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All right, everyone ready to dive in.

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Today we're going deep on organoid intelligence.

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Oh, yeah.

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Play, OI.

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Yeah, where brain cells meet computer chips.

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It's like something out of sci-fi, isn't it?

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It really is, but it's actually happening right now.

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We're talking about real science.

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Real science.

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And to guide us today, we have an interview with Brett Kagan,

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a neuroscientist who's at the forefront of this OI research.

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And he is just brilliant.

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You can tell he's really excited about the potential of OI.

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Absolutely.

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And I think what struck me was not only the potential,

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but also his awareness of the challenges and the complexity

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of it all, replicating even the most basic brain function.

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It's a huge undertaking.

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Yeah, so think of this as like a crash course

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in organoid intelligence.

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Exactly.

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We're going to break down what it is, how it works,

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and why it could actually revolutionize the world

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as we know it.

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By the end of this deep dive, you'll

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know what OI is, what it can do, and what some of the hurdles

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are that researchers are facing.

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OK, so let's start with the basics.

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What exactly is organoid intelligence?

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So imagine scientists growing these tiny 3D clusters

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of brain cells called organoids in a dish.

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Like mini brains.

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Mini brains, exactly.

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And these organoids, they actually

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have some of the functional properties of a real brain.

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Wow.

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They can learn and adapt.

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Seriously.

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And researchers like Kagan, they're

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connecting these mini brains to electronic circuits,

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basically creating this hybrid bio computer.

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OK, so we've got these mini brains on a chip.

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What can they actually do?

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Well, one of the most amazing demonstrations of OI

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was an experiment where they taught a network of these brain

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cells to play pong.

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Hold on, brain cells playing video games.

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How is that even possible?

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Sounds wild.

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I know, but get these neurons learned to play

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pong in just five minutes.

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Five minutes.

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Five minutes.

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It shows you how incredible the brain's natural learning

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ability is.

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That's crazy fast.

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Especially when you compare it to traditional AI.

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Yeah, traditional AI takes like hours or even days

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to learn something like that.

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Absolutely.

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This difference in learning speed

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is one of the things that has researchers so excited

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about the potential of OI.

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So why even bother with growing brain cells

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when we already have AI?

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I mean, what's the big advantage of OI?

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That's a great question.

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And Kagan addresses that directly.

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He says that brain cells are way more energy efficient

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than our current AI systems.

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So it's all about efficiency.

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Think about it.

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The human brain runs on roughly 20 watts of power.

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That's it?

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That's it.

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Now, compare that to the huge amount of energy

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used by data centers powering today's AI models.

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And you start to see the sustainability advantage of OI.

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OK, that makes sense.

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Less energy faster.

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Learning OI is sounding pretty impressive.

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It definitely has potential.

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Another area Kagan highlights is this idea of embodiment,

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which could be key to unlocking even more of OI's capabilities.

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Embodiment.

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What does that even mean when we're talking about brain cells

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in a dish?

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Imagine giving these brain cells a virtual body

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in a simulated environment.

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OK.

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So they can interact with objects,

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experience consequences, and learn through that interaction.

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So it's not just input and output, like with regular AI?

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Exactly.

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It's about allowing these neuron networks

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to really understand their world, you know,

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making their learning more meaningful, more like how

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we learn in the real world.

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Wow.

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OK, so we've got these organoids learning super fast,

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potentially using way less energy.

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And now they have virtual bodies to experience their environment.

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It's pretty mind blowing.

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What's next for OI?

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What are researchers focused on now?

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Well, one of the big things is developing hardware and software,

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specifically designed for OI.

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Right, because right now they're using what's already out there.

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Exactly.

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They're having to kind of hack things together

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to make even basic experiments like the Pong game work.

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So imagine what they could do with the right tools.

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Exactly.

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That's where a lot of the research is focused right now,

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developing those tools and platforms that could really

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take OI to the next level.

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What about scaling this up?

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Can we make these organoid brains bigger, more complex,

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you know, handle tasks beyond playing Pong?

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That is the million dollar question.

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And it's one of the biggest challenges

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that researchers are facing right now.

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Yeah.

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Can we create OI systems that are intelligent,

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but also robust, reliable, and able to tackle

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more complex problems?

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It's still an open question.

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So it seems like we're still in the early stages of figuring out

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what OI can really do.

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We are, but that's also what makes this field so exciting.

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We're on the cusp of a potential revolution in computing.

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With any new technology, there are definitely hurdles

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to overcome, and a lot we still don't know.

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Absolutely.

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But I think it's safe to say the future of OI

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is incredibly promising, and we're just scratching the surface.

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We've covered the basics of what OI is and how it works,

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but what can we actually deal with it?

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Where can we apply this technology?

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Well, that's exactly what we're going

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to be talking about in part two of this deep dive.

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Tattoo, and we'll be right back.

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We'll delve into the potential applications of OI,

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from revolutionizing medicine to changing the way we think

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about computing itself.

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Welcome back, everyone.

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So we're continuing our exploration of organoid

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intelligence, and this time we're

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looking at its potential applications.

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Like, where could OI make a real difference?

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The potential is huge.

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It really spans fields like medicine computing,

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even how we understand consciousness itself.

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So let's start with medicine.

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Kagan talked about drug discovery and disease modeling.

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How could OI have an impact there?

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Well, imagine testing new drugs on actual human brain cells,

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but without the ethical concerns of human trials.

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OI could revolutionize drug development.

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It could give us a faster and more efficient way

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to find new treatments.

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So speed things up and make it more effective.

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Exactly, and because these organoids come from human cells,

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they could also provide a much more accurate model

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for studying diseases like Alzheimer's or Parkinson's.

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So we could actually understand these diseases better.

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Yes, potentially leading to new therapies.

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That's incredible.

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It's like having a personalized testing ground

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for each patient.

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Yeah, that's the ultimate goal.

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Personalized medicine tailored to an individual's genes,

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and OI could play a big role in making that happen.

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So are we talking about curing diseases that

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are currently incurable?

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It's possible, although OI is still in its early stages.

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A lot of research needs to be done before we

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see those kinds of breakthroughs.

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But the potential is there.

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What about applications beyond medicine?

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Kagan mentioned OI-powered prosthetics.

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Now that's one of the most fascinating applications,

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I think.

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Imagine a prosthetic arm controlled not by motors,

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but by your thoughts seamlessly integrated

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with your nervous system.

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That sounds straight out of science fiction.

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It does, doesn't it?

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Yeah.

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But that's the potential of OI.

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How would that even work?

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It's all about creating a direct connection

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between the organoid and the nervous system.

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The organoid could learn to interpret brain signals

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and translate them into commands for the prosthetic limb.

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So the organoid would be like a translator between your brain

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and the prosthetic.

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That's a great way to put it.

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It's still experimental, but researchers

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are making progress in connecting organoids

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to peripheral nerves.

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Wow, the possibilities are amazing.

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What about computing itself?

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Could OI change the way we think about computers?

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That's what a lot of researchers are exploring.

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Kagan talked about heterogeneous compute

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combining different types of processing units.

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So instead of just CPUs and GPUs,

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you'd have these biological processing units, too,

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the organoids.

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Exactly.

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Each type of unit has its own strengths and weaknesses.

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By combining them, you create a system that's

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more powerful than the sum of its parts.

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So it's not about replacing our computers,

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but making them better with this new kind

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of biological intelligence.

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That's the idea.

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We need to think of OI as complementary to what we already

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have.

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It's about expanding what computers can do.

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Kagan also mentioned learning from OI

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to improve our understanding of how humans learn.

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Right.

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By studying how organoids learn, we

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could gain insights into the basic principles of learning

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and intelligence that could then be applied to how we learn.

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So we're not just building better computers,

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but understanding ourselves better.

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Exactly.

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OI could revolutionize technology,

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but it could also deepen our understanding of who we are

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and how we think.

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OK.

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So we've talked about all these applications,

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but what are some of the challenges that

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stand in the way of OI becoming a reality?

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One of the biggest is scalability.

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Can we actually grow these organoids

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to be big enough and complex enough

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to handle real-world tasks?

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Right.

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Playing pong is one thing, but controlling a prosthetic

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or designing a new drug is a whole other level.

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Exactly.

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Another challenge is robustness and reliability.

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Can we create OI systems that are stable

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and work consistently over time?

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Remember, these are biological systems.

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They can be quite fragile.

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That makes sense.

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And what about the hardware and software?

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We talked about the limitations of existing technology.

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How are researchers dealing with that?

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Well, there's a lot of work going on

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to develop specialized hardware and software that's

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designed specifically for OI.

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OK.

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For example, new types of biocompatible electrodes

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and sensors that can interface with the organoids

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more effectively.

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So it's about building an environment

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where these organoids can thrive and connect

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with our technology.

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Exactly.

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Bridging the gap between the biological and the digital.

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And that requires some really innovative engineering

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and a deep understanding of both biology and computer

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science.

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It sounds like there's so much exciting research

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happening in the field of OI.

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There is.

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And while there are definitely challenges,

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the potential is enormous.

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This technology could transform medicine, reshape computing,

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and even change how we understand ourselves.

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OK.

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So we're back for the final part of our deep dive

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into organoid intelligence.

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The home stretch.

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We've covered the basics, the potential applications,

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and now it's time to talk about something really important,

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the future implications of this technology.

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Yeah.

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Things get a little more philosophical here.

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It does.

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It's one thing to talk about brain cells playing pong.

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But when we start talking about creating systems

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with real biological intelligence,

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it brings up some big questions about the future

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for humanity and technology.

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Absolutely.

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I mean, we're essentially talking about creating

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a new form of intelligence.

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One that's based on biology, not just silicon and code.

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Right.

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And that changes everything.

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It really does.

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It changes how we design computers,

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how we understand intelligence, even consciousness itself.

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Exactly.

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It challenges our whole definition of what

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it means to be intelligent, to be sentient.

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Right.

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If we can create systems that think like humans,

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at least in some ways, how do we define their rights?

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Do they deserve the same moral consideration

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as any other living being?

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These are questions that philosophers

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have been debating forever.

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Yeah.

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But OI brings a whole new dimension to the debate,

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because we're not just theorizing about AI anymore.

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We're actually building it cell by cell.

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And it's happening so fast.

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The advancements in OI research are incredible.

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It feels like every few months there's a new breakthrough.

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Which is why it's so important to have these conversations.

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Now, while the technology is still young,

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we have a chance to shape how OI develops.

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Make sure it's used ethically.

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Kagan himself talked about that a lot.

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The need for responsible development

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and open discussion between scientists, ethicists,

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and the public, he seems very aware of the potential risks

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and is pushing for a cautious approach.

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I think that's crucial.

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We can't get so caught up in the excitement of new technology

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that we forget about the ethical implications.

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It's like a tightrope walk.

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It is.

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It's a balancing act, but an essential one.

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So what does responsible development actually

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look like in this case?

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What are the key things to consider?

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Well, for one, transparency being open about the research,

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the methods, and the potential risks and benefits.

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Yes.

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Everyone knows what's going on.

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Exactly.

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And ensuring that the research is done ethically.

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Prioritizing the well-being of both the organoids

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and the people who might use this technology.

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That makes sense.

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And having these discussions publicly,

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not just among scientists, but with policymakers,

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ethicists, and the general public.

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Everyone has a stake in this OI.

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Has the potential to affect all of us in profound ways.

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So we need to approach it with a sense of shared responsibility.

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It's a societal issue, not just a scientific one.

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Right.

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And we need to be asking some tough questions.

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What are the potential unintended consequences

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of creating systems with biological intelligence?

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How do we make sure this technology doesn't make

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existing inequalities worse or end up in the wrong hands?

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There are no easy answers to these questions.

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No.

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But at least we're acknowledging them

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and starting the conversation.

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And it's not just about avoiding the risks.

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It's also about using OI for good.

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How can we use this technology to improve lives

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to solve some of the world's biggest problems?

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That's where things get really exciting.

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Oh.

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00:12:24,960 --> 00:12:26,280
I mean, think about it.

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OI could be used to develop new clean energy sources

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to create sustainable materials to enhance our cognitive abilities.

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The possibilities are endless.

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It's about creating a better future, not just with technology,

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but also in terms of what it means to be human in a world

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where biological and artificial intelligence coexist.

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That's a future I'm really looking forward to.

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It'll have challenges, of course, but also incredible possibilities.

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And it's a future that we get to shape together.

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00:12:53,400 --> 00:12:57,040
So as we wrap up this deep dive into organoid intelligence,

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I'm left with a feeling of awe and a sense of cautious optimism.

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This technology has the power to change everything.

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It really does.

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It's up to all of us to make sure it changes things for the better

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00:13:08,080 --> 00:13:11,160
by asking the hard questions, having open conversations,

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and approaching this new frontier with a sense of responsibility

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and wonder.

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I couldn't have said it better myself.

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00:13:16,240 --> 00:13:19,400
Thanks for joining us on this deep dive into organoid intelligence.

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It's a topic that's sure to keep evolving,

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so keep those questions coming.

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And let's continue exploring this incredible new frontier together.

