I would like to take a moment and mention a pressing
issue we are seeing in our modern world. And
that is tech use and tech light. The data are
impressive and concerning on isolated wavelengths
of light, especially shorter wavelengths, which
is blue light. For those that don't know, We
have chromophores, which are special proteins
that absorbs specific wavelengths of light. For
blue light, the light that is LED light and tech
light, that protein is called melanopsin. Melanopsin
is responsible for our circadian biology, physiology,
and cell functioning. hormone regulation, and
even a connection to an area huge for mood. A
consideration we should include is this protein
was not even discovered until 1998. It seems
important for us to understand how our biology
uses the different wavelengths of light. for
various aspects of our biology. This blue light
chromophore is our master controller, our master
clock. Remember circadian rhythm is a two -part
process, two independent parts, light and dark.
For a quick reference, see the 2017 Nobel Prize
in Physiology medicine. But for now, I have something
exciting. I want to introduce a product unlike
any other product available. A highlight is the
product from Daylight Computer Company created
their product based on these factors. The Daylight
Computer is completely blue light free. It has
no flicker. Short wavelength flicker. is extremely
harmful for our eyes and downstream biology.
Light flicker is constantly turning our central
nervous system on and off. Essentially it is
like going to a light switch and repeatedly turning
it on and off. The problem is blue light and
LED light does this and it is so rapid You cannot
even perceive this in real time. The daylight
computer is the lowest stimulation and foremost
for sensory sensitive users. It is no question
that the alternative product, especially when
used at night, do not address or consider this
in their product. It is so toxic to human biology.
Big tech corporations have patents on how their
short wavelength implicate the human nervous
system. And a bonus, despite daylight computer
not having backlight, it is very functional for
outdoor use. And of course, increased sunlight
is always preferred. I am happy to offer a discount
for the Daylight Computer. You can use the code
Autism for a $25 off coupon. Again, use the code
Autism and the discount code for $25 off. See
the link in the show notes to Daylight Computer
Company or just give it a quick search in your
internet browser. Use the code Autism. for $25
off. For today's episode, we will cover the leptin
-melanocortin pathway, biophotons. We will expand
on some common biology discussed in the podcast
like mitochondria and melanocytes and POMC. We
will introduce new biology such as nitric oxide
and tetrahydro... biopterin or BH4. We will cover
these areas related to the fetal. We are going
to stick to this timeline of developing the central
nervous system through embryogenesis all the
way up through birth. In maternal fetal, the
leptin -melanocortin pathway regulates placental
physiology. and controls fertility and fecundity
through leptin. The placental mitochondrial DNA
emits ultra -weak biophotons that organize water's
hydrogen bonds in maternal blood. This forms
a liquid crystalline structure. Okay, that's
a lot. But remember the Cause of Autism episode.
And I want to really highlight to Patreon's Decentralized
Medicine number 16 and Quantum Engineering number
45. It's a great source from someone that's foremost
in quantum biology here. This is what we are
discussing here. This organizes and delivers
signals to the mother's brain and this triggers
Pro -opioid Mylonocortin POMC production. whereby
this increases melanin via the alpha of melanocyte
stimulating hormone, the one that's more responsible
for color. However, this is in the pathway of
the ACTH and the clip hormone. So the alpha melanocyte
stimulating hormone is downstream from this.
This is very telling here. So with the rising
UV, and the water content and melanin correlate
with maternal brain shrinkage, a phenomenon potentially
useful for predicting transgenerational risk
through cerebral volume analysis. For the fetal
brain development, or also called morphogenesis,
this is a process during the first five to six
months or so during pregnancy. while the brain
remains immature at this point. However, around
month six, around six months of pregnancy, the
neural growth stops and the adaptation ensuring
that the head will fit through the birth canal
while allowing the fetus to gain significant
weight. This shift is driven by fetal mitochondria.
And this emits a light spectrum that subtracts
the UV and infrared. It emits blue light via
melanopsin as a photo switch. This is crucial
for the developing womb, the child. This process
fattens the child. A lack of endocannabinoid
signaling will then turn off UV light around
380 nanometer, which is at the tail end of UVA.
So this is right where the visual spectrum begins.
And the infrared, 1280 nanometer. This photo
switch inhibits POMC translation and reduces
melanin. The consequence here is the brain development
stalls. However, fat accumulates. If you think
about leptin, you know that Society can easily
attach weight and insulin to the leptin. This
will bring mTOR, mammalian target of rapamycin,
into the equation and mitochondrial hydrogen
-deterium balance. Deterium is a new word for
us. I'm not going into detail about that. The
hydrogen with the mitochondria is very common.
It's a very well established region of interest
here with a hydrogen gradients pumping hydrogen
out of the matrix up into the inter mitochondria
membrane. In addition, the thalamus, that sensory
integration center, the sensory processing relay
center, modulates this via deuterium levels.
This affects seasonal timing and the neurogenesis.
A factor to consider is this. The fetal thalamus
disrupts this antenna -like system, this UV light
absorption, and this halts the brain growth in
the third trimester, thus promoting fat storage
instead for the postnatal brain maturation. UV
light at that 380 nanometer light postnatally
drives the cognitive development and this up
-regulates synaptic proteins and nitric oxide.
NO, a retrograde neurotransmitter enhancing blood
flow in dendritic spine growth. Huge in autism
research. The NO produced placentally with this
tetrahydrobiopterin. That BH4, this will inhibit
the fetal ATP production. Remember the oxferylation
and the electron transport chain. The fifth cytochrome
is ATP, which uses that hydrogen gradient that
we just discussed. ATP, this slows down the neurogenesis.
And this is a natural design. This is on purpose.
Now what's interesting here is BH4 is a cofactor
and it's huge for the aromatic amino acids often
discussed on the podcast. Tryptophan, tyrosine,
and phenylalanine, and sometimes histidine, but
the tryptophan and tyrosine are vast here. Tryptophan
is so huge in the fetal development. The BH4
helps convert the dopamine serotonin and nitric
oxide and such, while regulating cellular redox,
a huge problem with autism. These deficiencies
with the BH4 could be involved with intellectual
disability, movement problems, seizures, and
swallowing. Yes, with swallowing. All of these
features are common for the autistic phenotype.
Some environmental factors here, like the BPA
and fluoride, increase the issues because of
the deuterium absorption and distilling of the
UV electrons. Remember what light is, electromagnetic
fields. And this can impair the semiconduction
and the brain growth. We've often talked about
semiconductors and how autism is a loss of or
a lack of biological energy. This is all tied
here. This is what the main problem is with autism.
The environment of the mother has changed. So
the fetal, this embryogenesis through birth,
this living organism that's trying to develop,
is not developing. It's a loss of biological
energy. How is this so complicated? And here
I'm going to tie some more common autistic phenotype
problems here. This is so easy to understand
here. This BH4 deficit causes methylation defects
and endocrine dysfunctions. Sounds like autism.
In addition, there's a connection with gestational
diabetes. And with this deficit of the BH4 and
these semiconductors that we're talking about
here, with the leptin -melano -cortin pathway
even, this is an easy route for the gestational
diabetes. And with gestational diabetes, it's
a known, it's an undisputed risk factor for increasing
the risk of autism. In addition, the vitamin
D and risk of autism, this is all tied here.
This is so messed. I don't understand why this
is overlooked, why this isn't connected here.
The vitamin D and the NO production is crucial.
It's necessary for proper placental development
and the fetal development. This is why. The rates
of autism have increased with the amount of artificial
light, with the amount of being exposed to this
indoor environment and the types of the artificial
light. This is so easy if you consider these
biological processes and just connect all of
these dots that research has outlined for us,
but nobody makes these connections. I would like
to mention Chroma, lights designed for humans.
Chroma, a Seattle -based innovator founded by
ex -NASA and Air Force engineer Michael Shapiro,
is on a mission to enhance physical and mental
health with purpose -built devices, unlocking
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Shapiro launched Chroma to restore the natural
light lost to screens in indoor living and delivers
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Their products hit hard. The Iron Forge speeds
muscle repair with red and near -infrared light,
while the Skylight mimics sunlight to boost sleep
and energy. A standout. the Forge Lamp is a portable
gem that fires 660 nanometer and 850 nanometer
light to energize mitochondria and heal tissues
on the go. Remember the four red light chromophores
on cytochrome c oxidase frequently talked about
in the podcast. This is why their products are
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lasting impact. Chromis Tech fuses precision
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Chroma makes serves a purpose to create devices
that are precise, durable, and effective for
improving human life. Remember, humans use different
wavelengths of light for different functions
of life. Remember when I ask, What do you think
light is? Chroma designs with our biology in
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energy, full body lights and blue light blocking
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at checkout for a 10 % off discount. So let's
look at the leptin -melanocortin pathway specifically.
So leptin is a hormone. It is primarily produced
in adipose tissue. Now, over the last few years,
last several years, melanin and melanopsin is
found in leptin. And this is that pathway we're
talking about here, the leptin -melanocortin
pathway. This is all new in scientific literature.
This signals satiety and energy status to the
brain, particularly the hypothalamus. And this
interacts with that melanocortin system of POMC.
And it's a peptide that derived from the POMC
for bioactive properties such as the alpha melanocyte
stimulating hormone. This activates and regulates
the biological energy and signals for appetite
and metabolism. In this context of during pregnancy,
this pathway extends its influence for the placenta
and fetal development, the womb. Remember the
episode where Dr. Hannah Stevens talking about
the role of the placenta from the mother and
the womb. So placental physiology. This placenta
is a transient organ and it connects the mother
to the fetus. A huge region of interest here
is the melanocortin pathway that modulates its
function. A huge role here is it controls redundancy
and the fertility of the placenta by adapting
to the maternal energy availability. Now, just
a few minutes ago, I talked about the lack of
energy. This is where, this is the biology that
links this and connects this to this energy story.
During pregnancy, the leptin levels rise, and
it reflects an increased fat source and placental
production. And this, obviously, the main goal
here is to support nutrient transfer of the fetus,
the developing living organism. Placental mitochondrial
DNA, which remember is from the mother, Remember,
it emits ultra -weak biophotons, something we
haven't discussed yet, is the biophotons. And
this potentially amplifies these effects on that
POMC production with the leptin -melanocortin
pathway and the POMC cleaving of the alpha -melanocystimulating
hormone, which will boost melanin synthesis.
Remember, melanin is a semiconductor and it absorbs
all frequencies of light and its roles. Remember
its roles as an antioxidant, as a protecting
the cell and the living organism from insults,
environmental toxins and so forth, which is very
common in today's research about autism. However,
what is missed is What does biology, what does
Mother Nature and evolution give us to protect
us from these so -called insults? Another huge
region of interest for us ought to be melanin
and that UV light exposure. This is huge for
the maternal physiology, which will include the
brain volume. This is huge. The brain volume.
with the autistic phenotype at young ages, even
in the womb, the oversized brain. So the leptin
-melanocortin pathway and its influence on fetal
development, this indirectly shapes the development
by regulating placental efficiency and that maternal
to fetal communication. This is what connects
the mother to the living organism developing
in her stomach. So some main roles here, energy
allocation. Remember, one of the main goals of
the brain is allocating and conserving energy.
Leptin signals energy sufficiency. This is our
energy accountant. This is what the brain uses
to kind of get an inventory of the living organism's
energy state. POMC and alpha melanocyte stimulating
hormone. So that maternal hypothalamus remember
the endocrine disruptions and identifying risk
factors via that hypothalamus. For instance,
the hypothyroid. The leptin here upregulates
POMC and increases the alpha melanocyte stimulating
hormone. This oppresses Appetite to conserve
energy for pregnancy while enhancing the melanin
production. Fetal fat storage. This pathway suppression
and late gestation shifts the energy from the
brain growth to the subcutaneous fat. This is
why babies are getting fat and we want that increased
weight and a certain milestone on the weight.
This is why humans are chunky. They're kind of
abnormal compared to other species, especially
in the primates. Light integration. So with those
biophotons, this suggests a novel mechanism here.
But leptin may amplify mitochondrial light signals.
And this influences the Milano -Cortin pathway.
And that water production from the mitochondria,
remember, cytochrome C oxidase. So what are bio
photons? We need to talk about some bio photons
here. They are low -intensity light particles
emitted by living cells. This is huge in the
gastrointestinal story as well. So with the mitochondrial
activity, they play a significant role in cellular
communication. and the regulation during the
development. Bio photons are similar to any light.
They're electromagnetic waves. They're only in
the UV light wavelengths and the visual light
spectrum. So roughly 200 to 800 nanometer light.
And they are emitted by the biological systems
without any external stimulation. So As your
physiology and cells are functioning, it's going
to release these bio photons in the mitochondria.
This is a huge biomarker here that is hard to
test. It's nearly impossible to test. But when
your mitochondria are functioning and cells are
functioning, these bio photons are driving the
living organism, developing and giving the living
organism energy. It's a direct connection here.
We've covered the mitochondria in the solo episode
and the episode with Dr. Richard Fry. We talked
about reactive oxygen species and these excited
biomolecules running through that TCA cycle like
NADH or the flavins. So we're talking about kind
of providing nutrients to cytochrome 1, 2, and
3 here. And these released energy as photons.
This is huge for the connection from the mother
via the placenta down to the developing living
organism. This has major implications to placental
efficiency and maturation and development. In
addition, we've talked about timing before, clock
timing. These biophotons are huge for thalamic
timing, that sensory and timing hub that biophotons
will help modulate because if you think about
cellular efficiency and these things all of these
cells tissues and organs being clocked timed
the more they are in sync with one another the
more that they are operating efficiently the
more bio photons we will have the more energy
and development that matches normal development
will occur So some underrated roles here with
the biophotons, and that stem from the cytochrome
co -oxidase, the placenta amphetas. This will
tie to the reactive oxygen species production,
which is normal feature of pregnancy. In the
coherence, these wave -like natures suggest that
biophotons could synchronize cellular processes
across distances. A lot to do with the telepathy
tapes. This quantum coherence here kind of helps
signal these with that disruption of the speech
and communication that's seen with the children
of the telepathy tapes. This energy is kind of
disrupted here and used in abnormal ways. The
water interaction is huge here. And remember
the Dr. Hannah Stevens episode as well. returning
to that episode whenever I asked her about NFKB.
This is involved in this timeline here. This
is why I asked and she's perfect example to ask.
She's a perfect source to ask because of her
role with the placenta and womb. So mitochondrial
DNA for the fetal development and that light
spectrum dynamics. I want to briefly talk about
mitochondria to the nucleus so this is a retrograde
signaling and this sends the mitochondria will
send signals to the nucleus to adjust gene expression
based off of that energy status or the stress
or the environmental cues. Remember mitochondria
are environmental signals here. Now I always
want to return to the environment of the pregnant
mother in modern life and how that's changed.
And a result of that change is autism. So that's
a retrograde signaling. And then there's a nucleus
to mitochondria signaling, anterior grade signaling.
And this is when the nucleus regulates mitochondrial
biogenesis and the function via certain transcription
factors. So a couple of highlights here. Mitochondrial
heteroplasmy. And variations in the mitochondrial
DNA copies, which is heteroplasmy, can amplify
or dampen the signaling here of the environment
to mitochondria, mitochondria of the environment.
And a higher heteroplasmy from these maternal
stressors or toxins or the environment of the
mother. may disrupt biophoton coherence and this
impairs development and increases risk of disease.
Calcium and other metabolites so that mitochondrial
DNA actively influences calcium release and metabolites
like the acetylcholinezime A, remember with the
glycolysis in the pyruvate, we are essentially
attempting to make this acetyl coenzyme A, which
is used in the TCA cycle. And then during the
development with that thalamus, this thalamus
being a sensory integrative system, this sensory
relay system. And if you think about in the fetal,
in the fetus, the thalamus is constantly evaluating
its environment. So what does that look like
for the fetus and the thalamus? The fetal thalamus
has, it's very dense with mitochondria and it
uses these mitochondrial DNA signals to regulate
the neurogenesis, the timing of the neurogenesis,
and then the stopping of the neurogenesis. This
is huge in autism research. This isn't that complicated.
This is a problem. with the autistic phenotype.
So one of the risk factors here, one of the changes
is environmental light. And in the placenta,
this leptin -melano -corton pathway here. So
any deficits of light or environmental signals
are driving factors for these neurodevelopmental
problems or these metabolic problems often seen
now with children. We have an obesity crisis.
Remember the Cause of Autism episode where we
connect these obesity problems, and the various
diabetes, and neurodevelopmental problems, and
aging. We haven't even talked about the rapid
decrease in aging now. This is all tied to the
story here. The bio photons and the emergence
of research on the mitochondrial signaling connect
many problems with the autistic phenotype, especially
discovered in this time frame that we're talking
about. with the leptin that's being produced
by the placenta and that maternal adipose tissue.
This supports the neurodevelopmental by promoting
somnathogenesis and that neuromigration. The
somnathogenesis and migration here are implicated.
This will introduce the circadian abnormalities
with the autistic phenotype and the sensory processing.
So the POMC and melanin deficits here with the
autistic phenotype. So reduce melanin and the
endocannabinoid signaling. With the autism, this
could disrupt those independent two phases of
the circadian biology, light cycles and dark
cycles. Remember the environment of the mother
now, where we can extend the day and have exposure
to artificial light even during the night. Some
even work shift work. They work through the night.
And what that looks like for the developing fetus
during these time frames. They're completely
abnormal. They're 180 degrees off. Melanin's
role here with the separation and the neural
semiconduction. That's what melanin's role is.
This being inefficient, this being abnormal,
off the clock timing, so forth, leads to that
inefficient energy flow and that abnormal development.
This contributes to the hyper excitability and
the hyper connectivity of these brain networks,
either local or distal brain connectivities.
Remember the dorsal striata being heavily densed,
and the medial prefrontal cortex is heavily densed.
But the pathways throughout the brain are kind
of abnormal. There are poor connectivities. Remember
the Bronecki to Broca. Very bad connectivity
there. That's why there's so many abnormal connections
through the brain, especially at the early ages.
Remember the study at UCLA about the salience
network. six weeks old, they found abnormal salience
network connectivity. Salience network here is
involved with modulating our attention. What
does the living organism consider salient, important,
at that time? And with the autistic phenotype,
it is easy to see that we bias towards our inside.
We neglect the environment. We're not influenced
by the environment. We do not care for the environment.
the outside world is mostly chaotic and uninteresting.
Lastly, with the leptin -melanocortin pathway
and the autism, the fat brain imbalance. So this
is late gestational shift from brain fat and
brain growth driven by the mitochondrial light
dynamics of these bio photons. And this imbalance
might be skewed. towards excessive fat storage
without that proper prostenatal UV activation.
Children are they are post -birth they are under
these harmful wavelengths of light that are not
suitable for proper development. And we can see
this outside of autism. We can see this with
the disruptive behaviors in younger and younger
children now. It is easy to connect that data.
This is kind of independent of autism, but it's
very salient and a very big concern. If you go
to your school, local elementary school, just
ask teachers, school staff, or ask parents about
the behaviors of younger and younger children
now being so dysregulated. This is a huge concern.
This is why the connection with Daylight Computer
Company is very important to me and very exciting.
This is the way forward. People need to know
about these chromophores and what they do to
our physiology and our mood and our biological
energy. This is not that complicated. Our environments
with these isolated wavelengths of light are
huge for how we act and who we are. So some environmental
triggers of autism with that light deficiency.
So the maternal solar Deficiency is huge and
there's a direct correlation with that vitamin
D. You can see this and you go towards the equator
the risk of autism is Drastically shifted it's
drastically reduced If you are listening to the
podcast listening to the episode please feel
free to leave a review or rating. In podcasting,
reviews, ratings, and downloads are huge, and
I very much appreciate your feedback. You can
contact me on X at RPS 47586, and we can have
many discussions about autism. I'm always happy
to discuss autism. You can check out the hop
link for links to all of the podcasts across
many different platforms. You can check out the
YouTube channel for full -length videos and shorts
and clips. You can email me info .fromthespectrumatgmail
.com. Thank you for listening to From the Spectrum
Podcast.