WEBVTT 00:00:00.910 --> 00:00:05.610 My guest today is Nicole Rincon. Nicole is a 00:00:05.610 --> 00:00:08.830 board certified physician assistant graduating 00:00:08.830 --> 00:00:12.910 from UC San Diego with honors in biology and 00:00:12.910 --> 00:00:17.929 special focus on microbiology and genetics. Nicole 00:00:17.929 --> 00:00:20.989 continued her healthcare education at Western 00:00:20.989 --> 00:00:24.670 University of Health Sciences, where she graduated 00:00:24.670 --> 00:00:27.609 on the Dean's List with a master's degree in 00:00:27.609 --> 00:00:32.539 physician assistant studies. in 2007. Nicole 00:00:32.539 --> 00:00:36.460 is MAPS, Medical Academia of Pediatric Special 00:00:36.460 --> 00:00:39.859 Needs, attendee, and has extensive experience 00:00:39.859 --> 00:00:43.280 with pediatric special needs, integrative and 00:00:43.280 --> 00:00:47.340 functional medicine. Currently, Nicole works 00:00:47.340 --> 00:00:50.479 at the Rasignol Medical Center, which includes 00:00:50.479 --> 00:00:54.060 Dr. Dan Rasignol and former guest Dr. Richard 00:00:54.060 --> 00:00:58.840 Fry. The Razignol Medical Center strives to identify 00:00:58.840 --> 00:01:03.539 what may be causing abnormal functioning of cells 00:01:03.539 --> 00:01:07.400 in persons with autism and other disorders using 00:01:07.400 --> 00:01:12.680 biomarkers that are objective, testable, and 00:01:12.680 --> 00:01:16.760 treatable. Through functional medicine intervention, 00:01:17.219 --> 00:01:20.340 Nicole saw a dramatic change in her family when 00:01:20.340 --> 00:01:24.000 addressing basic metabolic needs, gut health. 00:01:24.219 --> 00:01:29.379 and environmental changes. Her goal is to empower 00:01:29.379 --> 00:01:33.620 and educate her patients to actualize their ideal 00:01:33.620 --> 00:01:37.000 selves through medicine and natural remedies. 00:01:39.140 --> 00:01:41.459 Through Nicole's work at the Rasenal Medical 00:01:41.459 --> 00:01:45.859 Center and her experience, she has vast information 00:01:45.859 --> 00:01:49.519 and knowledge about non -traditional treatments. 00:01:50.620 --> 00:01:54.579 For that reason, We plan on having several episodes 00:01:54.579 --> 00:01:58.680 to discuss Nicole's findings and share incredible 00:01:58.680 --> 00:02:04.060 insights to the public. And now my conversation 00:02:04.060 --> 00:02:09.879 with Nicole Rincon. Nicole, let's start with 00:02:09.879 --> 00:02:12.879 your education and professional history and then 00:02:12.879 --> 00:02:16.250 the path into autism specifically. Perfect, thanks, 00:02:16.330 --> 00:02:19.270 Ryan. I just want to thank you first, Ryan, before 00:02:19.270 --> 00:02:20.870 we even get started. I really appreciate you 00:02:20.870 --> 00:02:23.169 having me on the podcast, and I appreciate you 00:02:23.169 --> 00:02:25.150 reaching out. This is an honor to be here and 00:02:25.150 --> 00:02:27.169 to speak with you, and I'm really looking forward 00:02:27.169 --> 00:02:32.129 to it. So my experience, so I have an interesting 00:02:32.129 --> 00:02:35.069 story. So I'm a physician assistant. I've been 00:02:35.069 --> 00:02:38.349 practicing medicine for 17 years now, I believe, 00:02:39.189 --> 00:02:43.759 and let's see, 2007, yeah, 17 years. You know 00:02:43.759 --> 00:02:46.599 as a child just to even go way back further than 00:02:46.599 --> 00:02:48.939 that, you know, I was a pretty academic child 00:02:48.939 --> 00:02:51.280 I was very good in math. I actually got a scholarship 00:02:51.280 --> 00:02:56.620 to college in math so very very left brain there 00:02:56.620 --> 00:03:01.819 and I Went to UC San Diego and I loved biology. 00:03:01.819 --> 00:03:03.979 I love to study science. I got a bachelor's degree 00:03:03.979 --> 00:03:07.569 in biology pretty good grades. I ended up going 00:03:07.569 --> 00:03:10.949 to P .A. school at Western University in Pomona. 00:03:11.469 --> 00:03:14.330 I was the youngest P .A. in my graduating class 00:03:14.330 --> 00:03:18.289 because I just I'm intense. I just blasted through 00:03:18.289 --> 00:03:21.250 the program and I was on the dean's list. So 00:03:21.250 --> 00:03:23.750 I've always enjoyed academics and being in that 00:03:23.750 --> 00:03:30.050 world. I, you know, in the meantime, I got my 00:03:30.050 --> 00:03:33.090 P .A. degree. I met my husband and P .A. school. 00:03:34.520 --> 00:03:37.439 We ended up moving to San Diego and I ended up 00:03:37.439 --> 00:03:39.120 getting into the wellness field pretty early 00:03:39.120 --> 00:03:43.020 on so I was doing a lot of Just wellness coaching 00:03:43.020 --> 00:03:46.800 as far as vitamins supplements Dietary changes 00:03:46.800 --> 00:03:51.060 was primarily the focus so healthy healthy diet 00:03:51.060 --> 00:03:54.759 and Then basically after a few years we decided 00:03:54.759 --> 00:03:57.599 we're gonna try and get pregnant So my husband 00:03:57.599 --> 00:04:02.129 and I tried and tried and after a few years You 00:04:02.129 --> 00:04:04.590 know, we'd went to the doctor and tried a few 00:04:04.590 --> 00:04:08.250 of the medications didn't work went to a fertility 00:04:08.250 --> 00:04:13.750 specialist and they ended up putting me on some 00:04:13.750 --> 00:04:18.250 follicle stimulating hormone and We had the first 00:04:18.250 --> 00:04:21.589 time we tried I didn't get pregnant Second time 00:04:21.589 --> 00:04:24.889 we tried I got pregnant which was wonderful. 00:04:24.889 --> 00:04:27.550 And then I had a miscarriage like ten weeks later 00:04:29.079 --> 00:04:31.500 And it was very, you know, this period was super 00:04:31.500 --> 00:04:33.959 stressful for my husband and I. And we decided 00:04:33.959 --> 00:04:35.600 one more time, we're gonna try one more time. 00:04:36.420 --> 00:04:39.160 So I ended up getting pregnant on the third time, 00:04:39.199 --> 00:04:42.540 third and last. And they found out it was triplets, 00:04:43.079 --> 00:04:46.939 which was, you know, super scary, but super amazing. 00:04:48.420 --> 00:04:50.819 And we ended up, you know, I seen the pregnancy 00:04:50.819 --> 00:04:52.939 through. So I had some ups and downs with that. 00:04:53.019 --> 00:04:57.889 I had bed rest. That I had to start I think at 00:04:57.889 --> 00:05:01.529 10 weeks But we made it to 34 weeks gave birth 00:05:01.529 --> 00:05:04.529 to the kids the kids were I said two boys and 00:05:04.529 --> 00:05:08.029 a girl they're now 12 years old and They were 00:05:08.029 --> 00:05:10.689 developing normally hitting all their milestones. 00:05:10.689 --> 00:05:13.730 I was on cloud 9. My life was great I had my 00:05:13.730 --> 00:05:16.990 husband and my home and my three kids and my 00:05:16.990 --> 00:05:21.589 job and And then at about 18 months, I noticed 00:05:21.589 --> 00:05:25.089 my one stuff my one son started with a tremor 00:05:25.050 --> 00:05:27.629 interestingly in the morning and he was starting 00:05:27.629 --> 00:05:30.189 to stutter a little and I thought that's interesting 00:05:30.189 --> 00:05:32.970 so we we took him to the doctor and he said well 00:05:32.970 --> 00:05:35.110 maybe he has autism I don't know they send us 00:05:35.110 --> 00:05:37.089 to the regional center we were getting worked 00:05:37.089 --> 00:05:40.069 up and then about but it wasn't too severe and 00:05:40.069 --> 00:05:41.949 we didn't know what to think of it so about six 00:05:41.949 --> 00:05:45.490 months later when at the two -year mark um in 00:05:45.490 --> 00:05:50.589 the summertime my son my other son and my daughter 00:05:50.589 --> 00:05:55.300 um severely regressed. My son mostly regressed. 00:05:55.360 --> 00:05:57.480 My daughter, at the same time, started having 00:05:57.480 --> 00:05:59.980 seizures. So here I have these healthy triplets. 00:06:00.079 --> 00:06:04.420 At two years old, they regressed, especially 00:06:04.420 --> 00:06:09.500 my son that regressed at two. He started smearing 00:06:09.500 --> 00:06:12.120 feces all over the wall, absolutely no eye contact. 00:06:12.279 --> 00:06:14.500 He had at least 50 words, two -word sentences, 00:06:14.680 --> 00:06:17.699 lost all speech. Just spinning in the corner 00:06:17.699 --> 00:06:21.490 of the room, I couldn't get him back. And my 00:06:21.490 --> 00:06:23.529 daughter, like I said, she started having seizures. 00:06:24.089 --> 00:06:26.709 And so we were just I was just devastated at 00:06:26.709 --> 00:06:30.290 this time. And I really I really got I really 00:06:30.290 --> 00:06:32.370 got hit hard. I had some depression, you know, 00:06:32.490 --> 00:06:35.129 temporarily. I mean, I couldn't get out of bed. 00:06:35.269 --> 00:06:36.649 I had to take a little leave of absence from 00:06:36.649 --> 00:06:40.350 work. And then I did what most parents do at 00:06:40.350 --> 00:06:42.209 that time are a lot of parents with kids on the 00:06:42.209 --> 00:06:44.610 spectrum. And I just. dove into the research. 00:06:44.730 --> 00:06:46.269 I said, I'm tired of feeling sorry for myself. 00:06:46.910 --> 00:06:49.769 There's something going on. I went to the doctor. 00:06:49.889 --> 00:06:54.230 They said, well, your son, we don't know, but 00:06:54.230 --> 00:06:56.470 he's stimming now, so let's put him on Risperidone. 00:06:56.529 --> 00:07:01.569 It's the only FDA approved drug. I'm like, but 00:07:01.569 --> 00:07:03.490 what's wrong with him? Why is this happening? 00:07:03.990 --> 00:07:06.769 Well, we don't know. It's autism. It's a psychological 00:07:06.769 --> 00:07:09.470 disorder. And, you know, I'm just me being me, 00:07:09.470 --> 00:07:12.329 I just didn't accept it. So I said, no, OK. So 00:07:12.329 --> 00:07:16.449 I went into the research and I stayed up till 00:07:16.449 --> 00:07:19.310 2 a .m. every morning and just looking at studies, 00:07:19.410 --> 00:07:22.009 looking at studies. What can I do? And so I he 00:07:22.009 --> 00:07:24.089 was diagnosed. They gave him a diagnosis of apraxia. 00:07:24.250 --> 00:07:28.970 So I went on to Google apraxia on PubMed and 00:07:28.970 --> 00:07:33.449 basically I read a study. I think it was a double 00:07:33.449 --> 00:07:37.720 blind placebo controlled study about Fish oil 00:07:37.720 --> 00:07:40.259 and vitamin E and the combination helping apraxia 00:07:40.259 --> 00:07:41.980 and it was a pretty big study for the time So 00:07:41.980 --> 00:07:44.180 I thought okay, let's try it. So I gave my son 00:07:44.180 --> 00:07:47.540 who was still severely Gone at that point for 00:07:47.540 --> 00:07:51.939 me. I gave him this fish oil omega -3 Vitamin 00:07:51.939 --> 00:07:56.220 E and within I swear it was like a week. He calmed 00:07:56.220 --> 00:08:00.240 down. He stops. He stopped spinning and he actually 00:08:00.240 --> 00:08:02.100 started making eye contact with me again and 00:08:02.100 --> 00:08:04.120 this I mean it was only within a week and I thought 00:08:04.120 --> 00:08:07.220 holy cow like we are on to something and I felt 00:08:07.220 --> 00:08:10.180 this huge rush of energy and like okay okay we 00:08:10.180 --> 00:08:11.860 can do this like okay so we're gonna keep the 00:08:11.860 --> 00:08:13.740 vitamin E and I just you know keep the fish oil 00:08:13.740 --> 00:08:16.300 and I I kept going down this rabbit hole we added 00:08:16.300 --> 00:08:18.759 things I added I found a trial on N acetylcysteine 00:08:18.759 --> 00:08:20.740 and I buy the I bought the exact brand at the 00:08:20.740 --> 00:08:22.560 dose that they had recommended because I'm a 00:08:22.560 --> 00:08:24.980 PA like I'm gonna do this clinically And I go 00:08:24.980 --> 00:08:27.959 down the B12, the methyl B12, and I go down the 00:08:27.959 --> 00:08:30.540 multivitamin with the B vitamins. And so I start 00:08:30.540 --> 00:08:34.480 adding on these substacks myself, and I was seeing 00:08:34.480 --> 00:08:36.480 improvement. Now, it wasn't miraculous. My son 00:08:36.480 --> 00:08:41.500 still didn't have speech. But I realized that 00:08:41.500 --> 00:08:43.179 maybe there was a fungal component. And so I 00:08:43.179 --> 00:08:45.379 started treating them with grapefruit seed extract 00:08:45.379 --> 00:08:48.279 at the time, which is what I had. And I noticed 00:08:48.279 --> 00:08:51.970 that their repetitive behaviors went down. And 00:08:51.970 --> 00:08:54.149 so I thought, okay, I need help. This is great. 00:08:54.250 --> 00:08:56.970 I'm on the right track. And so I ended up going 00:08:56.970 --> 00:09:00.809 to the Medical Academy of Pediatric Special Needs 00:09:00.809 --> 00:09:03.809 Conference. And so it's a conference that trains 00:09:03.809 --> 00:09:06.190 clinicians how to treat children with autism. 00:09:07.519 --> 00:09:11.340 and neurodevelopmental disorders. And I was so 00:09:11.340 --> 00:09:13.139 bold. I walked right into the conference. It 00:09:13.139 --> 00:09:14.500 was my first time there. And I'm like, who is 00:09:14.500 --> 00:09:17.259 the guy in charge? Who's the man? Who's the director? 00:09:17.379 --> 00:09:19.159 And they're like, oh, that's Dr. Rossignol. I 00:09:19.159 --> 00:09:20.779 said, great. Where is he? Does anybody know who 00:09:20.779 --> 00:09:21.759 he is? I don't even know what it looks like. 00:09:21.840 --> 00:09:23.419 And they're like, he's over there. So I just 00:09:23.419 --> 00:09:25.559 stomp up to him on the lunch break. I'm like, 00:09:25.559 --> 00:09:27.460 hey, I'm Nicole Rincon. I'm a physician assistant. 00:09:27.559 --> 00:09:31.240 I'd like to work with you. Can you hire me? And 00:09:31.240 --> 00:09:32.720 he says he looked at me and kind of laughed. 00:09:32.779 --> 00:09:35.429 And he's like, well. Do you have a license to 00:09:35.429 --> 00:09:37.230 practice in California? I said, yeah. He said, 00:09:37.269 --> 00:09:39.269 okay. Yeah, okay. Yeah, send me your resume. 00:09:39.309 --> 00:09:41.250 Sure. And then like that was it. The interview 00:09:41.250 --> 00:09:43.149 process was over. And so he hired me, you know, 00:09:43.149 --> 00:09:46.629 and obviously we communicated more, but I started 00:09:46.629 --> 00:09:48.809 working for him like two weeks after that. I 00:09:48.809 --> 00:09:50.470 ended up putting in my resignation and my old 00:09:50.470 --> 00:09:52.529 job. I quit. So I was all in. I was going to 00:09:52.529 --> 00:09:54.830 do autism research, autism treatments, help my 00:09:54.830 --> 00:09:57.669 kids, help other kids. It's been great. So that 00:09:57.669 --> 00:10:00.070 kind of starts my story at Rossignol Medical 00:10:00.070 --> 00:10:04.169 Center. That was eight years ago. And so Yeah, 00:10:04.169 --> 00:10:07.450 from there, you know, I, Dr. Rosignol's helped 00:10:07.450 --> 00:10:11.169 me with my own kids. We've done, I mean, all 00:10:11.169 --> 00:10:13.090 the things, well, not all, but almost all the 00:10:13.090 --> 00:10:14.669 things I've recommended to my patients. We've 00:10:14.669 --> 00:10:17.570 tried, we are in this, you know, I'm a mother. 00:10:17.970 --> 00:10:22.830 Both of my boys had a moderate to severe diagnosis 00:10:22.830 --> 00:10:25.750 of autism at this point. Now that they're 12, 00:10:25.909 --> 00:10:28.330 my son is, one son, the severe son, ironically, 00:10:28.549 --> 00:10:30.929 has lost his diagnosis. And then my other son 00:10:30.929 --> 00:10:35.070 is very mild. And we still have issues. We have 00:10:35.070 --> 00:10:37.730 some OCD and still some repetitive and social 00:10:37.730 --> 00:10:40.889 stuff going on. But they're now in general education 00:10:40.889 --> 00:10:43.710 in seventh grade. They're getting A's and B's. 00:10:44.210 --> 00:10:46.769 There are no behavioral issues. I'm very proud 00:10:46.769 --> 00:10:50.429 of them. And I'm very blessed. I'm very grateful. 00:10:51.169 --> 00:10:54.610 And frankly, I'm proud of myself because my husband 00:10:54.610 --> 00:10:56.570 has been so wonderful too. I mean, he supported 00:10:56.570 --> 00:10:58.570 me through this whole process. And so it was 00:10:58.570 --> 00:11:01.399 really a team effort to really and, you know, 00:11:01.500 --> 00:11:05.120 to really dedicate our lives to change the trajectory 00:11:05.120 --> 00:11:08.519 of our kids' future. So the reason I'm here, 00:11:09.379 --> 00:11:12.019 the short of it is, for my long -winded intro, 00:11:12.519 --> 00:11:16.820 is that I really, I feel grateful, I feel inspired, 00:11:16.840 --> 00:11:20.559 and I really want to help other families to know 00:11:20.559 --> 00:11:23.000 that there are things we can treat, that this 00:11:23.000 --> 00:11:25.340 is not just a psychological disorder, that they 00:11:25.340 --> 00:11:27.820 were... Necess born with that. There's nothing 00:11:27.820 --> 00:11:30.399 you can do. You know, I don't believe that I 00:11:30.399 --> 00:11:31.980 think there's a lot of hope I think there's a 00:11:31.980 --> 00:11:36.059 lot of changes. I think that certain things We 00:11:36.059 --> 00:11:38.440 may not be able to change and you can't necessarily 00:11:38.440 --> 00:11:41.519 project the trajectory of every child but there's 00:11:41.519 --> 00:11:44.279 so much you can do and so I'm just here to give 00:11:44.279 --> 00:11:47.019 parents hope and Hopefully, you know talk more 00:11:47.019 --> 00:11:49.200 with you about various treatments that you they 00:11:49.200 --> 00:11:51.299 can do things they can look at things they can 00:11:51.299 --> 00:11:56.309 talk to their doctor about that really Can like 00:11:56.309 --> 00:11:58.669 I said change their future in in a positive way 00:11:58.669 --> 00:12:00.929 because the brains only get so long to grow and 00:12:00.929 --> 00:12:03.669 obviously the brain is there's neuroplasticity 00:12:03.669 --> 00:12:07.049 it can change at any age even at old age, but 00:12:07.049 --> 00:12:09.789 You know, there are critical windows that really 00:12:09.789 --> 00:12:12.730 helps them early. There's critical windows It 00:12:12.730 --> 00:12:15.990 really helps, you know, it says it makes it easier 00:12:15.990 --> 00:12:18.129 children typically respond better the younger 00:12:18.129 --> 00:12:21.809 they are so yes or not to wait If you're if you're 00:12:21.809 --> 00:12:24.649 if you're on the fence about it, you know just 00:12:24.669 --> 00:12:26.570 try something, you know, just start something, 00:12:26.590 --> 00:12:28.289 you know, and, you know, obviously get help. 00:12:28.350 --> 00:12:31.009 And I do want to disclaimer too, that what I'm 00:12:31.009 --> 00:12:33.990 about to tell you and in future podcasts is not, 00:12:35.129 --> 00:12:36.909 is not to be taken as direct medical advice. 00:12:37.289 --> 00:12:39.090 So please talk to your doctor about any of these 00:12:39.090 --> 00:12:41.110 interventions. I'm not your personal clinician. 00:12:41.850 --> 00:12:45.009 So yeah, please, please understand. It's not 00:12:45.009 --> 00:12:47.070 to be implemented directly from me, but there 00:12:47.070 --> 00:12:49.190 are suggestions that you maybe you can look at. 00:12:49.370 --> 00:12:54.029 Yeah. For the listener, PubMed, Nicole references 00:12:54.029 --> 00:12:58.230 an excellent resource for everything that really 00:12:58.230 --> 00:13:04.470 in medicine. I've talked about PubMed quite a 00:13:04.470 --> 00:13:10.830 bit, so maybe the listener is aware of it. Tell 00:13:10.830 --> 00:13:18.860 me about how you discovered the Omega. So again, 00:13:19.000 --> 00:13:22.519 if you look at PubMed, there's actually, out 00:13:22.519 --> 00:13:27.399 of supplements, it's one of the most studied 00:13:27.399 --> 00:13:30.799 supplements with double -blind placebo -controlled 00:13:30.799 --> 00:13:34.240 trials in autism. So there's a decent amount 00:13:34.240 --> 00:13:38.500 of literature. I can't remember the amount of 00:13:38.500 --> 00:13:41.679 studies. We're currently writing a paper on supplements 00:13:41.679 --> 00:13:43.549 and placebo -controlled. controlled substances, 00:13:43.649 --> 00:13:46.230 we're doing a review paper, Dr. Ross and I, so 00:13:46.230 --> 00:13:49.309 I'm trying to, I think it was maybe 12, but I'm 00:13:49.309 --> 00:13:52.850 guest, I'm eating here. So, you know, the most 00:13:52.850 --> 00:13:56.190 studied supplements they have, I believe currently 00:13:56.190 --> 00:14:01.590 for placebo controlled trials are omegas, melatonin, 00:14:02.230 --> 00:14:06.169 and vitamin D, I believe. But there's a lot of 00:14:06.169 --> 00:14:07.950 randomized controlled trials for different supplements 00:14:07.950 --> 00:14:09.809 as well. But yeah, I just did a PubMed search 00:14:09.809 --> 00:14:14.120 and looked and saw you know, what could be helpful? 00:14:14.919 --> 00:14:16.600 And there was an article, I could pull it up 00:14:16.600 --> 00:14:19.139 for our next podcast, but it specifically addresses 00:14:19.139 --> 00:14:23.940 apraxia and autism with omega threes. Okay. Well, 00:14:23.960 --> 00:14:28.100 I'm so curious about that is I've, I've, I was 00:14:28.100 --> 00:14:32.399 taught I was, I've learned that omega and these 00:14:32.399 --> 00:14:36.559 things like EPA, DHA, or they're like fiber optic 00:14:36.559 --> 00:14:41.320 cables to transfer electrons and electrons are 00:14:41.399 --> 00:14:45.860 so critical for our biology. And I think maybe 00:14:45.860 --> 00:14:50.120 confusing and underrated, or at least a lot of 00:14:50.120 --> 00:14:54.340 people don't know about them. What is known about 00:14:54.340 --> 00:15:01.019 regression? So that's a big topic. And I could 00:15:01.019 --> 00:15:02.320 probably talk for about a half an hour on it. 00:15:03.820 --> 00:15:10.830 But there's varying literature. Dr. Fry and Me 00:15:10.830 --> 00:15:13.190 is the second author and also Dr. Rosgenahl wrote 00:15:13.190 --> 00:15:17.029 a study published actually earlier this year, 00:15:17.450 --> 00:15:19.970 correlating mitochondrial dysfunction with regression. 00:15:21.950 --> 00:15:25.450 So they find that especially mitochondrial respiration 00:15:25.450 --> 00:15:29.409 has been associated with it in certain kids. 00:15:30.840 --> 00:15:34.139 There's also some trials that show that there's 00:15:34.139 --> 00:15:38.159 regression found with seizures in kids and with 00:15:38.159 --> 00:15:43.419 epileptiform discharges. Seizures are, again, 00:15:43.539 --> 00:15:46.639 another topic, but a lot of kids have comorbid 00:15:46.639 --> 00:15:49.539 seizure disorder with autism. Then there's also 00:15:49.539 --> 00:15:51.940 a subset of kids that don't actually have seizure 00:15:51.940 --> 00:15:54.799 disorder, but they have epileptiform discharges. 00:15:55.120 --> 00:15:56.899 They're typically seen at night when the child 00:15:56.899 --> 00:16:02.019 is sleeping. for every kid you want to get a 00:16:02.019 --> 00:16:05.440 24 -hour EEG or an overnight EEG and Even if 00:16:05.440 --> 00:16:07.639 you're not seeing seizures, you can often see 00:16:07.639 --> 00:16:10.659 these spikes in Various areas of the brain that 00:16:10.659 --> 00:16:12.299 aren't normal. I mean, they're not physiologic. 00:16:12.299 --> 00:16:14.919 They're not supposed to be there and so These 00:16:14.919 --> 00:16:17.539 can correlate with actually autism behaviors 00:16:17.539 --> 00:16:20.480 and functioning and they're found and actually 00:16:20.480 --> 00:16:22.039 we're writing another paper on this that this 00:16:22.039 --> 00:16:24.840 may be associated with Agroaggression as well. 00:16:25.200 --> 00:16:28.379 So seizures epileptiform discharges possibly 00:16:28.379 --> 00:16:30.360 correlating now, that could have a mitochondrial 00:16:30.360 --> 00:16:32.139 dysfunction component to it. So they may all 00:16:32.139 --> 00:16:36.700 be related. And so, and there's also some, some 00:16:36.700 --> 00:16:41.740 talk about, you know, parents with, you know, 00:16:41.840 --> 00:16:44.960 vaccinations, there's a lot of literature that's 00:16:44.960 --> 00:16:48.659 very mixed on the topic. So what they found is 00:16:48.659 --> 00:16:50.419 that, at least from the studies I've found is 00:16:50.419 --> 00:16:53.559 that febrile regression specifically. So if a 00:16:53.559 --> 00:16:58.299 child has a fever, that can be associated with 00:16:58.299 --> 00:17:02.940 regression after post -vaccination. But like 00:17:02.940 --> 00:17:04.759 I said, the literature, there's a lot of studies 00:17:04.759 --> 00:17:09.940 with MMR, specifically in the thimerosal adjuvant, 00:17:10.619 --> 00:17:12.660 kind of the mercury component of it. And there's 00:17:12.660 --> 00:17:14.500 a lot of literature that says it's not associated 00:17:14.500 --> 00:17:19.099 with autism or regression. Anecdotally, I mean, 00:17:19.200 --> 00:17:21.240 I hear a lot of patients or not a lot. I would 00:17:21.240 --> 00:17:23.579 say there's a subset of patients that's that 00:17:23.579 --> 00:17:25.319 say that and they come to me and they said, yeah, 00:17:25.319 --> 00:17:27.519 they have their second year vaccines or their 00:17:27.519 --> 00:17:30.259 18 month. And then a few days later, they lost 00:17:30.259 --> 00:17:33.559 speech. So it's hard to know what to make of 00:17:33.559 --> 00:17:35.880 that. I think that the literature is mixed and 00:17:35.880 --> 00:17:37.660 I think you and I've talked privately about this 00:17:37.660 --> 00:17:42.500 is that I think there may be a component. for 00:17:42.500 --> 00:17:43.759 vaccinations. I'm just going to say it because 00:17:43.759 --> 00:17:46.240 it's the controversial topic. But I think, you 00:17:46.240 --> 00:17:48.400 know, I mean, I hate putting it out there, but 00:17:48.400 --> 00:17:50.099 also, I mean, I think there may be a component 00:17:50.099 --> 00:17:55.440 to vaccinations and autism, especially with the 00:17:55.440 --> 00:17:58.759 aluminum adjuvant that's recently been added. 00:17:59.200 --> 00:18:02.440 There are a lot of studies that correlate autism 00:18:02.440 --> 00:18:05.799 with metal toxicity. And so there's a study that 00:18:05.799 --> 00:18:08.799 was published in 2014, and it was looking at 00:18:08.799 --> 00:18:12.319 environmental trends, looking at Well, we know 00:18:12.319 --> 00:18:15.599 the incidence of autism has risen exponentially 00:18:15.599 --> 00:18:20.180 since the 90s, basically late 80s, mid 90s. So 00:18:20.180 --> 00:18:24.160 the author looked at what toxicants, what environmental 00:18:24.160 --> 00:18:26.859 exposures are we having that have been increasing 00:18:26.859 --> 00:18:28.900 commensurate with the rate of increasing autism? 00:18:29.579 --> 00:18:34.559 And the author postulated that it was the aluminum 00:18:34.559 --> 00:18:36.900 adjuvants in the vaccines that have been increasing. 00:18:37.160 --> 00:18:40.400 that correlated with the curve of autism. And 00:18:40.400 --> 00:18:45.240 they also correlated glyphosate, which is Roundup, 00:18:45.559 --> 00:18:47.900 and that's a brand name Roundup, but it's glyphosate 00:18:47.900 --> 00:18:53.119 that they put into the foods. And specifically, 00:18:53.299 --> 00:18:55.779 a lot of the seed oils, wrapping it back around 00:18:55.779 --> 00:19:00.240 to your omega -3 fatty acids. So a lot of these 00:19:00.240 --> 00:19:02.950 children, when they study them, They've found 00:19:02.950 --> 00:19:04.849 that many kids on the spectrum are deficient 00:19:04.849 --> 00:19:07.869 in omega -3s and specifically DHA that are found 00:19:07.869 --> 00:19:10.109 in fish oil. And a lot of these kids have an 00:19:10.109 --> 00:19:14.769 overburden of omega -6. So if you look at the 00:19:14.769 --> 00:19:17.849 glyphosate, I bring it around because our diet 00:19:17.849 --> 00:19:20.269 is mostly composed of these omega -6 fatty acids 00:19:20.269 --> 00:19:22.869 and these seed oils, which may be inflammatory 00:19:22.869 --> 00:19:28.390 in and of itself. But then when you combine glyphosate, 00:19:29.390 --> 00:19:33.789 which is... a very potent antibiotic in its own 00:19:33.789 --> 00:19:37.529 sense. So when you study the toxic effects of 00:19:37.529 --> 00:19:39.789 glyphosate, you find that it actually selectively 00:19:39.789 --> 00:19:43.289 reduces lactobacillus in the gut, and it increases 00:19:43.289 --> 00:19:47.130 Clostridia species. And we see that exact profile 00:19:47.130 --> 00:19:49.309 in a lot of children with autism. We see that 00:19:49.309 --> 00:19:51.349 there's lack of bifidote, lack of lactobacillus, 00:19:51.390 --> 00:19:54.789 and a lot of them have C. difficile, a lot of 00:19:54.789 --> 00:20:00.700 them. And so this is a profile. that can be very 00:20:00.700 --> 00:20:03.579 severe in these kids and then it skews propionic 00:20:03.579 --> 00:20:08.160 acid and basically causes autistic behaviors 00:20:08.160 --> 00:20:12.740 even in mouse models. This is how they induce 00:20:12.740 --> 00:20:15.039 autism in mouse models is that they give them 00:20:15.039 --> 00:20:17.359 propionic acid which is a Clostridium byproduct. 00:20:17.720 --> 00:20:20.680 So we kind of can correlate that these gut changes 00:20:20.680 --> 00:20:23.900 are increasing behavioral changes and that can 00:20:23.900 --> 00:20:26.359 be correlated with the glyphosate. Now it's all 00:20:26.359 --> 00:20:28.259 speculation and this is where you know but this 00:20:28.259 --> 00:20:31.049 is where some of the literature is going and 00:20:31.049 --> 00:20:34.049 people are looking at this. So anyway, the full 00:20:34.049 --> 00:20:36.150 circle of regression is that there I think there's 00:20:36.150 --> 00:20:39.150 multifactorial issues here. And I don't think 00:20:39.150 --> 00:20:42.390 it does the service to the autism community and 00:20:42.390 --> 00:20:45.250 the medical community at large to give a simple 00:20:45.250 --> 00:20:47.869 answer to say, oh, it's it's the vaccines, or 00:20:47.869 --> 00:20:51.670 it's roundup or it's You know, I mean when when 00:20:51.670 --> 00:20:53.609 autism first came out they used to blame like 00:20:53.609 --> 00:20:55.490 they called it refrigerator mothers You know, 00:20:55.529 --> 00:20:56.849 it's like oh, it's the mother's fault. They weren't 00:20:56.849 --> 00:20:58.509 loving enough with their children I mean, it's 00:20:58.509 --> 00:21:01.410 it's really folly to blame one specific thing 00:21:01.410 --> 00:21:03.650 when we can test it and see that there are metabolic 00:21:03.650 --> 00:21:06.329 issues There are microbiome issues. There are 00:21:06.329 --> 00:21:08.690 mitochondrial issues their inflammation issues 00:21:08.690 --> 00:21:11.190 lack of key fatty acids and vitamins and minerals 00:21:11.190 --> 00:21:15.390 and so Many of this is you know, fairly simply 00:21:15.390 --> 00:21:20.579 corrected as well. So that's why I'm here With 00:21:20.579 --> 00:21:24.700 you dialing in specific supplementations and 00:21:24.700 --> 00:21:27.059 kind of correcting each one of those kind of 00:21:27.059 --> 00:21:29.440 items that you mentioned, I think most of them 00:21:29.440 --> 00:21:33.660 or a lot of them were tied to the GI, gastrointestinal. 00:21:35.480 --> 00:21:40.240 So your history and your experience even gives 00:21:40.240 --> 00:21:44.119 you insight and information on this specific 00:21:44.119 --> 00:21:49.329 treatment. Yes. What is it like working at Rossignol 00:21:49.329 --> 00:21:54.650 Medical Center? And how does it kind of set apart 00:21:54.650 --> 00:21:59.630 from other interventions? That's a great question. 00:21:59.750 --> 00:22:04.150 Yeah, I really love it. Again, I met Dr. Rossignol. 00:22:04.269 --> 00:22:06.569 I'm working with him over the last eight years. 00:22:11.259 --> 00:22:13.740 we consider ourselves kind of a functional medicine, 00:22:14.119 --> 00:22:16.980 integrative medicine clinic. And what that means 00:22:16.980 --> 00:22:19.980 is that instead of just treating a symptom or 00:22:19.980 --> 00:22:24.579 looking at one part of the body, you know, like, 00:22:24.900 --> 00:22:27.740 oh, you know, so for example, autism is typically 00:22:27.740 --> 00:22:31.299 a, it's a DSM, it's a psych diagnosis, right? 00:22:31.680 --> 00:22:34.079 So it's a psychological diagnosis. And so what 00:22:34.079 --> 00:22:36.220 we know that just, if we were to just treat them 00:22:36.220 --> 00:22:39.029 with, Psychologic meds, risperidone, you know, 00:22:39.069 --> 00:22:41.789 anti -dopamine or pro -serotonin or whatever. 00:22:42.970 --> 00:22:45.549 It really doesn't address any core symptoms in 00:22:45.549 --> 00:22:48.490 the sense that these kids, yeah, may reduce behaviors 00:22:48.490 --> 00:22:50.769 and maybe the scores will improve, but they're 00:22:50.769 --> 00:22:55.130 not, their metabolic profile doesn't change. 00:22:55.230 --> 00:22:57.730 They're not actually improving. their function 00:22:57.730 --> 00:22:59.829 of their cells, the function of their metabolism, 00:22:59.970 --> 00:23:01.670 the function of their mitochondria. So that's 00:23:01.670 --> 00:23:03.930 where functional medicine comes into is how are 00:23:03.930 --> 00:23:06.789 these things functioning in the body and how 00:23:06.789 --> 00:23:09.049 can we optimize that? Because if you fix the 00:23:09.049 --> 00:23:13.349 core problems with the immune system and all 00:23:13.349 --> 00:23:17.049 these, like the microbiome, the mitochondria, 00:23:17.150 --> 00:23:20.990 then the kids actually get better without having 00:23:20.990 --> 00:23:23.150 to address the neurotransmitters because you're... 00:23:23.119 --> 00:23:26.000 fixing the underlying root cause. So that's kind 00:23:26.000 --> 00:23:28.240 of the premise of our practice. I love practicing 00:23:28.240 --> 00:23:33.039 this way. It's very holistic in looking at all 00:23:33.039 --> 00:23:35.019 the body systems and how, like you said, how 00:23:35.019 --> 00:23:37.579 the gut or the diet interferes with the brain, 00:23:37.740 --> 00:23:39.339 interferes with the mitochondria, interferes 00:23:39.339 --> 00:23:43.099 with neurotransmitters. And so you get to really 00:23:43.099 --> 00:23:46.680 play, you get to put on your scientific doctor 00:23:46.680 --> 00:23:49.420 hat and really every visit is different when 00:23:49.420 --> 00:23:51.960 I see each patient. Every visit is tailored. 00:23:52.569 --> 00:23:57.210 When I see a patient, we don't have like a protocol, 00:23:57.369 --> 00:23:58.990 like, oh, this is what we do and this is how 00:23:58.990 --> 00:24:00.609 you do it. No, I mean, really it's tailored to 00:24:00.609 --> 00:24:02.549 every kid's needs. What are the symptoms we're 00:24:02.549 --> 00:24:07.150 seeing? Autism is a very heterogeneous disease. 00:24:08.170 --> 00:24:13.029 It's very varied. It's very different in how 00:24:13.029 --> 00:24:16.670 it presents for every child or adult. And so 00:24:16.670 --> 00:24:19.250 we really have to target individual systems. 00:24:20.509 --> 00:24:22.690 And so I can talk about that process, Ryan, if 00:24:22.690 --> 00:24:25.470 you wanted to, a little more in depth. Yeah. 00:24:25.930 --> 00:24:29.170 First, I just have a comment that like these 00:24:29.170 --> 00:24:31.690 supplements that you're providing instead of, 00:24:31.849 --> 00:24:34.390 and I'm glad that you brought up the psychological 00:24:34.390 --> 00:24:37.970 drugs as an alternative because the supplements 00:24:37.970 --> 00:24:41.369 are upstream of like what synthesizes proteins 00:24:41.369 --> 00:24:44.869 that make the neurotransmitters. So instead of 00:24:44.869 --> 00:24:49.799 blocking them or manipulating them, like the 00:24:49.799 --> 00:24:53.819 synaptic level or the vesicle level or the uptake, 00:24:54.000 --> 00:24:59.279 et cetera, you're helping them create the proteins 00:24:59.279 --> 00:25:03.180 and these neuromodulators, neurotransmitters 00:25:03.180 --> 00:25:07.660 in a more organic way, in a more functional way. 00:25:07.900 --> 00:25:11.400 Yes. So for example, yes, absolutely. So for 00:25:11.400 --> 00:25:14.880 example, I wanted to bring this up because I 00:25:14.880 --> 00:25:17.660 think one of the biggest things that we can do 00:25:17.660 --> 00:25:20.619 to help kids right now with autism is folate 00:25:20.619 --> 00:25:24.319 and You know, there's many there's different 00:25:24.319 --> 00:25:28.380 forms of folate but kids on this autism spectrum 00:25:28.380 --> 00:25:32.019 typically have problems with methylation and 00:25:32.019 --> 00:25:36.200 methylation is part of a folate cycle and and 00:25:36.200 --> 00:25:39.299 It helps produce neurotransmitters specifically 00:25:39.299 --> 00:25:43.160 and so Kids have if kids have weak you mentioned 00:25:43.160 --> 00:25:47.869 in in talking previously with me, MTHFR deficits. 00:25:48.289 --> 00:25:53.109 They say that most kids have at least 25 to 50 00:25:53.109 --> 00:25:55.650 % deficits if you're on the autism spectrum. 00:25:55.829 --> 00:25:58.309 I rarely see, and I do see them sometimes, but 00:25:58.309 --> 00:26:00.670 I rarely see a kid that does not have an MTHFR 00:26:00.670 --> 00:26:03.029 mutation with autism. So that means that they're 00:26:03.029 --> 00:26:05.289 not methylated folate properly. And without this 00:26:05.289 --> 00:26:09.549 folate methylation, they're not going to properly... 00:26:11.880 --> 00:26:14.539 Produce appropriate neurotransmitters and also 00:26:14.539 --> 00:26:17.819 detoxification like glutathione a lot of these 00:26:17.819 --> 00:26:20.480 things that are really important for neurodevelopment 00:26:20.480 --> 00:26:23.019 at a critical age and there's also something 00:26:23.019 --> 00:26:25.660 called folate receptor antibodies that up to 00:26:25.660 --> 00:26:28.140 80 percent 70 to 80 percent depending on the 00:26:28.140 --> 00:26:31.519 trial you look at of kids on the autism spectrum 00:26:31.519 --> 00:26:34.440 have positive folate receptor antibodies and 00:26:34.440 --> 00:26:36.940 so what that means is that they're their bodies 00:26:36.940 --> 00:26:40.180 blocking there's two different kinds of antibodies 00:26:40.180 --> 00:26:43.460 but in either case their body is blocking folate 00:26:43.460 --> 00:26:45.680 from getting into the brain, active folate from 00:26:45.680 --> 00:26:50.339 getting into the brain. So what we find is that 00:26:50.339 --> 00:26:54.630 most kids are have these antibodies and they're 00:26:54.630 --> 00:26:57.509 responding positively. The trials are really 00:26:57.509 --> 00:27:00.349 good as far as treating core symptoms of autism 00:27:00.349 --> 00:27:02.390 when giving them high dose folate. And it's just 00:27:02.390 --> 00:27:06.289 folinic acid. So it's not folic acid is synthetically 00:27:06.289 --> 00:27:09.609 made, folinic acid is just the unmethylated portion 00:27:09.609 --> 00:27:12.130 that the brain, the body can take up and then 00:27:12.130 --> 00:27:13.990 cross the blood brain barrier to help treat what 00:27:13.990 --> 00:27:16.799 we call cerebral folate deficiency. So maybe 00:27:16.799 --> 00:27:19.240 a lot of the core symptoms of autism, at least 00:27:19.240 --> 00:27:21.940 in part, are cerebral folate deficiency. So one 00:27:21.940 --> 00:27:25.480 supplement at a high dose to treat that, and 00:27:25.480 --> 00:27:28.980 also to treat the methylation. In different combinations, 00:27:29.099 --> 00:27:30.880 is it methylated, is it not, how much do we give 00:27:30.880 --> 00:27:33.839 of each? just that one simple supplement can 00:27:33.839 --> 00:27:35.720 really change, like you said, the downstream 00:27:35.720 --> 00:27:37.539 effect of how we make neurotransmitters, how 00:27:37.539 --> 00:27:40.839 we detoxify our body. And so we're really treating 00:27:40.839 --> 00:27:43.019 a root cause that will then in turn help the 00:27:43.019 --> 00:27:46.299 mitochondria, help the neurotransmitters, help 00:27:46.299 --> 00:27:49.000 the gut function, help your metabolism, help 00:27:49.000 --> 00:27:54.000 all these immune function. So it's really awesome 00:27:54.000 --> 00:28:00.259 to start at the root of the tree. Yeah. For my 00:28:00.259 --> 00:28:04.539 understanding is this methylation process, it's 00:28:04.539 --> 00:28:08.539 circular, and it's also dependent on methionine 00:28:08.539 --> 00:28:11.859 and amino acid, a very special one. This is where 00:28:11.859 --> 00:28:16.180 all protein synthesis and DNA sequencing, I should 00:28:16.180 --> 00:28:21.039 say, start. It's like these two circular things 00:28:21.039 --> 00:28:28.000 on a bicycle. I envision it as a bicycle whereby 00:28:28.000 --> 00:28:33.039 if one's not running in this circular fashion, 00:28:33.819 --> 00:28:37.299 then the other process is going to be off. Yes. 00:28:37.940 --> 00:28:40.380 And the byproduct of the of on the downstream 00:28:40.380 --> 00:28:42.359 of that bicycle, the bottom of that bicycle wheel, 00:28:42.359 --> 00:28:44.619 if you look at the diagrams as often, like I 00:28:44.619 --> 00:28:47.779 said, cysteine and the glutathione as well. Yeah. 00:28:47.859 --> 00:28:51.319 So so you're you're getting this and there's 00:28:51.319 --> 00:28:53.500 more it's more complicated than this. But just 00:28:53.500 --> 00:28:56.819 for simplicity sake, you're interfering with 00:28:56.819 --> 00:29:00.609 the the neurotransmitter the methionine portion 00:29:00.609 --> 00:29:03.230 of it and you're also really impairing the glutathione 00:29:03.230 --> 00:29:06.170 component component of it, which is the body's 00:29:06.170 --> 00:29:13.230 master antioxidant, it's it's the master You 00:29:13.230 --> 00:29:17.670 know grabber of toxins if you will and these 00:29:17.670 --> 00:29:20.549 kids typically are low in glutathione and likely, 00:29:20.549 --> 00:29:23.789 you know as a result of They typically have a 00:29:23.789 --> 00:29:26.789 cysteine deficiency as well So I will often give 00:29:26.789 --> 00:29:28.990 some N -acetylcysteine or some kind of sulfur 00:29:28.990 --> 00:29:33.390 support. But in essence, if you optimize these 00:29:33.390 --> 00:29:37.089 few cycles, if you optimize the folic acid cycle, 00:29:37.269 --> 00:29:40.569 you optimize the Krebs cycle, which is the citric 00:29:40.569 --> 00:29:45.630 acid cycle, optimize the electron transport chain 00:29:45.630 --> 00:29:48.410 for mitochondrial functioning. I mean, once you 00:29:48.410 --> 00:29:52.720 kind of look at these core things that are really 00:29:52.720 --> 00:29:56.220 driving the cell for energy production and health 00:29:56.220 --> 00:30:00.500 and protection, then things just get better. 00:30:02.180 --> 00:30:06.059 And again, every kid is varied. And we do know 00:30:06.059 --> 00:30:09.700 that there are also some DNA changes that we 00:30:09.700 --> 00:30:13.220 have seen, particularly with mitochondrial DNA. 00:30:14.480 --> 00:30:19.029 So there are a lot of mitochondrial DNA. Increased 00:30:19.029 --> 00:30:21.230 copy number variants basically some duplicates 00:30:21.230 --> 00:30:23.609 and there's things that we've seen that are that 00:30:23.609 --> 00:30:28.289 can change But it doesn't it's not it's kind 00:30:28.289 --> 00:30:30.109 of a subset of autism and I don't think that 00:30:30.109 --> 00:30:34.829 it certainly represents the majority Yeah, so 00:30:34.829 --> 00:30:36.150 so there are there are multiple things to look 00:30:36.150 --> 00:30:39.730 at what I'm what I'm hearing and learning about 00:30:39.730 --> 00:30:43.069 The approach here is you're starting at the very 00:30:43.069 --> 00:30:46.529 upstream process the very start of the process 00:30:46.529 --> 00:30:50.440 that if this is abnormal, all of these downstream 00:30:50.440 --> 00:30:53.740 processes are going to be off. And this explains 00:30:53.740 --> 00:30:57.799 why there are so many autism and XYZ, autism 00:30:57.799 --> 00:31:01.579 and dyspraxia, autism and allergies, eczema, 00:31:02.539 --> 00:31:06.660 the GI problems. This is all getting to the bottom 00:31:06.660 --> 00:31:11.720 of what people need to know. We need to go upstream 00:31:11.720 --> 00:31:17.000 and not at this downstream levels. It's not helping. 00:31:18.119 --> 00:31:20.400 Absolutely. And yeah, one study I believe, I 00:31:20.400 --> 00:31:22.859 mean, I think it was from the CDC or some kind 00:31:22.859 --> 00:31:27.000 of a health NIH maybe guideline was saying that 00:31:27.000 --> 00:31:31.680 the average child diagnosed with autism has four 00:31:31.680 --> 00:31:33.920 core morbidities on average, in addition to the 00:31:33.920 --> 00:31:37.519 autism diagnosis, functional constipation and 00:31:37.519 --> 00:31:41.500 ADHD and, you know, yeah, allergic rhinitis and 00:31:41.500 --> 00:31:43.559 eczema, whatever, you know, so yeah, there's, 00:31:43.740 --> 00:31:47.990 it's not just a neurologic disorder. And we see 00:31:47.990 --> 00:31:51.089 that. I think that's why a lot of research now 00:31:51.089 --> 00:31:55.250 is coming out about the risk of developing Alzheimer's 00:31:55.250 --> 00:31:57.869 and Parkinson's because all of these downstream 00:31:57.869 --> 00:32:01.950 or these upstream processes that's responsible 00:32:01.950 --> 00:32:05.150 for cell development and the nervous system development 00:32:05.150 --> 00:32:10.569 is already kind of off. So they're more susceptible 00:32:10.569 --> 00:32:16.039 to those aging problems. Yes. Yeah, I mean, I 00:32:16.039 --> 00:32:19.619 have a family history of Parkinson's, and then 00:32:19.619 --> 00:32:22.259 I have my children with autism. I have a sibling 00:32:22.259 --> 00:32:25.180 with Guillain -Barre. And so I'm looking around, 00:32:25.319 --> 00:32:28.180 I'm like, there's probably some underlying related 00:32:28.180 --> 00:32:30.380 thing, even though they're different presentations. 00:32:30.920 --> 00:32:34.160 And, you know, it's very odd because in previous 00:32:34.160 --> 00:32:36.240 to this, we didn't have any history of this, 00:32:36.920 --> 00:32:39.839 like, you know, previous to my parents' generation. 00:32:41.039 --> 00:32:42.839 You know, it's not like this was a thing in my 00:32:42.839 --> 00:32:45.700 family for Seven generations, you know, yeah, 00:32:45.880 --> 00:32:48.019 so it's just odd that we're kind of looking at 00:32:48.019 --> 00:32:50.019 this and I think in my family's case I think 00:32:50.019 --> 00:32:51.859 a lot of it the cornerstone is mitochondrial 00:32:51.859 --> 00:32:53.619 dysfunction And I think that's why you know, 00:32:53.640 --> 00:32:56.279 my kids regressed there were several things going 00:32:56.279 --> 00:32:59.559 on at the time when my kids regressed that I 00:32:59.559 --> 00:33:04.460 can kind of point to but I you know, I don't 00:33:04.460 --> 00:33:05.779 know if you want me to share my family story, 00:33:05.779 --> 00:33:09.740 but just personally I know that My kids had a 00:33:09.740 --> 00:33:11.660 copper dominance and we see this a lot in autism. 00:33:11.920 --> 00:33:16.099 So There's a very skewed increased copper to 00:33:16.099 --> 00:33:18.160 low zinc ratio and they're supposed to be at 00:33:18.160 --> 00:33:20.940 a fairly similar ratio in neurotypical individuals. 00:33:22.779 --> 00:33:25.799 So copper dominance is one of the number one 00:33:25.799 --> 00:33:28.559 findings that they find with metallopathies in 00:33:28.559 --> 00:33:32.380 kids on the spectrum. So my kid's hair was red. 00:33:32.480 --> 00:33:34.200 I mean, looking back, my daughter and my son, 00:33:34.220 --> 00:33:36.500 I mean, they were redheads. I mean, copper redheads. 00:33:36.920 --> 00:33:38.259 And I remember thinking about, my husband and 00:33:38.259 --> 00:33:39.519 I would talk about this, oh, why are they red? 00:33:39.559 --> 00:33:41.940 Oh, isn't that cute? Because my husband's Hispanic. 00:33:42.539 --> 00:33:45.220 black hair. I'm, you know, I'm, you know, Italian 00:33:45.220 --> 00:33:47.579 and I have brown hair. And so we're like, well, 00:33:47.680 --> 00:33:49.319 look at how cute our kids are redheaded. And 00:33:49.319 --> 00:33:51.660 now looking back, you know, um, they were probably 00:33:51.660 --> 00:33:53.440 severely copper dominant because when I started 00:33:53.440 --> 00:33:56.039 testing them, they were really zinc deficient. 00:33:56.400 --> 00:34:00.539 Um, and so that probably set the tone. Um, you 00:34:00.539 --> 00:34:03.440 know, and then, you know, at the time as well, 00:34:03.900 --> 00:34:06.480 we had, um, just to wrap this around, we actually, 00:34:07.319 --> 00:34:08.960 I thought it was interesting that my kids all 00:34:08.960 --> 00:34:10.559 regressed at the same time. And I thought, well, 00:34:10.559 --> 00:34:12.260 there has to be something environmental. And 00:34:12.260 --> 00:34:14.960 I was young, and I wasn't in the space yet. And 00:34:14.960 --> 00:34:19.340 I didn't realize we had a water leak in my bathroom 00:34:19.340 --> 00:34:24.380 downstairs. And we kind of let it sit there for 00:34:24.380 --> 00:34:26.539 a while. The back of the bathtub wall was getting 00:34:26.539 --> 00:34:28.619 a little squishy. And we thought, oh, OK, OK, 00:34:28.659 --> 00:34:30.360 let's bring somebody out. And we brought out 00:34:30.360 --> 00:34:32.300 a plumber, and they opened up the whole wall. 00:34:32.360 --> 00:34:34.940 And I'm sure that there was just a ton of black 00:34:34.940 --> 00:34:36.559 mold back there, because it was right around 00:34:36.559 --> 00:34:38.739 that time when we opened up the wall and we didn't 00:34:38.739 --> 00:34:42.800 properly remediate it. We didn't wall anything 00:34:42.800 --> 00:34:44.900 off or move out while they're doing it. And it 00:34:44.900 --> 00:34:46.280 was around that time that our kids got really 00:34:46.280 --> 00:34:49.099 sick. And I thought, oh, I bet it was a huge 00:34:49.099 --> 00:34:51.179 dose of mold exposure on top of everything else 00:34:51.179 --> 00:34:53.960 that was going on. And it was part of it too. 00:34:55.340 --> 00:34:57.119 And I noticed, like I was telling you, they had 00:34:57.119 --> 00:34:58.980 a big fungal overgrowth at that point that I 00:34:58.980 --> 00:35:02.750 had to kind of treat. And so once we... Properly 00:35:02.750 --> 00:35:05.110 remediated it symptoms did get a little better 00:35:05.110 --> 00:35:07.750 But it wasn't actually ironically. It wasn't 00:35:07.750 --> 00:35:11.010 really Till we moved out of that home two years 00:35:11.010 --> 00:35:14.130 later that my son started speaking again now 00:35:14.130 --> 00:35:17.849 I Don't know if it was moving out of the home 00:35:17.849 --> 00:35:19.670 or all of the interventions because we were doing 00:35:19.670 --> 00:35:22.849 a lot of that time With Roz ignore that really 00:35:22.849 --> 00:35:26.489 brought his speech back But there's yeah, there's 00:35:26.489 --> 00:35:28.570 a lot to look at and there's a lot environmentally 00:35:28.780 --> 00:35:31.139 You know, I think I think a lot of these things 00:35:31.139 --> 00:35:36.940 play play a part. Yeah. Things like Alzheimer's 00:35:36.940 --> 00:35:41.380 was 1910 whenever I hit medical literature, autism, 00:35:41.940 --> 00:35:45.260 1943 for Canter. Like we're writing all of these 00:35:45.260 --> 00:35:48.059 things just appeared, which is very interesting. 00:35:52.679 --> 00:35:56.239 What is it like working alongside Rasenal and 00:35:56.239 --> 00:36:00.539 Richard Fry and how that accelerates your ability 00:36:00.539 --> 00:36:03.960 to learn? Yeah, it's amazing. I mean these guys 00:36:03.960 --> 00:36:07.440 are really smart and I'm always trying to pry 00:36:07.440 --> 00:36:11.440 information from them. They're ironically, for 00:36:11.440 --> 00:36:14.760 as much as prolific as they are writing papers, 00:36:14.960 --> 00:36:17.980 they're kind of short -winded with conversations. 00:36:18.440 --> 00:36:20.619 And you know, I'm like the chatter in the group. 00:36:21.379 --> 00:36:23.159 I'm always trying to pry info from them. But 00:36:23.159 --> 00:36:25.800 yeah, they're very intelligent. And like I said, 00:36:25.840 --> 00:36:28.380 when it comes to explaining mitochondrial function 00:36:28.380 --> 00:36:31.960 and things, I mean, and cell biology, you know, 00:36:32.079 --> 00:36:34.440 these are the guys to talk to. I mean, I have 00:36:34.440 --> 00:36:37.239 a basic understanding of the function, but I'm 00:36:37.239 --> 00:36:41.639 more, you know, I do all of the research, well, 00:36:41.679 --> 00:36:43.179 not all of it, but I do a lot of the research. 00:36:43.219 --> 00:36:45.320 So I'm the one that's kind of scouring the trials, 00:36:45.480 --> 00:36:48.409 reading them. aggregating the data for them, 00:36:48.710 --> 00:36:50.210 presenting it to them, and they usually do the 00:36:50.210 --> 00:36:53.250 write -ups and kind of the finishing touches. 00:36:55.070 --> 00:36:56.809 Learned something new every day. I mean, I'm 00:36:56.809 --> 00:36:59.869 doing you know autism research and I literally 00:36:59.869 --> 00:37:01.869 my husband gets tired of hearing about it because 00:37:01.869 --> 00:37:06.510 I'm just like You know, there's so much out there 00:37:06.510 --> 00:37:09.510 to learn so it's it's a it's a fantastic opportunity. 00:37:09.510 --> 00:37:13.610 I I do part -time Research for Roscoe Medical 00:37:13.610 --> 00:37:15.889 Center and then I see patients part -time as 00:37:15.889 --> 00:37:20.909 well. Yeah as a PA having that insight to the 00:37:20.909 --> 00:37:26.599 research is very It's different. A lot of PAs, 00:37:26.679 --> 00:37:28.920 to my understanding, you don't see a lot of PAs 00:37:28.920 --> 00:37:33.719 on papers in like Nature or Neurobiology of Disease 00:37:33.719 --> 00:37:37.500 and all of these wonderful journals. Yeah. Well, 00:37:37.639 --> 00:37:39.980 PAs, you know, their structure, I mean, their 00:37:39.980 --> 00:37:43.420 function in the modern medical world is really 00:37:43.420 --> 00:37:45.960 to be a clinician, is to see patients to help 00:37:45.960 --> 00:37:48.139 ease, I think, some of the healthcare burden 00:37:48.139 --> 00:37:51.039 that we have. You know, there's not... you know, 00:37:51.199 --> 00:37:53.059 the number of clinicians or physicians is going 00:37:53.059 --> 00:37:55.739 down. So, I mean, I think their primary role 00:37:55.739 --> 00:37:59.840 is to see patients. And I think a lot of PAs 00:37:59.840 --> 00:38:02.519 are very well -intentioned. I mean, I love my 00:38:02.519 --> 00:38:05.599 colleagues. I've went to school with some really 00:38:05.599 --> 00:38:07.820 good hearted people. I find that they're very 00:38:07.820 --> 00:38:11.639 down to earth. And they really just want to help 00:38:11.639 --> 00:38:15.000 people. I'm a little bit different. You know, 00:38:15.000 --> 00:38:16.619 I've just I've always been kind of a nerd at 00:38:16.619 --> 00:38:19.849 heart. And I just I really like the study of 00:38:19.849 --> 00:38:22.230 science. And so and I just find it fascinating 00:38:22.230 --> 00:38:24.269 in addition to my like personal interest because 00:38:24.269 --> 00:38:28.230 of my family. But you know, I think most like 00:38:28.230 --> 00:38:30.789 I said, I think most PAs are well intentioned. 00:38:30.789 --> 00:38:32.909 They just don't go through the training maybe 00:38:32.909 --> 00:38:35.050 because of lack of time. And I think it's mostly 00:38:35.050 --> 00:38:37.409 because employers don't encourage this. You know, 00:38:37.429 --> 00:38:39.570 the modern medical model is not following this 00:38:39.570 --> 00:38:43.909 functional medicine model. And I think that we 00:38:43.909 --> 00:38:47.300 because we are, you know, We're just a niche 00:38:47.300 --> 00:38:50.739 private practice. You know, we're not part of 00:38:50.739 --> 00:38:52.360 Kaiser or some of these other, you know, Blue 00:38:52.360 --> 00:38:54.539 Cross or these other conglomerates. We're just 00:38:54.539 --> 00:38:56.579 here to practice medicine the way we want to. 00:38:57.059 --> 00:38:59.500 But most PAs are controlled by protocols. They're, 00:38:59.500 --> 00:39:01.800 you know, if you have, you know, if you have 00:39:01.800 --> 00:39:04.920 a, you know, headache, then we're gonna do this 00:39:04.920 --> 00:39:06.239 or that. And then we're gonna give them this 00:39:06.239 --> 00:39:08.079 med. And we're not really, they're not looking 00:39:08.079 --> 00:39:09.440 at, well, why do they have a headache? Is it 00:39:09.440 --> 00:39:11.139 a histamine intolerance? Is it a food allergy? 00:39:11.380 --> 00:39:12.679 Is there something else? You know, like, what 00:39:12.679 --> 00:39:15.550 are we? What's the trigger? And that's just not 00:39:15.550 --> 00:39:20.030 how PA school is taught. And I think it's really 00:39:20.030 --> 00:39:24.070 just this disease, drug, disease, drug, disease, 00:39:24.190 --> 00:39:26.630 drug. And, you know, and a lot of these things 00:39:26.630 --> 00:39:28.369 are very topical. And some of these things are 00:39:28.369 --> 00:39:30.289 effective. I mean, we prescribe meds. We do. 00:39:30.289 --> 00:39:32.550 And I think that there is a place for medications. 00:39:32.630 --> 00:39:35.489 I'm grateful I'm a PA. But really, what is the 00:39:35.489 --> 00:39:37.610 medication doing and why and how could it be 00:39:37.610 --> 00:39:41.630 treating a core symptom? Or, you know, how can 00:39:41.630 --> 00:39:43.809 we assist in the functioning of this person while 00:39:43.809 --> 00:39:45.610 we're treating the core symptoms? Because sometimes, 00:39:45.630 --> 00:39:48.329 you know, it'll take, I mean, it took took my 00:39:48.329 --> 00:39:50.670 kid like almost 10 years to lose his diagnosis 00:39:50.670 --> 00:39:52.630 and eight years. So, I mean, what can we do in 00:39:52.630 --> 00:39:55.329 the meantime to help him function while we're 00:39:55.329 --> 00:39:58.190 help detoxing his body and helping his, you know, 00:39:58.230 --> 00:40:03.489 his metabolism and things like that. So there's 00:40:03.489 --> 00:40:05.670 a place for that. But yes, the medical model 00:40:05.670 --> 00:40:08.269 teaches in a way that does not know how to approach 00:40:08.269 --> 00:40:10.809 autism. And I think that when we were specifically, 00:40:11.150 --> 00:40:13.050 you know, when I'm here telling everybody, like 00:40:13.050 --> 00:40:15.570 there is a way to approach autism that is very 00:40:15.570 --> 00:40:17.610 medical and that is also very critical thinking 00:40:17.610 --> 00:40:20.829 and that it is it is not just a psychological 00:40:20.829 --> 00:40:24.469 diagnosis. And we can see this in the body of 00:40:24.469 --> 00:40:28.969 literature that is vast. And so I think it takes, 00:40:28.969 --> 00:40:31.230 you know, a lot of curiosity and time and employers 00:40:31.230 --> 00:40:33.309 like Dr. Rosignol and Dr. Fry that are willing 00:40:33.309 --> 00:40:35.809 to, you know, pay me to do research because, 00:40:36.010 --> 00:40:38.980 you know, I have a family. I have to make money. 00:40:39.239 --> 00:40:41.019 But I want to do this research. I want to do 00:40:41.019 --> 00:40:42.900 the hard work. I want to I want to figure it 00:40:42.900 --> 00:40:45.400 out. You know, and so it's a nice to have people 00:40:45.400 --> 00:40:47.219 that are out there supporting this community 00:40:47.219 --> 00:40:49.219 that are like, yes, let's all pull in together. 00:40:49.280 --> 00:40:51.280 We'll all figure this out. We're in this for 00:40:51.280 --> 00:40:54.239 the for the betterment of humanity, for the betterment 00:40:54.239 --> 00:40:56.760 of our kids, because I I believe that, you know, 00:40:56.760 --> 00:40:59.840 we all have, you know, a God given right to health. 00:41:00.059 --> 00:41:02.920 I think that, you know, I think I believe this 00:41:02.920 --> 00:41:06.280 like I don't think that. That we should be sick 00:41:06.280 --> 00:41:09.239 and that and that you know our water or food 00:41:09.239 --> 00:41:13.360 or these systems You know should be just putting 00:41:13.360 --> 00:41:16.219 band -aids on things. You know, I I want to see 00:41:16.219 --> 00:41:18.400 everybody well, and I'm gonna do whatever I can 00:41:18.400 --> 00:41:23.460 to that to that end Yeah, yeah, I'm not a big 00:41:23.460 --> 00:41:26.159 fan of the medical paradigm with that prescription 00:41:26.159 --> 00:41:29.440 first approach and not finding root cause like 00:41:29.440 --> 00:41:32.539 Like your practice and Residential Medical Center. 00:41:32.820 --> 00:41:38.730 Yeah It's just the way it ought to be. And you 00:41:38.730 --> 00:41:40.630 said two things there that really captured me 00:41:40.630 --> 00:41:44.369 because I say this quite a bit, but it's not 00:41:44.369 --> 00:41:47.349 relevant. But you said critical thinking and 00:41:47.349 --> 00:41:50.809 curiosity. That's the master combo. If you really 00:41:50.809 --> 00:41:54.530 want to learn. Well, this is the scientific method. 00:41:54.730 --> 00:41:56.309 I mean, this is this is what science used to 00:41:56.309 --> 00:41:59.730 be. This is what I love about science, you know, 00:41:59.730 --> 00:42:03.969 because I'm very like analytically minded and 00:42:03.969 --> 00:42:06.650 so I like math I like science and I but I like 00:42:06.650 --> 00:42:08.849 the curiosity of I like the thought experiments 00:42:08.849 --> 00:42:11.530 of well what if it's this what if it's this driving 00:42:11.530 --> 00:42:13.530 this and not driving that okay what are the studies 00:42:13.530 --> 00:42:15.789 about that oh okay somebody's done that maybe 00:42:15.789 --> 00:42:18.329 we should do a study on this or you know it's 00:42:18.329 --> 00:42:22.789 really that curiosity combined with just um where 00:42:22.789 --> 00:42:25.989 are we at who whose shoulders what Giants shoulders 00:42:25.989 --> 00:42:29.500 can we stand on to really elevate our level of 00:42:29.500 --> 00:42:34.239 knowledge and of course apply that in a in a 00:42:34.239 --> 00:42:37.980 way that is meaningful that the people are meaningfully 00:42:37.980 --> 00:42:41.179 gaining skills and gaining health and gaining 00:42:41.179 --> 00:42:45.820 longevity and expanding the edges expanding the 00:42:45.820 --> 00:42:48.179 like you say expanding the edges yeah let's keep 00:42:48.179 --> 00:42:50.480 expanding those edges you know and i i love science 00:42:50.480 --> 00:42:52.480 i think it's I think it's fabulous. I couldn't 00:42:52.480 --> 00:42:55.340 imagine me. I was so bored in high school. Oh, 00:42:55.340 --> 00:42:58.280 history was such a drag for me. I was like, I 00:42:58.280 --> 00:42:59.960 don't, this is not my thing. And my son is the 00:42:59.960 --> 00:43:01.980 same way. He just hates it. And I'm like, you 00:43:01.980 --> 00:43:03.760 know, honey, we got to do it. I get it. You know, 00:43:03.780 --> 00:43:05.639 and he struggles in school because he's very 00:43:05.639 --> 00:43:09.420 science focused too. So it's, um, it's just an 00:43:09.420 --> 00:43:11.699 analytic mind. Um, it's, and it's, it's a beautiful 00:43:11.699 --> 00:43:13.340 thing when you can apply it towards something 00:43:13.340 --> 00:43:16.219 meaningful. Like I think you're doing, I'm doing, 00:43:16.599 --> 00:43:19.400 let's spread the word. Let's, let's do, you know, 00:43:19.400 --> 00:43:21.559 let's talk about it. Let's talk about what is 00:43:21.559 --> 00:43:24.840 happening. You've definitely taught me to take 00:43:24.840 --> 00:43:28.559 a step back whenever I see a physician assistant 00:43:28.559 --> 00:43:34.639 to maybe not all of them are prescription first 00:43:34.639 --> 00:43:38.179 approaches. And you even said that they're often 00:43:38.179 --> 00:43:40.179 that's the protocol that they have to follow, 00:43:40.599 --> 00:43:43.559 which is, you know, it's. I mean, that's that's 00:43:43.559 --> 00:43:45.460 unfortunately the world that we're in. I mean, 00:43:45.460 --> 00:43:47.679 if I don't follow certain protocols in a primary 00:43:47.679 --> 00:43:51.670 care practice, you know, I can be I can be sued, 00:43:51.909 --> 00:43:54.750 or I can be brought to the medical board for 00:43:54.750 --> 00:43:57.170 negligence. Oh, you didn't prescribe this statin 00:43:57.170 --> 00:43:58.929 for this person with high cholesterol. And it's 00:43:58.929 --> 00:44:01.550 like, well, you can tell them, I think this, 00:44:01.650 --> 00:44:05.230 I think that. Perhaps they have mitochondrial 00:44:05.230 --> 00:44:07.150 dysfunction symptoms, and I don't think it's 00:44:07.150 --> 00:44:11.909 appropriate, and all these things. Because statins 00:44:11.909 --> 00:44:16.699 implicate ubiquinol in mitochondria. Exactly. 00:44:17.159 --> 00:44:20.139 People should know that. Exactly. If I were to 00:44:20.139 --> 00:44:22.300 put somebody on a statin, I'd probably throw 00:44:22.300 --> 00:44:25.639 in ubiquinol in there. But if you're severely 00:44:25.639 --> 00:44:29.659 deficient and you're having problems with the 00:44:29.659 --> 00:44:31.559 electron transport chain in general and your 00:44:31.559 --> 00:44:33.599 cells, then yeah, it might really affect you. 00:44:33.679 --> 00:44:35.940 You might get some severe muscle cramps or fatigue 00:44:35.940 --> 00:44:43.739 or things that... Yeah. It's not really... It's 00:44:43.739 --> 00:44:45.519 just not talked about there's just protocols 00:44:45.519 --> 00:44:49.949 that that fit this model And there's not a lot, 00:44:49.949 --> 00:44:53.070 unfortunately, of critical thinking, especially 00:44:53.070 --> 00:44:56.030 when most PAs have to see, you know, five, six 00:44:56.030 --> 00:44:58.570 patients an hour. I mean, it's kind of out of 00:44:58.570 --> 00:45:01.210 control. You walk in there and it's unfortunately, 00:45:01.250 --> 00:45:02.590 in my experience, because I've been doing this 00:45:02.590 --> 00:45:05.250 17 years, it's been getting worse. You know, 00:45:06.510 --> 00:45:08.630 you used to be able to kind of take your time 00:45:08.630 --> 00:45:09.969 and you could bill for a few things. But now 00:45:09.969 --> 00:45:11.590 everything's like maximize the billing, hurry, 00:45:11.590 --> 00:45:13.090 you've got five minutes to be in there and you've 00:45:13.090 --> 00:45:15.250 got a chart and this and that. And now the kind 00:45:15.250 --> 00:45:17.059 of the standard of care is to have a medical 00:45:17.059 --> 00:45:19.099 assistant follow you around and chart for you 00:45:19.099 --> 00:45:20.639 because you need to be able to see more patients 00:45:20.639 --> 00:45:22.960 to be more profitable. And so it's just this 00:45:22.960 --> 00:45:25.260 rat race. And most clinicians I know are really 00:45:25.260 --> 00:45:28.059 tired. They're really burned out. Like I said, 00:45:28.119 --> 00:45:30.360 I think they have the good intentions, but the 00:45:30.360 --> 00:45:34.539 system that they're operating in now is... It's 00:45:34.539 --> 00:45:37.420 very difficult to be heart -first to really care 00:45:37.420 --> 00:45:39.480 because they don't have enough time their hands 00:45:39.480 --> 00:45:41.619 are tied what they can do There's too much peer 00:45:41.619 --> 00:45:44.820 pressure And and there's not enough knowledge. 00:45:44.820 --> 00:45:46.920 I mean, no one knows any I mean most clinicians 00:45:46.920 --> 00:45:49.159 pediatricians today still say well, there's just 00:45:49.159 --> 00:45:50.820 there's not enough evidence about autism There's 00:45:50.820 --> 00:45:52.159 not enough evidence. You know, we don't have 00:45:52.159 --> 00:45:54.780 any We don't we don't have any clinical trials 00:45:54.780 --> 00:45:56.800 and you know, we just don't know what it is and 00:45:56.800 --> 00:45:59.360 it's just Unfortunately, that's just ignorance. 00:45:59.519 --> 00:46:03.500 It's not true. And I don't blame them because 00:46:03.500 --> 00:46:05.699 they're so busy. I mean, this is why it's nice 00:46:05.699 --> 00:46:07.500 to have a niche. This is why it has a specialty. 00:46:07.719 --> 00:46:10.159 We are a pediatric special needs. I mean, we 00:46:10.159 --> 00:46:15.320 do treat ADHD and OCD and PANS, PANDAS, other 00:46:15.320 --> 00:46:18.659 kind of comorbidities, but it's primarily autism 00:46:18.659 --> 00:46:22.449 in the practice. And I will note, too, that another 00:46:22.449 --> 00:46:24.650 great thing that we do that I like what we do 00:46:24.650 --> 00:46:27.610 is that we look at the mothers, too. So I do 00:46:27.610 --> 00:46:31.170 preconception care as well. A lot of the stuff 00:46:31.170 --> 00:46:33.610 is like, well, we've found that the moms have 00:46:33.610 --> 00:46:37.230 a lot of these issues to begin with. And so we'll 00:46:37.230 --> 00:46:38.869 do an evaluation if a mom's really going to get 00:46:38.869 --> 00:46:43.889 pregnant again. What happened? What did you do 00:46:43.889 --> 00:46:45.550 during your pregnancy? Okay, let's not do that 00:46:45.550 --> 00:46:47.449 again. And how can we optimize your metabolic 00:46:47.449 --> 00:46:51.550 health now? She probably needs extra methylfolate. 00:46:51.590 --> 00:46:53.630 That's a great thing. Vitamin D, we probably 00:46:53.630 --> 00:46:57.250 should put her on some extra. We have kind of 00:46:57.250 --> 00:46:59.949 a whole protocol or just kind of general guidelines, 00:47:00.050 --> 00:47:01.989 but we'll look at these things that we often 00:47:01.989 --> 00:47:03.650 look at with kids in the spectrum and we find 00:47:03.650 --> 00:47:06.630 that they're frequently abnormal. Thyroid is 00:47:06.630 --> 00:47:10.699 a very common one too. Yeah, tyrosine. Thyroid 00:47:10.699 --> 00:47:15.860 hormone. Yeah, but the synthesizing from tyrosine 00:47:15.860 --> 00:47:20.199 is an aromatic amino acid and it requires 200 00:47:20.199 --> 00:47:26.840 to 400 nanometer light to activate. I'm glad 00:47:26.840 --> 00:47:29.739 you mentioned the mother because the environment 00:47:29.739 --> 00:47:32.579 of the pregnant mother has changed so much over 00:47:32.579 --> 00:47:36.679 the last 50 to 100 years. Yeah. It's just like, 00:47:37.139 --> 00:47:41.179 okay. We need to be aware of that. Yeah. Yeah. 00:47:41.559 --> 00:47:43.420 It's very unfortunate. I mean, there's a lot 00:47:43.420 --> 00:47:48.199 of maternal studies that's saying that air pollution, 00:47:48.400 --> 00:47:50.980 so 2 .5 parts per million air pollution exposure 00:47:50.980 --> 00:47:53.940 increases your risk of autism during pregnancy. 00:47:55.579 --> 00:47:58.559 Maternal SSRI use, antidepressant use, increases 00:47:58.559 --> 00:48:05.130 the risk of autism. Like I said, hypothyroid, 00:48:05.650 --> 00:48:10.409 PCOS, vitamin D deficiency, zinc deficiency. 00:48:10.489 --> 00:48:12.710 There's a lot of things we can look at that correlate 00:48:12.710 --> 00:48:15.429 with maternal health. And that's kind of why 00:48:15.429 --> 00:48:18.550 just to kind of full circle about these vaccines, 00:48:18.630 --> 00:48:20.909 for example, maybe being a part of it, but maybe 00:48:20.909 --> 00:48:23.389 not being the whole part, is I've had several 00:48:23.389 --> 00:48:27.650 families. I had a family that they had a child 00:48:27.650 --> 00:48:30.780 with autism, the mother. you know, and then she 00:48:30.780 --> 00:48:32.480 vaccinated him and she swore it was the vaccines, 00:48:32.599 --> 00:48:34.400 which, you know, I believe her, you know, I mean, 00:48:34.639 --> 00:48:36.760 I never tell patients no. And they tell me like, 00:48:37.039 --> 00:48:38.579 this is what I think it is. I say, OK, let's 00:48:38.579 --> 00:48:41.400 investigate that. I mean, that's not my I'm I 00:48:41.400 --> 00:48:43.539 want to look at other things as well. But I, 00:48:43.559 --> 00:48:46.900 you know, I believe people as it were. And so 00:48:46.900 --> 00:48:49.320 we look at that and I say, OK, you know, we talk 00:48:49.320 --> 00:48:52.400 about it. And she kind of disappears for a while. 00:48:52.579 --> 00:48:54.139 I hadn't seen the kid. And then she comes back 00:48:54.139 --> 00:48:55.940 a couple of years later and she's like, oh, I 00:48:55.940 --> 00:48:59.289 had another kid. And we didn't vaccinate him 00:48:59.289 --> 00:49:01.250 at all. Not one vaccine for this whole for this 00:49:01.250 --> 00:49:04.329 child. And he has autism. And so she was really 00:49:04.329 --> 00:49:06.070 upset because she swore that was the only thing. 00:49:06.510 --> 00:49:09.730 And I think, you know, I kind of tried to convince 00:49:09.730 --> 00:49:12.010 her, you know, that we, hey, let's do some maternal 00:49:12.010 --> 00:49:14.030 testing as well. If you want to have another 00:49:14.030 --> 00:49:17.949 child, you know, let's look at you. And I hate 00:49:17.949 --> 00:49:20.289 to say that to mothers as a mother, like with 00:49:20.289 --> 00:49:22.510 three kids. I don't, you know, I. Parents get 00:49:22.510 --> 00:49:24.469 so upset and I'm not blaming the moms because 00:49:24.469 --> 00:49:27.809 gosh I had my own my own time of blaming myself 00:49:27.809 --> 00:49:29.489 And what did I do and I shouldn't have taken 00:49:29.489 --> 00:49:32.090 that Tylenol or I shouldn't have done, you know 00:49:32.090 --> 00:49:34.550 We have all these woulda shoulda coulda moments, 00:49:34.550 --> 00:49:36.949 but it's it's the mother's love. These mothers 00:49:36.949 --> 00:49:39.989 love their babies I I believe that and it's nobody's 00:49:39.989 --> 00:49:44.210 fault and I think you know, we need to look at 00:49:44.210 --> 00:49:45.469 everybody's health, you know maternal health 00:49:45.469 --> 00:49:48.570 is very important And by the way, sorry to keep 00:49:48.570 --> 00:49:50.769 expanding, but also paternal health is important. 00:49:52.130 --> 00:49:55.289 So the age of the father, increasing age actually 00:49:55.289 --> 00:50:00.130 increases the risk of autism as well. So father's 00:50:00.130 --> 00:50:08.550 health matters too. Yeah, absolutely. Yeah. I 00:50:08.550 --> 00:50:09.889 know I'm throwing a lot of truth bombs at you. 00:50:09.909 --> 00:50:13.969 No, it's like you're preaching to the preacher 00:50:13.969 --> 00:50:19.389 now. It's like, oh my goodness, I have an episode 00:50:19.389 --> 00:50:24.230 on autism research and a proposal for research. 00:50:24.489 --> 00:50:27.489 And it's just, I think it could do something. 00:50:28.469 --> 00:50:30.829 And I don't know, there's a lot to the light 00:50:30.829 --> 00:50:34.150 story and how humans use light because of that 00:50:34.150 --> 00:50:36.630 electromagnetic field, both the sunlight and 00:50:36.630 --> 00:50:40.250 artificial light. There's electrons and magnetism 00:50:40.250 --> 00:50:44.329 attached to it and everything with mitochondria. 00:50:44.599 --> 00:50:47.940 is the electron transport chain and it's a lot 00:50:47.940 --> 00:50:51.780 of magnetism with the iron sulfur clusters and 00:50:51.780 --> 00:50:54.840 that spinning fo head that's producing out the 00:50:54.840 --> 00:50:58.599 ATP a lot of magnetism there and that's why like 00:50:58.599 --> 00:51:02.320 iron is so important for hemoglobin it's it's 00:51:02.320 --> 00:51:08.480 all magnetic yes but i mean that will it's it's 00:51:08.480 --> 00:51:11.300 tough for people to comprehend that because they 00:51:11.300 --> 00:51:15.900 don't they don't Care to know that well, I think 00:51:15.900 --> 00:51:18.539 a lot of it and I can't speak for you But I know 00:51:18.539 --> 00:51:22.079 that I'm very much in this world. And so I know 00:51:22.079 --> 00:51:25.860 I think that some people with autism Not all 00:51:25.860 --> 00:51:28.380 of course but have like a sixth sense So I've 00:51:28.380 --> 00:51:30.579 always been really sensitive to fluorescent lights 00:51:30.579 --> 00:51:34.219 and a lot of these LED lights and it really is 00:51:34.219 --> 00:51:36.699 neurostimulating for me. I have a very hard time, 00:51:36.699 --> 00:51:39.599 like in certain lighting situations. And, um, 00:51:39.739 --> 00:51:42.300 and I also have, uh, I have had periods in my 00:51:42.300 --> 00:51:44.699 life where I've had a hard time with EMF as well. 00:51:44.820 --> 00:51:46.420 You know, there were points in my life where 00:51:46.420 --> 00:51:48.539 I could tell I was next to a router and I turn 00:51:48.539 --> 00:51:53.039 off my wifi every night and I, I, yeah. Oh yeah. 00:51:53.039 --> 00:51:56.099 And I, I absolutely, I mean, I feel like at points, 00:51:56.119 --> 00:51:58.199 not always, but I, I can feel these things and 00:51:58.199 --> 00:52:00.280 I feel like my son can feel them as well. Like 00:52:00.280 --> 00:52:04.050 my, my kids, um, They are very sensitive and 00:52:04.050 --> 00:52:07.989 I'm very I'm very Aware of how important the 00:52:07.989 --> 00:52:10.349 sunlight is This is why I'm like still kind of 00:52:10.349 --> 00:52:12.650 tan because I make our kids go outside. I'm like 00:52:12.650 --> 00:52:14.760 we're gonna go outside and they go now because 00:52:14.760 --> 00:52:16.440 of the screens, but I make sure my kids are tan. 00:52:16.519 --> 00:52:18.239 We get at least an hour to a sunlight a day. 00:52:18.559 --> 00:52:21.199 It's very important to me and I think that it 00:52:21.199 --> 00:52:23.559 is a baseline of health. I mean, in addition 00:52:23.559 --> 00:52:25.539 to vitamin D that it's producing, there's a whole 00:52:25.539 --> 00:52:29.059 cascade of anti -microbials and anti -inflammatories 00:52:29.059 --> 00:52:31.199 that the sunlight, I mean, I think you're onto 00:52:31.199 --> 00:52:32.940 something. We're meant to be in the sun. I mean, 00:52:33.340 --> 00:52:36.940 we're not meant to be in a box and you know. 00:52:37.000 --> 00:52:39.579 made of chemicals and fluorescent lights. And 00:52:39.579 --> 00:52:41.579 so, yeah, I'd be interested to hear what you 00:52:41.579 --> 00:52:43.440 have to say on a paper or looking that up. I 00:52:43.440 --> 00:52:45.500 mean, I absolutely believe that there's a lot 00:52:45.500 --> 00:52:47.440 of forces, of course, we know we can't see and 00:52:47.440 --> 00:52:49.619 that are affecting us super directly. I mean, 00:52:49.900 --> 00:52:54.659 that's not voodoo science. That's real science. 00:52:55.239 --> 00:52:57.539 That's a lot of people don't know about the different 00:52:57.539 --> 00:53:01.000 wavelengths in light. Like light has wavelengths 00:53:01.000 --> 00:53:06.280 and how our human biology takes those wavelengths, 00:53:06.440 --> 00:53:09.679 what they do with those wavelengths. And it's 00:53:09.679 --> 00:53:13.059 missing. Something you mentioned earlier about 00:53:13.059 --> 00:53:19.880 tailoring to each individual or client, patient, 00:53:20.139 --> 00:53:24.679 child. Can you talk a little bit about the comprehensive 00:53:24.679 --> 00:53:28.940 evaluation process? Yeah, and I will, absolutely. 00:53:29.239 --> 00:53:33.119 And I have a whole other talk that I've given 00:53:33.119 --> 00:53:36.559 a presentation on this through Taka, which is, 00:53:36.579 --> 00:53:40.159 it's like takanow .org. But anyway, it's an hour 00:53:40.159 --> 00:53:42.699 long and it talks about my comprehensive evaluation 00:53:42.699 --> 00:53:44.860 of what it includes and it goes into in detail. 00:53:45.659 --> 00:53:47.880 Obviously, we don't have an hour now, but it 00:53:47.880 --> 00:53:51.320 is posted on my ex -profile under Nicole, at 00:53:51.320 --> 00:53:54.280 Nicole Ranconpied. It's also posted on my website, 00:53:54.420 --> 00:54:03.300 which is but to just start out, when I see a 00:54:03.300 --> 00:54:08.440 patient, the first thing that I personally look 00:54:08.440 --> 00:54:13.400 at is how is their detox functioning? Because 00:54:13.400 --> 00:54:16.239 when you throw in a bunch of novel interventions 00:54:16.239 --> 00:54:18.599 to these kids, a lot of times, unfortunately, 00:54:18.619 --> 00:54:20.679 we see that there are a lot of toxicities, either 00:54:20.679 --> 00:54:23.820 metals or molds or... pesticides or things, you 00:54:23.820 --> 00:54:29.519 know, that, um, that was an issue. And so, um, 00:54:29.579 --> 00:54:32.000 I first evaluate how is their, their constipation 00:54:32.000 --> 00:54:33.719 or, you know, how is their bowel movements? Because 00:54:33.719 --> 00:54:35.440 a lot of these kids are constipated and, and 00:54:35.440 --> 00:54:38.860 I find that that's really a key factor. Um, you 00:54:38.860 --> 00:54:41.699 know, so we will make sure, cause to back up 00:54:41.699 --> 00:54:44.340 the four ways your body really eliminates actually 00:54:44.340 --> 00:54:47.920 excretes toxins is, uh, feces. So bowel movements, 00:54:48.219 --> 00:54:54.170 urine, um, sweat. and exhalation, so breathing. 00:54:55.090 --> 00:54:57.130 And so we need to make sure these are being optimized. 00:54:57.630 --> 00:54:59.909 If you're not urinating, drinking enough, not 00:54:59.909 --> 00:55:01.469 urinating enough, you're gonna have a problem 00:55:01.469 --> 00:55:03.409 with any kind of protocols that we implement, 00:55:03.570 --> 00:55:04.909 because a lot of things that we're gonna be doing 00:55:04.909 --> 00:55:08.349 are stimulating your body's response to improve. 00:55:08.650 --> 00:55:11.150 And oftentimes, if the detox pathways aren't 00:55:11.150 --> 00:55:13.400 optimal, then... the kids are not gonna have 00:55:13.400 --> 00:55:15.559 a good response. They're gonna say, oh my gosh, 00:55:15.659 --> 00:55:16.960 Nicole, you made me worse. And they're gonna 00:55:16.960 --> 00:55:19.440 leave and they're not gonna be happy. And you 00:55:19.440 --> 00:55:21.199 know, we just pushed them too hard too quick. 00:55:22.320 --> 00:55:24.239 So basically making sure that they're having 00:55:24.239 --> 00:55:26.139 at least one to two daily bowel movements. I 00:55:26.139 --> 00:55:29.059 really like oxy powder. It's like an ozonated 00:55:29.059 --> 00:55:33.300 magnesium to help stimulate the bowels in kids 00:55:33.300 --> 00:55:35.199 that are constipated, which most of them are, 00:55:35.199 --> 00:55:38.619 I find. Making sure they're drinking good quality 00:55:38.619 --> 00:55:41.340 of water. and frequently. So I have, I'm a big 00:55:41.340 --> 00:55:43.800 fan of reverse osmosis water. Uh, we have one 00:55:43.800 --> 00:55:46.920 in our house. I think that they're a great alternative 00:55:46.920 --> 00:55:49.860 to certainly, you know, not drinking tap water. 00:55:50.019 --> 00:55:53.719 Yeah. What's the fluoride? but also, I mean, 00:55:53.780 --> 00:55:55.559 you know, there's a website called, what is it? 00:55:55.559 --> 00:55:59.119 I think it's EWS, but it evaluates, you know, 00:55:59.139 --> 00:56:02.480 the water in your public water system, the chemicals. 00:56:02.940 --> 00:56:05.340 So, I mean, you can look and mine has a ton of 00:56:05.340 --> 00:56:09.480 arsenic and it's got, you know, nitrates and 00:56:09.480 --> 00:56:13.699 nitrites and... chromium way above the upper 00:56:13.699 --> 00:56:15.940 limit and it's got even uranium. I mean this 00:56:15.940 --> 00:56:17.440 is like stuff that we're drinking you know so 00:56:17.440 --> 00:56:20.039 and you're showering with. Anyway so getting 00:56:20.039 --> 00:56:23.059 an RO. I even put you know in all my shower heads 00:56:23.059 --> 00:56:24.920 I always put at least a carbon filter over my 00:56:24.920 --> 00:56:28.500 shower heads to kind of get rid of some of the 00:56:28.500 --> 00:56:32.679 chlorine. And you know making sure that they're 00:56:32.679 --> 00:56:34.760 they're getting enough sweat so they're exercising 00:56:34.760 --> 00:56:37.599 ideally out in the sunlight And then they're 00:56:37.599 --> 00:56:39.920 excellent the exhaling so part of that is the 00:56:39.920 --> 00:56:44.760 exercise So, you know basically optimizing those 00:56:44.760 --> 00:56:48.559 functions first before I do anything But then 00:56:48.559 --> 00:56:52.940 typically I will get Some basic blood work and 00:56:52.940 --> 00:56:54.719 I don't want to go into like every single test 00:56:54.719 --> 00:56:56.239 because like I said, that's an hour long but 00:56:56.239 --> 00:57:01.789 a lot of it is We can look at methylation like 00:57:01.789 --> 00:57:05.909 MTHFR genes. I look at basic stuff like anemias, 00:57:06.349 --> 00:57:09.230 iron levels, liver function, kidney function. 00:57:10.050 --> 00:57:12.250 We're looking at amino plasma amino acids and 00:57:12.250 --> 00:57:14.750 we're looking for mitochondrial markers. Sometimes 00:57:14.750 --> 00:57:17.269 we'll get a lactic acid for that. We'll look 00:57:17.269 --> 00:57:19.730 at alanine lysine ratio. You can get a CoQ10 00:57:19.730 --> 00:57:24.210 level. We'll look at carnitine. You can look 00:57:24.210 --> 00:57:27.289 at both acyl carnitines and total free carnitine. 00:57:27.449 --> 00:57:29.789 Again, which is a whole nother discussion, but 00:57:29.789 --> 00:57:32.449 carnitine levels are frequently low and easily 00:57:32.449 --> 00:57:36.570 treated. We'll look at, you know, vitamin D, 00:57:36.710 --> 00:57:38.710 some immune functions, some kids that are always 00:57:38.710 --> 00:57:43.849 sick. I get an IgG subclass, IgA, which looks 00:57:43.849 --> 00:57:46.070 at kind of gut immune function. Is it low? Is 00:57:46.070 --> 00:57:48.409 it high? Do you have SIBO or lack of diversity? 00:57:48.550 --> 00:57:51.929 So there's a ton we can do. Just even a blood 00:57:51.929 --> 00:57:53.530 work that's typically covered by insurance, which 00:57:53.530 --> 00:57:58.679 is really nice. Not always but usually and then 00:57:58.679 --> 00:58:02.019 I'll get a I would I mentioned zinc zinc super 00:58:02.019 --> 00:58:05.340 important to I love testing for RBC zinc and 00:58:05.340 --> 00:58:10.599 magnesium for minerals And then we'll get a stool 00:58:10.599 --> 00:58:13.519 analysis so a lot of these kids have fungal overgrowth 00:58:13.519 --> 00:58:16.139 either in their upper intestine lower intestine 00:58:16.139 --> 00:58:20.639 both a lot of gram -negative bacteria. So you 00:58:20.639 --> 00:58:22.800 see a kid with a lot of inflammation. I'm thinking, 00:58:22.800 --> 00:58:25.019 okay, probably gram -negative bacteria in the 00:58:25.019 --> 00:58:29.300 colon that creates that LPS production, lipopolysaccharides. 00:58:29.760 --> 00:58:31.760 So a lot of times we'll see kids with a lot of 00:58:31.760 --> 00:58:34.300 Proteus mirabilis or Klebsiella or Citrobac, 00:58:34.300 --> 00:58:36.719 these crazy really kind of toxic bacteria. So 00:58:36.719 --> 00:58:40.360 we can treat that. We see in the stool analysis, 00:58:40.360 --> 00:58:42.579 you can see if they're under producing digestive 00:58:42.579 --> 00:58:45.920 enzymes or if they just have like frank inflammatory 00:58:45.920 --> 00:58:48.960 bowel, like indicated of like Crohn's disease, 00:58:49.179 --> 00:58:51.539 celiac disease, things like that, I see sometimes. 00:58:53.099 --> 00:58:56.880 We'll do what's called a urine organic acid test, 00:58:57.179 --> 00:58:59.920 where it looks for metabolites in the urine of 00:58:59.920 --> 00:59:05.659 certain bacteria and of mitochondrial function 00:59:05.659 --> 00:59:09.619 byproducts. And so this is oftentimes how you 00:59:09.619 --> 00:59:12.119 can find C. diff, because Custardia difficile 00:59:12.119 --> 00:59:16.989 won't culture necessarily on on a stool test 00:59:16.989 --> 00:59:19.409 because it's it's an anaerobic bacteria and when 00:59:19.409 --> 00:59:21.429 you're introducing it to stool it's an aerobic 00:59:21.429 --> 00:59:23.989 environment so it won't grow in an aerobic culture 00:59:23.989 --> 00:59:25.230 and you think oh they don't have it but they're 00:59:25.230 --> 00:59:27.510 just not testing for it the right way so you 00:59:27.510 --> 00:59:30.489 have to get an organic acid test to rule out 00:59:30.489 --> 00:59:33.150 um c diff and you know then you treat that you 00:59:33.150 --> 00:59:35.570 know so um like i said there's a lot of in that 00:59:35.570 --> 00:59:37.789 organic acid test you could look for mold metabolites 00:59:37.789 --> 00:59:39.730 if they have a ton of these fungal markers that 00:59:39.730 --> 00:59:42.289 are maybe aspergillus markers fusarium markers 00:59:42.289 --> 00:59:44.909 um you know candida markers and you go okay they're 00:59:44.889 --> 00:59:49.050 I got some serious fungus on board. And then, 00:59:49.449 --> 00:59:50.989 what else will I usually get? I'll usually try 00:59:50.989 --> 00:59:52.949 and convince him to get an overnight EEG. That 00:59:52.949 --> 00:59:54.969 one's a little hard, but because the parents, 00:59:55.090 --> 00:59:56.469 the kids have to wear a cap and they have to 00:59:56.469 --> 01:00:02.349 sleep on it. There are some outpatient services 01:00:02.349 --> 01:00:05.530 that are really good. that can do it for the 01:00:05.530 --> 01:00:06.650 kid and they can do it in the comfort of their 01:00:06.650 --> 01:00:08.929 own home or at a hotel instead of going into 01:00:08.929 --> 01:00:11.690 the hospital. Because looking for seizures is 01:00:11.690 --> 01:00:13.269 important and treating seizures can actually 01:00:13.269 --> 01:00:15.250 help the behaviors as well and the functioning 01:00:15.250 --> 01:00:17.590 of the brain, decreasing inflammation certainly. 01:00:19.309 --> 01:00:21.130 The other thing that I love that I always test 01:00:21.130 --> 01:00:23.769 for on the blood is a folate receptor antibody 01:00:23.769 --> 01:00:27.250 test like I mentioned earlier. That's a private 01:00:27.250 --> 01:00:29.369 test you have to send to a private lab so insurance 01:00:29.369 --> 01:00:32.500 won't cover it. But those are crucial. Like I 01:00:32.500 --> 01:00:35.039 said, up to 80 % of kids have high folate receptor 01:00:35.039 --> 01:00:37.460 antibodies, and they found that the higher the 01:00:37.460 --> 01:00:41.519 levels, the more severe autism symptoms generally 01:00:41.519 --> 01:00:45.440 are. And then also the better they respond to 01:00:45.440 --> 01:00:48.320 leukovorin, which is the, it's just a prescription 01:00:48.320 --> 01:00:51.019 folinic acid, high dose folate, essentially. 01:00:51.679 --> 01:00:55.360 So higher the titers, more sick, but they also 01:00:55.360 --> 01:00:58.260 respond better to leukovorin. So I've seen some 01:00:58.260 --> 01:01:00.320 super huge gains with just that treatment alone. 01:01:00.460 --> 01:01:03.539 Um, yeah, I mean, it's, it's, it's really good 01:01:03.539 --> 01:01:06.119 stuff. Like as far as one, one, like kind of 01:01:06.119 --> 01:01:08.179 a one size fits all. And, you know, as far as 01:01:08.179 --> 01:01:10.519 parent rating scales and, and the, the double 01:01:10.519 --> 01:01:12.840 blind placebo studies back this up. I mean, the, 01:01:13.039 --> 01:01:15.780 the literature is across the board positive and 01:01:15.780 --> 01:01:17.920 it's, um, it has very little side effects. I 01:01:17.920 --> 01:01:20.340 mean, it's very well tolerated and anything you 01:01:20.340 --> 01:01:22.980 don't need you urinate out. So it's, it's, it's 01:01:22.980 --> 01:01:24.780 kind of, you know, it's kind of incredible. That's 01:01:24.780 --> 01:01:28.199 my, that's been my, my kind of. one of my favorite 01:01:28.199 --> 01:01:30.059 treatments because it just seems to be effective. 01:01:31.980 --> 01:01:33.900 And what else do we measure? You know, we can 01:01:33.900 --> 01:01:35.820 do other things. We can look more specifically 01:01:35.820 --> 01:01:38.460 into mitochondrial dysfunction like a mito swab. 01:01:38.500 --> 01:01:41.760 It looks at the... Electron transport chain kind 01:01:41.760 --> 01:01:44.940 of complex functioning looks at like complex 01:01:44.940 --> 01:01:47.960 one complex three citrate synthase But you know 01:01:47.960 --> 01:01:50.559 a lot again when you see a new patient it really 01:01:50.559 --> 01:01:52.719 you want to look at does this kid look like Mito 01:01:52.719 --> 01:01:54.940 You know because if he has really low muscle 01:01:54.940 --> 01:01:58.079 tone really poor growth You're thinking maybe 01:01:58.079 --> 01:02:01.900 it's Mito dysfunction But if he's just sick all 01:02:01.900 --> 01:02:04.619 the time we're thinking maybe you're immune or 01:02:04.619 --> 01:02:07.469 maybe The parents are like, his stool is just 01:02:07.469 --> 01:02:10.170 awful. And it's been awful. And like, we can't 01:02:10.170 --> 01:02:11.969 seem to get it anywhere near awful, you know? 01:02:12.190 --> 01:02:14.789 And so you kind of guide what we need to target 01:02:14.789 --> 01:02:17.170 first, you know, because based on like, what 01:02:17.170 --> 01:02:19.329 are their most severe symptomology and, you know, 01:02:20.050 --> 01:02:23.590 and we take it stepwise, you know? Yeah. So you're 01:02:23.590 --> 01:02:28.050 approaching this from a different perspective 01:02:28.050 --> 01:02:31.889 from somebody like in a ABA or mental health 01:02:31.889 --> 01:02:36.210 or a psychological assessment. type thing where 01:02:36.210 --> 01:02:38.289 they don't really get answers. They just get 01:02:38.289 --> 01:02:41.369 an answer of diagnosis. Yes or diagnosis. No. 01:02:43.349 --> 01:02:46.210 And, you know, I mean, to be fair, I mean, you 01:02:46.210 --> 01:02:48.469 know, I've talked to Dr. Fry about this not too 01:02:48.469 --> 01:02:50.469 long ago, and he's like, you know, Nicole, you 01:02:50.469 --> 01:02:52.769 know what the best treatment is? And it's like, 01:02:52.789 --> 01:02:55.530 what? Okay, give me this truth bomb. He's like, 01:02:55.530 --> 01:02:57.130 oh, it's the kitchen sink approach. So there 01:02:57.130 --> 01:02:59.530 was a study that, you know, kids that basically 01:02:59.530 --> 01:03:02.550 did all the interventions for the longest period 01:03:02.550 --> 01:03:05.340 of time had the best recovery. So And I do believe 01:03:05.340 --> 01:03:09.820 that as far as ABA, some parents say it's cruel 01:03:09.820 --> 01:03:12.519 because the kids are, if they don't like it or 01:03:12.519 --> 01:03:14.159 they're not high functioning and they're not 01:03:14.159 --> 01:03:16.780 getting it, it can be very upsetting. And it's 01:03:16.780 --> 01:03:18.219 probably not the right treatment if you're feeling 01:03:18.219 --> 01:03:20.860 that way about it. But the studies do show that 01:03:20.860 --> 01:03:23.019 it helps in general. It does help functioning. 01:03:23.239 --> 01:03:26.199 I mean, the scores are there as far as controlled 01:03:26.199 --> 01:03:29.199 trials that it can help. So what I tell parents 01:03:29.199 --> 01:03:32.539 is just... Try everything. Do everything. Do 01:03:32.539 --> 01:03:35.099 the exercise therapy, which can be shown to be 01:03:35.099 --> 01:03:38.420 good. Do the probiotics. Do the ABA or the OT. 01:03:38.639 --> 01:03:40.880 Put them in early school. Get them in socialization 01:03:40.880 --> 01:03:45.179 groups. Do the floor time. Come see me. Let's 01:03:45.179 --> 01:03:46.760 talk about your diet. We got to change your diet, 01:03:46.920 --> 01:03:50.300 your water, your exercise. Let's try some meds 01:03:50.300 --> 01:03:53.199 if we're not getting there. And so you just kind 01:03:53.199 --> 01:03:56.460 of do this. Multi -factorial approach and then 01:03:56.460 --> 01:03:58.260 you know if it's not fitting if something's not 01:03:58.260 --> 01:04:00.119 fitting take it out and you know, but if you 01:04:00.119 --> 01:04:03.840 know It seems to unfortunately or fortunately 01:04:03.840 --> 01:04:07.000 be dependent a lot on Kind of the amount of effort 01:04:07.000 --> 01:04:10.179 you put into it, you know if you're just like 01:04:10.179 --> 01:04:12.199 eh, we tried a couple supplements It didn't do 01:04:12.199 --> 01:04:14.760 anything or you know, like, you know, and you 01:04:14.760 --> 01:04:16.699 know and then some kids that don't you know not 01:04:16.699 --> 01:04:19.039 all kids make all the gains that other kids do 01:04:19.039 --> 01:04:22.360 but um, and I understand I mean these parents 01:04:22.360 --> 01:04:25.030 are really tired and they're they're very exhausted 01:04:25.030 --> 01:04:28.409 and it's very financially consuming sometimes. 01:04:30.170 --> 01:04:34.070 I think these things are an alternative though 01:04:34.070 --> 01:04:37.510 that could give them hope and provide answers, 01:04:37.690 --> 01:04:43.070 at least get them off of the standardized path 01:04:43.070 --> 01:04:51.570 that is very inconsistent and provide them with 01:04:51.570 --> 01:04:55.449 something else, a different alternative. And 01:04:55.449 --> 01:04:59.309 I just can't get over, like we mentioned earlier 01:04:59.309 --> 01:05:03.630 about going upstream and investigating all these 01:05:03.630 --> 01:05:07.429 biological processes. This is so fascinating. 01:05:07.849 --> 01:05:10.570 It's really fun. I'm here to tell you. I really 01:05:10.570 --> 01:05:13.070 enjoy it. Because this is where it's at. This 01:05:13.070 --> 01:05:17.170 is where the autistic phenotype starts. And all 01:05:17.170 --> 01:05:19.829 of those co -morbids. And it's the future of 01:05:19.829 --> 01:05:23.429 medicine. It really is. It's the way people want 01:05:23.429 --> 01:05:25.630 to be treated, you know, like want to be medically 01:05:25.630 --> 01:05:28.030 treated, you know, and it's the way that it's 01:05:28.030 --> 01:05:29.389 appropriate. And it's certainly the way that 01:05:29.389 --> 01:05:32.889 worked for my family. And, you know, we focus 01:05:32.889 --> 01:05:34.750 on autism in our clinic, but, you know, yeah, 01:05:34.789 --> 01:05:36.389 I mean, there's so many other metabolic diseases 01:05:36.389 --> 01:05:38.849 that could be treated very similarly the way 01:05:38.849 --> 01:05:42.719 we do this, you know. between, you know, diabetes 01:05:42.719 --> 01:05:46.219 and like you said, Alzheimer's and, you know, 01:05:46.440 --> 01:05:48.719 just a slew of thyroid disease and things like 01:05:48.719 --> 01:05:51.079 that. You know, I mean, a lot of this goes back 01:05:51.079 --> 01:05:53.099 to the functional medicine, the functioning of 01:05:53.099 --> 01:05:55.880 the cells. Yeah. And how they all integrate with 01:05:55.880 --> 01:05:59.139 the systems. And I'm so excited for the future. 01:05:59.260 --> 01:06:01.800 I really think like all this literature, you 01:06:01.800 --> 01:06:03.280 know, we mentioned earlier when we were talking 01:06:03.280 --> 01:06:07.150 about, you know, on the media now being with 01:06:07.150 --> 01:06:09.409 RFK jr. And he's bringing up that we need to 01:06:09.409 --> 01:06:11.690 clean up the food and you know, and I'm so excited 01:06:11.690 --> 01:06:13.349 to hear that because I've been saying that for 01:06:13.349 --> 01:06:15.710 a decade. It was just like, you know, a lot of 01:06:15.710 --> 01:06:19.389 this is is a disease of environmental toxicity, 01:06:19.409 --> 01:06:23.030 unfortunately. And yes, there's finally movement 01:06:23.030 --> 01:06:24.829 and people are talking about and people are looking 01:06:24.829 --> 01:06:26.610 at their water and they're looking at their food 01:06:26.610 --> 01:06:28.510 and they're, they're thinking about maybe taking 01:06:28.510 --> 01:06:30.489 a few supplements to help optimize, you know, 01:06:30.610 --> 01:06:33.489 whatever you know, maybe MTHFR deficits they 01:06:33.489 --> 01:06:35.429 have or other genetics or just whatnot, just, 01:06:35.570 --> 01:06:37.010 you know, whatever lifestyles that they're living 01:06:37.010 --> 01:06:39.170 that that they need to help, you know, kind of 01:06:39.170 --> 01:06:42.849 accommodate. So it's it's a really, really, really 01:06:42.849 --> 01:06:45.469 cool time to be practicing medicine. Yeah. You 01:06:45.469 --> 01:06:48.710 know, it's like I'm super excited about it. It's 01:06:48.710 --> 01:06:55.469 becoming in people's radar. And it's obviously 01:06:55.469 --> 01:06:59.900 a lot of our health trends are not trending in 01:06:59.900 --> 01:07:02.539 a good direction. And people want to know why. 01:07:03.099 --> 01:07:04.920 And yeah, there's a lot of hope coming around 01:07:04.920 --> 01:07:08.940 the corner, I think. So with everything that 01:07:08.940 --> 01:07:14.219 you know, and some of the things that you introduced 01:07:14.219 --> 01:07:18.400 here, we'll do more episodes and talk more in 01:07:18.400 --> 01:07:20.960 depth about some of these and even maybe introduce 01:07:20.960 --> 01:07:25.699 some new items. So people know about this. People 01:07:25.699 --> 01:07:29.900 needs to know about this. Yeah, absolutely. Yeah, 01:07:29.900 --> 01:07:34.059 I mean like I said, there's you know, I I I have 01:07:34.059 --> 01:07:36.539 my clinical practice and kind of see what works 01:07:36.539 --> 01:07:38.840 and what doesn't and I also you know I really 01:07:38.840 --> 01:07:40.579 focus on a lot of the research and I know the 01:07:40.579 --> 01:07:43.400 Ross Rossignol and fry, you know, so we're trying 01:07:43.400 --> 01:07:47.699 to blend How does this? how does this functionally 01:07:47.699 --> 01:07:50.260 land on the patient? How is this actually working 01:07:50.260 --> 01:07:52.380 out? How do we read some study on paper and then 01:07:52.380 --> 01:07:53.840 actually implement this treatment and then how 01:07:53.840 --> 01:07:56.960 are we seeing that this is working out? And then 01:07:56.960 --> 01:07:58.920 sometimes I don't, sometimes I'm like, eh, I 01:07:58.920 --> 01:08:00.780 didn't see that that correlated too much in my 01:08:00.780 --> 01:08:05.360 own view or sometimes it's really great. So yeah, 01:08:05.659 --> 01:08:09.449 it's an exciting time. I like that. that we're 01:08:09.449 --> 01:08:11.329 looking at the literature and kind of making 01:08:11.329 --> 01:08:13.289 it more scientific again, like we talked about, 01:08:13.289 --> 01:08:15.530 you know. I mean, not everything is a trial. 01:08:15.809 --> 01:08:17.829 Not everything has to be trialed. Sometimes you 01:08:17.829 --> 01:08:20.029 just have to go for it. On the other hand, I 01:08:20.029 --> 01:08:22.630 mean, sometimes you just have to base it on clinical 01:08:22.630 --> 01:08:24.270 suspicion. The parent's like, you know what I 01:08:24.270 --> 01:08:26.130 noticed, you know, when he eats garlic, he feels 01:08:26.130 --> 01:08:29.750 better and okay, you know. And so you just, you 01:08:29.750 --> 01:08:32.130 know, sometimes you just go for it, but based 01:08:32.130 --> 01:08:37.390 on parent ratings. But yeah, it's... It's a very 01:08:37.390 --> 01:08:38.970 cool model that I think we're gonna see a lot 01:08:38.970 --> 01:08:40.689 more of it in the future I think a lot of people 01:08:40.689 --> 01:08:42.310 are gonna be starting to practice medicine this 01:08:42.310 --> 01:08:46.510 way and I think that You know and I'd like I 01:08:46.510 --> 01:08:48.890 said, I think that a lot of practitioners want 01:08:48.890 --> 01:08:52.250 this to I think that a lot of PAs and you know 01:08:52.250 --> 01:08:53.710 to be biased But I think a lot of people are 01:08:53.710 --> 01:08:55.989 gonna jump on board, you know, once it becomes 01:08:55.989 --> 01:08:59.210 more mainstream. I think this is what Frank I 01:08:59.210 --> 01:09:01.430 don't blame the doctors and PAs for the system, 01:09:01.430 --> 01:09:05.899 right? good people and they just this is just 01:09:05.899 --> 01:09:07.819 where the model they fit in and they have families 01:09:07.819 --> 01:09:09.800 they have medical debt they're just they're trying 01:09:09.800 --> 01:09:11.779 and you know i know i know there's there's some 01:09:11.779 --> 01:09:16.850 bad stories and there are um but you know I see 01:09:16.850 --> 01:09:18.850 a lot of them that are leading heart first. I 01:09:18.850 --> 01:09:20.789 have some, most of my best friends are PAs and 01:09:20.789 --> 01:09:22.430 they're just, man, Nicole, you know, they're 01:09:22.430 --> 01:09:24.170 really trying and they're telling me about their 01:09:24.170 --> 01:09:25.710 patients and they care. You know, they really 01:09:25.710 --> 01:09:27.689 - Yeah, that's why I got them into healthcare. 01:09:27.989 --> 01:09:30.930 Yes, yes, yeah. Like I very rarely see, oh, you 01:09:30.930 --> 01:09:33.630 know, like some people are jaded in any career, 01:09:33.890 --> 01:09:37.189 but you know, I think that things will turn around 01:09:37.189 --> 01:09:38.810 and I think that most people will get on board. 01:09:39.020 --> 01:09:42.079 Yeah. Sometimes the trial has already been proven 01:09:42.079 --> 01:09:44.220 to us. We don't need a randomized controlled 01:09:44.220 --> 01:09:48.380 trial through Mother Nature. Yeah. And everything 01:09:48.380 --> 01:09:50.920 that you're testing, well, Mother Nature gave 01:09:50.920 --> 01:09:55.279 us through evolution, many generations of evolution. 01:09:55.600 --> 01:10:00.420 So just get it back to that. Yes. We're talking 01:10:00.420 --> 01:10:04.539 about less, not more. Yeah. Yeah. Right. Thank 01:10:04.539 --> 01:10:08.340 you for sharing today. We'll put together some 01:10:08.340 --> 01:10:12.479 items for future episodes for sure. Okay. Well, 01:10:12.539 --> 01:10:14.939 thanks, Ryan. Thanks for having me on. And again, 01:10:14.939 --> 01:10:18.899 for viewers, like I said, I have a website and 01:10:18.899 --> 01:10:24.579 I have my Twitter page and I am also still seeing 01:10:24.579 --> 01:10:27.159 new patients for now at Rossignol Medical Center. 01:10:27.380 --> 01:10:31.560 We're out of Orange County in California. So 01:10:31.560 --> 01:10:34.119 let me know if you guys need any help. But I 01:10:34.119 --> 01:10:35.460 look forward to making more podcasts. This is 01:10:35.460 --> 01:10:38.810 fun. Uh, I put all your information in the show 01:10:38.810 --> 01:10:43.109 notes and, um, definitely promote, um, the clinic 01:10:43.109 --> 01:10:45.970 and your work for sure. Yeah, we got, we got 01:10:45.970 --> 01:10:47.550 three trials coming out too. So be on the look, 01:10:47.590 --> 01:10:49.750 I'm going to share those on my profile. So once 01:10:49.750 --> 01:10:51.630 pretty quick and we got, yeah, we got two more. 01:10:52.010 --> 01:10:54.170 So hopefully by the end of the year, I don't 01:10:54.170 --> 01:10:55.810 know how it's kind of pushing it, but we'll hopefully 01:10:55.810 --> 01:10:57.949 get them out. We'll see. Yeah. Maybe you can 01:10:57.949 --> 01:11:04.689 give us some teasers from it. Um, Well, two of 01:11:04.689 --> 01:11:06.689 them are review trials. So we're trying to do, 01:11:06.729 --> 01:11:09.050 like I said, we're actually reviewing all medications 01:11:09.050 --> 01:11:12.350 affiliated with autism that are randomized control 01:11:12.350 --> 01:11:16.010 trials. And so what is the entire body of evidence? 01:11:16.170 --> 01:11:18.850 So these pages are like 100 pages long paper. 01:11:19.250 --> 01:11:21.630 So it's a lot, but just what are the medications 01:11:21.630 --> 01:11:24.760 that help? what symptoms are they helping, which 01:11:24.760 --> 01:11:26.640 don't help, which have the highest side effects, 01:11:26.659 --> 01:11:28.460 which don't, you know. And we're doing the same 01:11:28.460 --> 01:11:30.699 thing for another paper for supplements. So what 01:11:30.699 --> 01:11:32.760 is the most, let's kind of know about these supplements. 01:11:32.880 --> 01:11:36.560 And so just to give us as clinicians a map of 01:11:36.560 --> 01:11:38.979 like, this is pretty decent quality evidence 01:11:38.979 --> 01:11:42.300 and this is what you can try to use. Cause we 01:11:42.300 --> 01:11:44.220 even get specific, a lot of the trials are specific 01:11:44.220 --> 01:11:46.579 with dosing. So you can not just guess at where 01:11:46.579 --> 01:11:50.460 to start. And then, you know, it'll also, you 01:11:50.460 --> 01:11:52.220 know, give, like I said, the clinicians a start, 01:11:52.399 --> 01:11:54.500 but also the patients too. If you're like, hey, 01:11:54.500 --> 01:11:56.800 I was thinking about Omega and I, you know, I 01:11:56.800 --> 01:11:59.279 read this trial and okay, you know, like this 01:11:59.279 --> 01:12:02.500 looks good. And I don't encourage people to like 01:12:02.500 --> 01:12:04.100 practice medicine, you know, without a doctor, 01:12:04.220 --> 01:12:07.340 but I know what happens and I want to encourage 01:12:07.340 --> 01:12:09.640 people to do something, you know, like, you know, 01:12:10.359 --> 01:12:12.920 I don't want people to freeze, you know, some 01:12:12.920 --> 01:12:15.560 of this stuff. Yeah, don't go buy random medications 01:12:15.560 --> 01:12:17.439 in Mexico that, you know, or, you know, from 01:12:17.439 --> 01:12:19.100 India that you don't know what you're implementing. 01:12:19.609 --> 01:12:20.989 That's pretty dangerous. But you know, some of 01:12:20.989 --> 01:12:22.409 these things are over the counter for a reason. 01:12:22.609 --> 01:12:25.449 You know, officials pretty safe, you know. Yeah. 01:12:25.970 --> 01:12:28.050 Most of the stuff you can buy is pretty safe. 01:12:28.750 --> 01:12:32.250 You're giving them informed consent that way 01:12:32.250 --> 01:12:35.689 they are fully informed to make a decision. Yes. 01:12:36.210 --> 01:12:39.550 Yes. And yes, exactly. So, you know, I want I 01:12:39.550 --> 01:12:44.489 want people to to feel empowered to not not feel 01:12:44.489 --> 01:12:47.279 just feel hope. Like, well, let's try it, or 01:12:47.279 --> 01:12:49.939 whatever. Know that there is evidence out there. 01:12:50.239 --> 01:12:54.659 This is not snake oil. I mean, really, and it's 01:12:54.659 --> 01:13:00.979 true. We're not profiting. We're just putting 01:13:00.979 --> 01:13:04.220 this knowledge out there. When we publish trials, 01:13:05.100 --> 01:13:09.479 they've always been open source, free. They're 01:13:09.479 --> 01:13:14.739 not behind a paid wall. I work with good guys. 01:13:14.819 --> 01:13:18.439 They believe in this stuff. There's a lot of 01:13:18.439 --> 01:13:23.779 passion. Dr. Fry, whenever he was on, he was 01:13:23.779 --> 01:13:26.539 just so interested in just sharing the information 01:13:26.539 --> 01:13:31.560 and even teaching me and just coming on and spreading 01:13:31.560 --> 01:13:37.680 all this knowledge. Well, thank you and looking 01:13:37.680 --> 01:13:40.500 forward to the next ones. All right, Ryan. Thanks, 01:13:40.579 --> 01:13:46.590 me too. If you are listening to the podcast or 01:13:46.590 --> 01:13:49.289 listening to the episode, please feel free to 01:13:49.289 --> 01:13:53.869 leave a review or ratings. In podcasting, review 01:13:53.869 --> 01:13:57.609 and ratings are crucial and I very much appreciate 01:13:57.609 --> 01:14:03.050 your feedback. You can contact me on X at RPS 01:14:03.050 --> 01:14:08.829 47586 or click on the hop link so you can have 01:14:08.829 --> 01:14:11.909 links to all the show platforms and contact information. 01:14:12.939 --> 01:14:19.579 you can email me info .fromthespectrumatgmail 01:14:19.579 --> 01:14:24.600 .com. And thank you for listening to From the 01:14:24.600 --> 01:14:25.880 Spectrum Podcast.