WEBVTT 00:00:00.240 --> 00:00:03.500 I would like to take a moment and mention a pressing 00:00:03.500 --> 00:00:09.859 issue we are seeing in our modern world. And 00:00:09.859 --> 00:00:15.140 that is tech use and tech light. The data are 00:00:15.140 --> 00:00:19.600 impressive and concerning on isolated wavelengths 00:00:19.600 --> 00:00:25.320 of light, especially shorter wavelengths, which 00:00:25.320 --> 00:00:29.989 is blue light. For those that don't know, We 00:00:29.989 --> 00:00:33.649 have chromophores, which are special proteins 00:00:33.649 --> 00:00:39.429 that absorbs specific wavelengths of light. For 00:00:39.429 --> 00:00:43.429 blue light, the light that is LED light and tech 00:00:43.429 --> 00:00:49.649 light, that protein is called melanopsin. Melanopsin 00:00:49.649 --> 00:00:55.409 is responsible for our circadian biology, physiology, 00:00:55.710 --> 00:01:00.380 and cell functioning. hormone regulation, and 00:01:00.380 --> 00:01:06.480 even a connection to an area huge for mood. A 00:01:06.480 --> 00:01:10.439 consideration we should include is this protein 00:01:10.439 --> 00:01:16.120 was not even discovered until 1998. It seems 00:01:16.120 --> 00:01:20.900 important for us to understand how our biology 00:01:20.900 --> 00:01:25.680 uses the different wavelengths of light. for 00:01:25.680 --> 00:01:30.560 various aspects of our biology. This blue light 00:01:30.560 --> 00:01:35.640 chromophore is our master controller, our master 00:01:35.640 --> 00:01:40.319 clock. Remember circadian rhythm is a two -part 00:01:40.319 --> 00:01:47.239 process, two independent parts, light and dark. 00:01:48.079 --> 00:01:53.239 For a quick reference, see the 2017 Nobel Prize 00:01:53.239 --> 00:01:58.939 in Physiology medicine. But for now, I have something 00:01:58.939 --> 00:02:01.920 exciting. I want to introduce a product unlike 00:02:01.920 --> 00:02:06.799 any other product available. A highlight is the 00:02:06.799 --> 00:02:10.759 product from Daylight Computer Company created 00:02:10.759 --> 00:02:15.199 their product based on these factors. The Daylight 00:02:15.199 --> 00:02:20.759 Computer is completely blue light free. It has 00:02:20.759 --> 00:02:25.219 no flicker. Short wavelength flicker. is extremely 00:02:25.219 --> 00:02:29.020 harmful for our eyes and downstream biology. 00:02:30.080 --> 00:02:32.879 Light flicker is constantly turning our central 00:02:32.879 --> 00:02:37.860 nervous system on and off. Essentially it is 00:02:37.860 --> 00:02:41.099 like going to a light switch and repeatedly turning 00:02:41.099 --> 00:02:46.460 it on and off. The problem is blue light and 00:02:46.460 --> 00:02:51.680 LED light does this and it is so rapid You cannot 00:02:51.680 --> 00:02:56.500 even perceive this in real time. The daylight 00:02:56.500 --> 00:03:01.199 computer is the lowest stimulation and foremost 00:03:01.199 --> 00:03:06.240 for sensory sensitive users. It is no question 00:03:06.240 --> 00:03:10.419 that the alternative product, especially when 00:03:10.419 --> 00:03:15.240 used at night, do not address or consider this 00:03:15.240 --> 00:03:20.159 in their product. It is so toxic to human biology. 00:03:20.520 --> 00:03:25.379 Big tech corporations have patents on how their 00:03:25.379 --> 00:03:28.319 short wavelength implicate the human nervous 00:03:28.319 --> 00:03:34.120 system. And a bonus, despite daylight computer 00:03:34.120 --> 00:03:38.520 not having backlight, it is very functional for 00:03:38.520 --> 00:03:43.520 outdoor use. And of course, increased sunlight 00:03:43.520 --> 00:03:48.900 is always preferred. I am happy to offer a discount 00:03:48.900 --> 00:03:52.800 for the Daylight Computer. You can use the code 00:03:52.800 --> 00:03:59.900 Autism for a $25 off coupon. Again, use the code 00:03:59.900 --> 00:04:05.900 Autism and the discount code for $25 off. See 00:04:05.900 --> 00:04:09.039 the link in the show notes to Daylight Computer 00:04:09.039 --> 00:04:11.939 Company or just give it a quick search in your 00:04:11.939 --> 00:04:17.160 internet browser. Use the code Autism. for $25 00:04:17.160 --> 00:04:22.899 off. For today's episode, we will cover the leptin 00:04:22.899 --> 00:04:28.699 -melanocortin pathway, biophotons. We will expand 00:04:28.699 --> 00:04:32.759 on some common biology discussed in the podcast 00:04:32.759 --> 00:04:38.740 like mitochondria and melanocytes and POMC. We 00:04:38.740 --> 00:04:43.019 will introduce new biology such as nitric oxide 00:04:43.019 --> 00:04:51.939 and tetrahydro... biopterin or BH4. We will cover 00:04:51.939 --> 00:04:57.180 these areas related to the fetal. We are going 00:04:57.180 --> 00:05:01.220 to stick to this timeline of developing the central 00:05:01.220 --> 00:05:03.519 nervous system through embryogenesis all the 00:05:03.519 --> 00:05:09.740 way up through birth. In maternal fetal, the 00:05:09.740 --> 00:05:14.180 leptin -melanocortin pathway regulates placental 00:05:14.180 --> 00:05:19.689 physiology. and controls fertility and fecundity 00:05:19.689 --> 00:05:23.910 through leptin. The placental mitochondrial DNA 00:05:23.910 --> 00:05:29.670 emits ultra -weak biophotons that organize water's 00:05:29.670 --> 00:05:34.050 hydrogen bonds in maternal blood. This forms 00:05:34.050 --> 00:05:37.889 a liquid crystalline structure. Okay, that's 00:05:37.889 --> 00:05:41.709 a lot. But remember the Cause of Autism episode. 00:05:41.949 --> 00:05:46.269 And I want to really highlight to Patreon's Decentralized 00:05:46.269 --> 00:05:49.829 Medicine number 16 and Quantum Engineering number 00:05:49.829 --> 00:05:54.050 45. It's a great source from someone that's foremost 00:05:54.050 --> 00:05:56.889 in quantum biology here. This is what we are 00:05:56.889 --> 00:06:00.810 discussing here. This organizes and delivers 00:06:00.810 --> 00:06:04.750 signals to the mother's brain and this triggers 00:06:04.750 --> 00:06:10.600 Pro -opioid Mylonocortin POMC production. whereby 00:06:10.600 --> 00:06:14.379 this increases melanin via the alpha of melanocyte 00:06:14.379 --> 00:06:17.480 stimulating hormone, the one that's more responsible 00:06:17.480 --> 00:06:23.779 for color. However, this is in the pathway of 00:06:23.779 --> 00:06:29.420 the ACTH and the clip hormone. So the alpha melanocyte 00:06:29.420 --> 00:06:32.720 stimulating hormone is downstream from this. 00:06:33.379 --> 00:06:38.240 This is very telling here. So with the rising 00:06:38.240 --> 00:06:42.649 UV, and the water content and melanin correlate 00:06:42.649 --> 00:06:47.110 with maternal brain shrinkage, a phenomenon potentially 00:06:47.110 --> 00:06:50.529 useful for predicting transgenerational risk 00:06:50.529 --> 00:06:56.110 through cerebral volume analysis. For the fetal 00:06:56.110 --> 00:07:00.490 brain development, or also called morphogenesis, 00:07:00.829 --> 00:07:04.709 this is a process during the first five to six 00:07:04.709 --> 00:07:08.350 months or so during pregnancy. while the brain 00:07:08.350 --> 00:07:14.110 remains immature at this point. However, around 00:07:14.110 --> 00:07:18.189 month six, around six months of pregnancy, the 00:07:18.189 --> 00:07:22.350 neural growth stops and the adaptation ensuring 00:07:22.350 --> 00:07:25.850 that the head will fit through the birth canal 00:07:25.850 --> 00:07:30.089 while allowing the fetus to gain significant 00:07:30.089 --> 00:07:35.449 weight. This shift is driven by fetal mitochondria. 00:07:35.850 --> 00:07:40.410 And this emits a light spectrum that subtracts 00:07:40.410 --> 00:07:44.870 the UV and infrared. It emits blue light via 00:07:44.870 --> 00:07:48.970 melanopsin as a photo switch. This is crucial 00:07:48.970 --> 00:07:54.750 for the developing womb, the child. This process 00:07:54.750 --> 00:07:58.629 fattens the child. A lack of endocannabinoid 00:07:58.629 --> 00:08:02.709 signaling will then turn off UV light around 00:08:02.709 --> 00:08:08.560 380 nanometer, which is at the tail end of UVA. 00:08:08.680 --> 00:08:12.040 So this is right where the visual spectrum begins. 00:08:12.860 --> 00:08:17.540 And the infrared, 1280 nanometer. This photo 00:08:17.540 --> 00:08:21.800 switch inhibits POMC translation and reduces 00:08:21.800 --> 00:08:26.639 melanin. The consequence here is the brain development 00:08:26.639 --> 00:08:32.059 stalls. However, fat accumulates. If you think 00:08:32.059 --> 00:08:35.990 about leptin, you know that Society can easily 00:08:35.990 --> 00:08:41.470 attach weight and insulin to the leptin. This 00:08:41.470 --> 00:08:45.690 will bring mTOR, mammalian target of rapamycin, 00:08:46.149 --> 00:08:49.769 into the equation and mitochondrial hydrogen 00:08:49.769 --> 00:08:53.750 -deterium balance. Deterium is a new word for 00:08:53.750 --> 00:08:57.009 us. I'm not going into detail about that. The 00:08:57.009 --> 00:09:00.789 hydrogen with the mitochondria is very common. 00:09:01.029 --> 00:09:03.870 It's a very well established region of interest 00:09:03.870 --> 00:09:07.529 here with a hydrogen gradients pumping hydrogen 00:09:07.529 --> 00:09:11.230 out of the matrix up into the inter mitochondria 00:09:11.230 --> 00:09:17.129 membrane. In addition, the thalamus, that sensory 00:09:17.129 --> 00:09:19.990 integration center, the sensory processing relay 00:09:19.990 --> 00:09:23.850 center, modulates this via deuterium levels. 00:09:25.370 --> 00:09:29.190 This affects seasonal timing and the neurogenesis. 00:09:30.320 --> 00:09:35.519 A factor to consider is this. The fetal thalamus 00:09:35.519 --> 00:09:40.899 disrupts this antenna -like system, this UV light 00:09:40.899 --> 00:09:44.600 absorption, and this halts the brain growth in 00:09:44.600 --> 00:09:49.259 the third trimester, thus promoting fat storage 00:09:49.259 --> 00:09:54.320 instead for the postnatal brain maturation. UV 00:09:54.320 --> 00:09:58.899 light at that 380 nanometer light postnatally 00:09:58.899 --> 00:10:02.759 drives the cognitive development and this up 00:10:02.759 --> 00:10:05.799 -regulates synaptic proteins and nitric oxide. 00:10:06.379 --> 00:10:11.080 NO, a retrograde neurotransmitter enhancing blood 00:10:11.080 --> 00:10:17.399 flow in dendritic spine growth. Huge in autism 00:10:17.399 --> 00:10:22.860 research. The NO produced placentally with this 00:10:22.860 --> 00:10:27.899 tetrahydrobiopterin. That BH4, this will inhibit 00:10:27.899 --> 00:10:32.659 the fetal ATP production. Remember the oxferylation 00:10:32.659 --> 00:10:36.919 and the electron transport chain. The fifth cytochrome 00:10:36.919 --> 00:10:40.720 is ATP, which uses that hydrogen gradient that 00:10:40.720 --> 00:10:46.120 we just discussed. ATP, this slows down the neurogenesis. 00:10:46.419 --> 00:10:50.639 And this is a natural design. This is on purpose. 00:10:51.580 --> 00:10:55.990 Now what's interesting here is BH4 is a cofactor 00:10:55.990 --> 00:11:00.490 and it's huge for the aromatic amino acids often 00:11:00.490 --> 00:11:04.990 discussed on the podcast. Tryptophan, tyrosine, 00:11:05.690 --> 00:11:09.309 and phenylalanine, and sometimes histidine, but 00:11:09.309 --> 00:11:13.309 the tryptophan and tyrosine are vast here. Tryptophan 00:11:13.309 --> 00:11:19.950 is so huge in the fetal development. The BH4 00:11:19.950 --> 00:11:23.899 helps convert the dopamine serotonin and nitric 00:11:23.899 --> 00:11:28.480 oxide and such, while regulating cellular redox, 00:11:28.659 --> 00:11:34.620 a huge problem with autism. These deficiencies 00:11:34.620 --> 00:11:39.659 with the BH4 could be involved with intellectual 00:11:39.659 --> 00:11:46.519 disability, movement problems, seizures, and 00:11:46.519 --> 00:11:50.490 swallowing. Yes, with swallowing. All of these 00:11:50.490 --> 00:11:53.889 features are common for the autistic phenotype. 00:11:56.690 --> 00:12:00.490 Some environmental factors here, like the BPA 00:12:00.490 --> 00:12:05.309 and fluoride, increase the issues because of 00:12:05.309 --> 00:12:08.909 the deuterium absorption and distilling of the 00:12:08.909 --> 00:12:13.529 UV electrons. Remember what light is, electromagnetic 00:12:13.529 --> 00:12:18.879 fields. And this can impair the semiconduction 00:12:18.879 --> 00:12:22.700 and the brain growth. We've often talked about 00:12:22.700 --> 00:12:26.919 semiconductors and how autism is a loss of or 00:12:26.919 --> 00:12:30.919 a lack of biological energy. This is all tied 00:12:30.919 --> 00:12:34.679 here. This is what the main problem is with autism. 00:12:34.960 --> 00:12:38.600 The environment of the mother has changed. So 00:12:38.600 --> 00:12:42.580 the fetal, this embryogenesis through birth, 00:12:42.740 --> 00:12:45.340 this living organism that's trying to develop, 00:12:45.600 --> 00:12:50.740 is not developing. It's a loss of biological 00:12:50.740 --> 00:12:55.480 energy. How is this so complicated? And here 00:12:55.480 --> 00:12:58.879 I'm going to tie some more common autistic phenotype 00:12:58.879 --> 00:13:02.179 problems here. This is so easy to understand 00:13:02.179 --> 00:13:08.700 here. This BH4 deficit causes methylation defects 00:13:08.700 --> 00:13:13.480 and endocrine dysfunctions. Sounds like autism. 00:13:13.759 --> 00:13:18.919 In addition, there's a connection with gestational 00:13:18.919 --> 00:13:23.740 diabetes. And with this deficit of the BH4 and 00:13:23.740 --> 00:13:26.100 these semiconductors that we're talking about 00:13:26.100 --> 00:13:28.240 here, with the leptin -melano -cortin pathway 00:13:28.240 --> 00:13:32.620 even, this is an easy route for the gestational 00:13:32.620 --> 00:13:38.100 diabetes. And with gestational diabetes, it's 00:13:38.100 --> 00:13:41.779 a known, it's an undisputed risk factor for increasing 00:13:41.779 --> 00:13:47.000 the risk of autism. In addition, the vitamin 00:13:47.000 --> 00:13:50.899 D and risk of autism, this is all tied here. 00:13:52.059 --> 00:13:55.200 This is so messed. I don't understand why this 00:13:55.200 --> 00:13:58.799 is overlooked, why this isn't connected here. 00:13:59.259 --> 00:14:04.840 The vitamin D and the NO production is crucial. 00:14:05.379 --> 00:14:09.000 It's necessary for proper placental development 00:14:09.000 --> 00:14:15.480 and the fetal development. This is why. The rates 00:14:15.480 --> 00:14:21.240 of autism have increased with the amount of artificial 00:14:21.240 --> 00:14:25.000 light, with the amount of being exposed to this 00:14:25.000 --> 00:14:28.539 indoor environment and the types of the artificial 00:14:28.539 --> 00:14:33.340 light. This is so easy if you consider these 00:14:33.340 --> 00:14:37.500 biological processes and just connect all of 00:14:37.500 --> 00:14:40.919 these dots that research has outlined for us, 00:14:40.919 --> 00:14:46.360 but nobody makes these connections. I would like 00:14:46.360 --> 00:14:51.179 to mention Chroma, lights designed for humans. 00:14:52.080 --> 00:14:56.340 Chroma, a Seattle -based innovator founded by 00:14:56.340 --> 00:15:00.740 ex -NASA and Air Force engineer Michael Shapiro, 00:15:01.720 --> 00:15:04.980 is on a mission to enhance physical and mental 00:15:04.980 --> 00:15:09.759 health with purpose -built devices, unlocking 00:15:09.759 --> 00:15:14.299 peak human health, cognitive function, and performance. 00:15:15.379 --> 00:15:18.559 Shapiro launched Chroma to restore the natural 00:15:18.559 --> 00:15:23.960 light lost to screens in indoor living and delivers 00:15:23.960 --> 00:15:27.860 faster recovery, sharper minds, and better sleep. 00:15:28.860 --> 00:15:32.799 Their products hit hard. The Iron Forge speeds 00:15:32.799 --> 00:15:36.879 muscle repair with red and near -infrared light, 00:15:36.960 --> 00:15:41.539 while the Skylight mimics sunlight to boost sleep 00:15:41.539 --> 00:15:47.539 and energy. A standout. the Forge Lamp is a portable 00:15:47.539 --> 00:15:54.399 gem that fires 660 nanometer and 850 nanometer 00:15:54.399 --> 00:15:58.960 light to energize mitochondria and heal tissues 00:15:58.960 --> 00:16:03.240 on the go. Remember the four red light chromophores 00:16:03.240 --> 00:16:06.759 on cytochrome c oxidase frequently talked about 00:16:06.759 --> 00:16:11.879 in the podcast. This is why their products are 00:16:11.879 --> 00:16:15.950 built with military -grade durability that have 00:16:15.950 --> 00:16:21.389 lasting impact. Chromis Tech fuses precision 00:16:21.389 --> 00:16:28.309 and power. Gallium titride power supplies. Smaller, 00:16:28.330 --> 00:16:32.450 cooler, and stronger than silicone. Provide flicker 00:16:32.450 --> 00:16:36.590 -free light that's easy on the eyes. High -powered 00:16:36.590 --> 00:16:41.009 LEDs target key wavelengths for skin, tissue, 00:16:41.309 --> 00:16:44.950 and cellular health with smart heat management 00:16:44.950 --> 00:16:48.990 for the lasting impact. Every design decision 00:16:48.990 --> 00:16:53.190 Chroma makes serves a purpose to create devices 00:16:53.190 --> 00:16:57.909 that are precise, durable, and effective for 00:16:57.909 --> 00:17:02.929 improving human life. Remember, humans use different 00:17:02.929 --> 00:17:05.890 wavelengths of light for different functions 00:17:05.890 --> 00:17:12.079 of life. Remember when I ask, What do you think 00:17:12.079 --> 00:17:18.579 light is? Chroma designs with our biology in 00:17:18.579 --> 00:17:23.640 mind. From sleep aids and wound healing to mitochondrial 00:17:23.640 --> 00:17:27.680 energy, full body lights and blue light blocking 00:17:27.680 --> 00:17:32.759 glasses. They are US made and chroma ships globally 00:17:32.759 --> 00:17:41.349 and accepts FSA and HSA payments. Use autism 00:17:41.349 --> 00:17:47.650 at checkout for a 10 % off discount. That's autism 00:17:47.650 --> 00:17:55.430 at checkout for a 10 % off discount. So let's 00:17:55.430 --> 00:17:58.529 look at the leptin -melanocortin pathway specifically. 00:17:59.349 --> 00:18:02.410 So leptin is a hormone. It is primarily produced 00:18:02.410 --> 00:18:07.990 in adipose tissue. Now, over the last few years, 00:18:08.329 --> 00:18:14.220 last several years, melanin and melanopsin is 00:18:14.220 --> 00:18:17.660 found in leptin. And this is that pathway we're 00:18:17.660 --> 00:18:19.920 talking about here, the leptin -melanocortin 00:18:19.920 --> 00:18:24.140 pathway. This is all new in scientific literature. 00:18:25.779 --> 00:18:29.700 This signals satiety and energy status to the 00:18:29.700 --> 00:18:34.279 brain, particularly the hypothalamus. And this 00:18:34.279 --> 00:18:37.359 interacts with that melanocortin system of POMC. 00:18:38.440 --> 00:18:42.000 And it's a peptide that derived from the POMC 00:18:42.000 --> 00:18:46.920 for bioactive properties such as the alpha melanocyte 00:18:46.920 --> 00:18:51.940 stimulating hormone. This activates and regulates 00:18:51.940 --> 00:18:55.759 the biological energy and signals for appetite 00:18:55.759 --> 00:19:00.539 and metabolism. In this context of during pregnancy, 00:19:01.079 --> 00:19:05.099 this pathway extends its influence for the placenta 00:19:05.099 --> 00:19:09.160 and fetal development, the womb. Remember the 00:19:09.160 --> 00:19:11.500 episode where Dr. Hannah Stevens talking about 00:19:11.500 --> 00:19:15.000 the role of the placenta from the mother and 00:19:15.000 --> 00:19:22.460 the womb. So placental physiology. This placenta 00:19:22.460 --> 00:19:26.819 is a transient organ and it connects the mother 00:19:26.819 --> 00:19:30.920 to the fetus. A huge region of interest here 00:19:30.920 --> 00:19:35.319 is the melanocortin pathway that modulates its 00:19:35.319 --> 00:19:40.740 function. A huge role here is it controls redundancy 00:19:40.740 --> 00:19:46.180 and the fertility of the placenta by adapting 00:19:46.180 --> 00:19:50.579 to the maternal energy availability. Now, just 00:19:50.579 --> 00:19:53.779 a few minutes ago, I talked about the lack of 00:19:53.779 --> 00:19:57.420 energy. This is where, this is the biology that 00:19:57.420 --> 00:20:01.740 links this and connects this to this energy story. 00:20:04.519 --> 00:20:10.150 During pregnancy, the leptin levels rise, and 00:20:10.150 --> 00:20:13.529 it reflects an increased fat source and placental 00:20:13.529 --> 00:20:17.930 production. And this, obviously, the main goal 00:20:17.930 --> 00:20:22.250 here is to support nutrient transfer of the fetus, 00:20:22.349 --> 00:20:28.329 the developing living organism. Placental mitochondrial 00:20:28.329 --> 00:20:34.809 DNA, which remember is from the mother, Remember, 00:20:35.109 --> 00:20:38.529 it emits ultra -weak biophotons, something we 00:20:38.529 --> 00:20:43.690 haven't discussed yet, is the biophotons. And 00:20:43.690 --> 00:20:47.069 this potentially amplifies these effects on that 00:20:47.069 --> 00:20:49.410 POMC production with the leptin -melanocortin 00:20:49.410 --> 00:20:55.630 pathway and the POMC cleaving of the alpha -melanocystimulating 00:20:55.630 --> 00:20:59.710 hormone, which will boost melanin synthesis. 00:20:59.990 --> 00:21:03.190 Remember, melanin is a semiconductor and it absorbs 00:21:03.190 --> 00:21:06.730 all frequencies of light and its roles. Remember 00:21:06.730 --> 00:21:10.890 its roles as an antioxidant, as a protecting 00:21:10.890 --> 00:21:14.849 the cell and the living organism from insults, 00:21:15.289 --> 00:21:18.470 environmental toxins and so forth, which is very 00:21:18.470 --> 00:21:22.130 common in today's research about autism. However, 00:21:22.789 --> 00:21:27.119 what is missed is What does biology, what does 00:21:27.119 --> 00:21:30.440 Mother Nature and evolution give us to protect 00:21:30.440 --> 00:21:35.660 us from these so -called insults? Another huge 00:21:35.660 --> 00:21:39.960 region of interest for us ought to be melanin 00:21:39.960 --> 00:21:44.180 and that UV light exposure. This is huge for 00:21:44.180 --> 00:21:48.140 the maternal physiology, which will include the 00:21:48.140 --> 00:21:52.859 brain volume. This is huge. The brain volume. 00:21:53.230 --> 00:21:56.529 with the autistic phenotype at young ages, even 00:21:56.529 --> 00:22:02.769 in the womb, the oversized brain. So the leptin 00:22:02.769 --> 00:22:07.069 -melanocortin pathway and its influence on fetal 00:22:07.069 --> 00:22:11.569 development, this indirectly shapes the development 00:22:11.569 --> 00:22:15.930 by regulating placental efficiency and that maternal 00:22:15.930 --> 00:22:18.990 to fetal communication. This is what connects 00:22:18.990 --> 00:22:23.210 the mother to the living organism developing 00:22:23.210 --> 00:22:29.089 in her stomach. So some main roles here, energy 00:22:29.089 --> 00:22:32.130 allocation. Remember, one of the main goals of 00:22:32.130 --> 00:22:35.450 the brain is allocating and conserving energy. 00:22:36.450 --> 00:22:40.190 Leptin signals energy sufficiency. This is our 00:22:40.190 --> 00:22:43.890 energy accountant. This is what the brain uses 00:22:43.890 --> 00:22:49.089 to kind of get an inventory of the living organism's 00:22:49.089 --> 00:22:54.210 energy state. POMC and alpha melanocyte stimulating 00:22:54.210 --> 00:22:58.309 hormone. So that maternal hypothalamus remember 00:22:58.309 --> 00:23:02.230 the endocrine disruptions and identifying risk 00:23:02.230 --> 00:23:05.450 factors via that hypothalamus. For instance, 00:23:05.930 --> 00:23:11.289 the hypothyroid. The leptin here upregulates 00:23:11.289 --> 00:23:15.349 POMC and increases the alpha melanocyte stimulating 00:23:15.349 --> 00:23:19.720 hormone. This oppresses Appetite to conserve 00:23:19.720 --> 00:23:23.519 energy for pregnancy while enhancing the melanin 00:23:23.519 --> 00:23:30.359 production. Fetal fat storage. This pathway suppression 00:23:30.359 --> 00:23:34.559 and late gestation shifts the energy from the 00:23:34.559 --> 00:23:38.319 brain growth to the subcutaneous fat. This is 00:23:38.319 --> 00:23:42.779 why babies are getting fat and we want that increased 00:23:42.779 --> 00:23:45.660 weight and a certain milestone on the weight. 00:23:45.769 --> 00:23:52.529 This is why humans are chunky. They're kind of 00:23:52.529 --> 00:23:55.289 abnormal compared to other species, especially 00:23:55.289 --> 00:24:01.369 in the primates. Light integration. So with those 00:24:01.369 --> 00:24:04.730 biophotons, this suggests a novel mechanism here. 00:24:05.230 --> 00:24:08.910 But leptin may amplify mitochondrial light signals. 00:24:09.130 --> 00:24:13.049 And this influences the Milano -Cortin pathway. 00:24:13.119 --> 00:24:16.240 And that water production from the mitochondria, 00:24:16.339 --> 00:24:20.960 remember, cytochrome C oxidase. So what are bio 00:24:20.960 --> 00:24:23.640 photons? We need to talk about some bio photons 00:24:23.640 --> 00:24:27.099 here. They are low -intensity light particles 00:24:27.099 --> 00:24:31.819 emitted by living cells. This is huge in the 00:24:31.819 --> 00:24:37.880 gastrointestinal story as well. So with the mitochondrial 00:24:37.880 --> 00:24:41.819 activity, they play a significant role in cellular 00:24:41.819 --> 00:24:44.930 communication. and the regulation during the 00:24:44.930 --> 00:24:50.470 development. Bio photons are similar to any light. 00:24:50.849 --> 00:24:54.410 They're electromagnetic waves. They're only in 00:24:54.410 --> 00:24:58.130 the UV light wavelengths and the visual light 00:24:58.130 --> 00:25:02.369 spectrum. So roughly 200 to 800 nanometer light. 00:25:03.569 --> 00:25:07.769 And they are emitted by the biological systems 00:25:07.769 --> 00:25:11.769 without any external stimulation. So As your 00:25:11.769 --> 00:25:14.750 physiology and cells are functioning, it's going 00:25:14.750 --> 00:25:17.809 to release these bio photons in the mitochondria. 00:25:18.470 --> 00:25:21.990 This is a huge biomarker here that is hard to 00:25:21.990 --> 00:25:25.390 test. It's nearly impossible to test. But when 00:25:25.390 --> 00:25:27.950 your mitochondria are functioning and cells are 00:25:27.950 --> 00:25:32.069 functioning, these bio photons are driving the 00:25:32.069 --> 00:25:35.269 living organism, developing and giving the living 00:25:35.269 --> 00:25:39.470 organism energy. It's a direct connection here. 00:25:40.269 --> 00:25:43.289 We've covered the mitochondria in the solo episode 00:25:43.289 --> 00:25:46.609 and the episode with Dr. Richard Fry. We talked 00:25:46.609 --> 00:25:50.930 about reactive oxygen species and these excited 00:25:50.930 --> 00:25:54.589 biomolecules running through that TCA cycle like 00:25:54.589 --> 00:25:58.829 NADH or the flavins. So we're talking about kind 00:25:58.829 --> 00:26:04.170 of providing nutrients to cytochrome 1, 2, and 00:26:04.170 --> 00:26:08.869 3 here. And these released energy as photons. 00:26:09.289 --> 00:26:13.630 This is huge for the connection from the mother 00:26:13.630 --> 00:26:16.990 via the placenta down to the developing living 00:26:16.990 --> 00:26:21.849 organism. This has major implications to placental 00:26:21.849 --> 00:26:26.109 efficiency and maturation and development. In 00:26:26.109 --> 00:26:29.410 addition, we've talked about timing before, clock 00:26:29.410 --> 00:26:33.150 timing. These biophotons are huge for thalamic 00:26:33.150 --> 00:26:38.170 timing, that sensory and timing hub that biophotons 00:26:38.170 --> 00:26:41.980 will help modulate because if you think about 00:26:41.980 --> 00:26:46.019 cellular efficiency and these things all of these 00:26:46.019 --> 00:26:48.599 cells tissues and organs being clocked timed 00:26:48.599 --> 00:26:51.859 the more they are in sync with one another the 00:26:51.859 --> 00:26:55.279 more that they are operating efficiently the 00:26:55.279 --> 00:26:59.400 more bio photons we will have the more energy 00:26:59.400 --> 00:27:03.359 and development that matches normal development 00:27:03.359 --> 00:27:07.460 will occur So some underrated roles here with 00:27:07.460 --> 00:27:10.980 the biophotons, and that stem from the cytochrome 00:27:10.980 --> 00:27:14.299 co -oxidase, the placenta amphetas. This will 00:27:14.299 --> 00:27:17.980 tie to the reactive oxygen species production, 00:27:18.779 --> 00:27:22.220 which is normal feature of pregnancy. In the 00:27:22.220 --> 00:27:26.200 coherence, these wave -like natures suggest that 00:27:26.200 --> 00:27:29.019 biophotons could synchronize cellular processes 00:27:29.019 --> 00:27:33.339 across distances. A lot to do with the telepathy 00:27:33.339 --> 00:27:37.140 tapes. This quantum coherence here kind of helps 00:27:37.140 --> 00:27:41.160 signal these with that disruption of the speech 00:27:41.160 --> 00:27:44.759 and communication that's seen with the children 00:27:44.759 --> 00:27:48.819 of the telepathy tapes. This energy is kind of 00:27:48.819 --> 00:27:55.079 disrupted here and used in abnormal ways. The 00:27:55.079 --> 00:27:58.859 water interaction is huge here. And remember 00:27:58.859 --> 00:28:01.779 the Dr. Hannah Stevens episode as well. returning 00:28:01.779 --> 00:28:06.099 to that episode whenever I asked her about NFKB. 00:28:06.420 --> 00:28:09.000 This is involved in this timeline here. This 00:28:09.000 --> 00:28:13.039 is why I asked and she's perfect example to ask. 00:28:13.200 --> 00:28:15.240 She's a perfect source to ask because of her 00:28:15.240 --> 00:28:21.599 role with the placenta and womb. So mitochondrial 00:28:21.599 --> 00:28:25.359 DNA for the fetal development and that light 00:28:25.359 --> 00:28:29.960 spectrum dynamics. I want to briefly talk about 00:28:29.960 --> 00:28:33.880 mitochondria to the nucleus so this is a retrograde 00:28:33.880 --> 00:28:37.240 signaling and this sends the mitochondria will 00:28:37.240 --> 00:28:41.460 send signals to the nucleus to adjust gene expression 00:28:41.460 --> 00:28:45.039 based off of that energy status or the stress 00:28:45.039 --> 00:28:48.259 or the environmental cues. Remember mitochondria 00:28:48.259 --> 00:28:51.880 are environmental signals here. Now I always 00:28:51.880 --> 00:28:55.599 want to return to the environment of the pregnant 00:28:55.599 --> 00:29:00.079 mother in modern life and how that's changed. 00:29:00.349 --> 00:29:05.750 And a result of that change is autism. So that's 00:29:05.750 --> 00:29:09.230 a retrograde signaling. And then there's a nucleus 00:29:09.230 --> 00:29:14.509 to mitochondria signaling, anterior grade signaling. 00:29:15.170 --> 00:29:18.269 And this is when the nucleus regulates mitochondrial 00:29:18.269 --> 00:29:22.809 biogenesis and the function via certain transcription 00:29:22.809 --> 00:29:28.250 factors. So a couple of highlights here. Mitochondrial 00:29:28.250 --> 00:29:33.599 heteroplasmy. And variations in the mitochondrial 00:29:33.599 --> 00:29:38.400 DNA copies, which is heteroplasmy, can amplify 00:29:38.400 --> 00:29:42.440 or dampen the signaling here of the environment 00:29:42.440 --> 00:29:46.460 to mitochondria, mitochondria of the environment. 00:29:47.900 --> 00:29:51.359 And a higher heteroplasmy from these maternal 00:29:51.359 --> 00:29:54.720 stressors or toxins or the environment of the 00:29:54.720 --> 00:29:59.480 mother. may disrupt biophoton coherence and this 00:29:59.480 --> 00:30:04.400 impairs development and increases risk of disease. 00:30:05.839 --> 00:30:09.420 Calcium and other metabolites so that mitochondrial 00:30:09.420 --> 00:30:14.660 DNA actively influences calcium release and metabolites 00:30:14.660 --> 00:30:18.799 like the acetylcholinezime A, remember with the 00:30:18.799 --> 00:30:23.700 glycolysis in the pyruvate, we are essentially 00:30:23.700 --> 00:30:28.980 attempting to make this acetyl coenzyme A, which 00:30:28.980 --> 00:30:32.980 is used in the TCA cycle. And then during the 00:30:32.980 --> 00:30:36.559 development with that thalamus, this thalamus 00:30:36.559 --> 00:30:40.599 being a sensory integrative system, this sensory 00:30:40.599 --> 00:30:46.000 relay system. And if you think about in the fetal, 00:30:46.099 --> 00:30:52.039 in the fetus, the thalamus is constantly evaluating 00:30:52.039 --> 00:30:55.670 its environment. So what does that look like 00:30:55.670 --> 00:31:01.109 for the fetus and the thalamus? The fetal thalamus 00:31:01.109 --> 00:31:04.630 has, it's very dense with mitochondria and it 00:31:04.630 --> 00:31:09.109 uses these mitochondrial DNA signals to regulate 00:31:09.109 --> 00:31:13.029 the neurogenesis, the timing of the neurogenesis, 00:31:13.089 --> 00:31:18.730 and then the stopping of the neurogenesis. This 00:31:18.730 --> 00:31:22.410 is huge in autism research. This isn't that complicated. 00:31:22.609 --> 00:31:25.339 This is a problem. with the autistic phenotype. 00:31:26.400 --> 00:31:28.920 So one of the risk factors here, one of the changes 00:31:28.920 --> 00:31:32.700 is environmental light. And in the placenta, 00:31:32.859 --> 00:31:36.339 this leptin -melano -corton pathway here. So 00:31:36.339 --> 00:31:39.740 any deficits of light or environmental signals 00:31:39.740 --> 00:31:43.180 are driving factors for these neurodevelopmental 00:31:43.180 --> 00:31:46.859 problems or these metabolic problems often seen 00:31:46.859 --> 00:31:50.140 now with children. We have an obesity crisis. 00:31:50.299 --> 00:31:52.559 Remember the Cause of Autism episode where we 00:31:52.559 --> 00:31:56.049 connect these obesity problems, and the various 00:31:56.049 --> 00:31:59.430 diabetes, and neurodevelopmental problems, and 00:31:59.430 --> 00:32:03.150 aging. We haven't even talked about the rapid 00:32:03.150 --> 00:32:06.829 decrease in aging now. This is all tied to the 00:32:06.829 --> 00:32:12.869 story here. The bio photons and the emergence 00:32:12.869 --> 00:32:16.650 of research on the mitochondrial signaling connect 00:32:16.650 --> 00:32:19.509 many problems with the autistic phenotype, especially 00:32:19.509 --> 00:32:21.809 discovered in this time frame that we're talking 00:32:21.809 --> 00:32:25.269 about. with the leptin that's being produced 00:32:25.269 --> 00:32:28.470 by the placenta and that maternal adipose tissue. 00:32:29.430 --> 00:32:32.710 This supports the neurodevelopmental by promoting 00:32:32.710 --> 00:32:36.630 somnathogenesis and that neuromigration. The 00:32:36.630 --> 00:32:39.430 somnathogenesis and migration here are implicated. 00:32:40.569 --> 00:32:43.930 This will introduce the circadian abnormalities 00:32:43.930 --> 00:32:47.890 with the autistic phenotype and the sensory processing. 00:32:48.990 --> 00:32:52.390 So the POMC and melanin deficits here with the 00:32:52.390 --> 00:32:56.890 autistic phenotype. So reduce melanin and the 00:32:56.890 --> 00:33:00.769 endocannabinoid signaling. With the autism, this 00:33:00.769 --> 00:33:03.970 could disrupt those independent two phases of 00:33:03.970 --> 00:33:07.750 the circadian biology, light cycles and dark 00:33:07.750 --> 00:33:11.609 cycles. Remember the environment of the mother 00:33:11.609 --> 00:33:15.150 now, where we can extend the day and have exposure 00:33:15.150 --> 00:33:18.700 to artificial light even during the night. Some 00:33:18.700 --> 00:33:21.400 even work shift work. They work through the night. 00:33:21.900 --> 00:33:25.400 And what that looks like for the developing fetus 00:33:25.400 --> 00:33:28.460 during these time frames. They're completely 00:33:28.460 --> 00:33:35.099 abnormal. They're 180 degrees off. Melanin's 00:33:35.099 --> 00:33:39.259 role here with the separation and the neural 00:33:39.259 --> 00:33:42.839 semiconduction. That's what melanin's role is. 00:33:44.079 --> 00:33:47.220 This being inefficient, this being abnormal, 00:33:47.619 --> 00:33:51.480 off the clock timing, so forth, leads to that 00:33:51.480 --> 00:33:55.200 inefficient energy flow and that abnormal development. 00:33:56.420 --> 00:34:00.680 This contributes to the hyper excitability and 00:34:00.680 --> 00:34:04.660 the hyper connectivity of these brain networks, 00:34:05.599 --> 00:34:09.719 either local or distal brain connectivities. 00:34:10.280 --> 00:34:14.429 Remember the dorsal striata being heavily densed, 00:34:14.829 --> 00:34:18.510 and the medial prefrontal cortex is heavily densed. 00:34:19.449 --> 00:34:23.010 But the pathways throughout the brain are kind 00:34:23.010 --> 00:34:26.469 of abnormal. There are poor connectivities. Remember 00:34:26.469 --> 00:34:30.590 the Bronecki to Broca. Very bad connectivity 00:34:30.590 --> 00:34:34.469 there. That's why there's so many abnormal connections 00:34:34.469 --> 00:34:37.949 through the brain, especially at the early ages. 00:34:38.949 --> 00:34:41.769 Remember the study at UCLA about the salience 00:34:41.769 --> 00:34:45.699 network. six weeks old, they found abnormal salience 00:34:45.699 --> 00:34:49.980 network connectivity. Salience network here is 00:34:49.980 --> 00:34:52.500 involved with modulating our attention. What 00:34:52.500 --> 00:34:56.539 does the living organism consider salient, important, 00:34:56.639 --> 00:34:59.380 at that time? And with the autistic phenotype, 00:34:59.480 --> 00:35:03.400 it is easy to see that we bias towards our inside. 00:35:03.840 --> 00:35:06.559 We neglect the environment. We're not influenced 00:35:06.559 --> 00:35:09.659 by the environment. We do not care for the environment. 00:35:10.090 --> 00:35:16.449 the outside world is mostly chaotic and uninteresting. 00:35:17.929 --> 00:35:20.829 Lastly, with the leptin -melanocortin pathway 00:35:20.829 --> 00:35:25.750 and the autism, the fat brain imbalance. So this 00:35:25.750 --> 00:35:29.909 is late gestational shift from brain fat and 00:35:29.909 --> 00:35:33.030 brain growth driven by the mitochondrial light 00:35:33.030 --> 00:35:36.610 dynamics of these bio photons. And this imbalance 00:35:36.610 --> 00:35:40.340 might be skewed. towards excessive fat storage 00:35:40.340 --> 00:35:43.719 without that proper prostenatal UV activation. 00:35:44.420 --> 00:35:50.679 Children are they are post -birth they are under 00:35:50.679 --> 00:35:55.900 these harmful wavelengths of light that are not 00:35:55.900 --> 00:35:59.179 suitable for proper development. And we can see 00:35:59.179 --> 00:36:01.320 this outside of autism. We can see this with 00:36:01.320 --> 00:36:04.300 the disruptive behaviors in younger and younger 00:36:04.300 --> 00:36:07.760 children now. It is easy to connect that data. 00:36:07.840 --> 00:36:10.739 This is kind of independent of autism, but it's 00:36:10.739 --> 00:36:15.000 very salient and a very big concern. If you go 00:36:15.000 --> 00:36:18.219 to your school, local elementary school, just 00:36:18.219 --> 00:36:22.800 ask teachers, school staff, or ask parents about 00:36:22.800 --> 00:36:25.000 the behaviors of younger and younger children 00:36:25.000 --> 00:36:30.079 now being so dysregulated. This is a huge concern. 00:36:30.440 --> 00:36:34.420 This is why the connection with Daylight Computer 00:36:34.420 --> 00:36:37.420 Company is very important to me and very exciting. 00:36:37.630 --> 00:36:40.530 This is the way forward. People need to know 00:36:40.530 --> 00:36:42.849 about these chromophores and what they do to 00:36:42.849 --> 00:36:47.869 our physiology and our mood and our biological 00:36:47.869 --> 00:36:52.869 energy. This is not that complicated. Our environments 00:36:52.869 --> 00:36:57.389 with these isolated wavelengths of light are 00:36:57.389 --> 00:37:04.489 huge for how we act and who we are. So some environmental 00:37:04.489 --> 00:37:07.690 triggers of autism with that light deficiency. 00:37:08.269 --> 00:37:12.489 So the maternal solar Deficiency is huge and 00:37:12.489 --> 00:37:14.929 there's a direct correlation with that vitamin 00:37:14.929 --> 00:37:19.070 D. You can see this and you go towards the equator 00:37:19.070 --> 00:37:24.710 the risk of autism is Drastically shifted it's 00:37:24.710 --> 00:37:29.829 drastically reduced If you are listening to the 00:37:29.829 --> 00:37:32.369 podcast listening to the episode please feel 00:37:32.369 --> 00:37:36.489 free to leave a review or rating. In podcasting, 00:37:36.750 --> 00:37:39.570 reviews, ratings, and downloads are huge, and 00:37:39.570 --> 00:37:42.489 I very much appreciate your feedback. You can 00:37:42.489 --> 00:37:49.510 contact me on X at RPS 47586, and we can have 00:37:49.510 --> 00:37:51.969 many discussions about autism. I'm always happy 00:37:51.969 --> 00:37:55.230 to discuss autism. You can check out the hop 00:37:55.230 --> 00:37:58.070 link for links to all of the podcasts across 00:37:58.070 --> 00:38:02.099 many different platforms. You can check out the 00:38:02.099 --> 00:38:05.619 YouTube channel for full -length videos and shorts 00:38:05.619 --> 00:38:13.719 and clips. You can email me info .fromthespectrumatgmail 00:38:13.719 --> 00:38:19.619 .com. Thank you for listening to From the Spectrum 00:38:19.619 --> 00:38:20.300 Podcast.