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Prepare to have your health questions answered here on Safe, Effective, Natural Solutions

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with Dr. Todd Binkley, owner of Binkley Healing Center in downtown Ventura.

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Now, here's Dr. Todd.

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Good afternoon.

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I'm Dr. Todd Binkley, board certified doctor of non-force, chiropractic, and practitioner

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of functional medicine.

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Functional medicine means using standard diagnostic tests that any doctor can do, but most doctors

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don't because usually your insurance doesn't want to pay for them, but it's more affordable

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than you might imagine to get a result that if you're in a situation where some doctors

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told you there's nothing wrong with you or there's nothing that can be done, there often

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is by improving your diet, exercising, and supplementing nutrients where identified on

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diagnostic evidence-based testing.

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The focus of today's talk is again going to be Alzheimer's, the fourth in a series of

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shows I've done about dementia in general.

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And at the end of the show, time permitting, I'm going to talk about some things, some

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specific things that anyone can do to have a fighting chance to give your, to heal your

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brain and to give your body a fighting chance to avoid the devastating effects that happen

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when your brain deteriorates, when you lose blood flow to your brain, when you lose brain

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cells.

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One of the most exciting research into this realm that's come out in the past few years

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and more recently published in November 2023 in the Journal of Alzheimer's Disease is the

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Bredesen Protocol.

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Dr. Dale Bredesen has been studying and developing a much better model for treating people with

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dementia and more importantly preventing and reversing dementia because most people wait

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until it's too late.

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So the problem is standard clinical trials have a single predetermined treatment modality,

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meaning there's a pharmaceutical company typically that develops a drug to treat and try to remove

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one specific type of basically scar tissue from your brain like beta amyloid plaque or

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neurofibular retangles.

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The problem as Dr. Bredesen states it, and by the way, who is Dr. Bredesen?

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Dale Bredesen MD is an internationally recognized neurologist with special expertise in the

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mechanisms of neurodegenerative diseases.

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He's the senior director of precision brain health at Pacific Neuroscience Institute and

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the chief scientific officer at Apollo Health.

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He's a neuroscientist, professor and author of several books in the field of neurodegenerative

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diseases and he's developed and directed over 30 years of laboratory research focused on

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the mechanisms underlying neurodegenerative diseases such as Alzheimer's.

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And you can read that on his website just like I just did.

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The point is his work is really amazing.

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No one else has figured out a way to actually reverse dementia.

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The standard drug trials that basically govern what everyone is currently being treated for

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everyone in America throughout the Western world, most of the world who has dementia

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is being treated with pharmaceutical drugs that don't work because they're only trying

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to treat one tiny aspect of complex condition that has at least 200 contributory factors

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and dozens of known and well-researched components that are addressable if you address all of

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them at the same time and not just one of them with a drug that has side effects and

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doesn't even work for its targeted effect.

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Where 400 clinical trials have failed to demonstrate a sustained clinical effect.

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The best they can do is not show any cognitive improvement at all but or even stabilization

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of the dementia but merely reduce the rate of the progression by maybe a third for a

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few years.

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Is that really good enough?

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I don't think so and Dr. Bredesen doesn't think so either.

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So the study entitled Precision Medicine for Approach to Alzheimer's Disease Successful

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Pilot Project uses a more comprehensive evaluation of each patient's genetics and biomarkers

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to try and figure out and optimize a personalized precision medicine protocol for each.

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And so this is a study led by three integrative physicians Dr. Kat Toops, Dr. Anne Hathaway

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and Deborah Gordon along with Dr. Bredesen.

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As mentioned in previous episodes I have had the privilege of seeing live presentations

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given by Dr. Toops, Dr. Hathaway and Dr. Bredesen earlier this year just a few weeks ago in

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fact and their proof of concept trial included 25 participants aged 50 to 76 all with mild

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cognitive impairment pre-Alzheimer's or early stage dementia.

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And each patient was assessed for multiple potential contributors such as inflammation,

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insulin resistance, nutrient and hormonal deficiencies and specific pathogens, toxins

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and genetics and then treated with a personalized protocol that was continued for nine months.

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So this proof of concept trial with 25% participants was published in the Journal of Alzheimer's

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Disease in 2022 but it began in 2012.

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In 21 of the 25 84% showed significant improvement and they still have less cognitive impairment

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and dementia than when they started the program over 10 years ago.

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Their MRI scans show that after nine months instead of an expected 2.2% shrinkage that

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average people have total gray matter the part of the brain where memories are stored

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their gray matter actually grew by 0.3% per year and most importantly shrinkage of the

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hippocampus.

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The hippocampus is the file clerk part of the brain that often goes bad first which

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causes this inability to store new memories.

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The hippocampus improved by 63% and the people on this protocol.

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So study participants had brain MRI scans at the start of the study and after nine months

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and they were evaluated by special software that evaluates and I don't want to go too

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much into this detail but the bottom line is they're documenting this both with blood

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tests and with the standard questionnaires that neurologists use to evaluate cognitive

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impairment and Alzheimer's blood tests the questionnaires and MRI scans that actually

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show changes in the brain on the scan.

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So one of the lead authors on the study Dr. Kat Tubbs noted quote I have been principal

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investigator on more than 20 long-term clinical trials for patients with mild cognitive impairment

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and dementia where the benchmark for success was merely slowing cognitive decline.

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This trial is the first to show actual improvement in multiple domains of functioning as well

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as improvements on MRI brain scans.

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This is incredible and most people are never going to hear about it because it's not yet

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part of the practice of standard medicine.

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Most neurologists don't do this.

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Most neurologists don't even know about this because they're just focused on the standard

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practice of conventional medicine one drug for one condition cross your fingers hope

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it works even though 400 times it's failed.

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It fails almost every time because there is no single cause for dementia.

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It's caused by so many different things and so if you just identify a half a dozen or

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even better a dozen of the most common causes of insult to the brain loss of blood flow

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insufficient nutrients etc. amazing things can happen including not just the slowing

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of dementia but reversal.

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So addressing these root causes in this type of functional medicine approach has previously

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led to the publication of a case study called reversal of cognitive decline 100 patients.

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Email me if you would like the copy of that study it was published in 2018 in the Journal

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of Alzheimer's disease and Parkinson ism and it outlines the progress of patients in their

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50s 60s 70s and 80s over several years on the protocol at six different sites around

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the country.

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A larger randomized controlled trial is currently seeking participants at sites in Miami Cleveland

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Nashville Sacramento and the Sacramento Bay San Francisco pardon me San Francisco Bay

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area currently recruiting still recruiting patients for an ongoing trial to find out

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more about this go to dementia reversal trial.com.

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So this this currently ongoing randomized controlled trial at six sites around the country to find

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out more about that and perhaps even enroll in it go to dementia reversal trial.com.

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I'm Dr. Todd Binkley you're listening to safe effective natural solutions to almost any

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health challenge today we're talking about actually reversing dementia Dr. Anne Hathaway

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one of the co-authors on the study with Dr. Bredesen commented quote with this precision

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medicine approach I've witnessed person after person regain lost brain function get back

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to their life's work reestablish friendships or start new creative activities.

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It's very gratifying to share this success publicly can you imagine a world where Alzheimer's

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is a rare disease.

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Well a lot of things will have to change for that to happen but the point is it's possible

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not just theoretical but actually proven with scientific dated data Alzheimer's dementia

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is a form of chronic encephalitis inflammation of the brain that was that represents a response

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to various insults.

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So the goal is with the Bredesen protocol to identify and address all the factors associated

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with this complex phenomena and it involves several things.

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Number one improve blood flow to the brain with better food exercise and supplements

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I'm going to come back to the specifics of each of these in a moment number two reverse

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diabetes and pre diabetes mainly with better food exercise sometimes supplements can help

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with this number three test for cholesterol and other lesser known and even worse bad

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fats and reduce them without drugs without taking statins Lipitor or Torvastatin Simvastatin

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etc.

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Number four maximize provision of essential nutrients to the brain most doctors never

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even think about this when you maximize essential nutrients to the brain with proper testing

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for specific deficiencies and eating better food and mostly considering a host of very

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well researched and relatively new supplements that most people have never heard of amazing

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things can happen and it's different for everyone I can't make any promises but for people that

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are looking for something they can do in a situation where no one else is helping them

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I've seen some really fascinating things happen number five test for inflammation and reduce

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it with better food exercise and supplements we're all subject to causes of inflammation

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and these things can be tested for and treated without drugs number six test for autoimmune

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conditions and reverse them also obviously with better food exercise and supplements

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drugs for autoimmune conditions are essential for people with severe autoimmune conditions

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but they don't often work much better than the drugs for cognitive decline and Alzheimer's

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number seven test for chronic infections like tick-borne diseases diseases viruses and bad

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bacteria in your gut and treat them with nutrients and sometimes when necessary medications sometimes

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you do need an antibiotic or an antiviral or some other kind of drug to kill off a bug

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and your gut but you don't know that unless you test for it and and that's not the most

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certainly not the most common contributor to Alzheimer's disease it's just something

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that Dr. Bredesen has included because if someone everyone is different you're as different

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on the inside as you are on the outside and one of these things could be a major contributor

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to your condition number eight test for toxins that all of us are exposed to to varying degrees

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heavy metals like lead mercury uranium cadmium arsenic chemical toxins like pesticides and

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chemical fertilizers that we all breathe in from conventional farms nearby that end up

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in our drinking water mold toxins that end up stored in our bodies throughout our lives

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even from brief exposures to some mold that you maybe saw or maybe never even saw in your

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home garage workplace whatever and then once identified establish a specific protocol for

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helping your body flush out these toxins safely and effectively so it's understandable if

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you've been listening closely to all of those elements of the Bredesen protocol your head

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might be spinning now oh my god who could do all of that well it depends on your motivation

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your age and what's possible for you everyone is different that's the whole point of getting

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precision medicine getting a personalized evaluation so if you come to see me I'm not

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going to recommend all of those things for every single patient that's something that

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Dr. Bredesen has been able to do and get dramatic results for but it's important to understand

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that even those eight things that I just talked about to review improve blood flow to the

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brain reverse pre-diabetes and diabetes improve cholesterol and other bad fats maximize provision

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of essential nutrients to the brain test for inflammation and reduce it test for autoimmune

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conditions and reverse them if possible test for chronic infections and treat them and

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test for toxins so not everybody needs all of those things these are things that functional

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medicine practitioners address in every patient that comes to our office every day starting

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with a simple case history so no one needs necessarily no one on the protocol on the

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Bredesen protocol got all of those things no one needs all of those things the point

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is it precision medicine means treating the patient not the disease identifying what a

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particular person in front of you is missing what's preventing their brain from healing

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and repairing itself what's possible to facilitate the reversal of dementia in this person versus

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the standard medical protocols that are used to develop all the does all the useless drugs

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that people are taking for Alzheimer's that create very temporary slight improvements

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and no long-term benefit their goal for a lot of these testings are stated as slowing

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decline who wants to slow the decline if you want to reverse it it basically means taking

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better care of your health in specific ways which can be identified number one this is

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the point of seeing a practitioner of functional medicine the most important test you do is

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meeting with someone who does anything other than conventional medical practice and just

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prescribing you a drug go to a functional medicine practitioner and get a good case

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history and some basic blood tests that's the starting point so simple blood tests and

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a good case history can identify what you might need to improve blood flow to your brain

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and reverse pre-diabetes and diabetes and your lipid profile your cholesterol levels

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and there's a whole bunch a whole host of other fats I don't want to get too much into

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that I covered it last month in the cardiovascular podcast but there's a bunch of other bad fats

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cholesterol is not a very good test of your heart health or your brain health or any other

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aspect of your health there are much better tests that most doctors don't do they're

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widely available we'll come back to that or send me an email number four maximize the

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provision of essential nutrients to the brain so this is the most important so the first

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three you know most doctors do some of that most doctors will prescribe you know tell

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you to eat better and exercise good that often doesn't help that much most doctors will put

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you on metformin or some other drug to help you with diabetes or pre-diabetes and most

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doctors will put you on a statin drug to lower your total and bad cholesterol but you know

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those what's the what's the verdict on that it's not it's not that great so maximizing

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the provision of essential nutrients to your brain is huge it just it just makes sense

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your bloodstream is a river of life construction projects are there's crews waiting on both

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river banks just imagine this go with me on this metaphor there's a river of life with

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construction crews on both banks waiting for the materials necessary to heal and repair

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things that are obviously need repair but if the materials to do the job are not available

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then that project just just gets put on hold indefinitely this is what happens with loss

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of brain tissue so when you flood your brain when you flood your river of life when you

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flood your bloodstream with nutrients that make their way to the brain to provide it

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with the nutrients it needs to heal and repair itself even people in their 80s you know it's

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i i i only say that because so many people show up in their 80s when they have severe

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dementia in my office i'm trying to get you to tell people who are in their 50s and 60s

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or even earlier to come in and get tested to find out when we can really get amazing

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results and completely completely reverse the devastating effects of dementia i'll come

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back to a couple of important tests that we can do that with but just to finish the list

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here not everyone has an autoimmune condition not everyone has chronic infections and not

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everyone has well actually everyone does have toxins but whether or not they have enough

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of them to contribute to mild cognitive impairment or dementia is different for everybody so

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those last three things are based on testing and that reticent protocol is based on testing

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so if you come to see me i will there are ways that i can find out when you come to

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see me with a simple case history and some kinesiology or muscle testing can give me

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a good idea which tests would be most important for you or someone you are concerned about

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most people wait till they have symptoms so they have memory loss so they have some of

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the other symptoms of dementia and this is just normal human behavior i don't want to

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you know i'm not trying to blame anybody for this this is what we all do but i'm just trying

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to encourage you to start earlier if you have a family history of dementia definitely get

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tested early get the APOE gene test which you can get through lab core or quest for

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seven or eight hundred dollars or maybe you can get your insurance to cover it if you

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can get any doctor affiliated with your insurance company to order it for you or you can get

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it for 150 bucks through 23andme and even more importantly well or as importantly there's

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an there's a relatively new test or at least the research on it substantiating its value

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was just published in the journal of american medical association in january of this year

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to be as accurate as much more invasive cerebral spinal fluid testing so usually you had to

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go in and get a spinal tap to see if you had this particular tau protein in your body indicative

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of the damage this scar tissue basically that forms in your brain to identify early dementia

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as early as possible so that you can start treating it earlier and it's called p tau

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217 and here's a study that was published in jamma the average age of the 786 participants

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was 66 years old and the study suggested that it would be valid for predicting risk and

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people much younger than this as accurately as having a much more invasive spinal tap

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so and again unfortunately most doctors don't order this test you can always ask if you

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have a great relationship with your doctor and your doctor is young especially and even

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more so a woman i'll be sexist there i said it women doctors are more likely to be progressive

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in my experience than old white guys like me and these tests that can identify early

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signs of dementia early enough to treat them with better food exercise and supplements

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are are things like p tau 217 p is in paul t a u 217 the one i just spoke of and also

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p tau 181 phosphorylated tau proteins these are basically proteins that identify scar

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tissue that is beginning to form in the brain as a result of normal brain cell turnover

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they're not it's not like identifying a bacteria or some kind of infection these are things

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that are always present they're a function of normal brain cell turnover but if they're

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elevated then it gives you an indication and hopefully a motivation to do something different

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so i can order these tests for a little over 200 dollars through lab core it really should

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be available and covered by insurance by your general practitioner but i'm providing this

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information for those who are frustrated or properly motivated and can't get it ordered

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these tests are available and extremely useful for identifying is it worth the expense and

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will they motivate you to change your lifestyle to eat better food and exercise more and maybe

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take a few supplements to to flood your brain with the nutrients it needs to heal itself

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you've been listening to safe effective natural solutions to almost any health challenge and

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early cognitive impairment and dementia is one of the greatest challenges for so many

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people i'd love an opportunity to identify the specific ways that someone you are concerned

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about could potentially reverse the effects of dementia email me with your questions and

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please tune in next friday at 4 p.m right here on kdar 98.3 fm have a fantastic weekend

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you've been listening to safe effective natural solutions with dr. tod binkley if you have

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a health question you want discussed on the show email your health questions to dr. binkley

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at binkley healing center dot com take advantage of this opportunity to ask questions for yourself

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and for your loved ones because our health matters join him next friday at 4 p.m for

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safe effective natural solutions right here on 98.3 the word kdar

