1 00:00:00,000 --> 00:00:12,240 Welcome to From the Spectrum Podcast. This is a podcast about autism. It is my goal to explain 2 00:00:12,240 --> 00:00:20,920 what is autism. I plan to use a mixture of scientific literature, personal experience, 3 00:00:20,920 --> 00:00:31,480 and opinion. With opinion, I will explain why, I fill the way I do, and give examples. I will 4 00:00:31,480 --> 00:00:39,440 provide links to various references for each episode. For each episode, we will discuss various 5 00:00:39,440 --> 00:00:50,720 aspects of autism. For today's episode, we will need two things. One, it's critical thinking, 6 00:00:50,720 --> 00:01:05,720 and two, it's curiosity. I cannot help but to wonder why autism just appears in society. I can't 7 00:01:05,720 --> 00:01:15,360 help to think about what people think is causing autism. I can't help but to play a game of tug 8 00:01:15,360 --> 00:01:25,400 of war with Barb Wire. For today's episode, I can't help but to expand on implications to 9 00:01:25,400 --> 00:01:37,760 embryogenesis, neuroectoderm, the genetic lineage, and tying these to one common environmental factor 10 00:01:37,760 --> 00:01:46,360 that is proven to be significant to human biology. I will tie other health implications 11 00:01:46,360 --> 00:01:55,640 things seen across societies and across the lifespan. For today's episode, we will cover the 12 00:01:55,640 --> 00:02:07,120 cause of autism. The question that needs to be asked, do you know about the energy in light? 13 00:02:07,120 --> 00:02:19,960 Light is an electromagnetic strip. The second question is, do you know how living organisms on 14 00:02:19,960 --> 00:02:33,880 earth use this energy? These are facts. The power grid dates back to 1880s. The World's Fair 15 00:02:33,880 --> 00:02:47,440 event in Chicago was 1893. Those lights were incandescent. More on that later. Dementia, 16 00:02:47,440 --> 00:03:01,440 studied by Alois Alzheimer's. First patient was 1906. Alzheimer's disease first named in 1910. 17 00:03:01,440 --> 00:03:12,200 Rates of type 1 diabetes are increasing. And the age of onset has kind of shifted. Previously, 18 00:03:12,200 --> 00:03:21,080 it was referred to as juvenile diabetes. But now, it's not uncommon that adults get diagnosed with 19 00:03:21,080 --> 00:03:30,120 type 1 diabetes. At one time, type 1 diabetes was associated with a lot of sugar intake, 20 00:03:30,120 --> 00:03:38,800 carbohydrates, eating things like candy and being obese. But this is largely false. 21 00:03:38,800 --> 00:03:52,920 Autism, our subject, you know, was first observed in 1938. The rates of obesity are increasing. 22 00:03:52,920 --> 00:04:03,040 The rates of type 2 diabetes increasing. Sometimes, those are related. Or scientifically speaking, 23 00:04:03,040 --> 00:04:14,160 type 2 diabetes and Alzheimer's can be a sequela to obesity. However, obesity is not required. 24 00:04:14,160 --> 00:04:25,160 Degenerative conditions are alarming too. But all of these conditions tied together and mentioned 25 00:04:25,160 --> 00:04:35,600 are alarming. Developmental delays and intellectual disabilities are increasing. The so-called 26 00:04:35,600 --> 00:04:44,400 attentional and hyperactivity are increasing. Mood disorders too, especially at younger ages. 27 00:04:44,400 --> 00:04:54,600 Society's answer, because it is comfortable to them, is increasing support in schools. Often, 28 00:04:54,600 --> 00:05:03,240 you will hear, we don't have enough providers or services. Those comments lack critical thinking. 29 00:05:03,240 --> 00:05:11,720 Those are stimulus response comments. Spoken words to return the speaker to comfort, 30 00:05:11,720 --> 00:05:26,240 to homeostasis. This is not the answer. This does not explain the problem. This does not fix 31 00:05:26,240 --> 00:05:37,360 the root cause. In addition, cardiovascular diseases, or CVD, are alarming and still a 32 00:05:37,360 --> 00:05:46,760 common cause of death. A majority of society, especially above the age of 40, is on a certain 33 00:05:46,760 --> 00:06:00,640 type of medication. Yet, leading causes of death are still CVDs. Same scenario as earlier. Not the 34 00:06:00,640 --> 00:06:13,640 answer. Doesn't explain the problem. Does not hit the root cause. Okay, let's go back to development. 35 00:06:13,640 --> 00:06:23,440 We've discussed genetic implications. Even the known common genetic implications tie to autism. 36 00:06:23,440 --> 00:06:35,560 If you have these, it does not mean the individual has autism. Why are those conditions connected? 37 00:06:35,560 --> 00:06:47,240 And why are they connected to the light source? Remember, the brain and skin are connected long 38 00:06:47,240 --> 00:06:59,640 before birth. This creates our complex nervous system. This is in the embryo. From the moment, 39 00:06:59,640 --> 00:07:10,960 the first cell divides. The moment embryogenesis begins. All the way to death. Let's paint this 40 00:07:10,960 --> 00:07:20,720 picture in a linear graph. A cell divides is the beginning, the beginning of the human. The moment 41 00:07:20,720 --> 00:07:32,000 the individual passes. This is a linear timeline. At some point, autism exists on this timeline. 42 00:07:32,000 --> 00:07:45,000 Now, one. 100 years ago, autism did not exist. At least, it was not recognized in literature. 43 00:07:45,000 --> 00:07:55,560 A side note. Remember Leo Kanner mentioned in 1938, the first observation. And these were roughly 44 00:07:55,560 --> 00:08:08,400 8 to 10 year olds. Same for Hans Asperger's. So roughly 1930 or so, for the birth. It's possible. 45 00:08:08,400 --> 00:08:18,240 Autism existed at smaller scales. Let's say in the 1920s or so. But that is not so important to 46 00:08:18,240 --> 00:08:26,400 our conversation. What is important is autism just magically shows up in human evolution. 47 00:08:26,400 --> 00:08:38,280 And two. Decade over decade, rates are increasing. Now, the moment autism begins on that linear 48 00:08:38,280 --> 00:08:49,640 timeline is early in development. Be it in the embryo or just after birth. We reviewed altered 49 00:08:49,640 --> 00:08:59,640 salience brain connectivity at six weeks old. The crucial consideration is, autism is new and 50 00:08:59,640 --> 00:09:09,920 follows the trends of those earlier mentioned conditions. Crucial in development are. Well, 51 00:09:09,920 --> 00:09:16,480 there are many crucial biological components for development. Some regions of interest for our 52 00:09:16,480 --> 00:09:26,000 conversation are vitamin A, various vitamin B's, vitamin D, the aromatic amino acids, 53 00:09:26,000 --> 00:09:42,640 histidine, water, melanin, melanopsin, pro-opio-melanocortin, or pom-C for short. And light, of course. 54 00:09:42,640 --> 00:09:52,600 And light. These are all crucial for our conversation. In addition to the genetic lineage and what we 55 00:09:52,600 --> 00:10:01,160 know about heritability, we also need to consider the environment the mother is in during pregnancy. 56 00:10:01,160 --> 00:10:10,360 This is crucial and it's shown. It is a worthy consideration about how the light is a primary 57 00:10:10,360 --> 00:10:18,200 environmental factor when people discuss environmental factors. The environment of the 58 00:10:18,200 --> 00:10:31,200 pregnant woman is also different from 100 years ago or 150 years ago. DNA is a magnetic strip and 59 00:10:31,200 --> 00:10:43,440 codes for proteins. Proteins are wide band gap semiconductors. For reference, see Albert St. 60 00:10:43,440 --> 00:10:55,560 Georgie's. When the magnetic footprint changes, implicated, it changes the light. It changes the 61 00:10:55,560 --> 00:11:08,360 power, function of our cells, because it changes the charge. Atoms and oxidated stress is this, 62 00:11:08,360 --> 00:11:21,040 is a cause. Humans use roughly 20 amino acids. Remember, these are proteins. These 20 amino 63 00:11:21,040 --> 00:11:30,480 acids are responsible for tens and tens of thousands of different proteins based on unique 64 00:11:30,480 --> 00:11:42,240 sequencing. Various elements from the periodic table and water and melanin and light are the 65 00:11:42,240 --> 00:11:53,920 components. Look at a periodic table. We use some, but not all. This powers or energizes our cells. 66 00:11:53,920 --> 00:12:08,360 So we use some of the elements from the periodic table, water, melanin and light. The aromatic 67 00:12:08,360 --> 00:12:19,080 amino acids receives light and targets various elements such as calcium, magnesium and sodium. 68 00:12:19,080 --> 00:12:35,440 Light is underestimated. Light is the only change. Light is the only change. One, a shift from the 69 00:12:35,440 --> 00:12:45,400 light source. Previously, it was more sunlight. Now, we have the ability to light the environment 70 00:12:45,400 --> 00:12:55,880 with artificial light. And we can extend the day under artificial light. And to the type of light 71 00:12:55,880 --> 00:13:07,440 from incandescent to the modern day LED and tech light. You know, children, especially at extremely 72 00:13:07,440 --> 00:13:18,240 young ages, have access to technology. And we can see, we know that children, young age, are right 73 00:13:18,240 --> 00:13:27,800 on top of the technology on the screen. The younger and developing brain is more implicated to this. 74 00:13:27,800 --> 00:13:38,480 And this is true. Now, by the time the child has access to this blue light and this tech, this 75 00:13:38,480 --> 00:13:47,360 technology, autism likely already exists. It's already manifested in the biology of that individual. 76 00:13:47,360 --> 00:13:57,680 However, what is the purpose here is blue light or modern light more generally implicates our 77 00:13:57,680 --> 00:14:06,960 biology. It's not so much autism occurs directly for that individual with the exposure to the blue 78 00:14:06,960 --> 00:14:17,080 light. It's more, this is more the lineage. This is more generational. Now, autism around 1938 was 79 00:14:17,080 --> 00:14:24,280 first discovered. And the light sources remember 1880. And then the power grid 1893. So this is, 80 00:14:24,280 --> 00:14:30,720 we've discussed this, this is just a couple of generations. So that makes sense for the lineage 81 00:14:30,720 --> 00:14:42,800 that hand me down of this biological implication. Blue light dehydrates cells, whereby, something 82 00:14:42,800 --> 00:14:53,080 called a TCA cycle is implicated. This involves cellular respiration and some oxidation. This 83 00:14:53,080 --> 00:15:02,440 was discovered by a Nobel laureate, Hans Krebs. You know, mitochondria. This is occurring in the 84 00:15:02,440 --> 00:15:13,920 mitochondria, more on mitochondria later. But the TCA cycle generates ATP. Now, if mitochondria is 85 00:15:13,920 --> 00:15:24,600 the energy source for the cell, it's the ATP that's creating this. Mitochondria absorbs light. Light 86 00:15:24,600 --> 00:15:32,120 is a major source of energy here. Various wavelengths. We'll discuss longer wavelengths in 87 00:15:32,120 --> 00:15:39,720 the red light later. But shorter wavelengths are here too. And melanin and some elements from the 88 00:15:39,720 --> 00:15:51,840 periodic table. All cells, except for bacteria, have the TCA cycle. In addition, water is a main 89 00:15:51,840 --> 00:16:00,600 factor here. Water is commonly known as being a part of the human body. This is occurring at the 90 00:16:00,600 --> 00:16:10,240 mitochondria metabolism. However, not common is the knowledge of the role water has and the 91 00:16:10,240 --> 00:16:20,520 differences of water. In mitochondria, there are cytochromes. Cytochromes are proteins. Specifically, 92 00:16:20,520 --> 00:16:30,680 cytochrome C1 or cytochrome 1 transfers electrons during phosphorylation. Phosphorous, iron and 93 00:16:30,680 --> 00:16:40,200 sulfur are huge here. But not to be overlooked is light. Cytochromes receive light. Specifically, 94 00:16:40,200 --> 00:16:48,720 red light and near infrared and infrared light. They are red light chromophores. This is a part 95 00:16:48,720 --> 00:16:59,640 of the oxidation process. This involves an enzyme called cytochrome C oxidase. It turns oxygen 96 00:16:59,640 --> 00:17:07,920 into water. And we will talk more about this through the episode. But this generates the ATP 97 00:17:07,920 --> 00:17:18,720 that is most commonly known when we think about mitochondria. The P is phosphate. Phosphate is 98 00:17:18,720 --> 00:17:28,440 phosphorous and oxygen. You're going to see oxygens playing a huge role here in cell health. And 99 00:17:28,440 --> 00:17:38,280 probably lastly, because this is getting in depth, but phosphate is a type of ion, adene ion, 100 00:17:38,280 --> 00:17:47,880 whereby it has more electrons than protons. Okay, last thing here. And just all of that 101 00:17:47,880 --> 00:17:55,440 explanation, all of that build up just to say this, mainly just to say this. Modern light 102 00:17:55,440 --> 00:18:06,520 dehydrates cells whenever it's just isolated to blue light. Now think about the embryo and that 103 00:18:06,520 --> 00:18:15,280 cell dividing and cell differentiation and migration development and the complex living 104 00:18:15,280 --> 00:18:23,760 organism coming to life, coming into life form. We know autism develops early, probably within 105 00:18:23,760 --> 00:18:35,000 the embryo, probably. But even after birth, postnatal, all of these things are huge. When cells 106 00:18:35,000 --> 00:18:42,200 function, whenever they are functioning properly, this is a very dynamic structure, a very dynamic 107 00:18:42,200 --> 00:18:49,880 operation, I should say, whereby it's using energy from the environment, like such as the light, 108 00:18:49,880 --> 00:18:58,040 and it uses the periodic elements and is creating energy. This could be the most important thing 109 00:18:58,040 --> 00:19:06,400 in the whole episode right here. This is instead of adding something to the biological processes, 110 00:19:06,400 --> 00:19:16,360 such as pesticides or vaccines or whatever it is that we want to add to the components of the 111 00:19:16,360 --> 00:19:23,160 biological processes. Let's just take the normal biological processes, these normal ingredients 112 00:19:23,160 --> 00:19:30,840 or components that we've discussed, such as the light, the periodic elements, the water, and so 113 00:19:30,840 --> 00:19:38,240 forth. And let's just change that. Let's just change one and see what it does to development and 114 00:19:38,240 --> 00:19:50,360 our cell functioning and our nervous system. Autism is a form of neuroplasticity. Neuroplasticity, 115 00:19:50,360 --> 00:20:00,120 we've changed, autistic people have changed based on the environment that they are in. And I think 116 00:20:00,120 --> 00:20:08,200 this is what's happening. Neuroplasticity is not limited to learning something new, such as 117 00:20:08,200 --> 00:20:16,320 knowledge or learning a new motor skill. Yes, that's neuroplasticity, but there are more complex 118 00:20:16,320 --> 00:20:25,520 types of neuroplasticity. Perhaps the most fascinating one is people that are blind will 119 00:20:25,520 --> 00:20:31,920 repurpose their visual cortex for the Braille reading. That's the type of neuroplasticity 120 00:20:31,920 --> 00:20:40,800 that we need to discuss and consider. Autism is an example of that type of neuroplasticity, 121 00:20:40,800 --> 00:20:50,400 whereby the living organism changed because something in the environment. Just know this, 122 00:20:50,400 --> 00:21:01,520 humans can harm themselves unlike any other species. We have, you've heard me say, never underestimate 123 00:21:01,520 --> 00:21:10,440 a human's capacity to think. This has a chance to be good and it has a chance to be bad, an 124 00:21:10,440 --> 00:21:20,400 infinite amount of good and bad. Somewhere along the line, we have to recognize that we can do harm 125 00:21:20,400 --> 00:21:31,000 to ourselves, maybe even indirectly. Of course. Remember, you know I've said the nervous system 126 00:21:31,000 --> 00:21:38,760 just wants to respond. It doesn't want to work. Now carry that out a little downstream to our 127 00:21:38,760 --> 00:21:46,160 behaviors. I don't think this is all that complicated. If this environmental factor, 128 00:21:46,160 --> 00:21:53,000 this environmental component that gets little attention can implicate cells like this, just 129 00:21:53,000 --> 00:22:00,120 imagine what it's doing in the embryo and through the lifespan, such as with the Alzheimer's and 130 00:22:00,120 --> 00:22:08,960 dementia. Now, innocence will happen. Yes, we can normalize for this. We will age, but the type 131 00:22:08,960 --> 00:22:16,680 of aging we are doing now and all of the health trends, just pick any health trend that you want 132 00:22:16,680 --> 00:22:25,680 to look up. Are we doing it right? Do we have any understanding of it? Now let's consider autism. 133 00:22:25,680 --> 00:22:34,040 So this is at the beginning of life, of course, but at the end of life, on the other end of the 134 00:22:34,040 --> 00:22:40,840 lifespan, the rates of dementia, the rates of autism, the rates of dementia are very similar. 135 00:22:40,840 --> 00:22:53,120 Obesity is also alarming. Remember leptin, it wasn't discovered until 1994. Dementia and even 136 00:22:53,120 --> 00:23:01,440 obesity can be picked up in an eye. Using an OCT scan, an ophthalmologist or optometrist can do 137 00:23:01,440 --> 00:23:08,520 this and this is shown. This is in the scientific literature. They can pick up eye damage with 138 00:23:08,520 --> 00:23:17,560 this melanin back in the eye, the retina, on an OCT scan years, many years before dementia and those 139 00:23:17,560 --> 00:23:25,360 symptoms that we know manifest later in life. It starts in the eye. It starts with the photoreceptors 140 00:23:25,360 --> 00:23:33,160 and these light sources. I don't think none of this is very complicated if we just look at it 141 00:23:33,160 --> 00:23:41,480 differently. If we just give ourselves a chance or said differently, just to wrap all of these 142 00:23:41,480 --> 00:23:50,280 things up, the rates of chronic diseases are concerning. The second thing is we can look 143 00:23:50,280 --> 00:23:59,840 up maps from space. NASA does this to look at Earth and the artificial light from let's say the 144 00:23:59,840 --> 00:24:09,600 1940s to the 60s to the 80s to the 2000s about every 20 years or so. You can see this artificial 145 00:24:09,600 --> 00:24:19,720 light at night expanding. It's a rapid increase. We are more exposed to this type of light. So a 146 00:24:19,720 --> 00:24:29,440 shift from the light source and then the increase of this artificial light. This is my opinion. 147 00:24:29,440 --> 00:24:38,800 Artificial light looks innocent. It doesn't look like much is going on other than it allows us to 148 00:24:38,800 --> 00:24:48,000 light up the inside environment. It allows us to light up our houses and we can extend the day 149 00:24:48,000 --> 00:24:57,040 and we can light up the house so we can enjoy our pleasures, enjoy our activities, our modern 150 00:24:57,040 --> 00:25:06,880 activities and pleasures. Further, it allows us to light up organization so we can have more job 151 00:25:06,880 --> 00:25:14,880 opportunities during the night and we can have more goods produced. But then we get shift work 152 00:25:14,880 --> 00:25:21,520 and all of these health implications associated with that which aren't a surprise in the medical 153 00:25:21,520 --> 00:25:29,800 literature. It might be a surprise to the lay public but that doesn't make it right. It doesn't 154 00:25:29,800 --> 00:25:37,800 make lighting up the homes at night and this being suffocated in artificial light right. We 155 00:25:37,800 --> 00:25:44,680 like that artificial light at night. We like it. We're drawn to that nightlife with those shiny 156 00:25:44,680 --> 00:25:54,480 lights, spotlighting, things to do, activities. Oh look at this. The artificial light even during 157 00:25:54,480 --> 00:26:01,840 the day allows us to be more comfortable but that doesn't make it right. And here's my last opinion 158 00:26:01,840 --> 00:26:10,440 because I want to move on. It's off topic. The light during that industrial revolution was really 159 00:26:10,440 --> 00:26:16,320 serious. It really allowed profits to be made and those goods to be produced like we mentioned 160 00:26:16,320 --> 00:26:25,240 earlier. And now after several generations of it, after all of these generations, it's just normal 161 00:26:25,240 --> 00:26:34,600 part of life now. Couldn't imagine living without it or reducing it or only using it at certain 162 00:26:34,600 --> 00:26:44,720 times, optimal times that's okay for your biology. Okay, let's talk more light and biology. Photo 163 00:26:44,720 --> 00:26:54,440 electric effect is photons hitting the surface and giving energy to electrons. In our case, 164 00:26:54,440 --> 00:27:04,560 different proteins require or activate based on various wavelengths of light. Artificial light 165 00:27:04,560 --> 00:27:18,720 has certain wavelengths, very specific wavelengths. Most modern light such as LED and tech light is 166 00:27:18,720 --> 00:27:29,840 blue light about 460 to 480 nanometer light. We've covered this. However, I don't think it hit. 167 00:27:29,840 --> 00:27:41,880 Incandescent light was mostly green all the way up to red and infrared light. Candles are red light 168 00:27:41,880 --> 00:27:55,160 to near infrared light and fire is too. The sun includes UVB about 250 nanometer light all the 169 00:27:55,160 --> 00:28:09,160 way up to 3100 nanometer light. And that includes various infrareds. So it's UVB, UVA, and then the 170 00:28:09,160 --> 00:28:19,760 visual light spectrum, the rainbow from violet to red light. So from 390 to 760. And then from 760 171 00:28:19,760 --> 00:28:36,000 to 3100 are various forms of infrared. I bet 99% 99% of society does not understand or know that 172 00:28:36,000 --> 00:28:45,400 infrared light is a tool against cancer cells. It is known. Go to your search bar right now and type 173 00:28:45,400 --> 00:28:54,720 in infrared light, Jack Hammers cancer cells, I believe to my knowledge. This is the latest research. 174 00:28:54,720 --> 00:29:03,880 And it comes out of Texas A&M. They use Jack Hammers whenever they discuss what infrared light is 175 00:29:03,880 --> 00:29:18,040 doing to a cancer cell. The sun is roughly 43 to 47% red and infrared light. So almost half of the 176 00:29:18,040 --> 00:29:26,760 sunlight that we get is in this range. Melatonin is going to be the human's powerhouse here. The 177 00:29:26,760 --> 00:29:35,200 human secret weapon for this. Here are some interesting data. These data are very interesting. 178 00:29:35,200 --> 00:29:45,000 Vitamin D and autism are anti correlated, whereby the higher the vitamin D, the less likelihood 179 00:29:45,000 --> 00:29:58,080 for autism. Okay. Autism rates closer to the equator are also lower. Now, artificial light in 180 00:29:58,080 --> 00:30:10,440 this modernization is becoming more and more. However, the sun and the power of the sun is 181 00:30:10,440 --> 00:30:20,800 still going to kind of cancel out. I know, I know. A biological cell is a so-called dissipative 182 00:30:20,800 --> 00:30:29,360 structure. A dissipative structure is built atomically to capture energy from the environment. 183 00:30:29,360 --> 00:30:40,240 It captures this energy and stores it. Melanin and water are major players here in the cell to 184 00:30:40,240 --> 00:30:49,760 capture that energy. The energy from the sunlight and that lux is the way this happens. What we 185 00:30:49,760 --> 00:30:59,720 want to look at is the sun power, the lux provided by the sun versus artificial light. So something 186 00:30:59,720 --> 00:31:06,640 to consider is the lux between artificial light and indoors versus outdoors in the sunlight. 187 00:31:06,640 --> 00:31:16,840 Indoors, roughly 3 to 500 lux is about the most that you will receive. And remember, 188 00:31:16,840 --> 00:31:27,280 it's a very specific wavelength. However, the sun, a sunrise and sunset are roughly 20,000 to 30,000 189 00:31:27,280 --> 00:31:37,880 lux. And the afternoon sun is upwards to 100,000 lux. And this is the energy source. This is the 190 00:31:37,880 --> 00:31:45,760 difference in energy source too. Remember the light as an electromagnetic strip and how we use that 191 00:31:45,760 --> 00:31:54,680 light. Here are just some brief benefits or some highlighted benefits of each wavelength of light 192 00:31:54,680 --> 00:32:05,880 and sun and the relationship to human biology. This list is not exhaustive. UVB, which is roughly 193 00:32:05,880 --> 00:32:17,720 250 or so to 315 nanometer light. Vitamin D, vitamin D and cholesterol have a close relationship. It's 194 00:32:17,720 --> 00:32:27,360 a very coordinated dance whereby they need to sulfate. They need to work together with UVB light 195 00:32:27,360 --> 00:32:36,920 for lipid metabolism. This is the lipid metabolism that is a problem in society today. And some 196 00:32:36,920 --> 00:32:44,560 details about that medication I mentioned previously in the episode. Testosterone. Remember 197 00:32:44,560 --> 00:32:54,600 testosterone's role in human biology. Sipolsky says testosterone makes effort feel good. The 198 00:32:54,600 --> 00:33:03,840 aromatic amino acids phenylalanine, tryptophan, tyrosine, tryptophan and methionine, another 199 00:33:03,840 --> 00:33:13,720 amino acid are very unique. They have one codon and methionine is the start signal for all protein 200 00:33:13,720 --> 00:33:23,680 and DNA sequencing. And histidine. Histidine is one of those amino acids that are vital for protein 201 00:33:23,680 --> 00:33:33,600 synthesis. It helps synthesize proteins, which is also a region of interest for us. Endogenous 202 00:33:33,600 --> 00:33:43,240 analgesic. So those pain receptors or that pain perception also associated with a pro opioid 203 00:33:43,240 --> 00:33:52,120 bolano-cortin. That wonderful subdivision in the hypothalamus. Leptin sensitivity. Now we've 204 00:33:52,120 --> 00:34:05,680 we've hit on that. So UVA, so roughly 315 to 390 nanometer light. Nitric oxide. This is huge for 205 00:34:05,680 --> 00:34:18,440 CVD. UVA is powerful for our cardiovascular system. UVA regulates blood pressure. Infrared light. So 206 00:34:18,440 --> 00:34:29,720 760 all the way up to 3100 light. Melatonin. Infrared creates a sun callus. So prevents harm 207 00:34:29,720 --> 00:34:37,480 from too much UV. The more you get infrared, which is really high in morning and evening, 208 00:34:37,480 --> 00:34:46,320 closer to sunset. This protects. This is an endogenous healthy sunscreen. This is Mother Nature 209 00:34:46,320 --> 00:34:56,960 sunscreen. Water. Infrared is huge for our water. The human body is roughly 80% water at birth. And 210 00:34:56,960 --> 00:35:07,440 this decreases decade over decade as we age. See Jared Pollock for water. This is primarily why 211 00:35:07,440 --> 00:35:16,120 younger humans are more resilient. And infrared is a wonderful anti-inflammatory. And of course, 212 00:35:16,120 --> 00:35:24,320 the wonderful cancer fighting abilities. Infrared can even penetrate bone. It penetrates bones. A 213 00:35:24,320 --> 00:35:34,640 process called DC electric current. And this is a semiconductor method here. The higher the 214 00:35:34,640 --> 00:35:41,360 wavelength of light, such as the red light at around 700 all the way up to the 3100 in the 215 00:35:41,360 --> 00:35:50,120 infrared light. The higher that number is, the more it penetrates the human body. A combination of 216 00:35:50,120 --> 00:36:00,560 UVA and infrared, a type of infrared light, regenerates photoreceptors. A lot of what we're 217 00:36:00,560 --> 00:36:07,520 talking about today is those photoreceptors that receives the light energy. Red light, 218 00:36:07,520 --> 00:36:18,720 which is 620 to 760 nanometer light. Mitochondria function. It's huge for mitochondria. That 219 00:36:18,720 --> 00:36:28,920 cytochrome C oxidase mentioned earlier, it has four chromophores. And they are all red light. 220 00:36:28,920 --> 00:36:35,520 You might ask, and you ought to ask, why are red light chromophores deep inside the mitochondria? 221 00:36:35,520 --> 00:36:45,320 And you ought to consider, where are we getting red light now? Artificial light doesn't have it. 222 00:36:45,320 --> 00:36:54,160 The sunlight does, but where are humans getting the red light if they're not outside? And think 223 00:36:54,160 --> 00:37:01,240 about the consequences. And thinning out blood viscosity, we don't want thick blood. So red 224 00:37:01,240 --> 00:37:09,720 light to infrared is wonderful for the cardiovascular. Red light also lowers blood glucose. Studies 225 00:37:09,720 --> 00:37:20,360 show by 27, 27% just the light. This is nature's way of giving us energy, giving us improving 226 00:37:20,360 --> 00:37:30,160 our metabolism. In contrast to the red light, blue light stimulates glucose corticoids. That's 227 00:37:30,160 --> 00:37:39,080 right. The blue light will cause us to generate cortisol and glucose without eating. And this 228 00:37:39,080 --> 00:37:48,560 is all through the POMC gene. Modern light is full of the blue light spectra, about 440 229 00:37:48,560 --> 00:37:56,680 to 480, 490. It's huge for circadian rhythm, those natural rhythms we had to follow before 230 00:37:56,680 --> 00:38:03,040 the creation of artificial light. We've talked about melanopsin. Melanopsin is a blue light 231 00:38:03,040 --> 00:38:10,720 chromophore. We've discussed this. Remember, melanopsin wasn't discovered until 1998. That's 232 00:38:10,720 --> 00:38:18,840 when it was discovered in the human eye. However, how it's sequenced and melanopsin being present 233 00:38:18,840 --> 00:38:28,960 in tissues, organs, and deep inside the brain didn't exist until six, eight, 10, 12 years 234 00:38:28,960 --> 00:38:35,160 ago. So all of this has happened recently. Why do we have this blue light chromophore 235 00:38:35,160 --> 00:38:40,920 all over the place? That's the question. That's the question you have to ask if you're going 236 00:38:40,920 --> 00:38:48,880 to follow along here and understand and give yourself a chance to consider what is going 237 00:38:48,880 --> 00:38:57,160 on. And the downstream implications or the power melanopsin have to all of the bodily 238 00:38:57,160 --> 00:39:08,240 physiology. This is very crucial and an alarming consideration for our health now in the modern 239 00:39:08,240 --> 00:39:17,360 world. The smaller the wavelength, such as in the UV area and the blue light, have greater 240 00:39:17,360 --> 00:39:28,600 photonic energy. You know this. You know UV light is strong. Visual light, which is the 241 00:39:28,600 --> 00:39:40,360 only light humans can see, the 390 to 760. Most modern light now, most artificial light, 242 00:39:40,360 --> 00:39:49,360 are shorter wavelengths because that light contains more energy. So it requires less 243 00:39:49,360 --> 00:40:00,140 electricity to power it. So let's expand on melanin, a black pigment now found across 244 00:40:00,140 --> 00:40:14,720 the brain that serves several purposes. Melanin is a semiconductor whereby each one, U melanin, 245 00:40:14,720 --> 00:40:26,480 few melanin, and neuro melanin, uses a different element on the periodic table. One uses nitrogen, 246 00:40:26,480 --> 00:40:39,560 one uses sulfur, and one uses phosphorus. Melanin comes from tyrosine and UVB. You know 247 00:40:39,560 --> 00:40:47,060 about color. You know about certain types of melanin. You melanin and feel melanin for 248 00:40:47,060 --> 00:40:57,060 the eyes, skin, and hair. However, neuro melanin, as we discussed previously, likely you've 249 00:40:57,060 --> 00:41:06,420 just heard melanin without detail, without understanding the purposes. Neuro melanin 250 00:41:06,420 --> 00:41:16,540 is slightly different. One, it protects against oxidative stress. Oxidative stress is extremely 251 00:41:16,540 --> 00:41:28,740 harmful for cells. And a major factor, maybe the primary factor for CVD and aging complications. 252 00:41:28,740 --> 00:41:33,880 Oxidative stress is a common theme throughout this whole episode. Everything we're talking 253 00:41:33,880 --> 00:41:43,820 about essentially is involving oxidative stress, specifically the mitochondria and the cytochrome. 254 00:41:43,820 --> 00:41:54,500 And two, neuronal function. Here we go. Cell function, beginning in the embryogenesis. 255 00:41:54,500 --> 00:42:07,500 Mitosis. Mitosis is trillions of cells dividing, giving life to a complex living organism. 256 00:42:07,500 --> 00:42:16,180 Cells begin to increase at rapid paces. They migrate. We've discussed cell migration. In 257 00:42:16,180 --> 00:42:23,840 episode three, one of the first things we discussed in episode three. Now autism and cell migration 258 00:42:23,840 --> 00:42:31,220 is a problem. This is a very big problem. In things like the cell functioning, the cells 259 00:42:31,220 --> 00:42:39,220 capability and the hydration, the cell metabolism, all of these things will factor into the migration. 260 00:42:39,220 --> 00:42:45,380 And blue light does not do any favors for this. In the complex living organism, such 261 00:42:45,380 --> 00:42:54,660 as the human, this is detrimental in the development, early in development, from embryogenesis 262 00:42:54,660 --> 00:43:01,020 and all the way up through lifehood to the whole lifespan. Remember that linear timeline 263 00:43:01,020 --> 00:43:09,020 that we painted earlier in the episode. This can implicate cells and problems and increase 264 00:43:09,020 --> 00:43:18,020 senescence all through lifespan. And you can see this in society. Melanin and light will 265 00:43:18,020 --> 00:43:27,980 be our best friend for this, for protection, for proper cell growth, migration, for proper 266 00:43:27,980 --> 00:43:40,980 cell function. Melanogenesis comes from UV light, UV radiation that up regulates melanocytes 267 00:43:40,980 --> 00:43:50,060 from pro-opioid melanocortin or POMC. This is a subdivision in the hypothalamus. We've 268 00:43:50,060 --> 00:43:58,820 discussed the hypothalamus. There are three types of melanocytes. Our region of interest 269 00:43:58,820 --> 00:44:07,180 is alpha melanocyte stimulating hormone. We've introduced this in episode four. We've introduced 270 00:44:07,180 --> 00:44:18,060 this to autism during that time. But this is far beyond autism. This is all cells for 271 00:44:18,060 --> 00:44:30,660 all conditions. Common with genetic implications with autism is cell and synapsis development. 272 00:44:30,660 --> 00:44:38,300 That is, much of those implications are tied to cell development and function and synaptic 273 00:44:38,300 --> 00:44:49,420 development and function. Both the pre and the post synapses. Neuromellanin is black. 274 00:44:49,420 --> 00:44:58,700 And this is why we use the melanin. The black absorbs all frequency of light. It receives 275 00:44:58,700 --> 00:45:08,500 all of that energy from that electromagnetic strip. Remember the sun spectrum from 250 276 00:45:08,500 --> 00:45:16,100 to 3100 and remember how certain wavelengths provide certain benefits to our biology. Now 277 00:45:16,100 --> 00:45:25,180 remember artificial light has very specific wavelengths. Another role with neuromellanin 278 00:45:25,180 --> 00:45:36,180 is protecting the cell whereby the pigments remove toxins and metals. Here we go. Society 279 00:45:36,180 --> 00:45:44,140 loves to speak about toxins and metals as a general cause and general reasons for rates 280 00:45:44,140 --> 00:45:55,020 of autism diagnosis. They think this is what's causing the increase. This reason is missing 281 00:45:55,020 --> 00:46:05,540 critical information. This is true about toxins and pesticides and metals and so forth. The 282 00:46:05,540 --> 00:46:14,780 reason would be neuromellanin. Neuromellanin protects the cell against those toxins, the 283 00:46:14,780 --> 00:46:24,980 pesticides and metals and so forth. It is mostly known. Neuromellanins role in degenerative 284 00:46:24,980 --> 00:46:35,740 conditions. As you know, it's role in cell health and protection. Interesting. Neuromellanin 285 00:46:35,740 --> 00:46:46,180 is the topic for Parkinson's. Most people would think dopamine and that's true. But 286 00:46:46,180 --> 00:46:55,580 neuromellanin and dopamine are closely related. It's in the biosynthesis. A hot spot for 287 00:46:55,580 --> 00:47:05,140 Parkinson's is a Cisthantia nigra or black substance. Neuromellanin is also plentiful 288 00:47:05,140 --> 00:47:16,540 and the locus ceruleus. The spot for brain adrenaline. Dopamine, melanin, adrenaline are 289 00:47:16,540 --> 00:47:28,260 all synthesized by tyrosine, one of the aromatic amino acids. This tyrosine protein needs 200 290 00:47:28,260 --> 00:47:40,140 nanometer light or UVB light. Within the past month, Neuroscience News highlighted a study, 291 00:47:40,140 --> 00:47:49,020 a recent study showing people with autism have a three fold increase, times three increase, 292 00:47:49,020 --> 00:47:59,980 chance of developing Parkinson's. If you go to PubMed and type in Neuromellanin, you 293 00:47:59,980 --> 00:48:09,460 can see trend of articles released. The articles are increasing mainly because, one, people 294 00:48:09,460 --> 00:48:16,620 are understanding its role in different than the peripheral melanin discussed earlier with 295 00:48:16,620 --> 00:48:27,820 the eye, hair and skin color. And two, the rates of Parkinson's. People, science is 296 00:48:27,820 --> 00:48:37,260 starting to study this more. Melanin is involved in the cell body. All cells and it is not 297 00:48:37,260 --> 00:48:46,700 limited to Parkinson's or any degenerative condition. Okay, moving on to tryptophan, 298 00:48:46,700 --> 00:48:56,140 another aromatic amino acid. Tryptophan is a wide band semiconductor for the eyes. The 299 00:48:56,140 --> 00:49:06,540 eyes are no way only vision. It's a passage into our deep biology and development. The 300 00:49:06,540 --> 00:49:15,780 eyes is a highway into our biology. This involves photoreceptors. We've discussed 301 00:49:15,780 --> 00:49:27,620 melanopsin and physiology and development, timing, etc. Also, we've discussed all 302 00:49:27,620 --> 00:49:37,940 opsin, have a weak covalent bond with vitamin A. You have probably heard how important vitamin 303 00:49:37,940 --> 00:49:49,900 A is for the eyes. As a kid, probably told carrots are good for your eyes. Anyway, blue 304 00:49:49,900 --> 00:50:01,860 light destroys this bond, vitamin A to opsin. Remember the implications, the damage of opsin 305 00:50:01,860 --> 00:50:12,900 and vitamin A, those weak covalent bonds. Vitamin A in the aldehyde form damages cells when 306 00:50:12,900 --> 00:50:22,260 the bond is broken. Remember, blue light breaks this bond and create free radicals. That broken 307 00:50:22,260 --> 00:50:33,020 bond of vitamin A in this aldehyde form is toxic to cell membranes, an area called lipid 308 00:50:33,020 --> 00:50:44,020 rafts and it causes a so-called dielectric collapse of the cell. This means we cannot 309 00:50:44,020 --> 00:50:52,740 control or understand the electromagnetic information coming in from the light. We cannot 310 00:50:52,740 --> 00:51:02,540 create order from that electromagnetic strip. And this seems to be at the core of a lot 311 00:51:02,540 --> 00:51:12,060 of the aging complications of modern day and chronic diseases. Free radicals in our biology 312 00:51:12,060 --> 00:51:24,060 is no good. It is an unstable molecule that promotes or creates ROS, that oxidative condition 313 00:51:24,060 --> 00:51:36,340 that is no good. ROS is reactive oxygen species and this damages DNA and cells, lipid and 314 00:51:36,340 --> 00:51:44,860 proteins and they are also responsible for cancer and aging. It sounds familiar. It sounds 315 00:51:44,860 --> 00:51:54,180 like this episode. Yes, free radicals is a normal part of the cell metabolism. However, 316 00:51:54,180 --> 00:52:03,700 it's the amount and it's the amount of antioxidants we have internally built into us that intends 317 00:52:03,700 --> 00:52:15,580 to keep us safe. However, these internal mechanisms rely on sunlight to create these antioxidants. 318 00:52:15,580 --> 00:52:26,580 Humans did not evolve with the need of exogenous antioxidants so much in a supplement form 319 00:52:26,580 --> 00:52:36,220 or medication or relying on nutrients from food. We have these already and they come 320 00:52:36,220 --> 00:52:48,740 from the sun. Vitamin A is crucial for eyes and skin and influences cell development. No 321 00:52:48,740 --> 00:53:00,820 surprise, cell growth and cell differentiation. All crucial parts of human development. Okay, 322 00:53:00,820 --> 00:53:14,420 from tryptophan is serotonin. Remember an aromatic amino acid activating for UVB light. 323 00:53:14,420 --> 00:53:23,020 Serotonin is the first molecule studied in autism from the 1960s. It was 1961 when it 324 00:53:23,020 --> 00:53:32,540 hit medical literature. Serotonin has a vital or is a vital molecule for modulating the 325 00:53:32,540 --> 00:53:44,380 nervous system. Today it is believed to be the closest to a biomarker for autism. That 326 00:53:44,380 --> 00:53:53,940 is according to Mueller et al. including Jeremy Finstra, Vanderwill. This paper was a collaboration 327 00:53:53,940 --> 00:54:05,620 between Vanderbilt and Columbia. They study serotonin and autism quite extensively. Serotonin 328 00:54:05,620 --> 00:54:16,380 is in the brain of course and in the gut and platelets and cutaneous tissues. Serotonin 329 00:54:16,380 --> 00:54:29,140 is synthesized on the skin. This is one biosynthesis path from the eyes and the skin. Remember 330 00:54:29,140 --> 00:54:39,020 the brain and skin are connected. There are two isoforms responsible for serotonin production. 331 00:54:39,020 --> 00:54:47,340 And the central nervous system or the brain serotonin. Remember our conversation about 332 00:54:47,340 --> 00:54:56,700 this as a neural modulator. And remember the RAFE located on the brain stem. This is tryptophan 333 00:54:56,700 --> 00:55:11,900 hydroxylase 2 or TPH2 which is an enzyme used for the biosynthesis of tryptophan into serotonin. 334 00:55:11,900 --> 00:55:21,100 And second for the peripheral nervous system synthesized by tryptophan hydroxylase 1 or 335 00:55:21,100 --> 00:55:32,620 TPH1 which is in the epidermis. More specifically the keratinocytes. So this is right on the 336 00:55:32,620 --> 00:55:41,660 skin surface essentially. The keratinocytes make up 90% of the epidermis and have a large 337 00:55:41,660 --> 00:55:54,100 role with cell proliferation and differentiation. This serotonin does not enter the brain. And 338 00:55:54,100 --> 00:56:05,740 remember 95% of all serotonin is located in the gut. Now something never mentioned on 339 00:56:05,740 --> 00:56:15,420 this podcast is the relationship between autism and GI issues. This is well documented, well 340 00:56:15,420 --> 00:56:23,740 studied. Just this week Nature Microbiology released a paper. I'm looking forward to 341 00:56:23,740 --> 00:56:32,900 learning more about how archaea and bacteria are involved here. Peripheral serotonin is 342 00:56:32,900 --> 00:56:44,260 vast for development and during pregnancy. Serotonin in the maternal pancreas is in the 343 00:56:44,260 --> 00:56:56,020 process of serotonin in the fetal forebrain. I'll say it again. Serotonin from the maternal 344 00:56:56,020 --> 00:57:09,660 pancreas is included in the process of serotonin for the fetal forebrain. Okay the gut serotonin 345 00:57:09,660 --> 00:57:20,820 has a large role in peripheral physiology. Additional roles in development includes and 346 00:57:20,820 --> 00:57:29,420 these processes ought to be familiar to us now. They include serotonin helps modulate 347 00:57:29,420 --> 00:57:41,980 the nervous system. Also cell proliferation, migration and differentiation. Perhaps the 348 00:57:41,980 --> 00:57:52,180 most interesting and a region of interest for us is serotonin's role in sensory processing. 349 00:57:52,180 --> 00:58:02,220 Scientifically referred to as somatosensory system. Somatosensory is more specific to 350 00:58:02,220 --> 00:58:13,420 object recognition, discriminating between textures and processing sensory to motor feedback 351 00:58:13,420 --> 00:58:28,540 and exchanging in social cues. Sounds familiar, sounds like autism. We as humans, we have 352 00:58:28,540 --> 00:58:38,420 a sensory map and this map is implicated. In addition, a path that is implicated is the 353 00:58:38,420 --> 00:58:49,540 thalamocortical connection. We've discussed this. So the thalamus to the cortex. In other 354 00:58:49,540 --> 00:58:59,860 words, the thalamus which is where all senses are processed to the cortex. The area that 355 00:58:59,860 --> 00:59:11,820 extends the head up more than any other species. The area that makes us dominant. However, a 356 00:59:11,820 --> 00:59:23,300 reason that gives humans an enormous capacity to think. This is a human function. This is 357 00:59:23,300 --> 00:59:38,020 a human feature. The somatosensory explains a lot with autism explains the autistic phenotype 358 00:59:38,020 --> 00:59:48,020 including all three social communication and interaction criteria. Remember criteria A, 359 00:59:48,020 --> 01:00:05,620 A1, A2 and A3 and it explains some criteria B, B1 and B4. Melanin is involved in all five 360 01:00:05,620 --> 01:00:16,420 senses. Melanin is in between the sitting organ and the brain. Different individuals 361 01:00:16,420 --> 01:00:26,220 and different species have different amounts of melanin in between certain senses and the 362 01:00:26,220 --> 01:00:37,820 brain. Think about dogs. Think about dogs and their ability for smell. Their olfaction process. 363 01:00:37,820 --> 01:00:49,780 Dogs have more melanin located at their olfaction senses. Remember at the beginning of the biosynthesis 364 01:00:49,780 --> 01:01:01,820 is tryptophan on the surface eyes, skin and gut. Additionally, serotonin is crucial for 365 01:01:01,820 --> 01:01:13,260 visual and auditory cortex. Undisputed, tryptophan is massive for the human eye. Please don't 366 01:01:13,260 --> 01:01:24,620 underestimate the biosynthesis of serotonin from the surfaces. Eyes, skin and skin via 367 01:01:24,620 --> 01:01:36,380 the gut. Returning to an earlier conversation, blue light or modern light implicates vitamin 368 01:01:36,380 --> 01:01:46,700 A and melatonin which is synthesized via tryptophan and serotonin. This is vast for mitochondria 369 01:01:46,700 --> 01:01:57,980 DNA and autophagy. Now, I've mentioned this briefly, mitochondria and this is very important 370 01:01:57,980 --> 01:02:08,900 for cells. It is very important for all human cells and autism. However, we haven't discussed 371 01:02:08,900 --> 01:02:19,860 it much and that is not because it is not important. It is very important. Mostly when 372 01:02:19,860 --> 01:02:33,300 we discuss a cell, we discuss the mitochondria. It uses photosynthesis. 95% of the body's 373 01:02:33,300 --> 01:02:43,340 melatonin is synthesized here in the mitochondria which comes from tryptophan. Remember, more 374 01:02:43,340 --> 01:02:55,660 need for UVB. Melatonin is the body's number one antioxidant. And remember what I just 375 01:02:55,660 --> 01:03:06,100 said about photosynthesis. Humans are solar powered. Humans use photosynthesis just the 376 01:03:06,100 --> 01:03:19,540 same as what you might know in chlorophyll to a plant. Humans are solar powered. Damage 377 01:03:19,540 --> 01:03:30,820 here is no good for cells. No good for aging. No good for anything downstream from these 378 01:03:30,820 --> 01:03:43,700 processes which are massive. The eyes are upstream in this process. Destroying this, 379 01:03:43,700 --> 01:03:56,020 everything is damaged. This is degeneration. This is accelerated aging. Okay, some things 380 01:03:56,020 --> 01:04:11,260 to note. Blue light, LED, tech light, all or most, modern light causes hypoxia. Hypoxia 381 01:04:11,260 --> 01:04:20,980 is well researched in autism and oxidative stress. This explains cancer. This explains 382 01:04:20,980 --> 01:04:30,380 accelerated aging. It also implicates development. Our region of interest. Remember that process 383 01:04:30,380 --> 01:04:40,620 in the mitochondria. Oxidation to water. This is not news. This is known. This developmental 384 01:04:40,620 --> 01:04:50,780 problem early on is known with the cell proliferation, differentiation, migration, etc. and how cells 385 01:04:50,780 --> 01:04:58,140 develop and function. But think about all of those processes running in reverse. This 386 01:04:58,140 --> 01:05:05,940 is the implications to aging and the cancer and dementia. All of these processes are kind 387 01:05:05,940 --> 01:05:13,340 of unwinding, if you will. And that's what we're seeing in society. If you have implications 388 01:05:13,340 --> 01:05:21,180 during development, yes, you'll see things like autism, ADHD, the neurodevelopmental 389 01:05:21,180 --> 01:05:30,740 problems, even schizophrenia, etc. But not all, obviously not all people have these. 390 01:05:30,740 --> 01:05:37,300 But on the back end, it's not necessary. You can be normal. You can be healthy or your 391 01:05:37,300 --> 01:05:47,140 biology can be perfect. But this exposure will begin to unwind this. You do not have 392 01:05:47,140 --> 01:05:54,300 to look hard to see examples of this. This is all known in medical research. Where we 393 01:05:54,300 --> 01:06:03,140 fell is it is not known by the masses. But why? Think about the human baby. We are much 394 01:06:03,140 --> 01:06:16,540 different than other species, other primates, especially chimps. We are 99% exact gene matches 395 01:06:16,540 --> 01:06:28,740 as chimps. Yet, from the first cell dividing in that embryogenesis to birth, let's say 396 01:06:28,740 --> 01:06:37,980 to three years old. I want to cut off here. There is massive things changing. Everything 397 01:06:37,980 --> 01:06:46,580 involved in these processes that we've discussed today. Autism is happening somewhere along 398 01:06:46,580 --> 01:06:56,020 this linear timeline. Humans, after birth, are very underdeveloped compared to other 399 01:06:56,020 --> 01:07:03,740 primates. To other species, regardless of a primate or not, our brains are very underdeveloped. 400 01:07:03,740 --> 01:07:10,460 We take on mass of changes from different life spans, different stages of the lifespan. 401 01:07:10,460 --> 01:07:17,380 We are also overweight. We are chubby, if you will. Chubby babies with underdeveloped 402 01:07:17,380 --> 01:07:28,460 brains. Our evolution, however, requires certain things for this undertaking, for this development 403 01:07:28,460 --> 01:07:37,340 of the brain and the nervous system. The energy system, our metabolism. We lose the baby weight. 404 01:07:37,340 --> 01:07:47,100 We grow a brain, a functional brain. At birth, we can even sit up. We have no muscle strength. 405 01:07:47,100 --> 01:07:55,180 With autism, we have the dyspraxia, that underdevelopment. But even with a normal child, they're still 406 01:07:55,180 --> 01:08:04,380 delayed here compared to other species. Remember how GABA, that inhibitory neuron, 407 01:08:04,380 --> 01:08:12,100 is excitatory during the critical period. Think about birth to that critical period, 408 01:08:12,100 --> 01:08:18,540 the end of it, and how it's pretty common that children will learn different languages 409 01:08:18,540 --> 01:08:26,100 that pick up on different languages quite easily. There's this rapid development occurring. 410 01:08:26,100 --> 01:08:34,980 However, with the spectrum, let's talk about the spectrum here. How some people with autism 411 01:08:34,980 --> 01:08:41,420 range from the high functioning, or the Asperger's so-called little professors, to the profound 412 01:08:41,420 --> 01:08:48,100 autism. We've discussed profound in that level three type. That's a big difference. 413 01:08:48,100 --> 01:08:55,100 But we can see that how these cells are implicated during the development, starting in the embryo 414 01:08:55,100 --> 01:09:02,740 likely, how this will manifest for the young child, two, three, four years old. It could 415 01:09:02,740 --> 01:09:09,420 be speech and language. It could be motor coordination. It could be sensory processing. 416 01:09:09,420 --> 01:09:19,540 It could be low social motivation, or desires in social motivation. Poor social communication. 417 01:09:19,540 --> 01:09:26,860 It could be poor eye gaze is common. And remember how much we've spoken about the eyes, and 418 01:09:26,860 --> 01:09:34,860 the downstream processes from the eyes. This is something. And then at the other end of 419 01:09:34,860 --> 01:09:45,660 the spectrum, children can, they need so much support, such as using the bathroom or riding. 420 01:09:45,660 --> 01:09:53,540 Riding is a common problem with autism, or feeding, getting dressed, etc. All of these 421 01:09:53,540 --> 01:10:03,580 basic life skills are missing. Or maybe the person with autism has GI issues. Some do, 422 01:10:03,580 --> 01:10:14,660 some don't. But with the cell proliferation, migration, and differentiation. This is it. 423 01:10:14,660 --> 01:10:21,500 The sun, and all of these mechanisms that we've discussed, is a part of this crucial 424 01:10:21,500 --> 01:10:31,500 part. It is all very underestimated. I don't know if it's direct or intentional or indirect. 425 01:10:31,500 --> 01:10:38,020 We just bypass it. And I think it could be, because we don't want that conflict within 426 01:10:38,020 --> 01:10:44,580 ourselves while we're discovering this. We're studying this. Humans hate when our beliefs 427 01:10:44,580 --> 01:10:51,220 are offended, when we can't figure out something. We need to figure it out. We need something 428 01:10:51,220 --> 01:10:57,740 that makes sense to us. Maybe, if you made it this far, you do have some critical thinking 429 01:10:57,740 --> 01:11:03,220 and curiosity. All of this stuff is known. Everything we've discussed is known. This 430 01:11:03,220 --> 01:11:09,700 isn't me. This isn't the medical literature. This isn't decentralized medicine. You can 431 01:11:09,700 --> 01:11:17,820 find people, doctors, PhDs, etc. Neurosurgeons talking about this stuff. But the masses, 432 01:11:17,820 --> 01:11:27,620 they don't know. Okay. Before we end, there's, vitamin Bs are very important in autism and 433 01:11:27,620 --> 01:11:33,460 development. I should say, in development. There's a couple of B vitamins here that we 434 01:11:33,460 --> 01:11:43,900 will discuss. Beginning with a well-studied vitamin B folate. It's vitamin B9. This is 435 01:11:43,900 --> 01:11:55,300 altered by light pollution and water. Remember, light controls DNA expression. Folate requires 436 01:11:55,300 --> 01:12:07,100 water. This water is made from the cells mitochondria metabolism. Easy water. You might have heard 437 01:12:07,100 --> 01:12:17,420 or fourth phase of water. Folate is involved in creating those neuromodulators previously 438 01:12:17,420 --> 01:12:27,300 discussed epinephrine, nor epinephrine and dopamine. All very crucial in the human nervous 439 01:12:27,300 --> 01:12:41,260 system. Folate provides one carbon for the regulation of DNA methylation and DNA synthesis. 440 01:12:41,260 --> 01:12:54,860 You know this process is abnormal in autism. Folate requires UVB light. B12 does too. Low 441 01:12:54,860 --> 01:13:09,140 folate potentially increases risk of CVD, colon cancer, anemia, pregnancy and birth complications, 442 01:13:09,140 --> 01:13:19,180 mood disorders and dementia. Melanin assist in the process. Remember those protective 443 01:13:19,180 --> 01:13:32,500 roles. Blue light also called modern light provides vast consequences for this process. 444 01:13:32,500 --> 01:13:43,100 Natural folate synthesis is broken today. Now it comes from supplement or exogenous and 445 01:13:43,100 --> 01:13:53,180 supplement form increases autism risk. It comes from manmade foods also in exogenous 446 01:13:53,180 --> 01:14:05,140 form. Those are synthetic also known as folic acid and bypasses crucial components of the 447 01:14:05,140 --> 01:14:16,260 natural biosynthesis. And that's a problem. I know a lot of people are going to discount 448 01:14:16,260 --> 01:14:27,900 this conversation today. We need critical thinking, curiosity to even consider. Autism 449 01:14:27,900 --> 01:14:38,180 just arrives in human evolution about 100 years ago. Autism just magically appears. There's 450 01:14:38,180 --> 01:14:47,220 a lot of effort going into discovering which genes. I want to know what is causing it. 451 01:14:47,220 --> 01:14:55,140 I want to know what would happen if a high likelihood children during birth, during pregnancy, 452 01:14:55,140 --> 01:15:02,140 if there's a family history, if the pregnant woman would spend time outdoors instead of 453 01:15:02,140 --> 01:15:13,780 underneath blue light. Would that help? Would changing the environment during pregnancy help? 454 01:15:13,780 --> 01:15:21,980 But instead the focus is on medication and maybe a shot. There I even say, it even pains 455 01:15:21,980 --> 01:15:33,280 me to say maybe there will be an autism vaccination. That does not sound like a fix to me. 456 01:15:33,280 --> 01:15:39,860 If you are listening and enjoy the episode or enjoy the podcast, please feel free to 457 01:15:39,860 --> 01:15:50,620 leave a review or rating. In podcasting reviews, ratings and downloads are crucial. And I very 458 01:15:50,620 --> 01:16:06,140 much appreciate your feedback. You can email me info.fromthespectrum.com. Thank you for 459 01:16:06,140 --> 01:16:21,020 listening to From the Spectrum podcast.