the body. And they basically make them into brain

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cells or neurons. And then those are like the

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building blocks of the computer. Wow. Yeah, pretty

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wild. That's amazing. But this isn't their first

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time doing this. They did this thing back in

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20... that got a lot of attention. The dish brain,

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right? The dish brain, yeah. So they basically

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grew like 800 ,000 human and mouse neurons on

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a chip. And they taught it to play pong. They

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taught it to play pong. That's crazy. You remember

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Elsie Blaine? Oh yeah. The science writer? Yeah.

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She was all over that. Yeah, she was all over

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that. Talking about how this neural network could...

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Teach itself it could adapt to new situations

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even make new connections based on like what

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was happening in the game That's wild really

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put cortical labs on the map. Yeah and and back

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in 2023 Brett Kagan who's the chief scientific

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officer at cortical labs? He was saying okay.

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This technology is like a whole new form of life

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Interesting. It's not an animal. It's not a human.

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It's something totally different right and he

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was saying it's like a mechanical and engineering

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approach to intelligence but built with like

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Real neurons which is just mind -blowing when

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you think about it It's like a totally different

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way of thinking about intelligence and maybe

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even life itself totally and now fast forward

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to today Yeah, the cl1 is not just some research

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project. It's like it's a product It's a product

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that you can buy that you can buy researchers

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can get their hands on it That's huge and start

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using it. So let's break it down. Okay, what

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is the cl1 biocomputer? Yeah, you know, what

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is it all about? So from what I've been reading

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the cl1 it's not just like a little chip that

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you stick in your computer. It's like a whole

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system. And the human brain cells, they're like,

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they live in this unit that takes care of them

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and keeps them alive. Oh, so it's like a... Yeah,

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like a life support system. The life support

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system for these brain cells. Yeah. Okay. Dr.

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Han Wangchang, who's the founder and CEO of Cortical

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Labs, he's been saying that this is like the

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biggest moment for the company in like their

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whole six -year journey. And he's even comparing

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it to that famous Pong experiment. that they

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published in Neuron. And it's cool to see how

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they've come from that research to this actual

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product. But it's also made it clear that they've

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always wanted to make this technology more accessible

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to more people. So you don't need like a million

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dollars in a special lab. Exactly. You don't

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need the fancy hardware, the fancy software.

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The CL1 is how they're doing that. They're making

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it so anyone can use it. And they came up with

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this very interesting term. What's that? wetware

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as a service. Okay, I like that. Yeah, so basically,

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customers can either buy the CL1, like the actual

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unit, or they can rent access to it. Or remotely.

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Remotely through the cloud. Interesting. It's

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like software as a service, but for brain power.

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but with real biological components. Yeah. That's

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fascinating. So it makes it a lot easier for

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people to use it. Right. Like it lowers the barrier

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to entry. Yeah. Dr. Chalm thinks this could empower

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millions of researchers and inventors and just

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people with big ideas who might not have the

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resources to build this kind of system themselves.

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Yeah. It's like democratizing this really advanced

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technology. Yeah. In cortical labs, they're not

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just providing the hardware. Right. They're providing

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the tools and the support. Yeah. To help people

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make new discoveries. So it's like a whole platform.

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Exactly. And when you think about the potential

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applications, it's like mind -blowing. It can

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change so many things. So many things. Like for

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example, substance discovery. Yeah. Like finding

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new drugs. Right. It could be way faster, way

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more efficient. Imagine being able to test like

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new drugs. Yeah. On actual living neural networks.

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Yeah. that are like, you know, human brain tissue.

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Like a mini brain. Yeah. And then you can see

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exactly what it does. You can see how the cells

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react. Yeah. See if it's effective. Yeah. Without

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having to, you know, use animal testing. Yeah.

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And it could be a lot more accurate, too, because

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it's like... It's the real thing. The real thing.

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Not a simulation. And it could change clinical

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trials. Like the way we test new treatments.

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Yeah. And even like robotics. Oh yeah. Like we

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could have robots that are like way more adaptable

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and customizable. Robots with real intelligence?

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Yeah. They can learn and grow. Yeah. That's incredible.

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And they're aiming to have this... widely available

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in the second half of 2025. Yeah, which makes

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me think they're pretty confident. Yeah. Yeah,

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they must be pretty far along if they're going

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to make it available to everybody. Yeah. And

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some researchers got to visit cortical labs in

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Melbourne. Oh, wow. And they were saying, it's

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not just about playing pong. It's way more than

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that. Much more. It's like a whole new way of

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computing. It is a new paradigm for computation.

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So what's so special about the CL1? Technologically.

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Technologically. What makes it tick? Okay, so

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even the name CL1. Yeah. Shows that it's a step

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up from the dish brain. Yeah. The hardware is

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simpler, it's more stable. Okay. But the really

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cool stuff is in the wetware. The wetware. The

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brain cells. Yeah. They figured out how to grow

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a neural network that's more like a real brain.

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Like a mini brain or something. They call it

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a minimal viable brain. Minimal viable brain.

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Yeah. OK. Amazing. And how do they connect to

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these brain cells? Well, they use these things

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called planar electrode arrays. OK. So these

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are like little flat structures made of metal

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and glass. OK. And they have like 59 electrodes

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on them. OK. And these electrodes, they're like

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the communication points between the computer

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system and the neurons. OK. They use this advanced

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CCOS technology to exchange information. So they

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can like stimulate the cells and also read what

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the cells are doing. Exactly. They can stimulate

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them and they can record the activity. Okay.

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And the coolest thing that they found in those

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dish brain experiments is that the neurons, they

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kind of like predictability. Predictability?

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Yeah. When they make connections that lead to

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like stable outcomes, they strengthen those connections.

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So they learn? They learn, yeah. Okay. But when

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their activity is like random and chaotic, they

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avoid that. They don't like that. They don't

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like that. They want order. They want order.

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So they're constantly, like, self -optimizing.

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Exactly. Based on what works and what doesn't.

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Yeah, it's like a built -in learning mechanism.

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That's why. Driven by this need for stability

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and efficiency. And they upgraded from that old

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CMOS ship. Oh, yeah. That they were using before.

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Which had some problems. Yeah, it was like opaque,

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so you couldn't see the cells. Right. And it

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could build up electrical charge. Yeah, which

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wasn't good for the cells. So they came up with

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a new system. They did. That's way more precise.

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Right. And it keeps the cells healthier. Yeah,

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it's a much better environment. So they can live

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longer. For the neurons to thrive. Yeah. And

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all of this is housed in this... Life support

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unit. This body in a box. The body in a box.

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Yeah, it's got like filtration, liquid storage

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pumps, gas mixing, temperature control. It's

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like a high -tech aquarium. Yeah, it's like a

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little world for the neurons. A little world,

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yeah. And they're building this crazy thing in

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Melbourne. What's that? It's a biological neural

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network server stack. Okay, so like a server

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farm. Yeah, but with brains. With brains. Yeah.

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Wow. 30 CL1 units all connected together. And

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that's just the beginning. It's just the beginning.

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They want to scale it up. Yeah. And they think

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it'll be online in a few months. Yeah, this is

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happening, like, right now. This is the future

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happening now. So what's next for them? Well,

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they want to have four of these stacks. Four?

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Yeah. Wow. By the end of the year. OK. And they're

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going to be accessible through the cloud. So

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even more people can use them. Exactly. Anyone

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with an internet connection can tap into this

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brain power. And the price is coming down. Yeah,

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it's still pretty expensive. $35 ,000 per unit.

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Right. But that's way cheaper than some of the

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other options. Some of the other systems are

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like $85 ,000. Yeah. But Cortical Labs, they're

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working on making it even cheaper. So it'll be

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more affordable. Yeah, for more researchers and

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companies. And it's super energy efficient. Yeah,

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a full rack of these CL1s only uses like 850

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to 1 ,000 watts. That's like nothing. It's way

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less than a traditional computer cluster. Yeah,

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it's crazy. For the same amount of processing

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power. And it's programmable. You can program

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the brain. Yeah, you can talk to the neurons.

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That's wild. And they can talk back. It's two

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-way communication. Yeah, so they can learn and

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adapt in real -time. Real -time learning. And

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you don't even need a separate computer to use

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it. It's a self -contained system. Yeah, it's

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amazing. The possibilities are endless. So what

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are they going to use this for? What are the

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immediate applications? Well, drug discovery

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is a big one. Yeah. Being able to actually see

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how neurons grow and connect under a microscope

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in response to different drugs or treatments,

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that's going to be huge for research. And it's

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accessible to anyone through the cloud. Right.

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So even if you can't afford to buy a CL1, you

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can still use it. That's really cool. It's democratizing

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science. And they're using these special stem

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cells. Induced. pluripotent stem cells. Yeah,

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from blood samples. Yeah, so they take a blood

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sample. Yeah. And they turn those cells back

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into stem cells. Wow. Which can become any type

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of cell. Yeah. And then they turn them into neurons.

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So it's like personalized brain cells. In a way.

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From your own blood. That's incredible. Yeah.

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It really is. And they use two methods to make

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the neurons. Right. One is with molecules. Yeah,

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they expose the stem cells to these molecules

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that mimic brain development. OK. And that way

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is faster. for making lots of cells. But is it

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as good? Well, the other way is to modify the

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genes. Okay. And that's more precise. Okay. You

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can get more specific types of neurons. But is

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it slower? It is slower. Yeah. Is there like

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trading off speed and precision? Yeah. It depends

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on what you need for your research. Right. But

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the ultimate goal is to build that minimal viable

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brain. Yeah. A functional brain. Yeah. That can

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do real thinking. And that's still a challenge.

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It is a huge challenge. Yeah. But the CL1 is

00:12:28.360 --> 00:12:30.860
a big step in the right direction. Yeah. It's

00:12:30.860 --> 00:12:32.740
a tool that can help us understand the brain

00:12:32.740 --> 00:12:35.419
better. And maybe even build a better brain.

00:12:35.740 --> 00:12:38.200
Exactly. And it could help us develop new treatments

00:12:38.200 --> 00:12:41.019
for brain disorders. Absolutely. And maybe even

00:12:41.019 --> 00:12:45.220
reduce the need for animal testing. Yeah. That's

00:12:45.220 --> 00:12:47.750
a big ethical consideration. Yeah. Yeah, so it's

00:12:47.750 --> 00:12:50.169
a really powerful technology. It is. With a lot

00:12:50.169 --> 00:12:51.950
of potential. And a lot of responsibility. We

00:12:51.950 --> 00:12:54.269
have to be careful with this. So to recap, we've

00:12:54.269 --> 00:12:56.590
been talking about the CL1. The world's first

00:12:56.590 --> 00:12:59.870
commercially available biocomputer. Powered by

00:12:59.870 --> 00:13:02.750
living human brain cells. It's amazing. It's

00:13:02.750 --> 00:13:04.929
totally different from traditional AI. Yeah,

00:13:05.090 --> 00:13:08.230
it learns faster, it's more flexible, it uses

00:13:08.230 --> 00:13:10.750
less energy. And it could change everything.

00:13:10.909 --> 00:13:13.690
From medicine to robotics. And everything in

00:13:13.690 --> 00:13:16.240
between. And the best part is, it's accessible

00:13:16.240 --> 00:13:19.220
to everyone. Through the cloud. Yeah, anyone

00:13:19.220 --> 00:13:22.559
can use it. So for you listening, think about

00:13:22.559 --> 00:13:26.940
this. This CL1, it can learn and adapt like a

00:13:26.940 --> 00:13:29.600
real brain. Right. So what does that mean for

00:13:29.600 --> 00:13:32.059
us? What are the implications? Yeah, what are

00:13:32.059 --> 00:13:34.559
the ethical implications? The philosophical implications.

00:13:34.639 --> 00:13:36.600
Yeah, as this technology gets more powerful.

00:13:36.659 --> 00:13:38.720
As it becomes more widespread. Yeah, and more

00:13:38.720 --> 00:13:40.879
integrated into our lives. It's a big question.

00:13:41.019 --> 00:13:42.960
Yeah, it's a big question. That we need to be

00:13:42.960 --> 00:13:44.879
thinking about. Yeah, because we're really at

00:13:44.879 --> 00:13:48.159
the beginning. The dawn of a new era. Of something

00:13:48.159 --> 00:13:51.200
completely new. Biological computing? Yeah. It's

00:13:51.200 --> 00:13:54.600
exciting and a little bit scary. Yeah, definitely

00:13:54.600 --> 00:13:57.340
a lot to think about. A lot to think about. But

00:13:57.340 --> 00:13:59.789
that's why we do this show. To explore these

00:13:59.789 --> 00:14:02.649
big ideas. Yeah, and to get you thinking. To

00:14:02.649 --> 00:14:05.009
get the conversation started. Yeah, so thanks

00:14:05.009 --> 00:14:07.070
for joining us. Thanks for having me. And we'll

00:14:07.070 --> 00:14:09.230
see you next time. Until next time. On the deep

00:14:09.230 --> 00:14:12.330
dive. On the deep dive. Into the future. Into

00:14:12.330 --> 00:14:13.389
the future.
