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Welcome to the Clinician Researcher podcast, where academic clinicians learn the skills

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to build their own research program, whether or not they have a mentor.

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As clinicians, we spend a decade or more as trainees learning to take care of patients.

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When we finally start our careers, we want to build research programs, but then we find

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that our years of clinical training did not adequately prepare us to lead our research

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program.

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Through no fault of our own, we struggle to find mentors, and when we can't, we quit.

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However, clinicians hold the keys to the greatest research breakthroughs.

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For this reason, the Clinician Researcher podcast exists to give academic clinicians

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the tools to build their own research program, whether or not they have a mentor.

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Now introducing your host, Tracey Onwemona.

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Welcome to the Clinician Researcher podcast.

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I'm your host, Toyosi Onwuemene, and it is such a pleasure to have you on the show.

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Today, I'm especially excited because we have a very special guest, Dr. Robert Winn, and

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he's got so many, so many wonderful things to share, so many deep insights.

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I can't wait for him to share them with you.

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I just want to say, Dr. Winn, welcome to the show.

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Yo, you know what?

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Thank you for having me and appreciate it.

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Oh, it's our pleasure.

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So, Dr. Nguyen, there's so much I could say about you, but I'd love for you to introduce

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yourself, but not just you as the researcher, as the very successful scientist and leader,

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but introduce yourself even from your early beginnings in academic medicine and the secret

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sauce that brought you to this spot where you are today.

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So it's a little bit like, you know, we used to say, you know, I didn't look for thug life,

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thug life found me.

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Well, I ain't looked for medicine.

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It literally found me.

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And what I mean by that is that I'm the example of when people see things in you before you

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even recognize them within yourself.

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And so, you know, I always sort of say to people, they look at me now and they say,

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oh my God, you must have been always, you know, focused and, you know, knew you were

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going to do this.

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And they say, I did not.

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But what I was, was curious enough to understand what an opportunity not to say no.

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And so the story goes that, you know, as I was growing up, I really wasn't thinking about

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becoming a doctor, let alone doing research.

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I mean, I literally was focused on trying to, you know, make some cash and, you know,

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I was thinking about working at GM and, you know, being the youngest formed over at GM

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and luckily that did not work out.

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You know, there were other plans and those other plans were that, you know, I'd wind

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up going to, you know, University of Notre Dame.

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And then I'd run into amazing people who actually, again, got me on a different path because

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I was maybe suspect that they saw something in me, but not actually resistant.

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It's a common theme for me in the context of, you know, wanting to do research, basic

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science.

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This was not something that inherently I grew up with or even was exposed to.

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But I think when I got my first taste of it and having, you know, people around campus

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at that time, University of Michigan, Francis Collins was there, there was a significant

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influence on sort of saying, huh, it's interesting that I could actually help out my people and

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do research.

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And by the way, instead of just helping out the patient in front of me, if I came up with

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something, right, I could really help communities times a hundred or a thousand.

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And so that really kind of got me into the, you know, the mindset that I could become

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a researcher.

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And I'm so glad I did.

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Not because it was just purpose of just generating paper, because it gave me not only a way of

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thinking, but a lifestyle, a lifestyle of not only being curious, but a lifestyle of

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being analytical in that kind of sense of being able to be critically minded.

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And when I actually think about certain things, which is extended, interesting, all the way

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into my work, into this sort of community to bench model where we really put community

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first, the scientific principle and the scientific approaches are still really, really relevant

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as I run a cancer center or when I'm out doing community based participatory activities.

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So it's interesting that in my life, it is not so much that I found it as if the steps

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were ordered so that it, in this case, science would find me.

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And so, I mean, as usually the best way to put it, you know, I mean, I, you know, I am

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the product of what happens when you have federal programs from like Head Start at a

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teenage mom to, you know, the minority supplement awards that came with NIH to all of those

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things that when you invest in us, the ROI can be great.

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And so again, you know, that's my story and I'm straight up sticking to it.

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Thank you, Dr. Nguyen.

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That was super awesome.

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Thank you.

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Thank you for sharing.

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Because what I hear in that is the legacy piece.

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Like I can contribute to something greater than myself.

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I think many young people and especially underrepresented faculty in the academic medicine want to have

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that same kind of impact, but they experience barriers.

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And I, you know, I think every generation feels like them barriers are more significant

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than the generations that came before them.

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But there is a sense that there is less incentive and less investment in clinicians today in

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becoming researchers.

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Can you speak to that?

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What's different today compared to when you came up in research?

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I think it's a mindset.

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Actually, I started thinking about the money.

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And if you look at the money, right, the gross amount, some money that are being spent right

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now versus what was being spent, I'm not quite sure that the money's not there.

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But what I'm sure is that the mindset and the, and really the focus, right, there was

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once upon a time where we really focused on understanding that there were lower numbers

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of minorities that were part of our medical school and lower numbers of minorities that

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were part of the science field.

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And then there was a societal sort of center, we should do something about that.

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What's eroded isn't the money.

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What's eroded is that ethos of making sure that we included diversity and that it was

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good for all of us.

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You know, the funny part is I used to talk about, you know, generation, you know, one

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of my ex, whatever the hell, you know, but I'm definitely not a millennial.

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I know that.

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So it was either ex or wherever in that zone, that early ex, whatever that was.

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And we, you know, we always dogged out, you know, the millennials and everything that

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came after.

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I don't even know where you're at.

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X, Y, Z, A, I don't know.

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But whatever is after us, we have done, I think all of us are dissatisfied by the following

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narrative.

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You guys are softer.

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Here's the reality that I was just talking with Dr. Vivian Penn, who's also a giant in

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our field, and without folks like Vivian Penn, I don't have a foundation to then stand on

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to take things to the next level.

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She and I were talking and she said something that was really just made a light bulb.

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She said, now listen, you know, the difference is that our generation, meaning the baby boomers

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and the exes, we didn't know what better looked like.

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It wasn't there.

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We were all struggling to quote get there.

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But generations that came after us actually had a taste of what good was.

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And in front of your eyes, you're seeing it eroded.

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Now when we talk about that, we don't really talk about these generational differences about

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what makes it different when I don't expect that anybody's going to give me anything.

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When I expect that there's going to be obstacles, because I assume that no one, even in getting

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as a 10 year old chocolate from a white store that when I went into a neighborhood and being

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able to be like shook, you know, shaking down and like, yo, why you in here buying a snicker

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bar?

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I'm like, because my daddy gave me a quarter.

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You know what I'm saying?

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That was an expectation that there was going to be obstacles and that there wasn't anybody

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that was going to set up something for me.

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I was like, what?

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You know, people would say, well, don't you expect that they're going to... No, my expectation

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was that there was going to definitely be like, that's not you, you don't belong here.

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That was, I mean, it's straight up.

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I can't even lie about it.

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So I had to change my mental and say, but what if I grew up in generations where the

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expectation was that things weren't supposed to be the same and that we, as a result of

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the previous generation, had a more of a taste of that, right?

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What then happens is if in my lifetime, I'm now seeing things roll back.

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That mental allows for a sense of saying that you're seeing loss as opposed to understanding

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that we already were in the negative column and people were going to keep you in the negative

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column and that was just normalized.

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What actually happens in the generations that followed when that wasn't the mindset that

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not having was normalized and having was to say, yeah, we're supposed to?

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So I'm actually sort of saying to you in a very roundabout way that I think when we come

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to obstacles, we have to actually have grace for one another in our cultures and our generational

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differences in a sense of younger people recognizing that people from the ex generation, particularly

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early ex, I can't speak for them later exes.

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The later exes, I can't speak for them.

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I'm talking about the ones right in that baby boom to the early ex.

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I can tell you for real, for real that that generation was like me sort of saying that

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we were being the last generation of forced busing where we were being integrated and

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where we actually were in communities where people didn't want us.

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It was an assumption that people didn't want you.

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It was an assumption that things weren't going to be fair and it was an assumption that there

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was always going to be obstacles.

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So once that's your normal, you're like, yeah, all right, but what would it be like if I

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didn't have that mental where I assumed that there was going to be an obstacle and all

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of a sudden in my mind and in my lifetime, we were seeing those things eroded.

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That is a different sort of mentality and that is something that I think when we talk

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about intergenerational, I hope we in the future are able to start those discussions

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so that the younger generations can have a little bit more grace for the older and that

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our older sort of generations can have a little bit more grace in understanding what's going

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on with the framework and the mental of the millennials and all.

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So I think that that's an important thing that in a black community in particular that

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we are not doing that I hope to have future conversations on what that looks like because

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I think that there goes the rubs because when I think of obstacles, I'm like, yeah, of course

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there's obstacles.

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I mean, we were like, well, what do you think about the obstacles?

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I mean, I don't know where it was.

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So, right?

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I love it.

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I appreciate you talking about that.

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I want to, you know, it's interesting.

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So I'm going to go back 10 years when I first started as an early career faculty and there

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were these obstacles that I wasn't expecting.

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And so when you're speaking, it really speaks to me because I'm like, I was not expecting

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those obstacles.

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And you know why?

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Because throughout undergrad, I was supported all the way.

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And then in medical school, I was mostly supported.

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In fact, I was in residency and even in fellowship.

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And then I got to the faculty position.

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And that was where it became clear that there are a lot more obstacles than I had ever experienced.

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And when I talk to someone-

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So that meant that the early work that we put in was working.

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That's a great point.

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That's a great point.

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To lead a medical student and to get the residencies and the fellowship supported because my generation,

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that was not an easy, like, support of what?

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They would be like, man, we hope you go.

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We hope you fail.

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Right?

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It was like, and they were pretty straight up with it.

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You don't belong here.

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And I was like, you're right, but we're going to finish anyway.

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So you are right.

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But what happened was, to your point though, that because of work, we made progress.

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Then what happens is that we need to actually make more progress.

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But in the current age and what you're getting at is that some of the progress being made,

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when you see that roll back, that has to actually hurt in a different way.

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Okay.

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So tell me now, how do we solve this problem?

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Because you're tackling this problem at many different levels.

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And I'm connected with you because I'm a member of the Wynn Career Development Award.

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You can say that again.

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I mean, open it up.

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You don't know me.

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You don't know me.

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I'm a weirdo.

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So I see you just working hard to remove these obstacles, at least give people tools to

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scale these obstacles.

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But I want you to speak to kind of your general perspective.

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And maybe if you want to speak for even your generation to the extent that you can, what

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are the things that you're doing to help us from a younger perspective understand the

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sacrifices and the investments that you're continuing to make to move us forward?

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You know what?

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And you just hit the nail on the head, right?

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There is a level of mission generated that while I think they use a young folks term,

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I'm into myself, there is a danger of being so much into yourself though that you become

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a me as opposed to a we.

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By the same token, the other philosophy of that there is no me, it's all we, right?

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I'm always giving allows for people to be burned out without even knowing.

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So there's this wisdom that interestingly that I've been watching about how do we move

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the needle forward about balance.

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Not balance, lifestyle balance and all this stuff.

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So you can say what you want to say, but at some point, you ain't going to always be balanced.

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Like keeping balanced diet, that takes a lot of strictness and I ain't that strict, right?

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So there's some days I'll be like, you know what?

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I know that pound cake ain't right, but I'm going to eat it.

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That's what's going to happen.

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I'm going to limit it to one, but I'm going to have a slice of that pound cake, right?

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So the reality is that's like life.

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So as we're talking about how do we move things ahead, it is interesting because the formula

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has not changed.

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The formula has not changed.

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It is making sure that we are not only at the table, but having opportunities to set

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the table.

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And what I think we need to do better on is how do we take care of our leaders once they're

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there and then how do the leaders take care of our younger generations as they're moving

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through to open up doors.

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You know, we, you're talking frankly, y'all know what's up.

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I mean, sometimes you get one brother, one sister there, they're like, listen, I'm the

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one.

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You know, what's the rest of y'all, right?

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But then you actually have folks who sort of say we never get to the tables.

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And that's the one thing I think we have to continue to fight.

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How do we do that?

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I do think that there will become a need over the next several years and probably over the

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next six months and certainly over the next year to double down in being deliberate about

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being seen, about being at the committees that are making the decisions.

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And by the way, I've always, you know, this is straight up hood.

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I'm like, if you ain't gonna let me at your table, I'll create a table and we're gonna

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actually come with it enough that you're gonna want to be in mine and then we'll figure it

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out.

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That's right.

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I do think that this sense of, you know, I mean, not to get all barby like and all the

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rest of that, but we do have to wake up to that we have models and we have frameworks

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that have already been shown.

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The problem is that most of those we haven't been passed down and we haven't been taught.

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And so I have made it a deal to make sure that I stay in contact with people like Charles

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Thomas, Theodos Brawley, Lucille Elms-Campbell, Asanya Springfield, the Tom Hage Kings, because

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the reality is that there are frameworks that based on their wisdom that they weren't able

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to do that they would say, if I had an opportunity, here's a model that I would use and I'm, aha.

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So I do think that how we're gonna do it, I think we need to have more intergenerational

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conversations than we are having now.

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And not the kind that are blaming like, ah, you know, I mean, it's true.

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You know, we, our generation, the baby boomers and the Xers were probably much more in line,

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I think, with the experience of having to be super adapters to pain.

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That is one of the elements that I think as an African American that we have actually

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become super or have, for whatever reasons we've had to, right, for survival, have to

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become super adapters to pain, which brings about its own pathology.

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And so I readily admit that.

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However, what I can say is that you can't be crying if somebody ain't letting you in

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the door.

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They're like, that door wasn't meant for you.

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So at some point you like, and then when you get there, you're like, oh, I'm all uncomfortable

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with these people.

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Of course, but I mean, what the hell?

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The dead man's place wasn't made for you.

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We have to get there, set the table and say, this is what we're gonna do and this is how

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I'm gonna do it.

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And to be quite honest with you, the whole concept of black excellence and your authenticity

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in doing it is scary, right?

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Because to make it in those early years, we do have to be able to adapt, not get assimilated.

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You see, I ain't saying get assimilated, because some folks get assimilated so much, you're

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like, well, come on back.

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I wanted to make sure that they understood at all times that the excellence that they

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were seeing is from me.

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And this is the way I came with whatever swag, whether they liked it or not.

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And in fact, people say, have you always quoted hip hop artists?

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I was like, yeah, since the day I was a woman, Tim's and mine was a resident with a bow tie

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and a suit.

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And people were like, those are construction, but I was like, don't call them construction

292
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boys, they're lieutenants.

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And in fact, I got my clinical Tim's and then I got the Tim's that I wear when I make rouse,

294
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so they're playing with me, right?

295
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So that sense of pride of I'm bringing all of me.

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And because when you see that at the end of the day, when I was a resident, I became resident

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of the year or intern of the year, that they also saw that I could learn and be me.

298
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And there was a sense of liberation in that.

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So how do we get there?

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More conversations, inter-general conversations, but making sure that we are deliberate in

301
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figuring out what are the committees of impact that when we show up, we not only show out,

302
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but we make room for other people to bring them up.

303
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That's what our grandparents taught us.

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The reality is we have had various levels of successes of that because sometimes you

305
00:18:48,840 --> 00:18:53,160
can get intoxicated once you get to the tables and figure you the one.

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All of a sudden you have all this praise on you, you're this and you're that.

307
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And then all of a sudden you recognize that you're lonely as hell.

308
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Because we have not done what our ancestors and what our grandparents and parents taught

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us is that when we come at those tables, we shouldn't just be sitting there.

310
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We should be setting part of that table up and bringing our folk up with us.

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And I think that that is something that needs to be re-looked at how we can do that.

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And the pride of just sort of saying, I understand people like we're just all human beings and

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I don't see color, but I'm like, well, like Tiger Wood, everybody else sees it except

314
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for you.

315
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But I mean, you can do what you want to do.

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But in this state, in this country, people see it.

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So why not embrace it and understand that let's lean into it and say, I am this, but

318
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also these other things.

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And this level of Andrew's Lord, I think the poet Lord, we talk about all that stuff about

320
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the intersectionality of things.

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I am more than just being an African-American, but by and large, I want to make sure that

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folk understand that I am that.

323
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I'm not all of that.

324
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I'm much more than that.

325
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I'm the son of people that lived in rural areas and blah, blah, blah.

326
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All these other things come with it too.

327
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But the fact of the matter is that that's my income and that's where I start from.

328
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And so again, you asked me, how do we make this work?

329
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We know how to make it work.

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We work hard.

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We communicate more.

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We need the network better, and we need to make sure that when we're at the tables, we're

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now already thinking about not only how long you're going to be there, but who else comes

334
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to follow you.

335
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And so instead of just bringing one, how do you bring three?

336
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You know what I'm saying?

337
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Kanichi was who take you want to meet all day long.

338
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I love it.

339
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I also love the analogy is about grandparents.

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Because I think about I'm a parent of young children.

341
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I think about this a lot.

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I think about the grandparents and they don't have the stress that they had when they were

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parents.

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And so I think it's very difficult to teach the younger generation something that perhaps

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the parents are too busy right now to teach.

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And so I love the idea of the conversations of the older and the younger generation because

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this idea of like, you expected to be taught is something that I do wish people had shared

348
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with me early on.

349
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So I wouldn't have been surprised when these obstacles came.

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And so I love what you shared.

351
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And I hope that there are so many more of these opportunities that we can take advantage

352
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of in making these connections.

353
00:21:16,320 --> 00:21:18,440
Oh, well, thank you so much.

354
00:21:18,440 --> 00:21:21,080
Well, you know, I do think that they're important conversations.

355
00:21:21,080 --> 00:21:24,520
And I got to tell you what trips me out is when I'm somewhere and everybody's nice to

356
00:21:24,520 --> 00:21:25,520
me, I'm like, what the hell?

357
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Stop it.

358
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I mean, hold on.

359
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I'm like, oh, don't somebody go down.

360
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I'm like, it's so but that I have to laugh at myself because that is my generation of

361
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how I grew up.

362
00:21:38,000 --> 00:21:42,520
Because when you like, yeah, I know that with the exit.

363
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Yeah.

364
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And my sense of the exit, I mean, sometimes I'll be like, literally a case in the room

365
00:21:48,160 --> 00:21:49,480
these days, like, where's the exit?

366
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So these people be too damn nice.

367
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What's up?

368
00:21:53,240 --> 00:21:56,420
And so it's wonderful, though, to see that we can change.

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But I think that we have the elephant in the room is that we have to recognize that we

370
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have also live in a generation now where there is a actual push to go backwards.

371
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And part of that is a fear of change, and part of that is a fear that we have not always

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as we've risen, made sure that we made sure that we've made sure that everyone is still

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visible.

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00:22:21,400 --> 00:22:25,740
We have invisible communities, which is why I work so hard and making sure that as we're

375
00:22:25,740 --> 00:22:29,940
pushing the science and we're pushing the clinical trials and we're pushing these things,

376
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that we also are not locked in into just pushing it for our communities, but making sure that,

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00:22:35,320 --> 00:22:39,800
for example, rural underserved communities, which are not just all white, but even those

378
00:22:39,800 --> 00:22:45,360
that are homogeneous white within the eastern parts of Kentucky benefit from our science.

379
00:22:45,360 --> 00:22:49,360
The truth of the matter is that if it only benefits the people that come to my hospital,

380
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then we fail because most people aren't getting to our hospitals.

381
00:22:52,880 --> 00:22:59,840
And so the question becomes, how do we make communities, just like Brother Hampton said,

382
00:22:59,840 --> 00:23:01,800
that Brother Hampton was one of my...

383
00:23:01,800 --> 00:23:04,120
I mean, listen, I know I'm talking Panther.

384
00:23:04,120 --> 00:23:08,720
But if I had to pick a Panther, it was Fred Hampton because Fred Hampton was the first

385
00:23:08,720 --> 00:23:11,720
that sort of said power to the people.

386
00:23:11,720 --> 00:23:13,640
It wasn't just power to black people.

387
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It was power to the people.

388
00:23:14,640 --> 00:23:19,480
And the first Rainbow Coalition before there was a Jesse Jackson was with Fred Hampton,

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00:23:19,480 --> 00:23:25,140
who understood the power that we all actually have sometimes similar struggles and we should

390
00:23:25,140 --> 00:23:26,400
benefit from those things.

391
00:23:26,400 --> 00:23:30,160
In our case, people should benefit, all people, from our medicines.

392
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And all people should benefit from our research.

393
00:23:32,400 --> 00:23:37,640
And all people should benefit from the molecules that becomes medicines, that become trials,

394
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that become really extension of healthcare to make people's life healthier.

395
00:23:42,160 --> 00:23:45,360
And that philosophy, I think it was not new.

396
00:23:45,360 --> 00:23:49,680
That's not a new 21st century philosophy or post Obama and all the rest of that.

397
00:23:49,680 --> 00:23:53,680
I mean, I never bought it to the post-racial thing anyways, but for sure this wanting to

398
00:23:53,680 --> 00:23:56,880
be that we are the world, we are one is okay.

399
00:23:56,880 --> 00:24:01,520
But understand, we don't have to be all of that and still not be us.

400
00:24:01,520 --> 00:24:06,000
It's my responsibility as a cancer center director to make sure definitely that the

401
00:24:06,000 --> 00:24:11,120
science that I do actually helps hopefully to inspire and hopefully impact African-American

402
00:24:11,120 --> 00:24:12,120
communities.

403
00:24:12,120 --> 00:24:17,120
But if it's not actually hitting Asian communities, Latino communities, rural communities, and

404
00:24:17,120 --> 00:24:24,000
even urban, very rich white communities, then I'm not doing my job.

405
00:24:24,000 --> 00:24:27,320
So this is a wonderful thing of being both, right?

406
00:24:27,320 --> 00:24:30,960
That both can exist at the same time, which I'm really digging.

407
00:24:30,960 --> 00:24:37,800
I think, and you set up the stage perfectly for us to talk now about the Robert Winn Diversity

408
00:24:37,800 --> 00:24:40,000
in Clinical Trials program.

409
00:24:40,000 --> 00:24:42,560
And can you just speak about that program?

410
00:24:42,560 --> 00:24:44,880
How does it fit within all that you've been sharing?

411
00:24:44,880 --> 00:24:45,880
What is this program?

412
00:24:45,880 --> 00:24:51,640
Yeah, I learned from John DeMonte, you know, saying from Maya Angelou, and that is that

413
00:24:51,640 --> 00:24:56,240
to change the system, you just can't do something different.

414
00:24:56,240 --> 00:24:58,540
You have to do a different thing.

415
00:24:58,540 --> 00:25:00,200
So here was the deal.

416
00:25:00,200 --> 00:25:04,520
We know that we have people who are very good people in outreach and engagement, but most

417
00:25:04,520 --> 00:25:10,340
of those folks are not aware of the difficulties and the pain or the knowledge and the expertise

418
00:25:10,340 --> 00:25:13,520
of how do you get a molecule to become a medicine.

419
00:25:13,520 --> 00:25:16,400
So that's a weakness.

420
00:25:16,400 --> 00:25:22,280
Then you have people who are physicians, well-intended clinical trialers who want to make high impact

421
00:25:22,280 --> 00:25:26,640
trials or doing basket trials or pragmatic trials or doing all these things.

422
00:25:26,640 --> 00:25:31,320
But we ain't got no freaking clue about the, I didn't just say outreach and engagement.

423
00:25:31,320 --> 00:25:35,160
I said the science of outreach and engagement.

424
00:25:35,160 --> 00:25:41,600
The program was meant to recognize that there was a big hole since the advent of clinical

425
00:25:41,600 --> 00:25:46,080
trials that we did not develop a quarterback for clinical trials.

426
00:25:46,080 --> 00:25:51,520
And what I mean by that is that someone who had knowledge of both how to design and implement

427
00:25:51,520 --> 00:25:58,160
a high impact trial and also that same person may not have the complete expertise, but was

428
00:25:58,160 --> 00:26:04,560
aware and had some expertise in the science of outreach and engagement.

429
00:26:04,560 --> 00:26:07,120
And why do I say the science of outreach and engagement?

430
00:26:07,120 --> 00:26:11,720
Well the science of outreach and engagement or the science of community-based type approaches

431
00:26:11,720 --> 00:26:15,960
means that it is built on literature, which there's a 40 plus year history on this.

432
00:26:15,960 --> 00:26:21,840
It also is built on frameworks so that when I design and implement my trials, the goal

433
00:26:21,840 --> 00:26:26,760
was to not only have someone design the arm one and arm two and we're going to have these

434
00:26:26,760 --> 00:26:33,640
two arms, but as they're developing their protocols, that at every step of the way,

435
00:26:33,640 --> 00:26:39,200
they're developing also a parallel protocol on how they're going to get more people from

436
00:26:39,200 --> 00:26:41,520
challenged backgrounds onto those studies.

437
00:26:41,520 --> 00:26:46,680
You know, my dream was to actually have one of my scholars, if you will, actually come

438
00:26:46,680 --> 00:26:51,000
up with a protocol that looked like not just here's a protocol of how we get more people

439
00:26:51,000 --> 00:26:56,320
on to clinical trials or say in this case African-American to rural or here's an event

440
00:26:56,320 --> 00:27:01,520
this is my trial, but to imagine a world in which we challenge the entire world of doing

441
00:27:01,520 --> 00:27:03,080
something different.

442
00:27:03,080 --> 00:27:07,840
And we actually meld with those two that as the same time we were actually designing and

443
00:27:07,840 --> 00:27:14,040
implementing a trial for getting rural patients with GLEO, you know, with GBMs, how do we

444
00:27:14,040 --> 00:27:19,360
get them onto trials that we would actually also be solving the problem of, yeah, here's

445
00:27:19,360 --> 00:27:26,160
a wonderful high impact trial for GBMs and other neurocancers, but we were also putting

446
00:27:26,160 --> 00:27:32,520
equal amount of attention to how do we leverage communities to help us get more people on.

447
00:27:32,520 --> 00:27:35,720
How do we connect with primary care doctors?

448
00:27:35,720 --> 00:27:40,560
How by the way, when we communicate, what's the effect of communication?

449
00:27:40,560 --> 00:27:45,180
How do we use asset maps, both functional, which is a new word, functional asset mapping

450
00:27:45,180 --> 00:27:46,520
and asset mapping?

451
00:27:46,520 --> 00:27:52,160
How do we put all of those, so not that it exists in one person, but that they are aware.

452
00:27:52,160 --> 00:27:57,000
For example, a quarterback of a team or a point guard has to know all the other positions,

453
00:27:57,000 --> 00:28:02,000
they don't play all the other positions, but they have to be aware of how things work so

454
00:28:02,000 --> 00:28:04,920
that they can get from point A to point B to make a play.

455
00:28:04,920 --> 00:28:12,120
We did not have that person in any of our clinical training period.

456
00:28:12,120 --> 00:28:18,280
So I said, well, since I don't see it, I ain't asking no questions, let's just do it.

457
00:28:18,280 --> 00:28:21,800
And in fact, people would say, well, that's, wow, that's going to be a lot of work and

458
00:28:21,800 --> 00:28:22,800
it's crazy.

459
00:28:22,800 --> 00:28:27,220
You're like, yeah, it's a lot of work, but every big thing is going to be a lot of work.

460
00:28:27,220 --> 00:28:30,920
So it really is trying to make sure that the first and the second and the third pancakes,

461
00:28:30,920 --> 00:28:35,560
they get better and better with iteration on what does it look like when you have someone

462
00:28:35,560 --> 00:28:40,320
who actually not only understands regulatory and how to get things from a molecule to a

463
00:28:40,320 --> 00:28:44,920
medicine into a trial and all the arms of a trial, but also they're understanding the

464
00:28:44,920 --> 00:28:50,240
difficulty and saying, yep, this is what we'll have to do operationally and from a protocol

465
00:28:50,240 --> 00:28:55,680
wise for this trial to actually have this percentage or to have this many people from

466
00:28:55,680 --> 00:28:56,920
the rural area.

467
00:28:56,920 --> 00:29:01,200
This is what I'm going to have to integrate into my protocol and take into account to

468
00:29:01,200 --> 00:29:02,840
get that outcome.

469
00:29:02,840 --> 00:29:06,960
Now that is a new idea.

470
00:29:06,960 --> 00:29:10,240
Back in the old days, up in the 80s and 90s, we'd be saying like, that's fat, but I'm going

471
00:29:10,240 --> 00:29:11,720
to be like, yo, that's hot.

472
00:29:11,720 --> 00:29:13,640
So that's what we're going for.

473
00:29:13,640 --> 00:29:16,520
Now the reality is, will we get there immediately?

474
00:29:16,520 --> 00:29:17,520
We won't.

475
00:29:17,520 --> 00:29:22,120
But just like everything, to get to the moon or to get to immunotherapy, nobody cries and

476
00:29:22,120 --> 00:29:28,720
we talk about it took 125 years from Cooley to all these other things to get to the checkpoint

477
00:29:28,720 --> 00:29:32,800
inhibitors, nobody cried that it took 125 years and there were some setbacks.

478
00:29:32,800 --> 00:29:40,200
So quit playing with me that this concept of having a group of, for the first time,

479
00:29:40,200 --> 00:29:46,280
first trained people in the country and maybe actually in the world, because I've checked,

480
00:29:46,280 --> 00:29:51,600
who are being taught and tried to train and what happens when you are skilled and you

481
00:29:51,600 --> 00:29:55,360
have two kids and extra teeth in both, what happens?

482
00:29:55,360 --> 00:29:58,480
I think it's going to be a game changer.

483
00:29:58,480 --> 00:30:03,560
That's going to take a while, but that's why, look here, Dr. Ode, this is why I'm so proud

484
00:30:03,560 --> 00:30:04,560
of you.

485
00:30:04,560 --> 00:30:08,200
I'm like, girl, listen, listen, you don't know how, look, I'm smiling ear to ear.

486
00:30:08,200 --> 00:30:09,200
My heart, you know what I'm saying?

487
00:30:09,200 --> 00:30:15,120
It's big, I'm just saying, because y'all will make the difference and be the game changers

488
00:30:15,120 --> 00:30:19,240
and really sort of set it off in a way that I'm just excited about seeing how that's going

489
00:30:19,240 --> 00:30:20,240
to go down.

490
00:30:20,240 --> 00:30:23,200
I'm excited to be part of the program.

491
00:30:23,200 --> 00:30:27,320
I thank you for your vision and building it together, because one of the things that I

492
00:30:27,320 --> 00:30:34,080
see is that there is an expectation that clinicians are going to finish clinical training and

493
00:30:34,080 --> 00:30:39,520
then all of a sudden be experts in research and not even to talk about being the science

494
00:30:39,520 --> 00:30:41,120
of community engagement.

495
00:30:41,120 --> 00:30:43,040
And I love that you emphasize that as well.

496
00:30:43,040 --> 00:30:46,720
It's like, well, clinical training should be about clinical training, but then the next

497
00:30:46,720 --> 00:30:52,000
step of training so that we can build diversity in clinical trials, actually it needs to happen.

498
00:30:52,000 --> 00:30:57,560
And so it's almost like, you know, the program is novel, it's amazing.

499
00:30:57,560 --> 00:31:01,280
And it's also like, but why haven't we been doing this all along?

500
00:31:01,280 --> 00:31:05,440
Why have we assumed that it was just all going to work out?

501
00:31:05,440 --> 00:31:08,240
And so I just want to thank you.

502
00:31:08,240 --> 00:31:10,400
You're a trailblazer in so many ways.

503
00:31:10,400 --> 00:31:16,280
And I mean, thank you.

504
00:31:16,280 --> 00:31:17,280
You know what I want to say?

505
00:31:17,280 --> 00:31:22,080
I want to say you're not just reaching out, you're not just reaching physicians, you're

506
00:31:22,080 --> 00:31:23,760
going further back.

507
00:31:23,760 --> 00:31:26,560
Talk about the CIPP pathway.

508
00:31:26,560 --> 00:31:30,800
Well, you know, it's going to be, you know, the reality is this is all about the phase

509
00:31:30,800 --> 00:31:31,800
game.

510
00:31:31,800 --> 00:31:33,240
So we have it moving forward and moving back.

511
00:31:33,240 --> 00:31:37,040
We actually recognize, and at some point we'll get into the high schools and middle schools,

512
00:31:37,040 --> 00:31:40,500
but you know, right now you got to take a step at a time when you're building this program.

513
00:31:40,500 --> 00:31:44,520
We have a component of taking those young, those young minds, people in medical school

514
00:31:44,520 --> 00:31:48,360
who haven't even thought about careers in oncology or haven't thought about careers

515
00:31:48,360 --> 00:31:51,760
in cardiology or haven't even thought about being clinical trialists.

516
00:31:51,760 --> 00:31:57,000
They just, and being able to expose them to you guys and expose them to the science and

517
00:31:57,000 --> 00:32:01,840
expose them to the importance of having a life of academic relevance.

518
00:32:01,840 --> 00:32:07,040
I say the people that my first half of my life was signatured by just pursuing academic

519
00:32:07,040 --> 00:32:09,240
excellence because that's what I was taught.

520
00:32:09,240 --> 00:32:12,960
But at some point I had to transition from chasing academic excellence and making that

521
00:32:12,960 --> 00:32:18,880
excellence turn into being academically relevant and ultimately looking at just from innovation

522
00:32:18,880 --> 00:32:22,040
to actually having a life of impact.

523
00:32:22,040 --> 00:32:25,040
And when you start putting that in front of these young people, and all of a sudden light

524
00:32:25,040 --> 00:32:28,320
bulbs go on and that's like the most amazing thing to see.

525
00:32:28,320 --> 00:32:32,080
By the way, the wonderful thing about this program is that it's growing in ways, leaps

526
00:32:32,080 --> 00:32:34,840
and bounds that I did not expect, you know, when I came out with this.

527
00:32:34,840 --> 00:32:38,720
I mean, sometimes, you know, some of y'all didn't know that this was supposed to be only

528
00:32:38,720 --> 00:32:41,040
a pilot grant for VCU.

529
00:32:41,040 --> 00:32:42,600
That's how it started.

530
00:32:42,600 --> 00:32:47,680
And then after George Floyd, John DeMonte, who is from Bristol Mines Squibb Foundation,

531
00:32:47,680 --> 00:32:51,680
called me up and said, Dr. Wynn, we need to go big.

532
00:32:51,680 --> 00:32:52,880
And we did.

533
00:32:52,880 --> 00:32:55,880
By the way, that's one of the people you want to talk about a game changer when it comes

534
00:32:55,880 --> 00:33:00,480
in the context of Canton, the context of how foundations can give resources to change the

535
00:33:00,480 --> 00:33:01,480
world.

536
00:33:01,480 --> 00:33:05,720
Before there was a PEPFAR and all the rest of these things, there was a John DeMonte

537
00:33:05,720 --> 00:33:12,080
who got Bristol Mines Squibb Foundation before there was anyone else to actually get into

538
00:33:12,080 --> 00:33:15,840
Africa and give HIV drugs and figure out how to do that.

539
00:33:15,840 --> 00:33:16,840
That was John.

540
00:33:16,840 --> 00:33:22,520
And in fact, there have been several prime ministers who've gotten up and said that John

541
00:33:22,520 --> 00:33:29,360
DeMonte from Bristol Mines Squibb Foundation has saved generations of young Africans because

542
00:33:29,360 --> 00:33:30,360
of his work.

543
00:33:30,360 --> 00:33:33,640
There are men like that that come in your life and people like that, Catherine Grimes,

544
00:33:33,640 --> 00:33:39,120
John DeMonte and others who come into your life who you just sort of say, yo, let's go

545
00:33:39,120 --> 00:33:40,820
do this.

546
00:33:40,820 --> 00:33:47,300
So in addition to having a medical student program, we now have for the Wynn CDA scholars

547
00:33:47,300 --> 00:33:54,800
another three-year program and being part of what we call the cooperative group trials

548
00:33:54,800 --> 00:33:57,280
and cancer cooperative group trials.

549
00:33:57,280 --> 00:34:01,920
Also we have now developing with a group of cardiology within the AHA that there's an

550
00:34:01,920 --> 00:34:05,000
additional three years of additional training.

551
00:34:05,000 --> 00:34:09,200
And we're about to actually play with the concept of we know people are going on a form

552
00:34:09,200 --> 00:34:11,960
of two, how do we give opportunities and exposure to that?

553
00:34:11,960 --> 00:34:18,040
So my job is really just to say we about training the next generation with one caveat that I'm

554
00:34:18,040 --> 00:34:21,240
not just training somebody who just do clinical trials.

555
00:34:21,240 --> 00:34:24,600
We talk in clinical trials plus.

556
00:34:24,600 --> 00:34:30,560
And the plus is how do we get the best, most effective clinical trials and how do we get

557
00:34:30,560 --> 00:34:37,240
the most number of people from diverse backgrounds onto those trials?

558
00:34:37,240 --> 00:34:40,880
And that is a science and that is a skill set.

559
00:34:40,880 --> 00:34:45,320
And that is something that as you guys even perfect, I think that you will be the first

560
00:34:45,320 --> 00:34:51,020
generation of people who will be widely recruited in the context of your ability to do that.

561
00:34:51,020 --> 00:34:52,020
Because you know what?

562
00:34:52,020 --> 00:34:56,280
Turns out the FDA and other people are going to expect big pharma companies and others

563
00:34:56,280 --> 00:34:58,460
to actually have diversity on a clinical trial.

564
00:34:58,460 --> 00:35:03,220
So interesting, it's building the workforce that we are going to need for tomorrow.

565
00:35:03,220 --> 00:35:05,440
That's the best part of this.

566
00:35:05,440 --> 00:35:06,440
That's beautiful.

567
00:35:06,440 --> 00:35:09,000
That's so awesome.

568
00:35:09,000 --> 00:35:11,000
And the innovation of it is awesome.

569
00:35:11,000 --> 00:35:15,800
Actually, as you were talking, I'm like, you're kind of building the bridge as you are like

570
00:35:15,800 --> 00:35:17,800
speeding on it.

571
00:35:17,800 --> 00:35:20,800
But I got y'all.

572
00:35:20,800 --> 00:35:21,800
Y'all make me look good.

573
00:35:21,800 --> 00:35:24,120
Y'all be coming up with these trials.

574
00:35:24,120 --> 00:35:29,120
The other day I saw I was actually one of the scholars was actually doing his work and

575
00:35:29,120 --> 00:35:34,280
he said, and so I automatically had this thing about I wanted to get more African Americans

576
00:35:34,280 --> 00:35:38,000
on it because this trial of prostate cancer until in my head I was doing this protocol.

577
00:35:38,000 --> 00:35:40,880
And so I integrated the protocol with my protocol.

578
00:35:40,880 --> 00:35:45,160
Now I don't show that to you know the drug, but I'm just showing you Dr. Wynn that here's

579
00:35:45,160 --> 00:35:48,200
from the very first step I was like, well, these neighborhoods I've had obstacles and

580
00:35:48,200 --> 00:35:49,840
so this is what I've not needed to do.

581
00:35:49,840 --> 00:35:51,880
And I said, you should write a paper about that.

582
00:35:51,880 --> 00:35:54,640
That is the beauty of what's going down.

583
00:35:54,640 --> 00:35:55,640
Yeah.

584
00:35:55,640 --> 00:35:56,640
Yeah.

585
00:35:56,640 --> 00:35:57,640
Y'all doing it.

586
00:35:57,640 --> 00:36:00,360
You know me, I'm just, you know, I just, you know, I set it up.

587
00:36:00,360 --> 00:36:02,440
I ain't the one, you know, I like Moses.

588
00:36:02,440 --> 00:36:04,440
I ain't going to get to the promised land with y'all.

589
00:36:04,440 --> 00:36:07,960
Y'all gonna get there, but I'm going to be so proud when you do.

590
00:36:07,960 --> 00:36:12,720
And it's, it's what you're speaking to is that just the power of community and all our

591
00:36:12,720 --> 00:36:16,320
different roles, but how important we all are in moving the workforce.

592
00:36:16,320 --> 00:36:17,320
No, it's phenomenal.

593
00:36:17,320 --> 00:36:19,320
I'm telling you it's like Wu-Tang.

594
00:36:19,320 --> 00:36:20,320
It ain't about me.

595
00:36:20,320 --> 00:36:21,320
It's Wu-Tang.

596
00:36:21,320 --> 00:36:22,320
Oh, he talk about all day.

597
00:36:22,320 --> 00:36:28,440
Oh, Dr. Wynn, it's been, it's been such a pleasure talking with you.

598
00:36:28,440 --> 00:36:29,920
We're coming to the end of the show.

599
00:36:29,920 --> 00:36:33,920
And I want to ask you, we've said a lot and then there are things we haven't even talked

600
00:36:33,920 --> 00:36:38,880
about, but you know, just thinking about just wrapping up our conversation.

601
00:36:38,880 --> 00:36:46,280
What is one thing that you feel like is left unsaid that you want to share with our audience?

602
00:36:46,280 --> 00:36:48,880
Drake started from the bottom.

603
00:36:48,880 --> 00:36:49,880
Now we're here.

604
00:36:49,880 --> 00:36:50,880
You know what I'm saying?

605
00:36:50,880 --> 00:36:53,680
He started from the bottom, now the whole crew's here.

606
00:36:53,680 --> 00:36:54,920
Like let's rise.

607
00:36:54,920 --> 00:36:56,240
We turning it up.

608
00:36:56,240 --> 00:36:57,240
Let's make it happen.

609
00:36:57,240 --> 00:37:01,560
And the reality is I ain't worried about a little white noise and all the other stuff

610
00:37:01,560 --> 00:37:02,800
and the distractions.

611
00:37:02,800 --> 00:37:03,920
Let's get focused.

612
00:37:03,920 --> 00:37:04,920
Let's get locked in.

613
00:37:04,920 --> 00:37:09,960
Let's understand that the success that we have is being watched and the success we have

614
00:37:09,960 --> 00:37:12,320
will build on other successes of the future.

615
00:37:12,320 --> 00:37:16,320
And in fact, to do that, one must have courage.

616
00:37:16,320 --> 00:37:19,600
And with courage comes vulnerability and sometimes risk.

617
00:37:19,600 --> 00:37:20,940
But so what?

618
00:37:20,940 --> 00:37:24,960
Because if somebody had to have courage for us to get us this far, somebody had to have

619
00:37:24,960 --> 00:37:28,860
the courage to say something to make sure that our medical schools and our residencies

620
00:37:28,860 --> 00:37:30,400
and our fellowships are better.

621
00:37:30,400 --> 00:37:32,100
Let's continue that courage.

622
00:37:32,100 --> 00:37:33,100
You know what I mean?

623
00:37:33,100 --> 00:37:35,320
Stand up, stand strong, show up.

624
00:37:35,320 --> 00:37:36,320
Let's do it.

625
00:37:36,320 --> 00:37:40,480
Because actually our people in our communities are banking on the fact that we can do this.

626
00:37:40,480 --> 00:37:44,680
So you know, I'm just like, let's get it done.

627
00:37:44,680 --> 00:37:46,600
That's a perfect place to end.

628
00:37:46,600 --> 00:37:49,240
And I feel like you should stand up now and take a bow.

629
00:37:49,240 --> 00:37:54,640
Girl, look, I'm just a little fella trying to do a little something.

630
00:37:54,640 --> 00:37:55,640
So that's all.

631
00:37:55,640 --> 00:37:58,560
Dr. Nguyen, thank you so much for being on the show.

632
00:37:58,560 --> 00:38:00,680
It's been a pleasure to have you.

633
00:38:00,680 --> 00:38:01,680
You know what?

634
00:38:01,680 --> 00:38:02,680
Thank you for having me.

635
00:38:02,680 --> 00:38:06,920
You know, much respect and I'm honored to be on the show and looking forward to the

636
00:38:06,920 --> 00:38:08,720
great things that you're going to do.

637
00:38:08,720 --> 00:38:09,720
Thanks, Dr. Nguyen.

638
00:38:09,720 --> 00:38:10,720
All right, everybody.

639
00:38:10,720 --> 00:38:22,120
We'll see you next time on the Clinician Researcher podcast.

640
00:38:22,120 --> 00:38:27,480
Thanks for listening to this episode of the Clinician Researcher podcast, where academic

641
00:38:27,480 --> 00:38:32,920
clinicians learn the skills to build their own research program, whether or not they

642
00:38:32,920 --> 00:38:34,280
have a mentor.

643
00:38:34,280 --> 00:38:40,240
If you found the information in this episode to be helpful, don't keep it all to yourself.

644
00:38:40,240 --> 00:38:42,120
Someone else needs to hear it.

645
00:38:42,120 --> 00:38:46,160
So take a minute right now and share it.

646
00:38:46,160 --> 00:38:51,640
As you share this episode, you become part of our mission to help launch a new generation

647
00:38:51,640 --> 00:38:57,600
of clinician researchers who make transformative discoveries that change the way we do healthcare.

