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My guest today is Dr. Eric Weiss M.D.

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Dr. Weiss is board certified in plastic and reconstructive surgery, an original leader in advanced regenerative medicine.

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This practice offers umbilical cord stem cell therapy as regenerative medicine treatments, including treatments for autism.

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In addition, these treatments are offered for osteoarthritis, rheumatoid arthritis, wound repair, and traumatic brain injury.

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Dr. Weiss attended College of Medicine at Duke University on a naval scholarship.

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That's right, Dr. Weiss is a veteran of the U.S. Navy.

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He completed residencies in plastic surgery at University of Miami, general surgery at the University of California in San Francisco, and general surgery at the University of California, Daedalus East Bay.

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Umbilical cord stem cells are living cells that are transplanted into the patient.

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These living cells must be alive during the infusion process.

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An industry standard is between 40 and 60% alive.

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However, Dr. Weiss and Duke University is seeing over 90% live cells during infusion process.

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So we're going to have Dr. Eric Weiss join us and tell us and learn all about this process.

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And now my conversation with Dr. Eric Weiss.

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Dr. Weiss, start with telling me a little bit about your medical journey, some things that were interesting you were interested in.

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And just take us up to the point of the autism research.

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Okay, well, I went to Davidson College and then from Davidson College, I went to Duke University Medical School.

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And Davidson and Duke are linked by the Duke brothers and Duke University used to be called Trinity College.

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But if you give anybody enough money and ask them to change their name, they change their name.

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In fact, I think they asked Princeton first, but Princeton wouldn't change their name to Duke.

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So they gave the money to Trinity College and they became Duke, but they gave a little bit of money to Davidson College as well.

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Davidson is kind of a feeder school to Duke Medical School, so there's a lot of people from my class that went to Duke University Medical School.

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After that, I went to University of California, San Francisco, where I did a residency in general surgery.

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Then after general surgery, I went to University of Miami and did a residency in plastic surgery.

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And then after that, I went to the United States Navy because the Navy sent me to medical school at Duke, which is very nice of them.

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And so I went into the Navy and was a plastic surgeon and then eventually got out of the Navy in 98 and started my plastic surgery.

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And my journey to stem cells and to autism, I think revolved around two things.

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One is when I was at UC San Francisco, it was a hotbed for research.

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They were doing surgery on pregnant sheep because there were some congenital anomalies that are found in humans that make it incompatible with life.

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You can live in the fetal environment, but as soon as you get born, you die.

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And one of those is called hypoplastic left heart syndrome, and that's due to a congenital diaphragmatic hernia.

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And so at that time, they were getting sheep pregnant and then in the first trimester, they were opening up the uterus, taking one of the baby or the fetal lambs out,

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opening the chest, creating a diaphragmatic hernia, putting it back in, and then letting it be born so they could study how to do that.

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And what they found out was if they do this injury too soon, not only is the sheep born without a scar, but the defect was fine too.

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That somehow it fixed itself.

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They cut a hole in the diaphragm instead of being born with a hole in the diaphragm.

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They were born with a complete diaphragm.

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So the big question is how are these fetal sheep healing by true regeneration and not scarring?

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And so that was a big question.

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And that research was done by a pediatric surgeon, but it got picked up by plastic surgeons.

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And I was going to be a transplant surgeon.

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And in my year, I think nine out of 11 of the chiefs went all went into plastics because of this research.

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So I had some kind of regenerative medicine in my background due to my early training.

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But then my son was born with autism.

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And it obviously became a lifelong passion of both my wife and I to heal him, you know, any way we could.

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And there was a landmark article in 2005 from John Hopkins, because autism rates were increasing.

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And they said, we need to look at some some fresh brains from people who died from autism.

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And so they did that.

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And, you know, kids that died in car accidents, kids that, you know, died, house fires, drownings, you know, anything.

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And what they found out where there was brain inflammation in these kids,

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there was something clearly different about their brains than normal brains.

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And this was the first time that that was described.

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And as soon as that happened, the people that do, you know, picked up on it.

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And I'll get back to how that how that happened is, is that the traumatic brain injury research people, you know, with chronic traumatic encephalopathy that were happening with the football players.

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And soccer players were was in the news.

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And they had discovered that you can get a concussive blow to the head or even a sub concussive blow.

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And then 20 years later be 30 times more likely to have dementia.

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And what happens to the brain with just a very small blow.

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And what they found out is, is some people develop neuro inflammation.

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And they, they did a 30, 30 different trials trying to figure out what they could give that would be neuroprotectant.

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And then the 30th thing they tried was on Biltrochord blood, because some other researchers found out that it really acted on the immune system.

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And as soon as they published a paper saying that, that for traumatic brain injury, it looks like on Biltrochord blood may turn off brain inflammation.

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The people from Duke said, wow, cerebral palsy is a is a brain inflammatory problem.

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So they took kids with with cerebral palsy and gave them on Biltrochord blood.

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And it got, you know, fabulous results.

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Almost 90% of the kids got measurably better.

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And I mean, crazy stuff.

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Kids in wheelchairs started walking, kids who couldn't see started seeing.

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And then the next thing was, well, let's do it with autism.

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We know from that one report that it looks to be a neuro inflammatory problem.

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And then the people at Duke did it, and sure enough, about 65% of the kids got significantly better.

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And when I say significantly better, I don't mean marginally better.

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I'd be better than can then can be explained by anything else, except what was what was given to them.

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And a single dose of a Biltrochord blood was shown to to grow more brain connections by MRI that their EEG started to normalize because kids with autism have a different brain wave pattern.

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It has less electricity, but more importantly, they have abnormal ratios of alpha waves to beta waves to theta waves to delta waves.

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And those started to normalize and then by sophisticated objective measurements, their socialization skills got better.

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And so as soon as I read that, I knew from my previous training that that this could be the answer.

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And so, you know, having trained at Duke and at UCSF, it was nice that I could call Duke.

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And I knew the people there, you know, the woman who was doing the research Joanne Kurtzberg, she got there as an intern during my fourth year of medical school.

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So we were only a year apart. So as I was rotating through the hospital, she was only one year above me.

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And in fact, she married, you know, somebody we knew as well.

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So when I called there, they were very nice and said, you know, you know, Eric, we're seeing some amazing stuff.

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But due to our protocol, we can't treat your son. He's too old.

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And I said, well, do you think he's too old to get a benefit? And they said, no, certainly not.

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But we don't know. We don't know for sure. Nobody's ever treated adults.

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And I went back to the original paper from Hopkins. And even though the study was on kids, they were sent two brains of adults.

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One was 33, one was 42. And both those brains had the same, you know, identical neuro inflammation like all the kids did.

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So I figured it was a lifelong problem.

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And so my wife found a tremendous physician surgeon in Chicago who was doing a pediatric brain injury study, a doctor named Thomas Loeb,

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who, you know, famous, he was the head of pediatric surgery at St. Jude's Children's Hospital.

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And they had pioneered stem cells for pediatric leukemias and lymphomas.

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So he was very adept at it. And so he was doing a brain injury study at, you know, I called him, you know, one day we talked on the phone for about an hour as I was driving home.

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And it turned out he was trained at UCLA when I was at UC San Francisco. You know, we knew people in common.

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And the more I talked and the more we talked, the more he said, why don't you bring your son up and let's give it a try.

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You know, we know it's safe. This stuff has been given medically in the United States for 60 years.

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So the safety profile is very well known. There's 80 different diseases that unbeholdable blood treats.

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And so this is not new to medicine. It's just new to autism.

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And so we knew that it was very safe. We knew how to give it. And so he did it and we saw remarkable results.

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You know, he was one of the responders. And that's how it all evolved.

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And that obviously, you know, happy life, happy wife, you know, my wife convinced me, pushed me into this because she said,

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are you going to do this for our son and not offer it for anybody else?

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And I tried to convince her I had a day job. And so it started off on Friday mornings and then it involved, you know, the Fridays all day and then it went to Wednesday mornings and it went to Wednesdays all day.

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Now it's on Tuesday mornings, Wednesdays all day, so I'm selected Fridays.

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And so very soon I'm going to give up operating and do this full time because it's very rewarding. We see tremendous results.

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It doesn't work on everybody, which we're still trying to figure out, but it works on about 70% of kids.

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And it offers hope to these, to not only the children, but the parents, you know, because, you know, we talk about neurodiversity and it's good and everybody, you know, wants to love the person the way they are.

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But if we can help the person interact with the world a little bit easier, it just will make their life easier. You know, it's like saying, well, let's don't tear paralysis, you know, that we can get around finding a wheelchair.

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Well, you know, you can get around finding a wheelchair, but in some instances, you know, it's nice to be able to walk as well.

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You know, and this stuff is starting to show promise and spinal cord injuries.

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So there's going to be a tremendous, I think it'll be the single biggest thing that happened to medicine since antibiotics will be harvesting the healing powers of umbilical cord blood.

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Well, that's very fascinating. How old was Marston at the time?

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Well, Marston was 22. And, you know, and anybody who was kind of, I talked to had never done it to that age, I actually called Panama and their cut off is 18.

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But, but Dr. Loeb did it at 22. And he got remarkably better. You know, he had probably 20 to 30 words, he could put two words together, mostly speaking for function.

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You know, he would say bathroom and you knew he wanted to know where the bathroom was if we were in a strange place.

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But he started making changes almost immediately. He started, you know, asking questions. We didn't tell any of our family, we did it.

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It probably had a month, maybe six weeks, our niece called us and just said, you know, what the f's up with Marston?

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You know, and I'm going like, what do you mean? Is he okay? I went to his bedroom, you know, and he goes, no, he just called me on the phone.

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And, and, you know, Carly was only one year above him. So, you know, he was 22, she was 23, and he kind of grew up with her.

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But that was the first time he ever used a cell phone to initiate a call.

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And he was just kind of missing her. And he said he asked me about my boyfriend and, and etc, etc.

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And so that's when we really knew something was crazy was happening.

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And then everybody else started saying, you know, something's different, he's talking more, he's acting, you know, he's following commands more, you know, and it just his life blossomed.

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Wow. Yeah, I'm almost thinking like, as he initiated that phone call previously, we could just imagine how much he wanted to interact and how much he was just so curious about others.

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And wonder maybe even why, why he couldn't do that or initiate that stuff.

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And, oh, I think it was frustrated. Yeah, as he, as he started to talk, he said, I wish I had Austin's brain, which is his older brother.

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You know, so he, he knew it was more difficult for him to, to speak.

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But it was just like when he was young, you could say, go get your purple pajamas and he could do it, but he couldn't say purple pajamas.

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And you, you know, you think of the people that, you know, were completely conversant and used to talking how to stroke and can't talk.

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It must be incredibly frustrating to have something to say and not be able to say it, but it, it certainly freed up his life.

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Yeah, that's incredible. Just, just sitting here trying to imagine this, that frustration that he went through and others as well.

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There's plenty of others as, as you described, and it kind of sounds like he's more level two or level three as the DS, the new DSM describes that needs substantial support.

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But can you explain to me about what it is exactly in this um, umbilical cord that is being infused or transplanted into the recipient?

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Yeah, I will. It's, um, well, first let's go back and we'll talk a little, you know, neurophysiology 101 here is that your brain is full of neurons and those are very specific cells.

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So specific that they really don't, you know, metabolize glucose too well. They don't do a lot of things well.

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So they have these support cells called glial cells that live right next to them that, that help them exist.

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And these glial cells can exist in three states. They can exist in the neutral state, meaning not much has happened.

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They can exist in the pro inflammatory state, which means there's some type of insult and they're secreting inflammatory mediators.

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And those mediators cause the neurons to die off, something called apoptosis, and it breaks up connections between neurons.

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And it's been shown with kids with autism that they have less connections in the areas of speech and socialization and language than other kids.

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And the third state they could be in is a, is a brain restorative capacity where they're causing new connections and new cells coming in and they're making everything right again.

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And it's been shown in certain situations, whether it's trauma, infection, inflammation that you can get stuck in that pro inflammatory state.

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And so when the researchers in traumatic brain injury were looking at it, they found out that the mesenchymal stem cell, the MSC, which is a found in a Biblical court blood, has the ability not to act on the glial cells

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and not only turn them from the pro inflammatory state, but they go back to neutral, but all the way to the pro restorative state.

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And they secrete something called brain derived neurotrophic factor, BDNM.

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I'm not going to ask you about that.

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Right, or something called nerve growth factor.

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And brain derived neurotrophic factor makes more connections.

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It causes cells and neurons to come together.

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And nerve growth factor causes your own brain cell, your brain stem cells, which live in your brain kind of in a far away area to migrate to the area and make more neurons.

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So when I think when you infuse these cells, they're very, it's a very, it's an amazing thing what they do, because when you get the umbilical cord blood transfusion, they get trapped in the liver lung and spleen.

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So all the cells get trapped in the liver lung and spleen right away, you know, or not all about 95%.

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Then starting on about day eight, they start migrating back into the bloodstream.

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And then they just circulate looking for things to do, looking for inflammation.

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And if you look at the experimental animals and they're experimental animals for autism, that by day eight is when they start to migrate to the brain.

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And by day 14, they're all in the brain.

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And they have the ability to cross the bloodstream barrier.

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People aren't sure how they do it, but they know they do it.

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And as soon as somebody published, you know, by day 14, they're all in the brain, the people who were using stem cells for leukemia and lymphoma, they wrote letters to the editor of the journal and said, you know, we saw something very similar.

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You know, we've been using stem cells for 50 years.

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We infuse them. We don't, we don't have any idea where they go, but we know at three weeks, they're all in the bone marrow.

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And since we've done it 10,000 times, we don't worry about it.

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And so it looks like that's a property of stem cells.

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Because when you, when you radioactively label them, or when you label them with immunofluorescence and you say you inject them in a puppy, they can circulate for two years because there's nothing wrong.

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But if you put them in an age of dog with bone problems and, you know, brain problems and heart problems, they attack the problem, you know, right away and get used up right away.

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So back to your original question.

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It's a simple IV.

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It looks like the MSC or the mesenchymal stem cell is the heavy lifter, but I'm not convinced of that.

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If you look at what's in umbilical cord blood, umbilical cord blood is like chicken soup for healing.

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There's five different types of stem cells.

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There's stem cells for the heart, there's stem cells for the liver, there's stem cells for the gut, there's stem cells for the lung, there's stem cells for the whole immune system.

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And this MSC.

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And there's also something called an undifferentiated somatic stem cell, which may be the precursor for the neuro stem cell.

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People aren't quite sure on that.

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And on top of these stem cells, there's something called natural killer cells, which help you with, with viruses.

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There's also something called T regulatory cells, which are really good for the immune system.

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So it's been shown that kids with autism also have inflammation of other parts of their body, you know, the gut and the skin and stuff like that.

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And so these help that as well.

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Autism and GI problems are so common.

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And yeah, and it's such an easy treatment.

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You know, it's a simple IV.

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You know, now it might not be simple to start an IV in an autistic child because they're very frightful.

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But once the IV is in, it literally takes minutes to you infuse it just like you would infuse IV vitamins, you know, it goes in over the course of several minutes.

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And I think that, you know, I'm uniquely, I want to say qualified, but I think parents find me unique is for two reasons.

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One is my son got this and I did it for my son.

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And I've seen it work. I understand the science.

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When you call my office or set up a console, you actually talk to me, you know, you don't talk to somebody in between.

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But the second thing is as a surgeon for the last 30 years, it's very easy for me to sedate people and sometimes these kids are very frightened.

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I can give them a quick shot or, you know, and then they just, you know, relax.

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We start the IV, you know, we have a time pretty well.

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They wake up in 20 minutes.

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The IV comes out, it's all done.

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You know, and it's just, it's not stressful on the parents, the child or even me, you know, nobody wants to hold the child down and to put an IV.

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And obviously if they don't need sedation, we don't sedate them.

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But it's a simple treatment.

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And I believe it's the only thing that can that you can do to train your to change your brain at a cellular level.

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Okay.

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Or the person that's giving the blood, the umbilical cord blood, what's that like?

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How do you select that?

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Well, it starts with the OBGYNs.

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And so almost anybody gets offered you want to save your own stem cells for you.

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But that can be costly and pay yearly.

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But then they usually follow that up. Would you like to donate your umbilical cord and your umbilical cord blood?

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And they say, you know, yes or no.

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But if they say yes, so the hospital knows they're going to donate it.

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So a woman has a baby.

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And all these are live healthy births in the United States.

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And as soon as the baby's born, the umbilical cord blood is harvested and then the umbilical cord is harvested.

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They're placed in a solution and they're FedEx to the lab.

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The lab is in Las Vegas and it's in Las Vegas because there's more direct flights to Las Vegas than any other city in our nation.

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And they have to be processed within 48 hours.

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And so they get processed, they get placed in the freezer.

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And then at that time they're waiting on data.

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They're doing genetic screening of the mother and father.

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And they're also, you know, checking the mother for infectious diseases.

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So the mother, you know, gives her blood and they're checking from, you know, HIV, human T cell leukemia virus, Lyme's disease, shagus, CMV, Zinc of West Nile.

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You know, anything you can think of, it's all that hepatitis A, B and C, all that's getting checked.

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And it takes about eight weeks to get all that data back.

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And then once the data comes in, the obviously the lab looks at it and says, you know, is this a go or no go?

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It's not just about depending on infectious disease, genetic screening and stuff like that.

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But before it can be released to the public, it has to be looked at by a third party physician, you know, who looks at it and agrees with them.

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And then it goes on a public bank.

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And most people don't know that there's a public bank just like if you were going to donate a kidney or something like that because bone marrow transplants really aren't done anymore.

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You don't care about bone marrow transplants.

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And that's because a whole immune system can be reconstituted from a Biccocort blood

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now.

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And so, like I said, there's 80 different diseases that are treated with this stuff.

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Some things need to be HLA matched with the mother, most not.

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But as soon as it's put on the public bank, then we can use it for autism.

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And the nice thing about it is that these cells don't have the ABO blood markers.

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They don't have HLA markers yet.

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So they're generic cells that can be given to anybody.

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It kind of sounds like once they're given or once they're infused, the body already

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knows what it's going to do with them.

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You don't have to manipulate them or kind of direct them.

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No, I feel like I'll give you a quick story, which is how this whole thing was started,

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which really was amazing, at least to me, it's kind of amazing.

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Back in the 50s, we win World War II.

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The Russians get the bomb.

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Cold wars and full swing.

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And the government makes our medical researchers look at radiation fallout, just in case we

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get nuked by the Russians.

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And so they were doing radiation research on rats, and they just noticed that young rats

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could tolerate radiation injury much better than older rats.

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And somebody got the idea and said, why don't we sew an old rat to a young rat and see what

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happens?

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And so what they did was they did that.

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They made them kind of like conjoined twins.

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Then they radiated the old rat and it healed like a young rat.

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Then they said, well, let's injure a leg.

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And they injured a leg and it healed like a young rat.

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Then they looked at the metabolic activity.

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Well, how many liver cells does it make per day?

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How many gut turnover cells?

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And what they found out was the biologic clock of the older rat got younger.

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And they said, what circulates in young animals that gives them the quality of youngness?

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And that question was asked like in 1957, but it took decades before we figured out

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there's something called the adult stem cell.

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Most people, which heal, there's two big types of stem cells, embryonic, they make a baby,

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adult, they heal.

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So these are adult stem cells designed to heal.

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They're designed to circulate in the body, find things that are broken and fix them.

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And so there's very little manipulation.

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You infuse them and let them do their thing.

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I've always heard that, I haven't always heard, but recently, over the last maybe two years

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that I heard that bone doesn't heal, it just regenerates and you can't find a scar on it.

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Is that something you're familiar with?

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Yeah.

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Well, first it develops something called a callus.

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When a bone breaks, and the question is how many living cells are in the bone?

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They're mostly calcium and stuff like that.

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And so they get made, a callus forms, which just looks like a callus on your hand.

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It's a bump on a bone and there's a lot of metabolic activity, but it lays down a sheet

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of calcium that gets remodeled exactly like the old bone.

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And so radiographically, you're right, there's no scar there.

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And that's just because if you think about it, it's more like a hole in your drywall.

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It gets patched and polished and sanded with the exact same stuff so you can't see it.

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It's a good anablet.

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As opposed to a skin injury, which there's that fine line of scar where there's no skin.

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But I believe with these cells, we're starting to get stuff, as a plastic surgeon, I've had

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huge traumatic injuries where I've treated that with stem cells and the scarring is down

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98%.

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And so there's people working on scarless healing now so that you can have an operation

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and not have any scar after it.

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Based on the timeline of the 1950s and everything you just said there and regeneration, I'm

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reminded of a guy named Robert O'Baker who was kind of canceled, which is kind of reminding

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me of like this whole process right now.

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He did legendary work with regeneration.

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He has the DC electric effect.

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But what would you think?

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And I want to kind of ask you about are there trials or clinical trials or what?

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Why is this more popular?

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I think there's two things.

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One first is new science.

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So it was really kind of written about and exploded on the scene in 2019 followed by

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the pandemic where everything kind of got shut down.

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And so it's been up and running and things are happening.

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But it's exploding regenerative work, just like the DC currents and stuff like that.

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We're starting to find out that cells migrate through electricity.

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We're finding that when the sunlight hits your skin, there's changes in your gut.

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That photon of energy gets transmitted.

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And I think we've done a disservice to people.

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Keep your clothes on, slap sunscreen on.

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Sure, you're not going to get a skin cancer, but you're not going to be as healthy either.

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And if you look at people that work outside, their skin cancer rates pretty low.

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None of those guys got COVID.

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COVID didn't blow through the homeless population or the people working outside.

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And so I think this renaissance in healing, which is happening, is going to be the biggest

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change we've seen in medicine.

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I think that we're just scratching the surface on this.

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We know now that people with congestive heart failure, where your heart's not being effectively,

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not everybody's a candidate for a heart transplant.

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We know now with an infusion of umbilical cord blood that your ejection fraction, the

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efficiency of your heart, gets better just by a simple infusion that's measurable and

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quantitable.

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And so I think after a heart attack, this will be first line therapy.

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After a stroke, this will be first line therapy, spinal cord injury, brain injury.

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It looks like it's going to be infected in Parkinson's disease, Alzheimer's, multiple

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sclerosis.

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You know, I think in burns where you lose skin, you know, it's going to start to, because

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your body has the ability to heal itself.

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And the biggest problem we see is that you're born with a bank of these adult stem cells

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and it goes down very quickly.

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You know, by the time you're through your teenagers, you've lost 90%.

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And by the time you're in mid-thirties, you've lost 95%.

324
00:32:38,680 --> 00:32:42,840
And so once we learn how to give these cells, we can do it.

325
00:32:42,840 --> 00:32:43,840
Yeah.

326
00:32:43,840 --> 00:32:45,840
You're spot on.

327
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100% over the target on the sunlight and healing.

328
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It's electrons.

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And I think that's what caused autism is the lack of electrons.

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And people going out in the sun don't get sunburn because they get more red light in

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the AM, which preconditions for the UV light.

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00:33:05,880 --> 00:33:13,480
And with the gut, it's 100% true because the enteric system and the bacteria emitting

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light and all of those aromatic amino acids are synthesizing those things like serotonin

334
00:33:21,240 --> 00:33:26,080
and dopamine and all of that, which is crucial for the development.

335
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And this whole gut brain axis, we're just trying to figure out.

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I've had several patients, you know, gut issues go with autism.

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The nice thing about infusing this stuff and let it work, you know, I've had kids seven,

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eight years old, nine years old, 10 years old, not potty trained, you know, product

339
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diarrhea, product constipation.

340
00:33:49,280 --> 00:33:53,800
Get this treatment, you know, and within days, they start to have normal bowel movement,

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within weeks they're potty trained.

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But then they start to get better, you know, and so this stuff, by great to the areas of

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00:34:02,200 --> 00:34:07,040
most concern, and it might be the brains, not the area of most concern.

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You know, I talked to a parent today where they've had gut issues from the word go, the

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kids 10.

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And I just said, I said, the nice thing about this stuff is, you know, I don't have to

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be a smart doctor.

348
00:34:20,600 --> 00:34:25,160
The only smart thing I have to do is give this to your kid and let the cells figure out what

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needs to be done.

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This is not big pharma.

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This is something that God gave us.

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And we just have to live a healthy lifestyle.

353
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We need to get outside.

354
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We need to walk.

355
00:34:35,480 --> 00:34:39,600
You know, you need to be grounded, you know, breathe fresh air, breathe salt air if you're

356
00:34:39,600 --> 00:34:43,160
close to the ocean, and let your body heal.

357
00:34:43,160 --> 00:34:44,160
Yeah.

358
00:34:44,160 --> 00:34:53,840
Evolution gave us these, either God or evolution gave us these and we should utilize them.

359
00:34:53,840 --> 00:34:58,200
You wiped out the randomized controlled trials.

360
00:34:58,200 --> 00:35:02,880
What we have works as long as we can properly utilize them.

361
00:35:02,880 --> 00:35:03,880
Right.

362
00:35:03,880 --> 00:35:04,880
Right.

363
00:35:04,880 --> 00:35:07,680
And this stuff should get start, you know, in first grade, you should get it.

364
00:35:07,680 --> 00:35:09,760
You should get this stuff.

365
00:35:09,760 --> 00:35:16,360
You know, and I've just seen amazing things, you know, autism primarily, but, you know,

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00:35:16,360 --> 00:35:18,240
now I'm starting to do neurodegenerative disorder.

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00:35:18,240 --> 00:35:24,680
I had a woman come in with Parkinson's who was using a walker, it's shaking, you know,

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00:35:24,680 --> 00:35:27,400
and in one dose, she's walking more normally.

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She's not using a walker anymore.

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You know, her brain is better.

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And so we have these cells which are there to fight inflammation.

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And the interesting thing, which I think is very interesting, is that these cells can

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turn into fat cells.

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00:35:48,840 --> 00:35:53,520
And most people don't understand with a poor diet, you're eating inflammatory things.

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Fatty acids are inflammatory in your bloodstream.

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00:35:57,840 --> 00:36:02,320
And so the way to get those inflammatory things out of your bloodstream is for these

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00:36:02,320 --> 00:36:08,800
cells to turn into a fat cell, you know, and then that takes the fatty acids out as a fat

378
00:36:08,800 --> 00:36:13,480
deposit, but it also makes your bank smaller.

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00:36:13,480 --> 00:36:19,800
And so with the obesity epidemic in the U.S. and the people that are overweight, they even

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have less of these cells, you know, and so it's all about living a healthy lifestyle,

381
00:36:26,440 --> 00:36:31,080
eating normally, you know, decreasing your inflammation, getting sunlight, using your

382
00:36:31,080 --> 00:36:39,960
body's natural ability to heal, and you could heal probably damn near anything, you know.

383
00:36:39,960 --> 00:36:44,520
I mean, there's going to be a role for traditional Western medicine.

384
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Don't get me wrong.

385
00:36:46,160 --> 00:36:52,120
But most doctors on talking about how to prevent disease, they're talking about how to treat

386
00:36:52,120 --> 00:36:56,840
disease when you should be trying to prevent it.

387
00:36:56,840 --> 00:36:57,840
Yeah.

388
00:36:57,840 --> 00:37:02,400
The obesity, I think, is a loss of electrons as well in the mitochondria.

389
00:37:02,400 --> 00:37:07,720
They're not getting those electrons and they're not pumping out water and cytochrome-siocides,

390
00:37:07,720 --> 00:37:10,240
and they're just not pumping out ATP.

391
00:37:10,240 --> 00:37:13,640
They're losing energy to the environment.

392
00:37:13,640 --> 00:37:19,160
And that concept, you know more than most, but if you get down into the nitty gritty,

393
00:37:19,160 --> 00:37:23,000
because we don't talk about the nitty gritty on how these mesenchymal stem cell works,

394
00:37:23,000 --> 00:37:27,000
because most people just want to know that they work, but they work by something called

395
00:37:27,000 --> 00:37:28,960
paracrine activity.

396
00:37:28,960 --> 00:37:34,760
And so when they sent an inflamed cell, they migrate to the cell and they make something

397
00:37:34,760 --> 00:37:35,760
called an exosome.

398
00:37:35,760 --> 00:37:41,520
They make a little packet of information, which goes from the stem cell to the inflamed

399
00:37:41,520 --> 00:37:42,640
cell.

400
00:37:42,640 --> 00:37:49,880
It goes inside the cell, fuses with the nucleus of that cell.

401
00:37:49,880 --> 00:37:54,480
It gives it the proteins and the signals to heal itself.

402
00:37:54,480 --> 00:37:59,200
But one of the things that it fuses with is the mitochondria, because it always comes

403
00:37:59,200 --> 00:38:05,320
down to mitochondrial dysfunction, and especially with age.

404
00:38:05,320 --> 00:38:10,480
But starting much earlier than most people think in our 20s, your mitochondria needs

405
00:38:10,480 --> 00:38:17,880
support, which is why there's these supplements, MNN and NADH.

406
00:38:17,880 --> 00:38:21,720
All these things help support healthy mitochondria.

407
00:38:21,720 --> 00:38:27,680
But that's how these things work, by actually changing the cell and affecting the mitochondria.

408
00:38:27,680 --> 00:38:28,960
Okay.

409
00:38:28,960 --> 00:38:37,040
As we age, our ability to make water in cytochrome cell stakes in the mitochondria are decreasing.

410
00:38:37,040 --> 00:38:42,120
And I think this might help kind of level that back up.

411
00:38:42,120 --> 00:38:47,760
Right, because they don't make ATPs like they used to.

412
00:38:47,760 --> 00:38:48,760
Yeah.

413
00:38:48,760 --> 00:38:52,040
So you're losing cellular energy.

414
00:38:52,040 --> 00:38:58,840
So the processes which were crucial are starting not to get enough energy to be a peak 100%.

415
00:38:58,840 --> 00:39:07,960
Now, your cytochrome P450 is at 95%, which is not so bad, but it's not 100%.

416
00:39:07,960 --> 00:39:12,600
But if you can drive that to 100%, because the goal in life is your health span to be

417
00:39:12,600 --> 00:39:15,880
equal to your life span.

418
00:39:15,880 --> 00:39:24,680
And so nobody wants to be in a nursing home in a wheelchair or an oxygen with dementia.

419
00:39:24,680 --> 00:39:31,040
You want to live a healthy life and then collapse with that.

420
00:39:31,040 --> 00:39:33,200
You win life when you do that.

421
00:39:33,200 --> 00:39:34,200
Yeah.

422
00:39:34,200 --> 00:39:40,760
All of these conditions, all of these modern health conditions started after electricity

423
00:39:40,760 --> 00:39:46,680
and artificial light was invented, because we're just getting isolated light.

424
00:39:46,680 --> 00:39:48,280
Isolated light is no good.

425
00:39:48,280 --> 00:39:50,520
You need the full spectrum of light.

426
00:39:50,520 --> 00:39:51,520
Right.

427
00:39:51,520 --> 00:39:57,000
So if you're from a farming people to an industrial people, people start to work it

428
00:39:57,000 --> 00:40:02,720
inside, then they're tincing even the windows of buildings so they don't have to heat them.

429
00:40:02,720 --> 00:40:07,560
But natural light is just good for you all the way around.

430
00:40:07,560 --> 00:40:13,120
All of these rates, including the rates of autism, follows humans removing themselves

431
00:40:13,120 --> 00:40:19,640
from the sun and getting under artificial light, both day and night, two different things,

432
00:40:19,640 --> 00:40:23,920
both severe problems, and the types of artificial light.

433
00:40:23,920 --> 00:40:30,280
The rates follow it identically.

434
00:40:30,280 --> 00:40:36,640
That's hard for people to hear and understand as a cause of something that's driving this,

435
00:40:36,640 --> 00:40:38,720
but I don't know.

436
00:40:38,720 --> 00:40:39,720
Right.

437
00:40:39,720 --> 00:40:46,840
Well, I think that what's interesting is now that we know the end, the end is there's

438
00:40:46,840 --> 00:40:51,160
some type of inflammation that's not being dealt with, then you have to work backwards

439
00:40:51,160 --> 00:40:52,160
and say why.

440
00:40:52,160 --> 00:40:56,200
But before doctors would throw up their arms and go, well, it just happens.

441
00:40:56,200 --> 00:40:57,760
Well, it doesn't just happen.

442
00:40:57,760 --> 00:41:05,160
The rates increasing and now that we have some type of, it's like jeopardy.

443
00:41:05,160 --> 00:41:06,160
We know the answer.

444
00:41:06,160 --> 00:41:08,440
The answer is inflammation.

445
00:41:08,440 --> 00:41:10,840
The question is how did it get there?

446
00:41:10,840 --> 00:41:15,760
What can we do to help our bodies deal with inflammation better?

447
00:41:15,760 --> 00:41:21,560
Something this magically happened in the 30s, Canter and Asperger started seeing these children

448
00:41:21,560 --> 00:41:22,960
from different parts of the world.

449
00:41:22,960 --> 00:41:25,640
It was like something's going on here.

450
00:41:25,640 --> 00:41:26,640
Right.

451
00:41:26,640 --> 00:41:27,640
It's amazing.

452
00:41:27,640 --> 00:41:29,480
It's taken 90 years.

453
00:41:29,480 --> 00:41:30,480
Yeah.

454
00:41:30,480 --> 00:41:36,520
And Alzheimer's, 1911, and this obesity over the last 50 years.

455
00:41:36,520 --> 00:41:40,080
Right.

456
00:41:40,080 --> 00:41:45,160
What does, you said that the process takes about 20 minutes.

457
00:41:45,160 --> 00:41:50,800
What does it look like for the person receiving the IV after that?

458
00:41:50,800 --> 00:41:55,680
Well, first of all, if they're not sedated, they feel fine.

459
00:41:55,680 --> 00:42:02,760
The one interesting thing that the stem cells that are preserved in it has kind of a funky

460
00:42:02,760 --> 00:42:03,760
odor.

461
00:42:03,760 --> 00:42:06,480
It comes out in your breath.

462
00:42:06,480 --> 00:42:14,480
We've heard it described as garlic, corn, strawberries, raspberries, olives.

463
00:42:14,480 --> 00:42:17,520
I've heard it, but I think it's kind of a sweet smell.

464
00:42:17,520 --> 00:42:19,960
I would say strawberries.

465
00:42:19,960 --> 00:42:22,560
It goes away after about five hours.

466
00:42:22,560 --> 00:42:30,320
Most people say they sleep really well that night, but it really is like a little bit

467
00:42:30,320 --> 00:42:34,920
of an energy boost, but that's it.

468
00:42:34,920 --> 00:42:38,920
The kids that are sedated, once they come out, by that afternoon they're playing, they're

469
00:42:38,920 --> 00:42:42,680
going to the beach or whatever they want to do.

470
00:42:42,680 --> 00:42:49,640
I think most of the, you really start to feel good at about two weeks because that's when

471
00:42:49,640 --> 00:42:51,600
the cells start to migrate out.

472
00:42:51,600 --> 00:42:58,560
I think from, there's a biphasic thing because the first thing they do is they stop inflammation.

473
00:42:58,560 --> 00:43:05,160
The second thing is they stimulate new cell growth.

474
00:43:05,160 --> 00:43:09,960
Even if I inject it in somebody's knee, who's got a bad knee, arthritic knee, they feel

475
00:43:09,960 --> 00:43:14,800
pretty good for the first couple of weeks just because the inflammation is getting better.

476
00:43:14,800 --> 00:43:19,640
But by three months they're going like, my knees never felt good, and that's this good.

477
00:43:19,640 --> 00:43:25,200
That's because now they're starting to recover that with normal cartilage and get rid of that

478
00:43:25,200 --> 00:43:26,840
bone on bone.

479
00:43:26,840 --> 00:43:36,520
I think with neurodegenerative disorders, whether it be Alzheimer's or Parkinson's or

480
00:43:36,520 --> 00:43:37,720
autism.

481
00:43:37,720 --> 00:43:42,120
It takes a while to start to get those new connections.

482
00:43:42,120 --> 00:43:45,360
Because I think there's kids out there that might have had an inflammatory hit, and they

483
00:43:45,360 --> 00:43:50,360
might not have a lot of inflammation now, but they have the end result of that.

484
00:43:50,360 --> 00:43:53,120
Because I've had parents say, not much is happening, not much is happening, not much

485
00:43:53,120 --> 00:43:54,120
is happening.

486
00:43:54,120 --> 00:43:58,560
Then at four months go, okay, he's a different kid.

487
00:43:58,560 --> 00:44:01,280
Now we're starting to see crazy things.

488
00:44:01,280 --> 00:44:07,680
I think if you think of it as a highway, as my wife said, those Bob barricades are up,

489
00:44:07,680 --> 00:44:09,760
and you just can't get through.

490
00:44:09,760 --> 00:44:12,920
Bob barricades start to get knocked down.

491
00:44:12,920 --> 00:44:19,320
Then you're starting to get normal neurologic transmission of electricity.

492
00:44:19,320 --> 00:44:21,680
You start to see good things happening.

493
00:44:21,680 --> 00:44:23,320
That's incredible.

494
00:44:23,320 --> 00:44:32,360
For the recipients that didn't work, there was a small percentage you mentioned earlier.

495
00:44:32,360 --> 00:44:34,400
The question is what to do.

496
00:44:34,400 --> 00:44:37,160
Is it an emergency thing?

497
00:44:37,160 --> 00:44:39,040
Everybody really knows that answer.

498
00:44:39,040 --> 00:44:41,400
Duke's been doing a lot of the studies when I was up there talking with him.

499
00:44:41,400 --> 00:44:44,520
I said, have you looked at the non-responders yet?

500
00:44:44,520 --> 00:44:47,640
They said, no, we really haven't.

501
00:44:47,640 --> 00:44:51,240
The question is, do they need more?

502
00:44:51,240 --> 00:44:52,360
Do they need a higher dose?

503
00:44:52,360 --> 00:44:55,800
Do they need multiple doses?

504
00:44:55,800 --> 00:45:02,880
Or is there another cause that may not be the classic inflammation that was seen in that

505
00:45:02,880 --> 00:45:04,920
one study?

506
00:45:04,920 --> 00:45:10,560
Because right now, there's not a great non-invasive way to document inflammation, and you can't

507
00:45:10,560 --> 00:45:13,440
buy up to the brain.

508
00:45:13,440 --> 00:45:17,560
A phase one study in the United States is it safe.

509
00:45:17,560 --> 00:45:19,760
A phase two study doesn't work.

510
00:45:19,760 --> 00:45:23,040
A phase three study is dosage administration.

511
00:45:23,040 --> 00:45:27,880
That's where we're just starting to get to phase three right now.

512
00:45:27,880 --> 00:45:35,200
When I did my son, I just, as a medical guy, said one dose is not a trial.

513
00:45:35,200 --> 00:45:37,880
I'll try it twice and see what happens.

514
00:45:37,880 --> 00:45:42,440
But he was so much better after one dose, it was much easier to give the second dose.

515
00:45:42,440 --> 00:45:47,520
But I work with all the parents, and I just say, the downside, the biggest downside is

516
00:45:47,520 --> 00:45:51,640
the stuff is not inexpensive, and it may not work.

517
00:45:51,640 --> 00:45:55,120
But it's not going to be bad for your child.

518
00:45:55,120 --> 00:46:03,040
But when I looked at people wanting to do supplements, they want you to, from hyperbaric

519
00:46:03,040 --> 00:46:12,440
to the speech therapy, the occupational therapy, the ABA, all that costs money too.

520
00:46:12,440 --> 00:46:18,360
If you look at the actual data, the data supports this treatment pretty well.

521
00:46:18,360 --> 00:46:23,400
It doesn't work for everybody, but it works for a lot.

522
00:46:23,400 --> 00:46:27,560
If you would just even compare it, and even some autistics are given like antipsychotics

523
00:46:27,560 --> 00:46:30,520
and stuff like that, it was just so wrong.

524
00:46:30,520 --> 00:46:31,520
But if you look at-

525
00:46:31,520 --> 00:46:33,240
Oh, I agree completely.

526
00:46:33,240 --> 00:46:39,080
So, one of the side effects, this stuff has side effects, but nothing long term.

527
00:46:39,080 --> 00:46:43,960
Short term side effects include a rash or a fever, and we usually pretreat with a little

528
00:46:43,960 --> 00:46:47,040
benadryl and a little hydrochlorosome to help prevent that.

529
00:46:47,040 --> 00:46:52,520
That can go and come in about the first six hours.

530
00:46:52,520 --> 00:46:55,080
Kind of midterm side effects.

531
00:46:55,080 --> 00:46:57,640
Kids with ADHD can get a little bit more hyperactive.

532
00:46:57,640 --> 00:47:00,280
Kids with aggression can get a little more aggressive.

533
00:47:00,280 --> 00:47:01,360
It's not continuous.

534
00:47:01,360 --> 00:47:02,360
It's episodic.

535
00:47:02,360 --> 00:47:06,920
It usually lasts a few months, but then it gets better, and it usually gets a lot better.

536
00:47:06,920 --> 00:47:11,160
But I was talking with a family last night, and they said, well, our daughter's really

537
00:47:11,160 --> 00:47:14,640
got caught aggressive.

538
00:47:14,640 --> 00:47:18,600
We're thinking about maybe we should talk about starting her on antipsychotic.

539
00:47:18,600 --> 00:47:20,680
And I was trying to convince them.

540
00:47:20,680 --> 00:47:23,200
That's not- you just want to manage it.

541
00:47:23,200 --> 00:47:24,560
This is a phase.

542
00:47:24,560 --> 00:47:25,560
It's been described.

543
00:47:25,560 --> 00:47:26,560
It doesn't happen in everybody.

544
00:47:26,560 --> 00:47:27,560
In fact, it doesn't happen in most.

545
00:47:27,560 --> 00:47:30,120
It happens in about 10% of kids.

546
00:47:30,120 --> 00:47:32,520
But it gets better on its own.

547
00:47:32,520 --> 00:47:36,080
And antipsychotics are a slippery slope.

548
00:47:36,080 --> 00:47:39,800
Manage it at home, and it'll get better.

549
00:47:39,800 --> 00:47:44,760
In fact, a lot of kids that we give this to can get off their antipsychotics.

550
00:47:44,760 --> 00:47:45,760
Oh, good.

551
00:47:45,760 --> 00:47:47,760
That's a nice thing as well.

552
00:47:47,760 --> 00:47:49,560
Yeah, that's fantastic.

553
00:47:49,560 --> 00:47:52,000
I don't like the medical paradigm.

554
00:47:52,000 --> 00:47:56,680
I'm not a big fan, even though you're a part of centralized medicine.

555
00:47:56,680 --> 00:47:58,600
Not a big fan of it.

556
00:47:58,600 --> 00:48:09,440
But from our conversation today, I mean, 100% know that you need my approval or judgment,

557
00:48:09,440 --> 00:48:12,800
but I am just enjoying what you've said so far.

558
00:48:12,800 --> 00:48:21,720
No, no, I think it was a watershed moment to me when there's such pushback on this.

559
00:48:21,720 --> 00:48:27,640
And I'm able to do it because the FDA has already approved it for a bunch of other different

560
00:48:27,640 --> 00:48:28,640
things.

561
00:48:28,640 --> 00:48:33,640
And so the FDA regulates drug companies.

562
00:48:33,640 --> 00:48:35,680
It doesn't regulate healthcare.

563
00:48:35,680 --> 00:48:42,000
And so if you and I agree that this is safe, it's indicated, and we want to do it, then

564
00:48:42,000 --> 00:48:43,000
we're allowed to do it.

565
00:48:43,000 --> 00:48:48,520
20% of all medications in the US are used off-label because they're discovered that they're

566
00:48:48,520 --> 00:48:51,320
beneficial for something else.

567
00:48:51,320 --> 00:48:56,560
We know 70% or 70% plus people benefit from this.

568
00:48:56,560 --> 00:48:58,600
We know it's safe.

569
00:48:58,600 --> 00:49:01,160
Why not use it?

570
00:49:01,160 --> 00:49:11,520
And I think that COVID pointed out to me drastically that Big Pharma is interested in making money.

571
00:49:11,520 --> 00:49:17,160
We know in that there's nothing better than a sick person because then you have a customer

572
00:49:17,160 --> 00:49:18,560
for life.

573
00:49:18,560 --> 00:49:23,960
And so we've been thinking about managing disease when we should be talking about preventing

574
00:49:23,960 --> 00:49:24,960
the disease.

575
00:49:24,960 --> 00:49:29,720
And once you prevent it, you can probably figure out how to cure it.

576
00:49:29,720 --> 00:49:32,800
And I think that this stuff will offer a lot.

577
00:49:32,800 --> 00:49:37,080
There'll always be a role for pharmaceuticals.

578
00:49:37,080 --> 00:49:44,040
Biotics help save a lot of people's lives, but people are doing antibiotics like chiklets

579
00:49:44,040 --> 00:49:45,040
or candy.

580
00:49:45,040 --> 00:49:51,160
And you can't do that either because people are just starting to understand the microbiome.

581
00:49:51,160 --> 00:49:56,320
And I think the next big thing will be, there'll be people with a super microbiome.

582
00:49:56,320 --> 00:50:00,640
They'll figure out that there'll be a percentage of people that they've got an A-number-one

583
00:50:00,640 --> 00:50:02,280
microbiome.

584
00:50:02,280 --> 00:50:07,720
And then we'll use that to put into people whose microbiome, if it's screwed up due to

585
00:50:07,720 --> 00:50:15,880
trauma, illness, antibiotics, genetics, whatever, and try to repopulate their gut with a microbiome

586
00:50:15,880 --> 00:50:18,240
we know is much better than their own.

587
00:50:18,240 --> 00:50:21,560
And then we can start seeing how that impacts the health care.

588
00:50:21,560 --> 00:50:22,560
Yeah.

589
00:50:22,560 --> 00:50:28,960
If I had to guess, it would be athletes or super lean people, super athletic people will

590
00:50:28,960 --> 00:50:31,000
have that super microbiome.

591
00:50:31,000 --> 00:50:35,720
That's why there's this metabolism is just kind of like an overdrive.

592
00:50:35,720 --> 00:50:36,720
Right.

593
00:50:36,720 --> 00:50:39,920
Well, I think we think that these people are genetic specimens.

594
00:50:39,920 --> 00:50:42,520
And it might be that their microbiome is better than everybody else.

595
00:50:42,520 --> 00:50:43,520
Yeah.

596
00:50:43,520 --> 00:50:44,520
And that might be the cause.

597
00:50:44,520 --> 00:50:45,520
Yeah.

598
00:50:45,520 --> 00:50:46,520
Right.

599
00:50:46,520 --> 00:50:47,520
Right.

600
00:50:47,520 --> 00:50:51,600
You know, because I think we're starting to see differences in people born by C-section,

601
00:50:51,600 --> 00:50:55,640
you know, verse coming through the birth canal, because that's your big first microbiome

602
00:50:55,640 --> 00:51:00,480
hit, you know, that might need to happen more than we think.

603
00:51:00,480 --> 00:51:01,480
Yeah.

604
00:51:01,480 --> 00:51:02,480
Yeah.

605
00:51:02,480 --> 00:51:03,480
Okay.

606
00:51:03,480 --> 00:51:08,240
That's very interesting.

607
00:51:08,240 --> 00:51:15,240
Something I learned about the womb and the maternal is she's providing so much serotonin.

608
00:51:15,240 --> 00:51:20,240
Her peripheral serotonin is providing so much for the womb central nervous system.

609
00:51:20,240 --> 00:51:28,240
And in large part, autism is that just abnormal central nervous system.

610
00:51:28,240 --> 00:51:34,360
And the serotonin is putting together the sensory map and help developing the central

611
00:51:34,360 --> 00:51:35,360
nervous system.

612
00:51:35,360 --> 00:51:36,360
Right.

613
00:51:36,360 --> 00:51:43,480
And that's why when women take antidepressants, you know, and select a serotonin, you know,

614
00:51:43,480 --> 00:51:45,720
it screws up the serotonin system.

615
00:51:45,720 --> 00:51:48,040
And those kids can certainly have issues.

616
00:51:48,040 --> 00:51:49,040
Yeah.

617
00:51:49,040 --> 00:51:50,040
Yeah.

618
00:51:50,040 --> 00:51:52,680
The autism or other things, autism and things.

619
00:51:52,680 --> 00:51:53,680
Yeah.

620
00:51:53,680 --> 00:51:54,680
Right.

621
00:51:54,680 --> 00:51:55,680
SSRIs.

622
00:51:55,680 --> 00:51:56,680
Yeah.

623
00:51:56,680 --> 00:51:57,680
Yeah.

624
00:51:57,680 --> 00:52:00,480
Just a couple more questions.

625
00:52:00,480 --> 00:52:03,240
I'm having a heck of a time here.

626
00:52:03,240 --> 00:52:05,640
This is so fun.

627
00:52:05,640 --> 00:52:13,000
Whenever you mentioned that crossing the blood brain barrier, I made a note and I just wanted

628
00:52:13,000 --> 00:52:14,000
to run it by you.

629
00:52:14,000 --> 00:52:17,680
Do you think vasopressin is involved there?

630
00:52:17,680 --> 00:52:25,200
Where by it kind of signals or something signals stress and the vasopressin through the pituitary

631
00:52:25,200 --> 00:52:29,520
will open up the blood brain barrier?

632
00:52:29,520 --> 00:52:32,200
That's interesting because we know the brain is stressed.

633
00:52:32,200 --> 00:52:40,800
We know that when injury or inflammation or something happens in the brain, that the

634
00:52:40,800 --> 00:52:44,760
blood brain barrier can be opened by internal mechanism.

635
00:52:44,760 --> 00:52:49,000
I mean, nobody knows quite what that is, but it could be.

636
00:52:49,000 --> 00:52:50,920
You know, I have no idea.

637
00:52:50,920 --> 00:52:58,440
All we know is that the cells go from the peripheral blood and they get access to the

638
00:52:58,440 --> 00:52:59,440
brain.

639
00:52:59,440 --> 00:53:04,800
And by 14 days, if you induce inflammation in the brain and then give these cells by

640
00:53:04,800 --> 00:53:07,080
day 14, they're right there.

641
00:53:07,080 --> 00:53:11,320
If you take the same animal and you don't induce inflammation, they're in the blood

642
00:53:11,320 --> 00:53:14,720
system running through the brain, but not into the brain proper.

643
00:53:14,720 --> 00:53:19,720
They haven't crossed the blood brain barrier yet.

644
00:53:19,720 --> 00:53:24,560
Blood leaks out and tells that cell to stick to the blood brain barrier and how does it

645
00:53:24,560 --> 00:53:25,560
zip through it?

646
00:53:25,560 --> 00:53:29,280
There's these things called tight junctions that are supposed to be tight.

647
00:53:29,280 --> 00:53:35,320
Maybe those junctions slide open for a second and slide back and then the stem cells in.

648
00:53:35,320 --> 00:53:42,320
But it's interesting that you can't detect a leak, a wide open leak, yet somehow these

649
00:53:42,320 --> 00:53:43,960
cells are in.

650
00:53:43,960 --> 00:53:48,080
So they pass through without causing damage.

651
00:53:48,080 --> 00:53:49,880
So it could be vasopressin.

652
00:53:49,880 --> 00:53:50,880
Yeah.

653
00:53:50,880 --> 00:53:51,880
That's...

654
00:53:51,880 --> 00:53:56,240
Oxytocin and vasopressin is very interesting.

655
00:53:56,240 --> 00:54:01,000
Two little molecules, they're very powerful things and they're very small peptides.

656
00:54:01,000 --> 00:54:07,080
There's only like nine proteins, but they're very powerful.

657
00:54:07,080 --> 00:54:12,280
What is something recently that you're most excited about before we wrap up professionally

658
00:54:12,280 --> 00:54:14,600
or personally or both?

659
00:54:14,600 --> 00:54:20,000
Well, I think professionally and personally, it's probably going to be the stem cells in

660
00:54:20,000 --> 00:54:22,200
this.

661
00:54:22,200 --> 00:54:25,240
It took some soul searching and talking with my wife.

662
00:54:25,240 --> 00:54:27,800
I've been a surgeon for 30 years.

663
00:54:27,800 --> 00:54:28,800
It's what I am.

664
00:54:28,800 --> 00:54:31,320
It's what I do.

665
00:54:31,320 --> 00:54:37,920
I like to be the guy called when the life is on the line, when traumatic injuries, car

666
00:54:37,920 --> 00:54:41,040
accidents, whatever.

667
00:54:41,040 --> 00:54:49,480
But I think that phase of my life is coming to an end because I think that these will

668
00:54:49,480 --> 00:54:51,600
be truly healing properties.

669
00:54:51,600 --> 00:54:53,280
Not many people are doing it.

670
00:54:53,280 --> 00:55:00,600
I think it gives hope to people that need hope and I think it can restore life like

671
00:55:00,600 --> 00:55:01,600
nothing else.

672
00:55:01,600 --> 00:55:06,600
And if you can ever figure out how to get the body to heal itself as opposed to a drug

673
00:55:06,600 --> 00:55:09,200
or surgery, you're much better off.

674
00:55:09,200 --> 00:55:12,360
And so I'm going to concentrate on this.

675
00:55:12,360 --> 00:55:18,400
I'm going to give up surgery and do this full time because I've seen remarkable things.

676
00:55:18,400 --> 00:55:20,560
I've seen tremendous healing.

677
00:55:20,560 --> 00:55:25,160
I had a woman who came in in a wheelchair with multiple sclerosis and after a single treatment,

678
00:55:25,160 --> 00:55:29,360
she was walking normally and went back to work.

679
00:55:29,360 --> 00:55:34,240
So I've seen it work and it's amazing.

680
00:55:34,240 --> 00:55:38,480
And so I'm excited for the next phase of my life to be honest.

681
00:55:38,480 --> 00:55:40,720
Yeah, it's very promising.

682
00:55:40,720 --> 00:55:47,880
It's just the amount of motivation and hope that you're giving me, just telling me about

683
00:55:47,880 --> 00:55:48,880
it.

684
00:55:48,880 --> 00:55:49,880
Right, right.

685
00:55:49,880 --> 00:55:50,880
It's a spiritual journey.

686
00:55:50,880 --> 00:55:56,600
I do believe that I was set up to do this, that I had a connection with you.

687
00:55:56,600 --> 00:55:58,400
I had a connection with UCSF.

688
00:55:58,400 --> 00:56:01,880
I had a connection with stem cells early.

689
00:56:01,880 --> 00:56:07,480
And then I've seen it in my plastic surgery practice and then I saw what it did to my

690
00:56:07,480 --> 00:56:13,320
son and it made him integrate into the world.

691
00:56:13,320 --> 00:56:14,320
He lives on his own.

692
00:56:14,320 --> 00:56:15,320
He drives a car.

693
00:56:15,320 --> 00:56:16,320
He has a job.

694
00:56:16,320 --> 00:56:17,840
He's interested in girls.

695
00:56:17,840 --> 00:56:20,000
He's had a girlfriend.

696
00:56:20,000 --> 00:56:29,280
He's living his best life through completely natural healing that most people don't even

697
00:56:29,280 --> 00:56:30,280
know about, to be honest.

698
00:56:30,280 --> 00:56:31,880
Most pediatricians don't know about.

699
00:56:31,880 --> 00:56:34,360
And that tells you it's crazy.

700
00:56:34,360 --> 00:56:39,000
That people who are in this field, especially people way before me, were ridiculed as nut

701
00:56:39,000 --> 00:56:41,440
cases.

702
00:56:41,440 --> 00:56:53,080
But that's what happens when you work outside the box, where you go like, the question is,

703
00:56:53,080 --> 00:56:57,080
why are we seeing all these diseases and we don't have enough sunlight?

704
00:56:57,080 --> 00:56:59,040
Why is all this stuff going?

705
00:56:59,040 --> 00:57:00,040
Yeah.

706
00:57:00,040 --> 00:57:02,800
I'm about to lose my battery here.

707
00:57:02,800 --> 00:57:08,000
I can either plug in or we can end it real quick.

708
00:57:08,000 --> 00:57:09,000
We can end.

709
00:57:09,000 --> 00:57:14,760
We've done an hour and I don't want to keep you, even though I could.

710
00:57:14,760 --> 00:57:20,960
I always say a big part of the podcast is like, research is right here and we're just

711
00:57:20,960 --> 00:57:22,600
constantly running in this circle.

712
00:57:22,600 --> 00:57:24,800
We're like a rat on a rat.

713
00:57:24,800 --> 00:57:28,680
I'm more interested in than just expanding the edges of science.

714
00:57:28,680 --> 00:57:34,800
I'm thankful you came on because I get the message that's what you're doing.

715
00:57:34,800 --> 00:57:35,800
Yeah.

716
00:57:35,800 --> 00:57:39,360
I love, I spend my time reading about this.

717
00:57:39,360 --> 00:57:43,120
It's nice that I can pick up a phone and call a major researcher and go, hey, I think

718
00:57:43,120 --> 00:57:44,840
our paths are going to cross this way.

719
00:57:44,840 --> 00:57:46,760
What have you ever thought about this?

720
00:57:46,760 --> 00:57:50,840
And I've called people from Stanford to Michigan to all sorts of people.

721
00:57:50,840 --> 00:57:55,280
And the people who are doing it are always interested in the clinicians point because

722
00:57:55,280 --> 00:57:56,760
they're doing the bench stuff.

723
00:57:56,760 --> 00:58:03,760
And I go, I think your research is going to be.

724
00:58:03,760 --> 00:58:06,760
Dang.

725
00:58:06,760 --> 00:58:16,640
Well, it looks like Dr. Weiss's battery died.

726
00:58:16,640 --> 00:58:18,560
That's my fault.

727
00:58:18,560 --> 00:58:23,960
I rambled a little bit too much at the end instead of just having a goodbye.

728
00:58:23,960 --> 00:58:27,640
And I wanted to mention to him happy Veterans Day and I didn't get to do that.

729
00:58:27,640 --> 00:58:30,840
So Dr. Weiss, this will be on the recording.

730
00:58:30,840 --> 00:58:37,640
If you, if you listen to it, happy Veterans Day and thank you for everything.

731
00:58:37,640 --> 00:58:42,600
Thank you for the conversation and your work and pushing the knowledge about this themselves

732
00:58:42,600 --> 00:58:50,120
practice.

733
00:58:50,120 --> 00:58:51,120
I think you go ahead.

734
00:58:51,120 --> 00:58:53,160
You asked me about what I was excited about.

735
00:58:53,160 --> 00:58:54,160
Yeah.

736
00:58:54,160 --> 00:58:57,920
And talking about the colleagues and stuff.

737
00:58:57,920 --> 00:58:58,920
Yeah, go ahead.

738
00:58:58,920 --> 00:58:59,920
Right.

739
00:58:59,920 --> 00:59:02,960
So there's one guy that I'm really intrigued with a guy named Bruce Patterson, who was

740
00:59:02,960 --> 00:59:09,080
a world class kind of molecular biologist and pathologist from, from Stanford.

741
00:59:09,080 --> 00:59:17,920
And he described a lot of cytokine and chemokine stuff in COVID and kind of the really molecular

742
00:59:17,920 --> 00:59:23,920
markers of inflammation, which really hadn't been studied, and he, he found out, you know,

743
00:59:23,920 --> 00:59:26,920
kind of what was killing people with cytokine storm.

744
00:59:26,920 --> 00:59:31,320
But he also afterwards, people have what they call long COVID.

745
00:59:31,320 --> 00:59:32,320
They had brain fog.

746
00:59:32,320 --> 00:59:35,920
They had the stuff and, you know, some doctors thought they were making it all up because

747
00:59:35,920 --> 00:59:37,840
all their tests were normal.

748
00:59:37,840 --> 00:59:42,680
And what he did was he measured their cytokines and there's 11 billion different combination

749
00:59:42,680 --> 00:59:46,520
of cytokines and he found out that they all had the same pattern.

750
00:59:46,520 --> 00:59:51,400
And so there was something molecular that was happening in these long COVID patients.

751
00:59:51,400 --> 00:59:57,600
And so he, he took 18 people and found out it was all the same.

752
00:59:57,600 --> 01:00:02,360
And then he showed that if you keep treating them and you drive down their cytokine levels,

753
01:00:02,360 --> 01:00:04,360
their symptoms got better.

754
01:00:04,360 --> 01:00:10,000
Then he decided to look at 45 people who, who all had long COVID just to see if he could

755
01:00:10,000 --> 01:00:11,240
reproduce his results.

756
01:00:11,240 --> 01:00:15,440
And then he found out that 40 had the same pattern of long COVID.

757
01:00:15,440 --> 01:00:21,440
But these five people over here had had a different pattern, but they all have the same

758
01:00:21,440 --> 01:00:22,920
pattern.

759
01:00:22,920 --> 01:00:24,760
So then he said, these people have long COVID.

760
01:00:24,760 --> 01:00:26,440
These people have something else.

761
01:00:26,440 --> 01:00:28,800
And then he looked at their medical history.

762
01:00:28,800 --> 01:00:30,920
They all had Lyme's disease.

763
01:00:30,920 --> 01:00:33,840
Then he goes, okay, Lyme's disease gives you a pattern.

764
01:00:33,840 --> 01:00:36,640
And then he said, I think I found a pattern for pandas.

765
01:00:36,640 --> 01:00:37,640
So I heard about them.

766
01:00:37,640 --> 01:00:41,960
I called them and I said, you know, Bruce, Eric, we introduced ourselves.

767
01:00:41,960 --> 01:00:48,040
But I said, you think there's a pattern for autism that, that there's going to be a basic

768
01:00:48,040 --> 01:00:52,280
pattern of inflammation that we can pick up on the cytokine level.

769
01:00:52,280 --> 01:00:54,920
And you know, he said, I don't know, let's do it.

770
01:00:54,920 --> 01:00:58,720
So we've taken blood on about six or seven kids now.

771
01:00:58,720 --> 01:01:02,960
And we've looked at 14 or actually 12, 13 different cytokines.

772
01:01:02,960 --> 01:01:11,880
And the, the most normal kid had had 12 have our 10 abnormalities at 13, you know, so they're

773
01:01:11,880 --> 01:01:17,680
they're profoundly inflammatory, inflammatory state.

774
01:01:17,680 --> 01:01:19,320
And so now we're trying to put it together.

775
01:01:19,320 --> 01:01:25,160
We're trying to get maybe 30 that we can get, you know, the infamedic guys to look at and

776
01:01:25,160 --> 01:01:27,360
go, okay, this looks like a pattern.

777
01:01:27,360 --> 01:01:28,360
These two are the same.

778
01:01:28,360 --> 01:01:29,360
What's different about this kid?

779
01:01:29,360 --> 01:01:31,440
Let's get more medical history.

780
01:01:31,440 --> 01:01:34,840
But I think two things can happen.

781
01:01:34,840 --> 01:01:41,400
One is that we now have something we can measure autistic kids that we can say we're getting

782
01:01:41,400 --> 01:01:42,400
better.

783
01:01:42,400 --> 01:01:46,040
Look, is inflammatory markers are dropping?

784
01:01:46,040 --> 01:01:49,880
And well, first of all, you know, as inflammation drops, should it does that correlate with

785
01:01:49,880 --> 01:01:50,880
getting better?

786
01:01:50,880 --> 01:01:53,920
And if it does, then we can really, really press it.

787
01:01:53,920 --> 01:01:58,000
And the same thing, you could use it almost as a diagnostic tool too.

788
01:01:58,000 --> 01:01:59,000
Yes.

789
01:01:59,000 --> 01:02:04,560
You know, this, this 18 month old, you know, something happened here, you know, and then

790
01:02:04,560 --> 01:02:10,000
you could start saying, okay, well, their initial blood sample at the hospital didn't

791
01:02:10,000 --> 01:02:14,240
have this inflammation, you know, is this acquired?

792
01:02:14,240 --> 01:02:20,000
Because in that initial autopsy study, they, they had blood or they had brains from kids

793
01:02:20,000 --> 01:02:27,280
that were so-called neurotypical and then degenerated or regressed into autism.

794
01:02:27,280 --> 01:02:31,560
And then they had kids that were never good, you know, that always had it.

795
01:02:31,560 --> 01:02:35,440
The interesting thing is they all had inflammation in the same place.

796
01:02:35,440 --> 01:02:40,320
And so now we're starting to think that there's something called maternal immune activation

797
01:02:40,320 --> 01:02:46,560
MIA, where if the mom gets infection or some type of inflammatory hit, they can transmit

798
01:02:46,560 --> 01:02:52,280
to that child, or if the child gets an inflammation early on when they're young, whether it be

799
01:02:52,280 --> 01:02:59,160
COVID or some other problem, that can, that neuroinflammation can cross the blood brain

800
01:02:59,160 --> 01:03:00,160
barrier.

801
01:03:00,160 --> 01:03:05,360
So it just opens up a lot of, of directed research, you know.

802
01:03:05,360 --> 01:03:10,840
So I think that's exciting, but just that's the most exciting thing happening in my life.

803
01:03:10,840 --> 01:03:11,840
Wow.

804
01:03:11,840 --> 01:03:12,840
That is exciting.

805
01:03:12,840 --> 01:03:14,480
What about those patterns?

806
01:03:14,480 --> 01:03:20,200
Cydecans, if I'm not, if I'm not mistaken, they're some of the roles or the role they're

807
01:03:20,200 --> 01:03:27,320
or cell signaling and a part of cydecans is interleukin.

808
01:03:27,320 --> 01:03:28,320
Is that right?

809
01:03:28,320 --> 01:03:29,320
Interleukins are cytokines.

810
01:03:29,320 --> 01:03:30,320
Oh, okay.

811
01:03:30,320 --> 01:03:31,320
So yeah, right.

812
01:03:31,320 --> 01:03:34,720
So you've got interleukin 2, 4, 5, 6, 7 all the way up to 35.

813
01:03:34,720 --> 01:03:40,040
Every time they, they figure out a new cytokine, it's interleukin 42a or 42b.

814
01:03:40,040 --> 01:03:46,800
So yeah, they're the, the, the, they're the cellular communications of inflammation.

815
01:03:46,800 --> 01:03:49,120
That's the lowest molecule there is.

816
01:03:49,120 --> 01:03:52,000
They're the ones that turn on the whole immune system.

817
01:03:52,000 --> 01:03:58,440
And so these kids and adults have, have issues with their cytokines and chemokines.

818
01:03:58,440 --> 01:04:03,360
And so now we just have to figure out when it all started and how to turn them off.

819
01:04:03,360 --> 01:04:09,800
I see, I see the interleukins in autism papers a lot.

820
01:04:09,800 --> 01:04:10,800
Correct.

821
01:04:10,800 --> 01:04:11,800
Yeah.

822
01:04:11,800 --> 01:04:15,840
It seems like, you know, that's the path there.

823
01:04:15,840 --> 01:04:18,400
You're on to something there with the patterns.

824
01:04:18,400 --> 01:04:21,080
I'm extremely excited about that.

825
01:04:21,080 --> 01:04:25,320
I want to look up Bruce Patterson, Dr. Kind of.

826
01:04:25,320 --> 01:04:26,320
Yeah.

827
01:04:26,320 --> 01:04:28,440
He would be, he would be an interesting guy to talk to.

828
01:04:28,440 --> 01:04:33,320
He might talk to, you know, most of his work is done with, with inflammation and disease

829
01:04:33,320 --> 01:04:38,080
disease, but I think he could tell an interesting story about COVID and long COVID and Lyme's

830
01:04:38,080 --> 01:04:44,680
disease, you know, stuff that most people don't know about, about immune activation

831
01:04:44,680 --> 01:04:46,840
and how to treat it.

832
01:04:46,840 --> 01:04:47,840
Yeah.

833
01:04:47,840 --> 01:04:48,840
Okay.

834
01:04:48,840 --> 01:04:56,840
How can people get ahold of you and if you want to share and I think there's two things

835
01:04:56,840 --> 01:04:58,600
I would share.

836
01:04:58,600 --> 01:05:05,680
One Eric Weiss MD.com, you know, is the one website, but NorthFortostemCells.com is, is

837
01:05:05,680 --> 01:05:07,720
my main one.

838
01:05:07,720 --> 01:05:12,280
But my wife wrote a book called Educating Marston, who is my son with autism.

839
01:05:12,280 --> 01:05:14,400
And it's everything we did for him.

840
01:05:14,400 --> 01:05:19,360
You know, the one bad thing about autism is that, you know, if your kid gets leukemia,

841
01:05:19,360 --> 01:05:23,160
there's a playbook, you know, but as soon as your kid gets autism, the pediatrician

842
01:05:23,160 --> 01:05:26,960
kind of, you know, patch on the back and says, go get therapy.

843
01:05:26,960 --> 01:05:29,000
But there are things we, you know, we did that work.

844
01:05:29,000 --> 01:05:30,320
There are things we did that didn't work.

845
01:05:30,320 --> 01:05:35,080
My wife was very honest, but I wrote the middle three chapters on stem cells kind of on the

846
01:05:35,080 --> 01:05:39,880
biologic basis of why they should work and how they work.

847
01:05:39,880 --> 01:05:46,600
And I think that'll give people a very nice baseline to know that this stuff has been

848
01:05:46,600 --> 01:05:47,800
studied a lot.

849
01:05:47,800 --> 01:05:49,040
It's not new to medicine.

850
01:05:49,040 --> 01:05:53,800
It's a new application for, for an old drug.

851
01:05:53,800 --> 01:05:55,840
It's safe and maybe it's something they want to do.

852
01:05:55,840 --> 01:05:57,800
Yeah, good.

853
01:05:57,800 --> 01:06:02,640
And Educating Marston can be found on Amazon or Barnes and Nobl or Books of Million, all

854
01:06:02,640 --> 01:06:03,640
those.

855
01:06:03,640 --> 01:06:04,640
Great.

856
01:06:04,640 --> 01:06:05,640
I'll put, definitely put show notes.

857
01:06:05,640 --> 01:06:07,640
There'll be links in the show notes.

858
01:06:07,640 --> 01:06:11,360
I'm excited about that.

859
01:06:11,360 --> 01:06:12,920
I just loved our conversation.

860
01:06:12,920 --> 01:06:15,680
No, I'm looking forward to seeing it.

861
01:06:15,680 --> 01:06:16,680
Nice meeting you as well.

862
01:06:16,680 --> 01:06:18,560
Where are you located?

863
01:06:18,560 --> 01:06:19,560
Tel City, Indiana.

864
01:06:19,560 --> 01:06:20,560
Southern Indiana.

865
01:06:20,560 --> 01:06:21,560
Southern Indiana.

866
01:06:21,560 --> 01:06:24,560
It's about two hours south of IU.

867
01:06:24,560 --> 01:06:25,560
Oh.

868
01:06:25,560 --> 01:06:29,160
About an hour west of Louisville, Kentucky.

869
01:06:29,160 --> 01:06:30,160
Oh, okay.

870
01:06:30,160 --> 01:06:32,160
Yeah, it's a very small town.

871
01:06:32,160 --> 01:06:34,040
Well, keep doing what you're doing.

872
01:06:34,040 --> 01:06:38,480
You're bringing knowledge and power to a bunch of people.

873
01:06:38,480 --> 01:06:39,480
Thank you.

874
01:06:39,480 --> 01:06:40,480
Yeah.

875
01:06:40,480 --> 01:06:46,240
I didn't want to, the other recording ended before I could say this, but Happy Veterans

876
01:06:46,240 --> 01:06:47,240
Day.

877
01:06:47,240 --> 01:06:48,240
Oh, thank you.

878
01:06:48,240 --> 01:06:49,240
And you screen your service.

879
01:06:49,240 --> 01:06:50,240
No, no, no.

880
01:06:50,240 --> 01:06:52,920
You know, I did my little bit, you know.

881
01:06:52,920 --> 01:06:54,600
So glad to help out.

882
01:06:54,600 --> 01:06:55,600
Thank you.

883
01:06:55,600 --> 01:06:56,600
Have a good night.

884
01:06:56,600 --> 01:06:57,600
Thank you.

885
01:06:57,600 --> 01:06:58,600
Thank you so much, Eric.

886
01:06:58,600 --> 01:06:59,600
Bye-bye.

887
01:06:59,600 --> 01:07:00,600
Bye.

888
01:07:00,600 --> 01:07:06,400
If you're listening to the podcast or listening to the episode, please feel free to leave

889
01:07:06,400 --> 01:07:09,200
a review or ratings.

890
01:07:09,200 --> 01:07:13,480
In podcasting, review and ratings are crucial.

891
01:07:13,480 --> 01:07:16,560
And I very much appreciate your feedback.

892
01:07:16,560 --> 01:07:26,400
You can contact me on X at RPS 47586 or click on the hop link so you can have links to all

893
01:07:26,400 --> 01:07:30,400
the show platforms and contact information.

894
01:07:30,400 --> 01:07:39,120
You can email me info.fromthespectrum at gmail.com.

895
01:07:39,120 --> 01:07:46,960
And thank you for listening to From the Spectrum podcast.