1 00:00:00,000 --> 00:00:06,520 In an upcoming episode as part of a series covering autism in the Basil Ganglia, there 2 00:00:06,520 --> 00:00:10,640 is an autism in Parkinson's episode. 3 00:00:10,640 --> 00:00:16,400 For now, just think of the Basil Ganglia as our go no go area. 4 00:00:16,400 --> 00:00:23,320 We'll cover that more in detail during these episodes. 5 00:00:23,320 --> 00:00:27,560 Sometimes I feel like this data that we're parsing out here are looking at us right in 6 00:00:27,560 --> 00:00:31,520 the face and we do nothing. 7 00:00:31,520 --> 00:00:33,480 We miss it so badly. 8 00:00:33,480 --> 00:00:40,280 It is so much that I envision a lost party shooting up flares or writing SOS or help 9 00:00:40,280 --> 00:00:44,880 even on the beach and we don't have eyes on it. 10 00:00:44,880 --> 00:00:51,360 There is a pressing issue in the future of autism in Parkinson's regarding how vulnerable 11 00:00:51,360 --> 00:00:55,920 autistics are for various dementias. 12 00:00:55,920 --> 00:01:02,560 While covering autism in Parkinson's, I can't help but mention something that is so simple. 13 00:01:02,560 --> 00:01:07,160 But for whatever reason, it's neglected or ignorance, I'm not sure, but it prevents 14 00:01:07,160 --> 00:01:10,240 any valuable connections. 15 00:01:10,240 --> 00:01:14,360 In autism, we are already on a path of Parkinson's. 16 00:01:14,360 --> 00:01:19,400 It's essentially a precursor to Parkinson's. 17 00:01:19,400 --> 00:01:24,880 We have problems in the so-called indirect pathway of the Basil Ganglia. 18 00:01:24,880 --> 00:01:30,840 In the episode of autism in Parkinson's, we'll parse out the direct pathway, our go area, 19 00:01:30,840 --> 00:01:35,840 and the indirect pathway, our no go area in more detail. 20 00:01:35,840 --> 00:01:39,800 But for today, there is a concern outside of that. 21 00:01:39,800 --> 00:01:42,840 And that is thyroid. 22 00:01:42,840 --> 00:01:49,200 Several things here are undisputed with autism, undisputed with Parkinson's, and undisputed 23 00:01:49,200 --> 00:01:56,560 in both the autism in Parkinson's research, such as that indirect pathway. 24 00:01:56,560 --> 00:02:03,080 Now, if you follow the long, and this is no shot against them, several guests have come 25 00:02:03,080 --> 00:02:11,480 on and mentioned how hypothyroid is a biomarker and a risk for autism. 26 00:02:11,480 --> 00:02:13,480 Risk the offspring. 27 00:02:13,480 --> 00:02:14,480 Okay. 28 00:02:14,480 --> 00:02:17,680 So data are impressive on this. 29 00:02:17,680 --> 00:02:20,240 Those guests were not wrong. 30 00:02:20,240 --> 00:02:28,120 And in Parkinson's, thyroid is a biomarker of Parkinson's, undisputed. 31 00:02:28,120 --> 00:02:29,960 This is well researched. 32 00:02:29,960 --> 00:02:37,280 If we parse out thyroid being synthesized from tyrosine and talk about the hypothalamus, 33 00:02:37,280 --> 00:02:42,520 the body's control center of hormones, the sort signal for the hormones, essentially. 34 00:02:42,520 --> 00:02:44,720 It's a hormone controller. 35 00:02:44,720 --> 00:02:49,160 It signals to the pituitary for thyroid functioning. 36 00:02:49,160 --> 00:02:52,560 And then we can talk about T3 and T4. 37 00:02:52,560 --> 00:02:57,080 The iodine are involved here for the three and the four. 38 00:02:57,080 --> 00:03:02,040 If you look at supplementing iodine during pregnancy, it's also used to mitigate the 39 00:03:02,040 --> 00:03:04,640 risk of autism. 40 00:03:04,640 --> 00:03:07,840 This stuff is pretty basic. 41 00:03:07,840 --> 00:03:14,600 If we begin to travel into our biology and parse out the synthesis of tyrosines, involvement 42 00:03:14,600 --> 00:03:22,320 in both dopamine, which is well researched, this molecule is well researched in Parkinson's. 43 00:03:22,320 --> 00:03:25,200 It's probably the front runner. 44 00:03:25,200 --> 00:03:27,600 Entirely involvement in melanin. 45 00:03:27,600 --> 00:03:29,600 Okay. 46 00:03:29,600 --> 00:03:35,760 Recently, recently there's been more involvement with neuro melanin in Parkinson's. 47 00:03:35,760 --> 00:03:38,120 And this is the right track. 48 00:03:38,120 --> 00:03:44,440 The reason why the substantia nigra and the basal ganglia, the reason why this is 49 00:03:44,440 --> 00:03:47,680 black is because of the neuro melanin. 50 00:03:47,680 --> 00:03:50,520 It's not really disputed either. 51 00:03:50,520 --> 00:03:54,360 This is all accepted in the research. 52 00:03:54,360 --> 00:04:00,680 I question the knowledge of melanin within autism research. 53 00:04:00,680 --> 00:04:08,960 So the first question I want to ask is, what do you think neuro melanin is? 54 00:04:08,960 --> 00:04:15,480 It's involvement in autism in Parkinson's is the flare being shot up right in the face 55 00:04:15,480 --> 00:04:17,240 of this. 56 00:04:17,240 --> 00:04:23,080 If you say Parkinson's is a disruption of dopamine in the substantia nigra and not 57 00:04:23,080 --> 00:04:32,680 having an ability to orchestrate these different go, no go areas with D1 dopamine or D2 dopamine 58 00:04:32,680 --> 00:04:36,080 excitation inhibition. 59 00:04:36,080 --> 00:04:39,280 This partially in line with what we're talking about. 60 00:04:39,280 --> 00:04:42,080 This is well accepted. 61 00:04:42,080 --> 00:04:48,800 What is missing though is the true synthesis of these molecules and the environmental signals 62 00:04:48,800 --> 00:04:50,600 that are required. 63 00:04:50,600 --> 00:04:53,640 This is where we lose track. 64 00:04:53,640 --> 00:04:56,080 This is where people get confused. 65 00:04:56,080 --> 00:05:00,800 But it's not that complicated. 66 00:05:00,800 --> 00:05:07,240 Two different things here, two different things that explains these problems, both autism 67 00:05:07,240 --> 00:05:15,000 and Parkinson's is a loss of or a lack of energy from the environment. 68 00:05:15,000 --> 00:05:24,480 Now we have to understand tyrosine, the aromatic amino acid, being a UV light detector, absorption 69 00:05:24,480 --> 00:05:31,160 and emission of 200 nanometer to 400 nanometer light. 70 00:05:31,160 --> 00:05:33,160 That's UV. 71 00:05:33,160 --> 00:05:35,160 UV ranges. 72 00:05:35,160 --> 00:05:36,720 That's not complicated. 73 00:05:36,720 --> 00:05:42,840 If we talk about the synthesis of tyrosine into thyroxine and the relationship of the 74 00:05:42,840 --> 00:05:49,440 iodine for T3 and T4, it is somewhat understood and accepted. 75 00:05:49,440 --> 00:05:51,680 We can parse out T3 in this rose. 76 00:05:51,680 --> 00:05:57,840 Here I'm going to read some notes from the episode on autism and Parkinson's. 77 00:05:57,840 --> 00:06:01,080 For T3, brain development. 78 00:06:01,080 --> 00:06:10,320 So during fetal development and early childhood, T3's role here is huge in cell differentiation 79 00:06:10,320 --> 00:06:12,080 and migration. 80 00:06:12,080 --> 00:06:20,400 Two very well understood and accepted facts about autism, well researched items. 81 00:06:20,400 --> 00:06:24,520 Another thing is maturation of neurons. 82 00:06:24,520 --> 00:06:32,320 Autism at its core is a collection of underdeveloped cells. 83 00:06:32,320 --> 00:06:33,320 Neuronal activity. 84 00:06:33,320 --> 00:06:38,240 T3 regulates gene expression in neurons. 85 00:06:38,240 --> 00:06:45,880 And this affects neurotransmitter synthesis, receptor expression and synaptic plasticity. 86 00:06:45,880 --> 00:06:53,000 All well understood and autism research. 87 00:06:53,000 --> 00:06:54,280 Neuro protection effect. 88 00:06:54,280 --> 00:06:55,280 Okay. 89 00:06:55,280 --> 00:07:00,080 Neuromellin in here is huge with the neuro protection as well. 90 00:07:00,080 --> 00:07:04,400 But this has roles with reducing oxidative stress. 91 00:07:04,400 --> 00:07:13,120 So here we're probably talking a lot of mitochondria, which we'll talk about a lot in the episode. 92 00:07:13,120 --> 00:07:18,880 And the metabolic rate of neurons and influencing energy availability. 93 00:07:18,880 --> 00:07:26,240 So this has implications in neuronal firing and maintaining neuronal health. 94 00:07:26,240 --> 00:07:31,320 In the episode, we'll talk about the clock timing, which is one of the factors. 95 00:07:31,320 --> 00:07:34,000 The other factor is the energy. 96 00:07:34,000 --> 00:07:39,080 So two different things here, the timing and the energy. 97 00:07:39,080 --> 00:07:41,220 This is what we need to really parse out. 98 00:07:41,220 --> 00:07:43,480 So what regulates these? 99 00:07:43,480 --> 00:07:45,480 It's not complicated. 100 00:07:45,480 --> 00:07:49,920 It's really not that complicated. 101 00:07:49,920 --> 00:07:53,080 Synaptic transmission is huge with the gene expression. 102 00:07:53,080 --> 00:07:58,400 So T3 can alter the efficiency of the synaptic transmission. 103 00:07:58,400 --> 00:08:03,600 And here we're talking about, especially with the roles of the basal ganglia with learning 104 00:08:03,600 --> 00:08:04,700 and memory. 105 00:08:04,700 --> 00:08:07,720 This is huge for learning and memory. 106 00:08:07,720 --> 00:08:08,880 But this is also huge. 107 00:08:08,880 --> 00:08:15,960 Because T3 helps regulate this, helps conduct this. 108 00:08:15,960 --> 00:08:27,440 Now what is missing in all of this that is so simple is a signal from the environment. 109 00:08:27,440 --> 00:08:30,480 And that is light. 110 00:08:30,480 --> 00:08:38,360 The second question I want to ask you, and I will leave it at that, is, what do you think 111 00:08:38,360 --> 00:08:40,200 light is?