Welcome to From the Spectrum Podcast. This is a podcast about autism. It is my goal to
explain what is autism. I plan to use a mixture of scientific literature, personal experience,
and opinion. With opinion, I will explain why. I show the way I do and give examples.
I will provide links to various references for each episode. For each episode, we will
discuss various aspects of autism. For today's episode, we will cover mitochondria. The
mitochondria, which is plural, mitochondrion, is singular, or vast for living organisms.
Often, mitochondria are considered the powerhouse of the cell. We've covered light, water, and
magnetism as the central foundation of life, including human life. Today, we will have
more understanding of these three critical components in our living organism.
Today's episode is an introduction because mitochondria is very critical in this discussion
and we cannot cover everything. We will prepare for a future episode featuring an expert, an
MD, and a PhD in biophysics to explain the roles of autism and mitochondria. If you
go to PubMed and type in just a broad search of mitochondria into the PubMed's search
engine, you will see recently, over the last one to two decades, the number of publishings
on mitochondria has a vast and sharp increase. The understanding of mitochondria is becoming
more apparent. The roles in human biology and health versus senescence and death is becoming
more recognized. What we will talk about are not topics that help our life. They are topics
in our biology that gives us life. Most cells have mitochondria. All cells accept red blood
cells and two types of cells from the autism and gastrointestinal episodes. Bacteria and
archaea. Red blood cells use deuterium water and you will find out mitochondria is a role
of producing water. Mitochondria needs a different type of water than blood or hemoglobin. Red
blood cells use hemoglobin which allows optimal oxygen transportation. You will soon find
out oxygen and the mitochondria is delicate. Bacteria and archaea, their absence of mitochondria
is because those are prokaryotic cells. Prokaryotic cells are less complex and then eukaryotic
cells are more complex. All the organelles within a cell nucleus including mitochondria,
it's believed that everything in the cell nucleus was once independent or separate from
each other. And the collection of these different organelles coming together in the cell nucleus
gives rise to more complex living organisms to more complex life. In the prokaryotic bacteria
and archaea it shares a cytochrome c-oxidase with eukaryotic mitochondria cells. In eukaryotic
cells that more complex cell nucleus and mitochondria, cytochrome c-oxidase is the fourth of five
cytochromes. We've talked about humans use photosynthesis. This is here and crucial parts
of hemoglobin and mitochondria. Hemoglobin and chlorophyll are nearly the same except
hemoglobin uses iron. Chlorophyll uses magnesium. Iron will be a critical part for today. Iron
in both blood and the mitochondria have magnetic properties. This is a heme sometimes called
hemo protein. These are molecules containing iron which binds to oxygen. Remember the magnetic
part of the story. Hems store and transport globins. Hence hemo-globin conserves energy.
Another area for today photosynthesis and respiratory cytochromes which will be most
of our conversation is also a catalyst meaning starting or accelerating and hemes since changes
in redox states. So more involvement with oxygen. So a brief recap the elements that
we will discuss. It's energy, oxygen, water, proteins, ions both negative ions which are
electrons and positive ions which are protons and the electromagnetic fields. Light is a
driving force. Light or a lack of light depending on the cellular state and function. Meaning
if the cell is active and functioning and healthy it's receiving optimal light, optimal
electromagnetic fields. If the cell is lacking energy or cell death even it is neglected
from these energy properties. The powerhouse of the cell, the mitochondria and cellular
respiration. There are three components that we will spend most of the time on. These are
all energy producing paths. One is glycolysis. Two is citric acid cycle or sometimes called
TCA cycle or even Crab cycle. This is briefly mentioned in cause of autism episode. Hans
Krebs the Nobel winner this was mentioned around minute 16 of the cause of autism episode.
Also Albert St. George's another Nobel winner has critical roles here with that the protein
discovering the semiconductor. Essentially what we're talking about with all of those
ingredients mentioned earlier those elements we are creating semiconductor properties.
And the third component of the cellular respiration is oxidative phosphorylation. This will include
the electron transport chain also briefly mentioned in previous episodes. The ATPase
and chymiosmosis or the movement of ions across membranes and across the gradient. First is
glycolysis. This is glucose metabolism that creates two molecules of pyruvate. You probably
know glucose is released for energy. This is where it takes action. This is the cells
cytoplasm. The goal is to break down glucose and use a transporter to enter the mitochondria.
Glucose binds to insulin and there is a straw like feature for a transporter which allows
the glucose to enter. Pyruvate kinase isoform M2 or PKM2 is labeled metabolic budgeting
system. This is a factor in autistic biology. Pyruvate has ATP and NADH outputs. ATP is
adenosine triphosphate which transfers energy. This is what we are trying to achieve in
cellular respiration. The NADH carries electrons. With oxygen and pyruvate, acetyl coenzyme
A sometimes shown as aceto coa is created and the citric acid the TCA cycle needs it.
It needs it. The citric acid cycle. This occurs in the mitochondria matrix and is central
driver for cellular respiration. The cycle is used to release stored energy from oxidation
of acetyl coenzyme A which is derived from carbohydrates and fats or protein into carbon
dioxide and chemical energy of ATP. It also produces NADH and FADH2. These are coenzymes.
FADH2 is a cofactor. These are required for metabolism. FADH2 and NADH are catabolism
which breaks down complex molecules which we've discussed into simpler forms. Simpler
molecules, then mechanisms can use these simple forms for energy. This is life. This is upstream
metabolism. NADH and FADH2, the electron carriers are crucial. We will cover all five of the
cytochromes in the electron transport chain and the ATPase momentarily. Both glycolysis
and the citric acid cycle uses NAD plus breaking it down to NADH. Glycolysis and the citric
acid cycle just many components moving parts. They are like conveyor belts feeding into
the cytochromes in the electron transport chain. Now oxidative phosphorylation. This
is where the magic happens but without glycolysis and without the citric acid oxidative phosphorylation
suffers. This is the final stage of cellular respiration. This includes the electron transport
chain and ATP synthase and chymiosmosis. ATP generated in one of these two metabolic pathways
glycolysis and or oxidative phosphorylation. We've discussed just briefly the electron
transport chain and the cytochromes involved. Cytochromes are chromophores. In other words
these are a unique type of protein. This translates into color and carriers of chromophores. I'll
say again translates into color and carriers of. It means they absorb specific wavelengths
of light and you know the position on the cause of autism and all of the chronic diseases
that are just downstream of essentially everything we're talking about today. Today's conversation
will take us essentially as far upstream in human functioning, human metabolism and biological
sequencing as we can go. Cytochrome 1 or sometimes called ubiquinone. The products of glycolysis
are oxidized here transferring two electrons from NADH to FMN or Flavin. You might have
heard of Flavin products such as green tea or supplemental form. The electrons are then
used in CoQ10. You might have even heard about this or seen it on your supplement aisle in
your supplement store or grocery store. CoQ10 is a coenzyme and these are lipophilic and
it's reduced form ubiquinol also in cytochrome 1 or 8 iron sulfur clusters. So here we are
with the iron. Remember the magnetic field and hydrogen. Hydrogen and electrons are produced.
They are broken down from these separate processes and produced here. Then we move to cytochrome
2. This uses electrons from succunate in the citric acid cycle and we are passing electrons
down the path using iron sulfur clusters and CoQ10 to cytochrome 3. Succunate is a catalyst
of the oxidative process being fed to cytochrome 3 which will turn these products into water.
Essentially we are making water and ATP. You might have heard of ROS, reactive oxidative
stress. This is cytochrome 3, this process that we are working up to will take oxygen
and create water. The whole purpose of breaking these molecules down into smaller molecules
is this. Cytochrome 3 is called cytochrome C reductase. Heme proteins and iron sulfur
clusters are used. Heme groups alternate between ferrous and ferric. Proton gradients begin
to add up a two step Q cycle is used to move into cytochrome C oxidase. This is a transfer
in breaking down of processes or elements because cytochrome C can only accept a single
electron at one time. So this occurs in two steps. The cytochrome 3 also releases the
four protons. Just a special note about the hydrogen 2. Hydrogen is building up and is
necessary. So we are processing different elements, different molecules I should say,
into the matrix and the inter membrane. And this brings us to maybe the most underrated
or not appreciated process in the whole mitochondria. And that's the creation of water. Now I ran
through the first processes to get to this point fairly quickly and I did not highlight
the elements or the molecules that's being produced, the amount of them and essentially
I didn't mention the reasons. However, we are here for these reasons right now. One
is to get to cytochrome C oxidase as fast as possible and two there are obviously lots
of molecules and atomic processes going on here. I want to be mindful of the podcast.
I want to be mindful of the information regarding autism because you might think we haven't
even talked about autism. However, I would hold off on that thought. So cytochrome C
oxidase. Remember this has four red light chromophores from the cause of autism episode
from 620 to 860 nanometer light. This process creates water. The electrons we've been transferring
and creating and the oxygen that's being created into water. Light. Remember the light story
the whole purpose of this topic. Light charge separates water. Water equals H plus the hydrogen
and oxygen and two electrons. So how does light create more water? We've established light
is electromagnetic. Understand it? We've established autism is a light story. Low electrons, low
melanin is a modern human phenomena. Also we've established isolated light, especially blue
light, dehydrates cells. Well this is it. This is where the damage is in the lipid rafts
of the process of exchanging these molecules from smaller molecules and transferring them
down the process. And here is a big takeaway because we've now explained the creation of
water and the mitochondria. Not all water is equal. It changes its physics based on
the environment it's in. Mitochondria is the reverse process of photosynthesis. Instead
of producing oxygen and sugar like the photosynthesis of a plant, the mitochondria produces carbon
dioxide and water. This water is an electromagnetic capacitor. It is a battery. An old car battery
uses this process. A key note here is water is a dipole, meaning the electrons has negative
charges and protons as positive charges. You know that we are creating electrons and
protons which are crucial ingredients to this process. Now you can understand that the
iron and some oxygen and water, the magnetic properties of these elements are crucial.
In addition, water is a paradoxity, meaning it is very responsible for the clock timing
mechanisms occurring within this mitochondrial matrix. Our clock timed mechanisms are crucial
and that begins in the SCN. We've discussed the SCN. How and when are all of these elements
and these biological ingredients functioning are critical. And another note about the water
here in the mitochondria and just water in general. Water is very heat tolerant and we
want our mitochondria to be this heat and dissipative structure. We want massive amounts
of energy and production here. Mother Nature chose water. It uses water accurately here.
It's by design. Water with heat tolerant, it can endure so much and be very reliable.
You can also remember melanin from the cause of autism episode. How melanin is also very
enduring and can absorb all frequencies of light. The light which is, you know, a vast
component of this story and also within melanin being that neuroprotective. We've discussed
that neuroprotective role here. It keeps this process functioning. Different light has different
effects on water, has different effects on our electron transport chain. Light has different
effects on the glucose getting to the cytoplasm released from the organs. Light, remember the
pom-C story. Remember now that we've discussed glycolysis and remember the previous conversations
about pom-C. Pro, opioid, malano, cortin and how cortisol and alpha malano site stimulating
hormones, the melanin found throughout the body on the surface and deep inside of us
and tissues and organs are implicated from the light source. Melanin here is a different
story. Melanin and light takes the water and is the semi-conductive properties. It uses
this in a dissipative structure. In other words, it is a method of creating more energy
and remember the pom-C and how insulin is generated from here, from CLIP, CLIP. If glucose
is affected and insulin sensitivity is infected, the process getting to the mitochondria for
glycolysis are implicated. Remember the blue light, our modern light now, about 440 to 480
nanometer light. That's modern LED and tech light. Most, nearly all of the light exposure
humans get now falls within this range and this dehydrates cells. Now maybe you can understand
why. We've talked about cytochrome c-oxidase. These dehydrated cells, the implications to
water production from cytochrome c-oxidase will cause hetero plasma which is a decrease
of water and this is where disease manifests in the body. This is lower dissipative ability.
Meaning as we age, water production drops. Okay, so there's an understanding that humans
are roughly 70% water or so. I don't know what the paradigm suggests but at birth we
are about 80% water and that is shown to be we decrease water about 10% every decade.
Now Doug Wallace is a good source of this and so is Jack Cruz. As we age and reduce our
water production we need to increase the electrons getting to the mitochondria level to produce
more water. We have to supplement our aging and the decrease of electrons with proper,
that's key here, proper electromagnetic fields. The melanin story which is frequently discussed
or mentioned at least throughout the several episodes of the podcast. This is underrated
here too. Melanin charge separates water like no other element or molecule in the human
body and lastly on the cytochrome c-oxidase for now. I mentioned there are four red light
chromophores and this one protein. Why are there four red light chromophores and cytochrome
c-oxidase? Why and how are humans using this? Especially with our modern light. Based on
some information from a decentralized neuro surgeon, he has over 10,000 surgeries in his
career. He suggests that the red light chromophores and cytochrome c-oxidase where water is produced
links the entire mitochondrial matrix including the protein metabolism, the TCA cycle glycolysis
and the red light chromophores. Red light is what spins the FO head and ATP synthase
which is the fifth and final cytochrome. Now you can understand maybe you can kind of attach
the rates of autism follows almost identically with the sources of light. One, the timing
of artificial light that we are under beginning back in the 1930s with an incandescent type
all the way up through the LED production and the shift to LED and now technology, technology
follows essentially every single human being especially around the ages of 6 to 8. I guess
maybe closer to 8 to 10 people are getting cell phones now and autism is a generational
issue. With this light exposure people's water production is decreasing and our melanin
inside of us is decreasing. This is why light and melanin are the key candidates for the
cause of autism. The light exposure follows identically the rates of autism. And second
thing we need to consider is that power source the sun spectra at 280 to 3100 nanometers our
biology is missing those components. Okay so we make water and now let's get to the
cytochrome 5 which is ATP synthase ATPase. The hydrogen charge separated in cytochrome
c-oxidase to produce water that charge separation or protons. The protons are H plus ions,
positive charged ions this is hydrogen. On the ATPase is an FO head. FO is a proton
channel. In ATPase the head spins 9000 to 12000 times per second and every 3 or 4 spins
creates 1 ATP. Okay so here's some more magnetic properties here the FO head with that spinning
that rapid spinning creates a magnetic field. This is a quantum nano rotary engine that
works on red light. Where are modern humans getting red light? Remember the rant just
a couple of minutes ago the sun is 43 to 47 percent red but it requires humans to spend
time under it and remember our photosynthesis. Okay so why the red light? You remember from
the cause of autism episode and probably some other episodes that red light penetrates the
body deeper than any other specter of light including bones. Red light penetrates bones
and remember the antioxidant effect here with the with the cancer treatment. Red light
is very powerful against carcinoma and tumors and that is shown in many many articles in
PubMed. In addition what people might fail to understand is our mitochondria is where
95 percent of our melatonin is generated. Melatonin is a light hormone that works at night the
absence of light and this is our number one antioxidant. So this is all from longer wavelengths
of light on one side of the sun spectra but also you can kind of come together here and
understand that this is more and more of the light story light water magnetism with the
light story it doesn't just include those longer wavelengths of light vitamin D receptors
are involved. Okay so more sun this is UVB remember the biosynthesis discussed in autism
and gastrointestinal problems it goes the biosynthesis it goes pre vitamin D2 and D3
is 216 nanometer light. Tachysterol the next process is 280 nanometer light and then pro
vitamin D3 is 293 nanometer light and then we get to vitamin D the full synthesis of
vitamin D is 312 nanometer light. The VDR blocks electron transport chain but that's
okay here that just means we don't need to eat as much when we are outside if you've
ever noticed that maybe you don't eat as much whenever you're outside in the sun that's
because that glucose used during glycolysis is kind of supplemented here with the VDR
structures. Our photobiomodulation and the mitochondria as dissipative structures in
the sense of nonlinear optics used in human biology. Healthy human biology is built in
mechanism to create energy and we do this we've discussed pom-C and that release of
cortisol and that coincides with glucose this is what it's all about we evolved under
the sun and this natural electromagnetic fields we've taken the electrons from the
sun and used it for energy production inside of us inside the so-called powerhouse of the
cell. Modern humans and all of our chronic diseases are electron deficient. Most ATP
from the cell happens from sun on cytochrome c-oxidase and ATPase from infrared and UV
on VDR receptors. Now you can begin to understand the obesity epidemic. Now you can understand
type 2 diabetes. Remember how we've mentioned the insulin sensitivity and the release of
glucose and metabolizing all of this energy production. Obesity is a cause of people
losing energy to the environment. It's not all cases of calories in versus calories
out food intake and the lack of movement and exercise. Now the lack of movement and exercise
could be explained here too because people don't have energy because they're not they're
not producing water. For the autism story now you can even understand the roles of autism
and metabolism and autism and inflammation. Cells and our biology are not adapted to our
new environments. You understanding this? We are adapting but these are not healthy adaptations.
Autism is neuroplasticity to our light and energy change. Research and people's beliefs
are in the wrong place. There are all of these autism and XYZ. I am tired of autism and XYZ.
I am tired quite frankly of autism and allergies or autism and eczema or autism and gastrointestinal
problems. Autism and dyspraxia. Autism has a higher rate of higher chance of Alzheimer's
and Parkinson's. On that note you ought to be able to understand a little bit better
now the role of light and these rapid cognitive declines that we are now seeing. And I've
said Alzheimer's is a reverse process of autism. Hopefully you can kind of make sense
of this. Now as we discussed the cell metabolism, the way that the cell is functioning, the
powerhouse with autism you know the problems exist on the cellular level and the synaptic
level. The cellular level here is explained. This is why cells aren't developing. Also
to note that remember our genes response to the environment. In other words our environmental
signals informs the genes how to respond. The environmental signals are the cues for
DNA sequencing and guess what? In the cell nucleus the organelle of DNA sequencing and
mitochondria are closely related. Genetic studies receives much attention. There's a
lot of money thrown at GWAS studies. This genome sequencing and genome-wide understanding
and with autism there are over 100 so-called risk genes. Now what this is saying is there
are many complicated factors here. There are many genes involved that might cause autism
or might not cause autism. This because you have duplications or deletions, copy number
variants and so forth of this gene. Well it might mean autism. In my opinion autism
research because of the amount of funding and attention thrown at it. But the genes
has reached a dead end and at the dead end it takes bulldozers and just kind of barrels
through trying to find some sort of hidden treasure. And this is all wrong. The genes
of humans the DNA is vastly different than the mitochondria genes. Mitochondria has
its own DNA. There are only 37 total for mitochondria. Now this is a huge difference and with everything
we've just discussed you ought to understand that huh mitochondria is very important to
the cell health, to our life. Not only is it just 37 genes but the cytochromes, the powerhouses,
the source of energy processing these electrons and protons and creating water and creating
ATP. There are only 13 DNA responsible of the mitochondria for this function. This meaning
13 genes that we can study to really find out some more information about. What is autism?
If you are listening to the podcast or listening to the episode please feel free to leave a
review or rating. In podcasting reviews, ratings and downloads are crucial and I very much
appreciate your feedback. You can contact me on X at RPS 47586. We can have discussions
about autism and especially the cause of autism. These atomic molecular levels. You can email
me info.fromthespectrum.com. Thank you for listening to From the Spectrum podcast.