WEBVTT

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There are a lot of women out there who don't

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quite feel right. They've had the test done.

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The tests all look normal. Women are under -researched

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anyway. We've stopped listening to the patient

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in front of us. Six minutes is enough time to

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say hello, write a script, say goodbye. There's

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also an element of women being told their pain

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is not real. I almost missed that too. I said,

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you know, I believe you. So many of us don't

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know who we are anymore playing roles that's

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why when it comes to perimenopause and your hormones

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say you know what fuck this shit when we fall

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off The wagon in perimenopause, we fall off spectacularly.

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It is not acceptable to not have that conversation.

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The only person we have to really live with for

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life is us, women in their 40s particularly.

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They really need to start loving themselves as

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much as they've loved everybody else. The 40s

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Formula. The 40s Formula. The 40s Formula. Hosted

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by Jasmine Dillon. Integrated health strategist

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specializing in gut health, hormones and midlife

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well -being. And Amanda Lim, director of Lift

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Clinic and a leading expert in female strength

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and metabolism. Named one of CNA's top podcasts

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and winner of the 2025 Asia Podcast Awards in

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the Best Health and Wellness Podcast category.

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The 40s Formula is your no fluff, science meets

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real life guide to thriving in your 40s. Have

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you ever noticed that your body reacts differently

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in your 40s? Your sleep feels lighter, anxiety

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feels louder, and energy is less predictable.

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And even though you're not doing less, things

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suddenly feel harder to manage. A lot of women

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experience this and struggle to explain why,

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because the symptoms just don't sit in one place.

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Our guest today is Dr. Olivia Lee -Lesler, an

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Australian medical doctor and an expert in psychoneuroimmunology

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and longevity medicine, known for her ability

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to connect the dots across complex, multi -system

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conditions that don't fit neatly into conventional

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frameworks. Before we get going today, we need

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your help. Subscribing is what allows us to bring

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you the people you want to hear from and the

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conversations women in their 40s actually need.

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So if this show helps you feel seen, understood,

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or less alone, That support really matters to

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us. Hi, Olivia. Thank you for joining us today.

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Hi, thank you so much. You know, it is my first

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podcast this year. Oh, thank you for kicking

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off the year with us. We're really honored to

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have you. Thank you. Oh, we are really excited

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for this conversation because there are a lot

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of women out there who don't quite feel right,

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but don't know what's going on. They've had this

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out there. In here as well. Yeah, I mean, I think

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you're 100 % right there. But, you know, they've

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had the test done. They know something's not

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the way it should be. The tests all look normal.

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What is going on with these women? Well, first

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of all, we all know that women are under -researched

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anyway. So we don't fit very neatly into all

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the algorithms that doctors have because a lot

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of those algorithms are actually built off men.

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And actually, specifically, white American men.

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There's no doubt that there are plenty of people

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and women who fall out of those algorithms. And

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so it's a little bit harder to pick up. I mean,

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what's the statistic? It's something like six,

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seven, eight years to get diagnosed with endometriosis.

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Yes. Right. And it's not the only thing that

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gets missed. So the reason why a lot of people,

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they don't feel quite right, but nobody can sort

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of tell them what's wrong is because too many

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doctors, not everyone, But too many practitioners

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are going off those algorithms. We've stopped

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listening to the patient in front of us, treating

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them as a whole person, listening to their story.

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It's the system that we're in. We don't have

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time to listen to our patients. Six minutes is

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enough time to say hello, write a script, say

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goodbye. So in part, it's the system. In part,

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it's the algorithm. And in part, I think. we've

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actually also lost interoceptive capacity. Interoception

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is that ability to know what's what in your body.

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How many of us women have very good intuition

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and it gets beaten out of us in our lifetime,

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right? We're meant to be the nice girls. We're

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meant to accommodate other people. We're meant

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to be the people to regulate others. We're meant

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to serve. Whatever the role is that we have assigned

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ourselves or being assigned by society. It tramples

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on our interoceptive capacity. So many of us

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don't know who we are anymore because we are

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playing roles. That's why when it comes to perimenopause

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and your hormones say, you know what? Fuck this

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shit. Oh yeah. Right? And your kids are now off

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to school. You know, you have to discover who

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you are again. And all of a sudden you're like,

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wow, this, I don't, I don't know. And this is

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the thing, you know, you just said that women

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are not, listening to their body or they can't

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hear their body and if they can't hear their

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body how are they meant to articulate it to somebody

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else who might be able to help them that's exactly

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it and i think there's also an element of women

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being told their pain is not real and that drives

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me back to your endometriosis yeah situation

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we just recently had a guest on the show talking

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about her own delayed diagnosis of endometriosis

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Because she was already a chronic pain sufferer.

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So a lot of doctors, they hear chronic pain,

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they immediately turn off because they're like,

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oh, woman's talking about pain. It's undiagnosable,

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you know, sporadically symptomatic, whatever

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it might be. She has stage four invasive endometriosis,

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but she didn't have the words for that specific

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kind of pain. And so it was dismissed. Yeah.

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You know how many stories there are like that

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out there? And thank God for social media, which

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I mean, you know, for all its flaws. it is at

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least bringing these sorts of issues to light.

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You know, stories of women's pain being dismissed

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because there is still in the older generations,

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you know, the idea that women can be hysterical.

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The one thing that I have come to understand

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in my practice, and it was a journey to get to

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where I am, you know, and I'm still on this very,

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very long journey, I'm sure, is that you really

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have to hear the patient. I almost made, this

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mistake not too long ago, where I had a 41 -year

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-old male, and he'd been with me for a couple

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of months or so. He knew something wasn't quite

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right. Seven years, all his tests were normal,

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right? And when I'm talking to him and listening

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to him, to be honest with you, he kind of came

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across as a little bit health anxious, okay?

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And I was... Just about to label him as such

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in my head and then sort of try to do the reassurance

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thing rather than the be curious thing. Big mistake

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for a doctor. I said, you know, I believe you.

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If you say something is wrong, I believe you.

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And that changed my frame of mind so that I started

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to look at things a little bit differently and

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started to investigate things a little bit differently.

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Early onset neurodegeneration. Wow. At 41. Wow.

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I almost missed it as well. Wow. So he'd seen,

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I think, two or three previous doctors. No one

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had picked it up. He's 41. He's a high -functioning

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C -sweeter, you know. And I was brought in just

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as kind of like a consultant, second opinion.

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Yeah. And I almost missed that too. Wow. How

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did you pick it up? It was from observation.

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One of the subtle things that I noticed with

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him is that about 6 to 10, 12 hours after a heavy

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gym session, his sense of humor would change

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very subtly. And his ability to multitask changed

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very subtly. So subtle, you couldn't pick it

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up. All the psychometric testing that we did,

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you know, you didn't pick it up, right? Word

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recall, fine. He's a C -suite executive. And

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because it's so early. You know, he was still

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compensating really well until he didn't. And

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then he was able to compensate until he didn't.

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And you just had to pick it. So it was looking

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for those very, very subtle signs. I wound up

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doing a neuroquant test. So a neuroquant test

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is a scan of the brain, which shows you all the

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different volumes of different parts of the brain

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matched against age match controls, basically.

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How big that part of the brain is compared to

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other people your age. and global atrophy to

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the brain. A friend of mine happens to be the

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chief scientific officer for Alzheimer's Research

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Australia. So I was able to get a test, which

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is actually available in the US. It's a blood

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test, 97 % sensitivity for Alzheimer's, or rather

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a amyloid process in the brain that has started.

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And his was high. Does the high intensity gym

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session relate to... Your muscles are the organ

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of fight flight. So it is going to prioritize

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the remodeling. It's going to prioritize the

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maintenance of expanded tissue mass. And when

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it's prioritizing that, something has to give.

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And so at that point in time, when the energetic

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demands are the most during remodeling and maintenance,

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there is a window of neurocognitive vulnerability.

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Does that actually mean that A equals B? No,

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there's a lot more things in between, but that's

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basically what happened. But that was the signal

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that you were able to pick up on. Yeah. How interesting.

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What about women? I'll tell the story again.

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Make it a woman. Oh, actually. Oh, yeah. As I

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saw this pattern, I started to ask more questions,

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not just of him, but people that I was seeing

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outside. who were gym goers. And I happened to

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meet a female bodybuilder in Bali. And so I kind

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of said to her, you know, when you guys are bulking

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up and preparing for competition, do you get

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brain fog or neurocognitive issues? And she goes,

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oh yeah, that's common. Anybody who's shredding

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gets brain fog. I was going to say, I feel like

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it would be the shredding situation rather than

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the bulking situation. I feel like the bulking

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is probably when you feel kind of your best.

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Exactly. And the literature does show that. So

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it's not a whilst you're bulking or whilst you're

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resistance training or anything like that, that

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you get this neurocognitive fatigue. It's a delayed

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window. Right. So it's a few hours later. That

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my hypothesis is on. And it's only for in context

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of people who have constrained bioenergetics

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and susceptible individuals. It's not universal.

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And this female bodybuilder was telling me that,

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you know, cognitive fatigue or brain fog is actually

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very common. It's almost universal when you're

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shredding. Now, of course, in bodybuilders, it's

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all confounded by the fact that many of them

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are using... steroids and stuff like that. So

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too difficult to sort of sift through to try

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and find a signal. But her experiences really

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helped sort of move me along in this path. And

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I've been working on this problem for about six

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months and I just finished the paper to then

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send to potential co -authors to then have that,

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to then send it in for peer review. So I'm very

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far away from publishing. That's so exciting.

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We have a little behind the scenes of what's

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upcoming. Obviously, people come to you when

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they need answers because the first pause of

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call hasn't given them the answers, the justification

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compared to what's actually going on and how

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they're feeling. Is there a common theme that

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you're seeing, especially women in their 40s?

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Yeah. So a lot of it would be symptoms that are

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not proportionate to what's happening in their

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life. So kind of like a PMS thing. or PMDD, so

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a premenstrual dysphoric disorder, perimenopause,

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you know, and all these things are frightening

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because it's not how you would normally react

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to X, Y, Z. So that's one of the first things.

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Neurocognitive strain, fatigue, brain fog, that's

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another thing for sure. But a lot of it in the

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40s is usually sort of dismissed as perimenopause,

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which to be fair. A lot of it is, but that's

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a very complex condition to be in. And the psychoneuroimmune

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endocrine system interactions are huge. It's

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not just a label you stick on someone and you

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get them out the door with a little bit of estrogen.

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We're talking a proper life transition, a beautiful

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concert. of all the different pathways interacting

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with each other and a whole person in front of

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you that's about to walk into the next phase.

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And so to dismiss them out of hand for bits and,

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oh, it's just anxiety. I'll just get some, get

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more sleep, whatever. It's very damaging. You

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know, for women, especially who many of us haven't

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been taken as seriously as we should have been

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when we were growing up, when we were at university,

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when we were in male dominant. dominated industries

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and this is yet another opportunity for the medical

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fraternity for health practitioners to step up

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and to validate someone's experience i think

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that's the thing a lot of women just don't have

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the capacity whether it's the physiological capacity

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or the psychological capacity everything just

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feels so much more limited in what they can do

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I've heard you speak about communication, like

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your body is trying to tell you something. Can

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you go into that for us? I truly believe that

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generally speaking, your body is trying to protect

00:14:50.100 --> 00:14:52.740
you. It's literally survival, right? It is going

00:14:52.740 --> 00:14:56.480
to implement physiological and behavioral patterns,

00:14:56.620 --> 00:14:59.460
which are going to hopefully help you survive

00:14:59.460 --> 00:15:01.539
in whatever environment you find yourself in.

00:15:02.440 --> 00:15:09.600
So when we see people with an itch we know from

00:15:09.600 --> 00:15:11.700
an evolutionary perspective that that itch is

00:15:11.700 --> 00:15:16.039
actually meant to help you scratch off a pathogen

00:15:16.039 --> 00:15:19.179
or something trying to get in asthma with the

00:15:19.179 --> 00:15:21.519
constriction of the bronchioles is to prevent

00:15:21.519 --> 00:15:24.960
a possible issue going deeper into the lungs

00:15:24.960 --> 00:15:28.500
which is a lot harder to get rid of so i see

00:15:28.500 --> 00:15:32.000
symptoms as your body trying to protect you in

00:15:32.000 --> 00:15:34.240
some way, shape or form. And it's responding

00:15:34.240 --> 00:15:37.279
to a threat, which does not have to be overt

00:15:37.279 --> 00:15:40.200
or objective for that matter, which is why one

00:15:40.200 --> 00:15:44.740
person's threat is another person's eh. And so

00:15:44.740 --> 00:15:47.860
a lot of it is about perception, not necessarily

00:15:47.860 --> 00:15:51.559
prefrontal cortex perception. You know, it can

00:15:51.559 --> 00:15:54.320
sometimes be a subconscious perception. Some

00:15:54.320 --> 00:15:56.080
of these things are running, these scripts are

00:15:56.080 --> 00:15:57.720
running in the background that we have no idea

00:15:57.720 --> 00:16:01.600
about. Then you can sort of go into the epigenetic

00:16:01.600 --> 00:16:04.960
stuff, intergenerational, transgenerational traumas.

00:16:04.960 --> 00:16:06.840
I mean, there is a lot of research and evidence

00:16:06.840 --> 00:16:08.879
for stuff like that. Actually, I was talking

00:16:08.879 --> 00:16:13.480
about the cherry blossom mouse study to someone

00:16:13.480 --> 00:16:16.860
recently. And basically what they did was they

00:16:16.860 --> 00:16:19.700
had a generation of mice and they exposed them

00:16:19.700 --> 00:16:22.019
to the smell of cherry blossoms and then they

00:16:22.019 --> 00:16:25.500
electrified the floor, causing them pain. Wow.

00:16:25.620 --> 00:16:29.289
So then, of course. They associate the smell

00:16:29.289 --> 00:16:31.509
of cherry blossom with pain. So when the smell

00:16:31.509 --> 00:16:36.309
comes down, they're then hiding. They had pups

00:16:36.309 --> 00:16:39.669
who were also afraid of the smell of cherry blossom.

00:16:39.909 --> 00:16:41.590
But had never been electrified. But had never

00:16:41.590 --> 00:16:44.509
been electrified. And had not had any contact

00:16:44.509 --> 00:16:48.370
with the parents. Wow. So it wasn't like... So

00:16:48.370 --> 00:16:50.909
they were just separated from birth. Right. And

00:16:50.909 --> 00:16:54.090
so did the grand pups. Wow. That is incredible.

00:16:54.110 --> 00:16:57.000
And then... So meaning they tracked it for two

00:16:57.000 --> 00:16:58.960
generations. Right. Well, and then the third,

00:16:59.000 --> 00:17:01.340
the great grandpups were fine. So, you know,

00:17:01.340 --> 00:17:03.980
there is something to be said about intergenerational

00:17:03.980 --> 00:17:06.930
and transgenerational issues, trauma. And that's

00:17:06.930 --> 00:17:09.710
just a smell, girl. Imagine some of the things

00:17:09.710 --> 00:17:12.170
that your patients and folks that we see as well

00:17:12.170 --> 00:17:14.730
are telling us. And this is encoded because it's

00:17:14.730 --> 00:17:16.950
going to help you with survival. Exactly what

00:17:16.950 --> 00:17:18.710
we were saying about some of these symptoms that

00:17:18.710 --> 00:17:21.130
women are experiencing. It's their body trying

00:17:21.130 --> 00:17:23.869
to make sense of this world that we find ourselves

00:17:23.869 --> 00:17:28.210
in, where we have ancient genes and an ancient

00:17:28.210 --> 00:17:31.670
brain trying to survive in a modern world. And

00:17:31.670 --> 00:17:36.410
a lot of our responses were. adaptive at some

00:17:36.410 --> 00:17:41.130
point but are now maladaptive and then we pathologize

00:17:41.130 --> 00:17:44.670
them instead of going let's be curious what's

00:17:44.670 --> 00:17:48.029
happening here how do we calm your system how

00:17:48.029 --> 00:17:52.630
do we let your body your heart your mind know

00:17:52.630 --> 00:17:56.430
that you are indeed safe how do we develop coping

00:17:56.430 --> 00:17:59.930
mechanisms how do we increase resilience how

00:17:59.930 --> 00:18:03.329
do we increase bandwidth like these are the questions

00:18:03.329 --> 00:18:07.849
that we should be doing asking instead of pathologizing

00:18:07.849 --> 00:18:11.190
everything and then the quick fix is a drug to

00:18:11.190 --> 00:18:14.230
numb there you go because that's not treating

00:18:14.230 --> 00:18:18.109
the actual issue no and it can increase bandwidth

00:18:18.109 --> 00:18:20.250
which is very important for some of us right

00:18:20.250 --> 00:18:23.809
yeah a an anxiolytic you know something to help

00:18:23.809 --> 00:18:25.750
with anxiety something to help with sleep can

00:18:25.750 --> 00:18:29.640
really help just put you in a position where

00:18:29.640 --> 00:18:32.960
you can begin the work of building your resilience.

00:18:33.519 --> 00:18:36.380
And sometimes that's a week and sometimes that's

00:18:36.380 --> 00:18:39.480
a year and sometimes that's forever. There's

00:18:39.480 --> 00:18:44.539
no shame with that. But when we doctors are in

00:18:44.539 --> 00:18:47.539
a position of authority where we tell someone

00:18:47.539 --> 00:18:50.259
that they're broken and that their only salvation

00:18:50.259 --> 00:18:53.160
is in this script, that's what I have issue with.

00:18:54.190 --> 00:18:56.089
And I think that is where the medical profession

00:18:56.089 --> 00:18:58.910
has unfortunately evolved to to quite some degree.

00:18:59.009 --> 00:19:01.490
And I think I see that even more here in Singapore.

00:19:01.569 --> 00:19:03.470
I don't say blind trust, but that's what comes

00:19:03.470 --> 00:19:08.170
to mind of physicians and medications. I do feel

00:19:08.170 --> 00:19:11.549
like there's less of a critical eye on anything

00:19:11.549 --> 00:19:14.289
the physician says here and any drug that's prescribed.

00:19:14.609 --> 00:19:16.609
Anytime you go to the doctors here, you know,

00:19:16.609 --> 00:19:18.809
you'll come back with a bag full of medicines.

00:19:19.049 --> 00:19:23.329
It's like, OK, which one do I really need? Exactly.

00:19:23.529 --> 00:19:25.910
So I suppose, I guess it's cultural in Asia maybe.

00:19:25.950 --> 00:19:28.849
But you know, in Australia, the TGA, which is

00:19:28.849 --> 00:19:33.609
like the equivalent of the FDA, they are funded

00:19:33.609 --> 00:19:38.109
by industry at the highest percentage in the

00:19:38.109 --> 00:19:45.410
entire world. 96, 94 % of the TGA is funded by

00:19:45.410 --> 00:19:48.579
industry. I'm not saying that that in and of

00:19:48.579 --> 00:19:51.559
itself is bad, but you can understand why our

00:19:51.559 --> 00:19:55.559
algorithms are very heavily skewed towards pharmaceuticals.

00:19:56.579 --> 00:19:58.819
Are pharmaceuticals inherently bad? No, of course

00:19:58.819 --> 00:20:02.259
not. This is a very nuanced topic, but I think

00:20:02.259 --> 00:20:05.200
that it's important for us to know who the players

00:20:05.200 --> 00:20:07.019
are, to know how much influence those players

00:20:07.019 --> 00:20:09.220
have, so that we can make informed decisions

00:20:09.220 --> 00:20:15.930
about how we practice the art of medicine. Because

00:20:15.930 --> 00:20:20.509
medicine does require us to interact with a person

00:20:20.509 --> 00:20:25.670
and all their fabulous genetic, social, psychological,

00:20:25.910 --> 00:20:31.289
emotional components too. And sometimes patients

00:20:31.289 --> 00:20:36.910
don't want to be numbed. Sometimes patients don't

00:20:36.910 --> 00:20:41.329
want a quick fix. A lot of people I feel now,

00:20:41.549 --> 00:20:45.220
more and more, They are willing to do the hard

00:20:45.220 --> 00:20:48.599
work. And we have more tools for people to do

00:20:48.599 --> 00:20:51.799
the hard work, right? And I think that the medical

00:20:51.799 --> 00:20:55.519
fraternity has to catch up a little bit. Can

00:20:55.519 --> 00:20:57.740
we talk about how no one prepares you for how

00:20:57.740 --> 00:21:00.400
your skin changes in your 40s? Honestly, one

00:21:00.400 --> 00:21:03.740
day it's fine. The next it's dull, dry and showing

00:21:03.740 --> 00:21:06.319
every single emotion you've ever felt. That's

00:21:06.319 --> 00:21:08.599
why I've actually been loving Love Indus. Their

00:21:08.599 --> 00:21:11.160
skincare actually feels like it's doing something.

00:21:11.380 --> 00:21:13.259
It's not just sitting on your face and looking

00:21:13.259 --> 00:21:16.099
sticky. It blends South Asian ingredients like

00:21:16.099 --> 00:21:18.460
ashwagandha and vegan ghee with proper New York

00:21:18.460 --> 00:21:21.380
dermatology tech. It's luxurious, but also very

00:21:21.380 --> 00:21:24.160
results driven. Their line limiter is especially

00:21:24.160 --> 00:21:26.720
good if you're starting, like me, to notice lip

00:21:26.720 --> 00:21:29.460
or laugh lines. People compare it to Botox, which

00:21:29.460 --> 00:21:31.680
I would happily take after all those needles

00:21:31.680 --> 00:21:33.940
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So don't forget to support the show by using

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code TFF. You mentioned modern life seems to

00:21:53.960 --> 00:21:58.819
be at the sort of crux of a lot, a lot of people's

00:21:58.819 --> 00:22:01.890
problems, you know, like food. the processed

00:22:01.890 --> 00:22:06.710
food, the lack of movement, the ingestion of

00:22:06.710 --> 00:22:11.109
risky substances, maybe not being able to manage

00:22:11.109 --> 00:22:15.369
their stress properly, that lifestyle is something

00:22:15.369 --> 00:22:18.950
that can actually help in a way that maybe medicine

00:22:18.950 --> 00:22:22.690
can not deal with, but medicine can assist with.

00:22:23.359 --> 00:22:25.160
But there needs to be other changes involved

00:22:25.160 --> 00:22:27.140
as well? Yeah, absolutely. I mean, lifestyle

00:22:27.140 --> 00:22:30.619
medicine has exploded. So central because a pill

00:22:30.619 --> 00:22:35.700
is something that you do in a split second, which

00:22:35.700 --> 00:22:38.839
obviously has some effects physiologically over

00:22:38.839 --> 00:22:43.740
a longer term. But lifestyle is intrinsic and

00:22:43.740 --> 00:22:46.960
it's something you do every day for the rest

00:22:46.960 --> 00:22:48.839
of your life. And the best part about lifestyle

00:22:48.839 --> 00:22:52.009
is that it's your choice. We're bringing agency

00:22:52.009 --> 00:22:54.450
back into the room. The other thing about lifestyle

00:22:54.450 --> 00:22:57.150
as well is that because there are so many lifestyle

00:22:57.150 --> 00:23:01.289
factors, tools to choose from, you pick your

00:23:01.289 --> 00:23:04.130
own adventure. You're able to experiment and

00:23:04.130 --> 00:23:07.750
see what works for you. Whereas when we do a

00:23:07.750 --> 00:23:11.230
drug or a supplement for that matter, it's got

00:23:11.230 --> 00:23:15.589
a very defined scope and it's kind of a one -size

00:23:15.589 --> 00:23:20.029
-fits -all situation. But lifestyle is just,

00:23:20.029 --> 00:23:21.809
there's just something a little bit more fluid

00:23:21.809 --> 00:23:26.269
about it. And there are so many lifestyle pieces

00:23:26.269 --> 00:23:29.390
to choose from. And you get to decide how you

00:23:29.390 --> 00:23:33.809
want to layer those behaviors when you introduce

00:23:33.809 --> 00:23:36.869
them, when you pull back on them. The best part

00:23:36.869 --> 00:23:39.470
about lifestyle factors is that most of them

00:23:39.470 --> 00:23:44.750
are free. Lifestyle is a huge, huge part of health.

00:23:44.960 --> 00:23:47.900
No question about it. If we boil down the top

00:23:47.900 --> 00:23:50.480
five causes of death and the relationship of

00:23:50.480 --> 00:23:52.099
lifestyle to that, I mean, it's clear, right?

00:23:52.359 --> 00:23:55.799
However, talk to me about your perspective on

00:23:55.799 --> 00:23:59.960
the role of lifestyle and the role of a specific

00:23:59.960 --> 00:24:02.960
drug. So GLP -1 receptor agonist in that group.

00:24:04.400 --> 00:24:07.680
You mentioned how sometimes the use of drugs

00:24:07.680 --> 00:24:10.720
is a tool. So we're prescribing clinic for these

00:24:10.720 --> 00:24:12.000
types of drugs, which is why I'm asking this

00:24:12.000 --> 00:24:16.119
question, right? It's interesting because patients

00:24:16.119 --> 00:24:19.660
come in, half of them are like, I want to get

00:24:19.660 --> 00:24:21.319
on this drug. I want to get on it quick so I

00:24:21.319 --> 00:24:23.819
can lose weight quick. Then on the flip side

00:24:23.819 --> 00:24:26.740
of that, we have patients presenting with obesity

00:24:26.740 --> 00:24:30.500
and diabetes that don't want to get on the drug

00:24:30.500 --> 00:24:34.009
because they want to do it. the right way, the

00:24:34.009 --> 00:24:37.549
lifestyle way without the assistance of pharmaceuticals.

00:24:37.549 --> 00:24:39.109
Because it's cheating. Because it's cheating.

00:24:39.210 --> 00:24:41.990
And because I should be able to do it myself.

00:24:42.589 --> 00:24:45.730
Can you talk about how you would have a conversation

00:24:45.730 --> 00:24:48.970
with that patient? Well, first of all, anything

00:24:48.970 --> 00:24:52.549
where you constrain a person morally, right?

00:24:52.589 --> 00:24:56.109
Because they put a moral judgment on the GLP

00:24:56.109 --> 00:24:59.750
-1s, right or wrong. And anytime you have moral

00:24:59.750 --> 00:25:01.809
constraints, philosophical constraints like that,

00:25:02.370 --> 00:25:06.089
that's stress on your system, right? That's where

00:25:06.089 --> 00:25:08.869
judgment comes into play. Then you've got guilt,

00:25:08.890 --> 00:25:10.910
then you've got regret, and you've got all these

00:25:10.910 --> 00:25:13.509
other low vibration emotions that will follow

00:25:13.509 --> 00:25:16.170
constraints like that. So the first thing I need

00:25:16.170 --> 00:25:18.849
to do, talk to the patient, is actually talk

00:25:18.849 --> 00:25:22.349
about why they have these philosophies around

00:25:22.349 --> 00:25:29.700
the right or wrong of whatever it may be. doing

00:25:29.700 --> 00:25:32.059
it the right way, that's already scary. But if

00:25:32.059 --> 00:25:35.039
they want to do the work, that's different from

00:25:35.039 --> 00:25:37.140
thinking that that is the right way. I think

00:25:37.140 --> 00:25:39.559
that patients who kind of, you know, no, doc,

00:25:39.740 --> 00:25:42.319
I don't know. I'm kind of happy to sort of lose

00:25:42.319 --> 00:25:44.720
weight slowly and go to the gym. And, you know,

00:25:44.720 --> 00:25:46.980
I don't want to take that. That's very different

00:25:46.980 --> 00:25:48.900
from, no, no, no, no, no. That's bad. This is

00:25:48.900 --> 00:25:55.960
good. I personally think that GLP -1s are like...

00:25:56.200 --> 00:26:02.140
every other drug and supplement where used for

00:26:02.140 --> 00:26:05.460
the right patient at the right dose the right

00:26:05.460 --> 00:26:09.880
frequency at the right time can be very appropriate

00:26:09.880 --> 00:26:14.319
the problem when you have such a effective let's

00:26:14.319 --> 00:26:19.240
just say tool is that there is infinite scope

00:26:19.240 --> 00:26:24.900
for overshooting absolutely And we do patients

00:26:24.900 --> 00:26:30.380
no services when we assist their wanting to not

00:26:30.380 --> 00:26:34.880
do the work. Weight is not just metabolic. It's

00:26:34.880 --> 00:26:38.019
psychological. It's emotional. Absolutely. We

00:26:38.019 --> 00:26:40.980
have only so much time before we become old.

00:26:41.660 --> 00:26:44.140
And this is another thing that we have to address.

00:26:45.160 --> 00:26:49.240
The fact that we feel that unless we are slim

00:26:49.240 --> 00:26:53.779
and young and beautiful, especially women, then

00:26:53.779 --> 00:26:57.160
we think that we are of no value. And this is

00:26:57.160 --> 00:27:00.720
a message that gets repeated at all levels, overt,

00:27:00.960 --> 00:27:06.759
subconscious, and weight is intricately linked

00:27:06.759 --> 00:27:12.099
to that message. So Peter Diamandis is in town

00:27:12.099 --> 00:27:14.920
at the moment. He's the co -founder of the X

00:27:14.920 --> 00:27:18.200
Prize. He was talking about three things that

00:27:18.200 --> 00:27:21.000
would be, you know, oh, you want to be young

00:27:21.000 --> 00:27:26.789
and bright and thin. I hate that word thin. Yeah.

00:27:27.470 --> 00:27:31.730
I also hate thin. Well, and skinny. Yeah. I hate

00:27:31.730 --> 00:27:34.789
the most that one. But thin is like what my mom

00:27:34.789 --> 00:27:37.730
would say. And no offense, mom, but meaning like

00:27:37.730 --> 00:27:40.410
neither of those terms are favorable to me. It's

00:27:40.410 --> 00:27:43.609
kind of like how we discuss men sometimes when

00:27:43.609 --> 00:27:46.559
we talk about height. When we say, oh, blah,

00:27:46.579 --> 00:27:48.799
blah, blah, and he was tall and he was this,

00:27:48.859 --> 00:27:51.779
implying that short is not attractive. There

00:27:51.779 --> 00:27:55.059
you go. Now, of course, weight is an important

00:27:55.059 --> 00:28:00.440
topic. Of course, it's about metabolism. It's

00:28:00.440 --> 00:28:03.000
about mobility. It's about strength. It's about

00:28:03.000 --> 00:28:07.380
a lot of things. But the discussion around weight,

00:28:07.440 --> 00:28:10.180
I think. has to be nuanced. We can't be talking

00:28:10.180 --> 00:28:13.299
about thin being an end goal. That's how we get

00:28:13.299 --> 00:28:17.000
eating disorders. Yes. And you know, when you

00:28:17.000 --> 00:28:19.900
say weight, what I always talk about with my

00:28:19.900 --> 00:28:23.859
clients is this idea of lightness. It's like,

00:28:23.900 --> 00:28:27.059
it's not about how light. You are on the scale.

00:28:27.240 --> 00:28:29.700
We can do that with osteoporosis. Sure. You want

00:28:29.700 --> 00:28:31.119
me to take something from you? I'll take your

00:28:31.119 --> 00:28:33.380
bones. But if you need something heavy, I'll

00:28:33.380 --> 00:28:36.240
take your bones out. But we always say we want

00:28:36.240 --> 00:28:37.940
you, for our patients at Live Clinic, we want

00:28:37.940 --> 00:28:41.599
you to be the heaviest version of a healthy weight.

00:28:42.240 --> 00:28:45.839
So the heaviest possible. healthy weight person

00:28:45.839 --> 00:28:47.640
you can be that's actually what we want from

00:28:47.640 --> 00:28:49.839
you because then you know that speaks to your

00:28:49.839 --> 00:28:52.359
most dense bones your most dense muscles you

00:28:52.359 --> 00:28:54.980
know and again healthy weight is a huge range

00:28:54.980 --> 00:28:56.440
right it's a huge range so it's not it's not

00:28:56.440 --> 00:28:59.500
pinpointing you to you know ideal weight which

00:28:59.500 --> 00:29:01.779
again is another term I actually hate ideal weight

00:29:01.779 --> 00:29:04.000
goal weight can't stand it yeah you know but

00:29:04.000 --> 00:29:07.140
if there's a range of weights at which your cycle

00:29:07.140 --> 00:29:09.319
is regular you're able to do the athletic activities

00:29:09.319 --> 00:29:12.500
you want move without pain that that weight within

00:29:12.500 --> 00:29:15.349
that range And then the heaviest version of that

00:29:15.349 --> 00:29:17.130
range, that's actually where you're thriving.

00:29:17.289 --> 00:29:19.950
You know, that's interception as well, right?

00:29:20.029 --> 00:29:22.329
Because people looking at a scale to tell them

00:29:22.329 --> 00:29:24.930
where they should be, that's a problem. You know

00:29:24.930 --> 00:29:27.390
when you're bloated and your hormones are playing

00:29:27.390 --> 00:29:30.069
up a little bit lethargic and whatever. Those

00:29:30.069 --> 00:29:34.029
are the signs that you know when something doesn't

00:29:34.029 --> 00:29:38.049
sit quite right. But looking at an external thing

00:29:38.049 --> 00:29:41.700
to tell you how you should feel. Slippery slope.

00:29:41.900 --> 00:29:45.000
That brings me to wearables. So what's your opinion

00:29:45.000 --> 00:29:47.519
then on wearables? Like people looking at their...

00:29:47.519 --> 00:29:51.299
We won't be offended. I'm doing it. So my resting

00:29:51.299 --> 00:29:53.480
heart rate right now for the last seven, eight

00:29:53.480 --> 00:29:55.420
months, I feel like it's been off. It's been

00:29:55.420 --> 00:29:58.519
months. It is high and I'm like freaking out.

00:29:58.640 --> 00:30:01.279
But the other day my battery died. It wouldn't

00:30:01.279 --> 00:30:03.299
charge. And I was like, you know what? I'm just

00:30:03.299 --> 00:30:05.599
going to ignore it. And I went to sleep and I

00:30:05.599 --> 00:30:08.380
woke up and I was like, I feel good. I don't

00:30:08.380 --> 00:30:09.640
know what my resting heart rate was like, but

00:30:09.640 --> 00:30:13.220
today it's still high. But what's your opinion

00:30:13.220 --> 00:30:15.980
on that? People looking at a wearable to decide

00:30:15.980 --> 00:30:20.680
how they feel. Okay. Again, goes back to interoception.

00:30:20.740 --> 00:30:24.319
And in part, I totally get the test don't guess.

00:30:24.599 --> 00:30:28.079
Yeah. And you can't change what you can't measure.

00:30:28.640 --> 00:30:33.220
Those are absolutes. And it's a bad idea to deal

00:30:33.220 --> 00:30:36.690
solely in absolutes. That was an absolute. Never

00:30:36.690 --> 00:30:43.630
do that ever. But there is obviously some logic

00:30:43.630 --> 00:30:50.369
and some wisdom to those tropes. But when a patient

00:30:50.369 --> 00:30:55.630
sacrifices their mental well -being to the scales,

00:30:55.769 --> 00:30:59.170
to their wearables, that's when that's a problem.

00:30:59.630 --> 00:31:06.190
When we completely ignore. how someone feels

00:31:06.190 --> 00:31:10.970
in deference to, but your tests are normal. That's

00:31:10.970 --> 00:31:13.450
the other side of the coin. I don't have a problem

00:31:13.450 --> 00:31:15.210
with wearables when they're used appropriately

00:31:15.210 --> 00:31:17.029
at the right time for the right patient, at the

00:31:17.029 --> 00:31:19.410
right dose, at the right frequency. But I would

00:31:19.410 --> 00:31:21.170
never tell my patient what to do for themselves.

00:31:22.349 --> 00:31:26.430
But I don't wear wearables. I did an Oura ring

00:31:26.430 --> 00:31:29.710
for a few months. And it's a really interesting

00:31:29.710 --> 00:31:34.299
concept where they're taking data to be able

00:31:34.299 --> 00:31:36.160
to tell you where your valence and intensity

00:31:36.160 --> 00:31:40.619
is with regards to arousal. In other words, it's,

00:31:40.619 --> 00:31:46.480
are you in a highly aroused state whereby it's

00:31:46.480 --> 00:31:50.779
probably going to be a speed hump to making good

00:31:50.779 --> 00:31:54.599
decisions? Therefore, if you were the president

00:31:54.599 --> 00:31:56.559
of the United States and you were hovering your

00:31:56.559 --> 00:31:59.890
hand over the rip, big red button to start nuclear

00:31:59.890 --> 00:32:02.109
war why don't you wait till your valence and

00:32:02.109 --> 00:32:05.029
arousal is a little bit lower it might open up

00:32:05.029 --> 00:32:08.170
some bandwidth to make better choices and what

00:32:08.170 --> 00:32:10.849
what um metrics is that running for how is it

00:32:10.849 --> 00:32:14.710
so it's it's hrv and yeah the algorithm has been

00:32:14.710 --> 00:32:17.250
sorted out by neuroscientists neurophysiologists

00:32:17.250 --> 00:32:20.599
i'm not privy to that The company is called InTruth

00:32:20.599 --> 00:32:22.880
Technologies and they've just launched actually.

00:32:22.920 --> 00:32:25.420
I'm really excited. And it's through Garmin?

00:32:26.180 --> 00:32:28.839
You can use, right now we're using Garmin, but

00:32:28.839 --> 00:32:31.059
I think you're going to be able to use a number

00:32:31.059 --> 00:32:33.440
of wearables. So InTruth is the technology? Yes.

00:32:33.440 --> 00:32:37.039
And the algorithm. You know, things like that

00:32:37.039 --> 00:32:40.450
where it doesn't tell you. Good, bad, yes, no.

00:32:40.589 --> 00:32:42.730
It just gives you information with which you

00:32:42.730 --> 00:32:46.369
can make decisions and you can experiment. Okay,

00:32:46.430 --> 00:32:48.329
when I'm in a highly aroused state like this,

00:32:48.529 --> 00:32:52.170
I actually feel clearer. It is helping me strategize.

00:32:52.450 --> 00:32:55.170
Okay, that's you. That's great. That's my husband.

00:32:55.210 --> 00:32:57.630
That's an emergency medicine doctor right there.

00:32:58.190 --> 00:33:01.329
It's like the most insane of situations. He is

00:33:01.329 --> 00:33:04.230
crystal clear. And then it's like your day -to

00:33:04.230 --> 00:33:06.430
-day stress. Took the kids to school yesterday,

00:33:06.589 --> 00:33:08.589
forgot one of my son's socks. I was like, bro,

00:33:08.650 --> 00:33:12.289
socks. There's an S at the end for a reason.

00:33:12.410 --> 00:33:16.029
Yeah. Interesting. But yeah, so it's like, you

00:33:16.029 --> 00:33:17.589
know, I think there are people that operate at

00:33:17.589 --> 00:33:19.789
that highest level in that highest state, but

00:33:19.789 --> 00:33:22.490
potentially that would never be everyone. Yeah.

00:33:22.589 --> 00:33:24.150
That's why we're not all emergency medicine doctors.

00:33:24.410 --> 00:33:27.349
And now you have this information which you can

00:33:27.349 --> 00:33:32.029
learn what that means for you. whereas I feel

00:33:32.029 --> 00:33:34.309
a lot of wearables where they have these reference

00:33:34.309 --> 00:33:37.950
ranges you know oh your heart rate variability

00:33:37.950 --> 00:33:41.390
is too high it can be very stressful for some

00:33:41.390 --> 00:33:43.390
patients not everybody some people are like eh

00:33:43.390 --> 00:33:46.230
and other patients I have this story actually

00:33:46.230 --> 00:33:49.049
a concierge patient this is a few years ago he

00:33:49.049 --> 00:33:53.789
woke up and he had to go film he was making a

00:33:53.789 --> 00:33:59.450
movie he woke up and his my readiness score is

00:33:59.450 --> 00:34:04.470
really low. Oh dear. And I'm thinking, oh my

00:34:04.470 --> 00:34:08.269
God, okay. And we spent like 45 minutes, an hour

00:34:08.269 --> 00:34:10.309
discussing what did you do differently today

00:34:10.309 --> 00:34:12.210
than yesterday? How was your sleep? What did

00:34:12.210 --> 00:34:13.710
you eat for dinner? How did that affect you?

00:34:13.730 --> 00:34:14.989
Blah, blah, blah, blah, blah. It was an aura

00:34:14.989 --> 00:34:18.289
ring. And then eventually, because we basically

00:34:18.289 --> 00:34:20.389
came up with nothing, I said, hey, hey, hey,

00:34:20.389 --> 00:34:27.860
how do you feel? I feel fine. Well, then go hit

00:34:27.860 --> 00:34:31.199
it. Go film that movie. I think they're all tools

00:34:31.199 --> 00:34:34.940
and tools are only as good as, you know, first

00:34:34.940 --> 00:34:36.920
of all, how you use it. But secondly, if they

00:34:36.920 --> 00:34:40.639
stay servants to you being the master, the minute

00:34:40.639 --> 00:34:43.380
it starts to run your life, that's a problem.

00:34:43.679 --> 00:34:46.760
And I think now's the perfect time to bring in

00:34:46.760 --> 00:34:49.260
our sponsored segment, which is Fuel Your 40s.

00:34:49.260 --> 00:34:51.000
And it's sponsored by The Meat Club, where they

00:34:51.000 --> 00:34:55.130
bring you sustainably sourced. produce and protein

00:34:55.130 --> 00:34:57.809
from Australia and New Zealand. And they have

00:34:57.809 --> 00:35:00.230
a question for you, Olivia, and that is from

00:35:00.230 --> 00:35:03.269
your perspective, what do you see when women

00:35:03.269 --> 00:35:05.210
are under fueling, especially when it comes to

00:35:05.210 --> 00:35:08.269
protein? How does that affect women? I think

00:35:08.269 --> 00:35:11.469
it can be said across the board that most people

00:35:11.469 --> 00:35:14.050
are not taking in enough protein, full stop,

00:35:14.110 --> 00:35:17.110
end of story. When it comes to women, we tend

00:35:17.110 --> 00:35:20.769
to not only be the people running the households,

00:35:20.969 --> 00:35:24.070
we also have important jobs where we're needed

00:35:24.070 --> 00:35:27.050
there. And we also tend to have the majority

00:35:27.050 --> 00:35:33.769
of the emotional and housekeeping labor. So before

00:35:33.769 --> 00:35:36.530
when I was talking about that finite substrate

00:35:36.530 --> 00:35:39.269
pool, that finite pool of resources that the

00:35:39.269 --> 00:35:42.969
mitochondria need, that includes protein. When

00:35:42.969 --> 00:35:45.469
we don't consume enough protein, we put ourselves

00:35:45.469 --> 00:35:49.179
at risk. For our mitochondria not being able

00:35:49.179 --> 00:35:52.440
to produce enough energy for us to meet all the

00:35:52.440 --> 00:35:55.340
demands that are placed on us, specifically as

00:35:55.340 --> 00:35:59.000
women in this day and age, quite a few more demands

00:35:59.000 --> 00:36:03.000
on us that are unseen, not taken into account.

00:36:03.920 --> 00:36:08.300
And so when you put yourself on the back foot

00:36:08.300 --> 00:36:10.659
like that with not enough protein, not enough

00:36:10.659 --> 00:36:14.099
substrates to feed your mitochondria, you actually

00:36:14.099 --> 00:36:17.519
do open up these windows of vulnerability. It

00:36:17.519 --> 00:36:19.519
doesn't have to be neurocognitive, doesn't have

00:36:19.519 --> 00:36:21.920
to be your muscle remodeling or maintenance.

00:36:22.780 --> 00:36:25.420
It can be emotional. It can be psychological.

00:36:26.420 --> 00:36:30.420
And because we're the ones sort of regulating

00:36:30.420 --> 00:36:32.860
the household sometimes, who's regulating us.

00:36:33.000 --> 00:36:36.880
That's so true. So many of you have got amazing

00:36:36.880 --> 00:36:39.519
partners and you're very lucky because there

00:36:39.519 --> 00:36:42.480
are many women who don't. Anyway, I'm glad that

00:36:42.480 --> 00:36:46.650
you guys, Talking about meat. This is a foundational

00:36:46.650 --> 00:36:49.789
sponsorship for us because we really believe

00:36:49.789 --> 00:36:54.230
in animal -based and quality proteins. And obviously

00:36:54.230 --> 00:36:57.230
sustainable sourcing is huge. Yeah, absolutely.

00:36:57.230 --> 00:36:59.570
For us, it's a non -negotiable. I believe in

00:36:59.570 --> 00:37:03.349
energetics. And so I do believe that if an animal

00:37:03.349 --> 00:37:09.769
is not kept in a well state before it's brought

00:37:09.769 --> 00:37:14.079
to the table to fuel our bodies. that we carry

00:37:14.079 --> 00:37:17.019
some of that energy forward, which is why when

00:37:17.019 --> 00:37:21.260
I do eat meat, it really, is this grass fed,

00:37:21.300 --> 00:37:23.639
grass finished? You know, is it pasture raised?

00:37:23.760 --> 00:37:26.559
Does it have a name? Do you have a photo? Did

00:37:26.559 --> 00:37:32.219
it smell cherry blossom at any point in its life?

00:37:32.699 --> 00:37:35.460
But you've hit the nail on the head. It's quality

00:37:35.460 --> 00:37:39.260
protein. Now, can some... Can women fuel themselves

00:37:39.260 --> 00:37:41.940
with plant protein? Of course they can. For example,

00:37:41.940 --> 00:37:44.820
I know my genetics. I have a BCMO1 SNP, which

00:37:44.820 --> 00:37:47.639
means that I do not convert beta carotene. So

00:37:47.639 --> 00:37:50.800
it's the pre -vitamin A in plants. I don't convert

00:37:50.800 --> 00:37:54.920
that well at all to a usable vitamin A that a

00:37:54.920 --> 00:37:58.860
human can use. That's so interesting. Does that

00:37:58.860 --> 00:38:02.380
mean that you have poor eyesight? It means that

00:38:02.380 --> 00:38:04.639
I have to be very conscious of where I get my

00:38:04.639 --> 00:38:07.579
vitamin A from. Or yes, my eyesight is left vulnerable

00:38:07.579 --> 00:38:10.219
and then can lead to poor eyesight. Maybe that's

00:38:10.219 --> 00:38:13.420
what I have. Why am I so blind, Dr. Olivia? That

00:38:13.420 --> 00:38:15.440
wasn't part of your circle. I mean, they don't

00:38:15.440 --> 00:38:17.380
give you the snips, do they? No, they don't.

00:38:17.380 --> 00:38:19.320
But does it say on there? I can't remember if

00:38:19.320 --> 00:38:21.579
it tells you what your eyesight is like epigenetically.

00:38:21.960 --> 00:38:25.119
We've both done circle DNA, which is kind of

00:38:25.119 --> 00:38:27.139
like Singapore's 23andMe. One of the things I

00:38:27.139 --> 00:38:30.510
did was I took my circle DNA. And I put it into

00:38:30.510 --> 00:38:33.849
chat GPT and I was like, tell me, you know, like.

00:38:33.909 --> 00:38:37.150
The real deal. Yeah, like evolutionarily. Who

00:38:37.150 --> 00:38:39.750
am I? Who am I? You know, like what role would

00:38:39.750 --> 00:38:43.389
I have had? What role would I have had if I was,

00:38:43.389 --> 00:38:46.269
you know, living in a tribe? Just because I 100

00:38:46.269 --> 00:38:48.809
% agree with you that, you know, as humans, our

00:38:48.809 --> 00:38:52.460
genetics haven't changed. But our world has,

00:38:52.539 --> 00:38:56.179
and there is this massive mismatch between, you

00:38:56.179 --> 00:38:58.420
know, who we're meant to be and who we are today.

00:38:58.619 --> 00:39:01.119
That comes with the mental load. That comes with,

00:39:01.139 --> 00:39:04.559
you know, everything that's going on. And like

00:39:04.559 --> 00:39:08.380
you mentioned earlier, that social media seems

00:39:08.380 --> 00:39:10.880
to be the forefront of what's happening in our

00:39:10.880 --> 00:39:12.659
lives today. You know, everyone jumps on and

00:39:12.659 --> 00:39:14.860
like sees what's going on on social media. And

00:39:14.860 --> 00:39:19.650
it is affecting us. in a big, big way. It's that

00:39:19.650 --> 00:39:23.050
unseen stress that we're not really taking on

00:39:23.050 --> 00:39:26.110
board. I had a client the other day and she was

00:39:26.110 --> 00:39:28.869
lamenting her Russian genes. So there's two types

00:39:28.869 --> 00:39:32.349
of Russian women. There's right off the catwalk,

00:39:32.510 --> 00:39:34.889
born skinny, gorgeous, tall, just outrageous.

00:39:35.170 --> 00:39:37.670
And if you've been to Russia, you will see these

00:39:37.670 --> 00:39:39.469
women lining the streets, no joke. And she said,

00:39:39.469 --> 00:39:41.889
then there's me. And my aunties and my grandma,

00:39:41.949 --> 00:39:44.929
grandma, and we're the working class. And, you

00:39:44.929 --> 00:39:47.389
know, and we just, you know, we're short, we're

00:39:47.389 --> 00:39:50.010
stocky. We're, we're, you know, we make it to

00:39:50.010 --> 00:39:52.690
105 years old. You know, the little Russian grandma

00:39:52.690 --> 00:39:55.210
that you imagine in your, in your caricature.

00:39:55.349 --> 00:39:57.949
And she's like, I just wish I was the other one.

00:39:58.530 --> 00:40:00.849
And I was like, I'm going to, I'm going to counterpoint

00:40:00.849 --> 00:40:03.670
that and say, if we view these through a lens

00:40:03.670 --> 00:40:08.469
of metabolic health, she's. muscle dense. And

00:40:08.469 --> 00:40:10.369
this is something you just kind of tangentially

00:40:10.369 --> 00:40:13.650
referred to about having too high in HRV. When

00:40:13.650 --> 00:40:16.510
she went through my InBody, all of her muscularity

00:40:16.510 --> 00:40:19.050
was over. The category that InBody gives you

00:40:19.050 --> 00:40:21.030
is over, right? And she was like, see, see. And

00:40:21.030 --> 00:40:23.769
I was like, no, over -muscled doesn't really

00:40:23.769 --> 00:40:26.869
exist. Optimally muscled is what I always say.

00:40:26.909 --> 00:40:28.730
If you want to see an O word on the page, it's

00:40:28.730 --> 00:40:32.599
optimal. Like you want to be over -muscled. The

00:40:32.599 --> 00:40:35.360
point being, social media and cultural conditioning

00:40:35.360 --> 00:40:38.480
are obviously why she sees her own body type

00:40:38.480 --> 00:40:41.679
as less than or as less desirable, right? Because

00:40:41.679 --> 00:40:45.579
right now, it's less congruent with what she's

00:40:45.579 --> 00:40:47.940
seeing on social media is the idea. Do you see

00:40:47.940 --> 00:40:50.780
that in patients even our age? Definitely for

00:40:50.780 --> 00:40:54.539
women our age, for sure. I think that the younger

00:40:54.539 --> 00:40:59.139
generation coming through seem to be less married

00:40:59.139 --> 00:41:04.210
to... archetypes. Partly, I think it's because

00:41:04.210 --> 00:41:07.969
they're rejecting what we're trying to shove

00:41:07.969 --> 00:41:11.309
down their throats. But then again, I don't see

00:41:11.309 --> 00:41:13.650
pediatric patients and I don't have kids. So

00:41:13.650 --> 00:41:16.730
this is what my corner of the Instagram is telling

00:41:16.730 --> 00:41:19.570
me. I just can speak about women in our 40s.

00:41:19.590 --> 00:41:24.530
Part of our burden is that we are at that, unfortunately,

00:41:24.670 --> 00:41:30.170
coming out of the block. where the Women's Health

00:41:30.170 --> 00:41:34.929
Initiative really trampled on doctors prescribing

00:41:34.929 --> 00:41:39.550
hormones for fear of cancer. And I tell this

00:41:39.550 --> 00:41:42.969
to all my female patients with whom I'm speaking

00:41:42.969 --> 00:41:46.230
about hormone replacement therapy. My mother

00:41:46.230 --> 00:41:50.210
had a full hysterectomy with a miscarriage after

00:41:50.210 --> 00:41:53.449
me. So she was quite, I think she was in her

00:41:53.449 --> 00:41:57.320
early 30s. And so from her early thirties, she

00:41:57.320 --> 00:42:02.059
was put on HRT. And she was that rare person

00:42:02.059 --> 00:42:07.380
who did get a breast cancer more than likely

00:42:07.380 --> 00:42:13.059
from the HRT. And I still recommend HRT. HRT

00:42:13.059 --> 00:42:18.159
now is not the HRT then. We understand far more

00:42:18.159 --> 00:42:22.130
about... more biologically identical hormones.

00:42:22.409 --> 00:42:25.650
This is not from pregnant mares anymore. We are

00:42:25.650 --> 00:42:28.909
talking about not just estrogen, but also progesterone

00:42:28.909 --> 00:42:32.250
and a touch of testosterone. We are monitoring

00:42:32.250 --> 00:42:35.590
our women far closer. We're also talking to them

00:42:35.590 --> 00:42:38.250
about their psycho -emotional, psychosocial health,

00:42:38.550 --> 00:42:43.449
stress reduction, stress resilience. HRT today

00:42:43.449 --> 00:42:47.630
is not the HRT of 20, 30 years ago. So any woman

00:42:47.630 --> 00:42:53.280
who is entering or in past perimenopause and

00:42:53.280 --> 00:42:56.219
they are not on HRT they need to have a very

00:42:56.219 --> 00:43:00.099
good clear discussion with a doctor who is not

00:43:00.099 --> 00:43:03.000
just empathetic and sympathetic but someone who

00:43:03.000 --> 00:43:09.880
is truly informed it is not acceptable to not

00:43:09.880 --> 00:43:11.539
have that conversation and that's what we're

00:43:11.539 --> 00:43:13.719
trying to determine here making sure that people

00:43:13.719 --> 00:43:15.980
understand that all we're saying is that it is

00:43:15.980 --> 00:43:19.989
appropriate very appropriate to have the conversation

00:43:19.989 --> 00:43:24.590
because estrogen is neuroprotective. Estrogen

00:43:24.590 --> 00:43:27.510
is actually also a mast cell stabilizer. When

00:43:27.510 --> 00:43:29.809
you don't have estrogen, for those people who

00:43:29.809 --> 00:43:32.230
have a propensity for your mast cells to degranulate

00:43:32.230 --> 00:43:34.269
so that you have these allergy -like symptoms,

00:43:34.570 --> 00:43:38.429
the hay fevers and the hives and the gut issues,

00:43:38.590 --> 00:43:43.469
that could be because of that loss of estrogen

00:43:43.469 --> 00:43:46.050
and your mast cells are a little bit more twitchy.

00:43:46.320 --> 00:43:49.079
Yes. We see that all the time in clinic, by the

00:43:49.079 --> 00:43:51.360
way. The unexplained hives and rashes. Okay.

00:43:51.480 --> 00:43:53.860
I used to have that. And so literally the patient

00:43:53.860 --> 00:43:55.679
will be sitting in front of us and she'll be

00:43:55.679 --> 00:43:57.699
in for, let's say, hot flashes or whatever, whatever.

00:43:57.840 --> 00:43:59.760
And at the very end of the conversation, she

00:43:59.760 --> 00:44:01.920
goes, oh, and do you have anything for like high,

00:44:02.039 --> 00:44:04.219
like thinking this, we've ended the conversation

00:44:04.219 --> 00:44:06.639
about hormones. Let me talk about skin. And it

00:44:06.639 --> 00:44:08.659
was like the same conversation. We're already

00:44:08.659 --> 00:44:10.960
in it. Same conversation. Let's continue this

00:44:10.960 --> 00:44:13.039
conversation. Tell us more. Or they'll bring

00:44:13.039 --> 00:44:14.960
up the frozen shoulder. Yes. They're like, okay,

00:44:15.059 --> 00:44:16.579
so yeah, so I need, you know, my sleep needs

00:44:16.579 --> 00:44:18.539
to improve, blah, blah. Oh yeah, doc, because

00:44:18.539 --> 00:44:20.119
my husband's also a sports med, right? So they're

00:44:20.119 --> 00:44:21.400
like, oh doc, you know, do you know about anything

00:44:21.400 --> 00:44:23.800
about this weird shoulder thing? Also hormones.

00:44:24.059 --> 00:44:26.360
Also hormones. And I think your point about the

00:44:26.360 --> 00:44:29.139
lack of knowledge around women's health in terms

00:44:29.139 --> 00:44:31.420
of what's public, why is it that the Women's

00:44:31.420 --> 00:44:34.340
Health Initiative study, it just won't die. I

00:44:34.340 --> 00:44:37.139
mean, the ramifications of, you know, or the

00:44:37.139 --> 00:44:39.860
mantra, you know, HRT causes breast cancer, right?

00:44:39.920 --> 00:44:42.400
That's in everyone's, somehow in everyone's mind.

00:44:42.519 --> 00:44:45.840
And yet the knowledge of these 70 plus documented

00:44:45.840 --> 00:44:48.380
symptoms of perimenopause that would warrant

00:44:48.380 --> 00:44:50.420
a conversation about menopause hormone therapy.

00:44:51.210 --> 00:44:53.090
Goes by the wayside. Including our eyesight,

00:44:53.170 --> 00:44:56.289
by the way. Yeah. And hearing. Whatever do you

00:44:56.289 --> 00:44:58.849
mean? I could never be in perimenopause at my

00:44:58.849 --> 00:45:01.789
age. Well, we heard it from a doctor as well.

00:45:01.789 --> 00:45:03.690
You're hearing. I was like, what the hell? A

00:45:03.690 --> 00:45:06.570
revelation. Now when my kids are talking to me,

00:45:06.570 --> 00:45:08.309
I'm like, I can't hear you. You need to look

00:45:08.309 --> 00:45:12.409
at me. You need to say it clearly. Articulate.

00:45:12.469 --> 00:45:16.889
Yes. I was actually 36. I had newborn twins and

00:45:16.889 --> 00:45:19.739
I started getting hot flushes. If it wasn't for

00:45:19.739 --> 00:45:21.980
the hot flashes, I wouldn't have connected that

00:45:21.980 --> 00:45:25.059
my anxiety, my wrist pain, which I thought it

00:45:25.059 --> 00:45:27.199
was because I was holding two bottles. There

00:45:27.199 --> 00:45:30.260
was a lot of stuff going on that I just thought,

00:45:30.360 --> 00:45:32.599
oh, this is happening because of the babies,

00:45:32.719 --> 00:45:36.119
my sleep. Obviously that was the babies, but

00:45:36.119 --> 00:45:38.699
it was also the perimenopause. Oh, you started

00:45:38.699 --> 00:45:40.800
perimenopause? Yeah, straight after the twins

00:45:40.800 --> 00:45:44.039
were born. I was 36 years old and... You know,

00:45:44.079 --> 00:45:47.139
I was sitting there, I was watching TV and I

00:45:47.139 --> 00:45:49.019
had a hot flush and I jokingly said to my husband,

00:45:49.119 --> 00:45:50.880
I think I'm in menopause. Because at the time,

00:45:50.920 --> 00:45:52.760
perimenopause wasn't a term that people used.

00:45:52.840 --> 00:45:55.460
So I booked a doctor's appointment. I went in

00:45:55.460 --> 00:45:57.039
to see them. They did some blood work and they

00:45:57.039 --> 00:45:58.920
basically told me I had premature ovarian failure.

00:45:59.099 --> 00:46:01.619
I remember crying, having this big conversation

00:46:01.619 --> 00:46:05.199
with the doctor and being like, you know, will

00:46:05.199 --> 00:46:08.019
I get cancer? She sat me down and we spoke about

00:46:08.019 --> 00:46:10.460
the bioidentical and I made that decision. I

00:46:10.460 --> 00:46:12.739
said, OK, let's do it. And I'm so glad I did.

00:46:12.860 --> 00:46:15.139
And then I've got friends now who, you know,

00:46:15.139 --> 00:46:17.559
are mid 40s and they're like, oh, I feel like

00:46:17.559 --> 00:46:19.599
this. Have you been to the doctors? Have you

00:46:19.599 --> 00:46:21.840
spoken about HRT? And they're like, no, I will.

00:46:21.920 --> 00:46:23.500
I will. And I'm like, why are you putting it

00:46:23.500 --> 00:46:26.199
off? I have this conversation. A lot of patients

00:46:26.199 --> 00:46:29.039
don't realize that there is a window within which

00:46:29.039 --> 00:46:32.639
you need to start the HRT or it doesn't confer

00:46:32.639 --> 00:46:35.659
as much benefit as it could if you wait too long.

00:46:36.519 --> 00:46:40.179
Especially for any woman out there who has got

00:46:40.179 --> 00:46:48.960
2E. which means ADHD, autism, OCD, giftedness,

00:46:48.960 --> 00:46:52.420
something. So it's two of these exceptional diagnoses.

00:46:52.619 --> 00:46:55.380
So especially twice exceptional women, women

00:46:55.380 --> 00:46:59.760
in particular. So when we have giftedness and

00:46:59.760 --> 00:47:04.880
ADHD, when we fall off the wagon in perimenopause

00:47:04.880 --> 00:47:09.409
because we lose the neuroprotectiveness. the

00:47:09.409 --> 00:47:14.610
neuroprotection of estrogen, we fall off spectacularly.

00:47:14.630 --> 00:47:21.750
Wow. And our mortality rate compared to non -2E

00:47:21.750 --> 00:47:27.190
counterparts is 15 years if we do not get on

00:47:27.190 --> 00:47:31.929
top of the hormone and then the subsequent neuroimmune

00:47:31.929 --> 00:47:37.590
dysregulation. So is that when women... go through

00:47:37.590 --> 00:47:40.769
burnout is that part of what's going on there

00:47:40.769 --> 00:47:43.889
yeah because you hear that a lot you hear that

00:47:43.889 --> 00:47:46.610
you know you know women are like is it adhd is

00:47:46.610 --> 00:47:49.829
it burnout but actually it could be because of

00:47:49.829 --> 00:47:53.750
the adhd the lack of estrogen is leading to this

00:47:53.750 --> 00:47:57.489
because adhd along with lots of other things

00:47:57.489 --> 00:47:59.909
right that the stress at work and balance you

00:47:59.909 --> 00:48:03.440
know balancing a family with twins and Three

00:48:03.440 --> 00:48:05.659
boys I've got, by the way. So it's just my household

00:48:05.659 --> 00:48:13.099
is nuts. But all these are drawing from a reserve

00:48:13.099 --> 00:48:16.079
and that reserve is finite. And of course we

00:48:16.079 --> 00:48:17.880
replenish, but if we don't get enough protein,

00:48:18.019 --> 00:48:20.960
if we don't get out in the sun enough, if we

00:48:20.960 --> 00:48:23.840
don't ground, if we don't have any of these practices

00:48:23.840 --> 00:48:26.599
that are going to feed us and not, I don't mean

00:48:26.599 --> 00:48:30.309
just calories here, right? Then your... pushing

00:48:30.309 --> 00:48:33.989
through your resources quicker than the next

00:48:33.989 --> 00:48:37.309
person. And that's why for us, where we go into

00:48:37.309 --> 00:48:41.590
perimenopause, we start to see symptoms that

00:48:41.590 --> 00:48:46.050
can be a lot more drastic than some of our counterparts.

00:48:46.530 --> 00:48:49.949
Wow. Olivia, this has just been an incredibly

00:48:49.949 --> 00:48:53.690
insightful conversation. I wish we could continue

00:48:53.690 --> 00:48:56.469
for another hour because it's just been so amazing

00:48:56.469 --> 00:48:58.650
being able to speak to you and hearing your insights.

00:48:59.369 --> 00:49:01.969
But we do have to finish up today. But before

00:49:01.969 --> 00:49:03.730
we do, we have one last question we'd like to

00:49:03.730 --> 00:49:06.289
ask you. And that is, what's your 40s formula?

00:49:06.510 --> 00:49:09.949
What can women do in their 40s to really help

00:49:09.949 --> 00:49:13.809
them thrive in this decade? So I recently, despite

00:49:13.809 --> 00:49:16.190
my profession and my age, but I recently discovered

00:49:16.190 --> 00:49:18.650
resistance training and, you know, really get,

00:49:18.690 --> 00:49:20.969
yes, really getting into it. And I'm loving it.

00:49:21.329 --> 00:49:23.650
And I still, that's still not my answer, even

00:49:23.650 --> 00:49:25.949
though that's so important. My answer, and it's

00:49:25.949 --> 00:49:29.429
driven by my own personal experiences. It's self

00:49:29.429 --> 00:49:35.889
-compassion. Because we've had to hold so much

00:49:35.889 --> 00:49:40.750
and some of us haven't had anyone hold us. And

00:49:40.750 --> 00:49:46.269
the self -compassion bit is about providing that

00:49:46.269 --> 00:49:51.429
space for ourselves to just be. And whatever

00:49:51.429 --> 00:49:55.349
you come as is okay. Doesn't matter if you're

00:49:55.349 --> 00:50:00.889
fat or thin or... you know, divorced or any of

00:50:00.889 --> 00:50:03.429
these other labels that get slapped on you, which

00:50:03.429 --> 00:50:06.369
tells you that you're not enough. The only person

00:50:06.369 --> 00:50:09.710
we have to really live with a whole life is us.

00:50:09.829 --> 00:50:12.389
And the self -compassion piece is really important.

00:50:12.510 --> 00:50:14.510
If we could campaign for a seventh pillar of

00:50:14.510 --> 00:50:16.250
lifestyle medicine. And I'm serious. I'm like

00:50:16.250 --> 00:50:18.170
actually serious. I think it would be self -compassion.

00:50:18.210 --> 00:50:21.769
Because, you know, when you give so much of yourself,

00:50:21.929 --> 00:50:24.309
which women do, you give so much of yourself

00:50:24.309 --> 00:50:28.849
your entire life. At some point, you hope that

00:50:28.849 --> 00:50:33.369
your neuroimmune system doesn't learn to not

00:50:33.369 --> 00:50:36.230
look within. The autoimmunities, possibly some

00:50:36.230 --> 00:50:39.969
cancers. Anyway, self -compassion. I'd love to

00:50:39.969 --> 00:50:41.929
say that that was the formula for the 40s. It's

00:50:41.929 --> 00:50:44.030
the formula for everyone at all ages. But yeah,

00:50:44.070 --> 00:50:46.789
I think women in their 40s particularly, they

00:50:46.789 --> 00:50:49.889
really need to start loving themselves as much

00:50:49.889 --> 00:50:51.829
as they've loved everybody else. That's right.

00:50:51.989 --> 00:50:54.210
And I love that. Yeah. Sooner the better, right?

00:50:54.309 --> 00:50:57.610
Yeah. Thank you so much. It's been amazing. Thank

00:50:57.610 --> 00:50:58.369
you. Thank you.
